Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AYN4_LEIMU

TriTrypDb:

LmxM.26.2530

Length:

503

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005955	calcineurin complex	3	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

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Expansion

Sequence features

E9AYN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYN4

Function

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Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	14
GO:0009987	cellular process	1	14
GO:0019722	calcium-mediated signaling	5	14
GO:0019932	second-messenger-mediated signaling	4	14
GO:0035556	intracellular signal transduction	3	14
GO:0050789	regulation of biological process	2	14
GO:0050794	regulation of cellular process	3	14
GO:0065007	biological regulation	1	14
GO:0097720	calcineurin-mediated signaling	6	14

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004721	phosphoprotein phosphatase activity	3	14
GO:0004722	protein serine/threonine phosphatase activity	4	14
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	5	14
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005516	calmodulin binding	3	12
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	14
GO:0016791	phosphatase activity	5	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.534
CLV_NRD_NRD_1	285	287	PF00675	0.362
CLV_NRD_NRD_1	40	42	PF00675	0.306
CLV_NRD_NRD_1	463	465	PF00675	0.335
CLV_NRD_NRD_1	472	474	PF00675	0.316
CLV_PCSK_KEX2_1	153	155	PF00082	0.337
CLV_PCSK_KEX2_1	197	199	PF00082	0.384
CLV_PCSK_KEX2_1	472	474	PF00082	0.414
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.337
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.384

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y2	Leptomonas seymouri	74%	92%
A0A0N1ILH2	Leptomonas seymouri	39%	100%
A0A0S4IIW0	Bodo saltans	44%	100%
A0A0S4JDD1	Bodo saltans	50%	100%
A0A0S4JKZ6	Bodo saltans	58%	100%
A0A0S4KLF4	Bodo saltans	24%	100%
A0A1X0NMS7	Trypanosomatidae	27%	100%
A0A1X0P6J3	Trypanosomatidae	53%	100%
A0A1X0P6Y9	Trypanosomatidae	33%	100%
A0A1X0P7H9	Trypanosomatidae	58%	100%

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