Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AYN4_LEIMU

TriTrypDb:

LmxM.26.2530

Length:

503

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005955	calcineurin complex	3	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

E9AYN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYN4

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	14
GO:0009987	cellular process	1	14
GO:0019722	calcium-mediated signaling	5	14
GO:0019932	second-messenger-mediated signaling	4	14
GO:0035556	intracellular signal transduction	3	14
GO:0050789	regulation of biological process	2	14
GO:0050794	regulation of cellular process	3	14
GO:0065007	biological regulation	1	14
GO:0097720	calcineurin-mediated signaling	6	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004721	phosphoprotein phosphatase activity	3	14
GO:0004722	protein serine/threonine phosphatase activity	4	14
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	5	14
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005516	calmodulin binding	3	12
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	14
GO:0016791	phosphatase activity	5	14
GO:0017018	myosin phosphatase activity	5	14
GO:0033192	calmodulin-dependent protein phosphatase activity	6	14
GO:0042578	phosphoric ester hydrolase activity	4	14
GO:0140096	catalytic activity, acting on a protein	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.534
CLV_NRD_NRD_1	285	287	PF00675	0.362
CLV_NRD_NRD_1	40	42	PF00675	0.306
CLV_NRD_NRD_1	463	465	PF00675	0.335
CLV_NRD_NRD_1	472	474	PF00675	0.316
CLV_PCSK_KEX2_1	153	155	PF00082	0.337
CLV_PCSK_KEX2_1	197	199	PF00082	0.384
CLV_PCSK_KEX2_1	472	474	PF00082	0.414
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.337
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.384
CLV_PCSK_SKI1_1	102	106	PF00082	0.337
CLV_PCSK_SKI1_1	144	148	PF00082	0.268
CLV_PCSK_SKI1_1	154	158	PF00082	0.244
DEG_APCC_KENBOX_2	260	264	PF00400	0.127
DEG_Nend_Nbox_1	1	3	PF02207	0.635
DEG_SCF_FBW7_1	493	500	PF00400	0.457
DEG_SPOP_SBC_1	18	22	PF00917	0.357
DOC_MAPK_MEF2A_6	112	121	PF00069	0.304
DOC_PP1_RVXF_1	348	355	PF00149	0.211
DOC_PP2B_LxvP_1	238	241	PF13499	0.279
DOC_PP4_FxxP_1	208	211	PF00568	0.279
DOC_PP4_FxxP_1	296	299	PF00568	0.242
DOC_USP7_MATH_1	167	171	PF00917	0.363
DOC_USP7_MATH_1	18	22	PF00917	0.463
DOC_USP7_MATH_1	477	481	PF00917	0.492
DOC_USP7_MATH_1	495	499	PF00917	0.461
DOC_USP7_UBL2_3	283	287	PF12436	0.474
DOC_WW_Pin1_4	190	195	PF00397	0.234
DOC_WW_Pin1_4	383	388	PF00397	0.554
DOC_WW_Pin1_4	429	434	PF00397	0.557
DOC_WW_Pin1_4	473	478	PF00397	0.563
DOC_WW_Pin1_4	487	492	PF00397	0.740
DOC_WW_Pin1_4	493	498	PF00397	0.530
LIG_14-3-3_CanoR_1	144	152	PF00244	0.275
LIG_14-3-3_CanoR_1	198	205	PF00244	0.279
LIG_14-3-3_CanoR_1	245	250	PF00244	0.228
LIG_14-3-3_CanoR_1	322	332	PF00244	0.292
LIG_14-3-3_CanoR_1	418	424	PF00244	0.619
LIG_14-3-3_CanoR_1	487	491	PF00244	0.581
LIG_Actin_WH2_2	181	199	PF00022	0.384
LIG_BRCT_BRCA1_1	21	25	PF00533	0.394
LIG_BRCT_BRCA1_1	342	346	PF00533	0.314
LIG_BRCT_BRCA1_1	416	420	PF00533	0.604
LIG_EH1_1	114	122	PF00400	0.384
LIG_FHA_1	339	345	PF00498	0.388
LIG_FHA_1	464	470	PF00498	0.362
LIG_FHA_1	487	493	PF00498	0.698
LIG_FHA_2	420	426	PF00498	0.490
LIG_FHA_2	430	436	PF00498	0.528
LIG_Integrin_isoDGR_2	470	472	PF01839	0.389
LIG_LIR_Apic_2	219	225	PF02991	0.227
LIG_LIR_Apic_2	341	345	PF02991	0.391
LIG_LIR_Gen_1	170	180	PF02991	0.305
LIG_LIR_Gen_1	417	425	PF02991	0.601
LIG_LIR_Nem_3	147	152	PF02991	0.272
LIG_LIR_Nem_3	170	175	PF02991	0.288
LIG_LIR_Nem_3	277	282	PF02991	0.307
LIG_LIR_Nem_3	417	423	PF02991	0.547
LIG_NRBOX	87	93	PF00104	0.225
LIG_Pex14_1	342	346	PF04695	0.314
LIG_Pex14_2	336	340	PF04695	0.311
LIG_PTB_Apo_2	179	186	PF02174	0.259
LIG_SH2_GRB2like	149	152	PF00017	0.259
LIG_SH2_GRB2like	251	254	PF00017	0.279
LIG_SH2_GRB2like	305	308	PF00017	0.286
LIG_SH2_NCK_1	251	255	PF00017	0.370
LIG_SH2_PTP2	103	106	PF00017	0.279
LIG_SH2_SRC	249	252	PF00017	0.384
LIG_SH2_STAP1	160	164	PF00017	0.247
LIG_SH2_STAP1	251	255	PF00017	0.303
LIG_SH2_STAP1	305	309	PF00017	0.300
LIG_SH2_STAT5	103	106	PF00017	0.230
LIG_SH2_STAT5	109	112	PF00017	0.242
LIG_SH2_STAT5	149	152	PF00017	0.259
LIG_SH2_STAT5	249	252	PF00017	0.317
LIG_SH2_STAT5	301	304	PF00017	0.343
LIG_SH2_STAT5	332	335	PF00017	0.311
LIG_SH3_1	6	12	PF00018	0.576
LIG_SH3_3	444	450	PF00018	0.536
LIG_SH3_3	6	12	PF00018	0.427
LIG_SUMO_SIM_anti_2	118	124	PF11976	0.244
LIG_SUMO_SIM_anti_2	264	270	PF11976	0.404
LIG_SUMO_SIM_anti_2	50	56	PF11976	0.296
LIG_UBA3_1	120	127	PF00899	0.285
MOD_CDK_SPK_2	429	434	PF00069	0.395
MOD_CDK_SPxxK_3	190	197	PF00069	0.244
MOD_CK1_1	394	400	PF00069	0.679
MOD_CK1_1	463	469	PF00069	0.336
MOD_CK2_1	394	400	PF00069	0.512
MOD_CK2_1	419	425	PF00069	0.511
MOD_CK2_1	429	435	PF00069	0.546
MOD_CK2_1	473	479	PF00069	0.663
MOD_Cter_Amidation	470	473	PF01082	0.327
MOD_DYRK1A_RPxSP_1	487	491	PF00069	0.464
MOD_GlcNHglycan	169	172	PF01048	0.337
MOD_GlcNHglycan	21	24	PF01048	0.482
MOD_GlcNHglycan	213	216	PF01048	0.233
MOD_GlcNHglycan	26	30	PF01048	0.512
MOD_GlcNHglycan	296	299	PF01048	0.248
MOD_GlcNHglycan	493	496	PF01048	0.500
MOD_GSK3_1	140	147	PF00069	0.253
MOD_GSK3_1	241	248	PF00069	0.360
MOD_GSK3_1	249	256	PF00069	0.134
MOD_GSK3_1	379	386	PF00069	0.646
MOD_GSK3_1	473	480	PF00069	0.709
MOD_GSK3_1	487	494	PF00069	0.687
MOD_GSK3_1	495	502	PF00069	0.685
MOD_N-GLC_1	241	246	PF02516	0.384
MOD_N-GLC_1	324	329	PF02516	0.354
MOD_N-GLC_2	300	302	PF02516	0.262
MOD_NEK2_1	19	24	PF00069	0.473
MOD_NEK2_1	25	30	PF00069	0.499
MOD_NEK2_1	324	329	PF00069	0.343
MOD_NEK2_1	340	345	PF00069	0.309
MOD_NEK2_1	354	359	PF00069	0.348
MOD_NEK2_1	419	424	PF00069	0.522
MOD_NEK2_1	71	76	PF00069	0.375
MOD_PIKK_1	53	59	PF00454	0.280
MOD_PIKK_1	96	102	PF00454	0.294
MOD_PK_1	465	471	PF00069	0.338
MOD_PKA_1	197	203	PF00069	0.279
MOD_PKA_2	197	203	PF00069	0.279
MOD_PKA_2	414	420	PF00069	0.616
MOD_PKA_2	463	469	PF00069	0.336
MOD_PKA_2	486	492	PF00069	0.463
MOD_Plk_1	324	330	PF00069	0.199
MOD_Plk_1	427	433	PF00069	0.588
MOD_Plk_4	130	136	PF00069	0.340
MOD_Plk_4	245	251	PF00069	0.259
MOD_Plk_4	354	360	PF00069	0.293
MOD_Plk_4	394	400	PF00069	0.481
MOD_Plk_4	50	56	PF00069	0.317
MOD_ProDKin_1	190	196	PF00069	0.234
MOD_ProDKin_1	383	389	PF00069	0.554
MOD_ProDKin_1	429	435	PF00069	0.564
MOD_ProDKin_1	473	479	PF00069	0.575
MOD_ProDKin_1	487	493	PF00069	0.741
MOD_SUMO_for_1	152	155	PF00179	0.279
MOD_SUMO_rev_2	193	199	PF00179	0.279
MOD_SUMO_rev_2	343	352	PF00179	0.355
TRG_DiLeu_BaEn_1	118	123	PF01217	0.279
TRG_DiLeu_BaEn_2	365	371	PF01217	0.380
TRG_ENDOCYTIC_2	103	106	PF00928	0.288
TRG_ENDOCYTIC_2	149	152	PF00928	0.258
TRG_ENDOCYTIC_2	165	168	PF00928	0.156
TRG_NLS_MonoExtC_3	282	287	PF00514	0.222

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y2	Leptomonas seymouri	74%	92%
A0A0N1ILH2	Leptomonas seymouri	39%	100%
A0A0S4IIW0	Bodo saltans	44%	100%
A0A0S4JDD1	Bodo saltans	50%	100%
A0A0S4JKZ6	Bodo saltans	58%	100%
A0A0S4KLF4	Bodo saltans	24%	100%
A0A1X0NMS7	Trypanosomatidae	27%	100%
A0A1X0P6J3	Trypanosomatidae	53%	100%
A0A1X0P6Y9	Trypanosomatidae	33%	100%
A0A1X0P7H9	Trypanosomatidae	58%	100%
A0A1X0P7Q5	Trypanosomatidae	43%	100%
A0A1X0P9R6	Trypanosomatidae	31%	100%
A0A3Q8I8M6	Leishmania donovani	32%	100%
A0A3Q8ID20	Leishmania donovani	90%	100%
A0A3R7M399	Trypanosoma rangeli	31%	100%
A0A3R7MBA3	Trypanosoma rangeli	55%	100%
A0A3S5H6K2	Leishmania donovani	25%	100%
A0A3S5H6T9	Leishmania donovani	35%	100%
A0A3S5H7Q6	Leishmania donovani	36%	100%
A0A3S7XAY3	Leishmania donovani	37%	100%
A0A422N1U7	Trypanosoma rangeli	27%	84%
A0A422N9D5	Trypanosoma rangeli	45%	100%
A4H6S0	Leishmania braziliensis	25%	100%
A4H7Z3	Leishmania braziliensis	34%	100%
A4HF98	Leishmania braziliensis	76%	100%
A4HJQ1	Leishmania braziliensis	36%	100%
A4HP65	Leishmania braziliensis	38%	100%
A4HV49	Leishmania infantum	25%	100%
A4HVT0	Leishmania infantum	32%	100%
A4HWC1	Leishmania infantum	35%	100%
A4I2J0	Leishmania infantum	90%	100%
A4I768	Leishmania infantum	36%	100%
A4IDH0	Leishmania infantum	37%	100%
C9ZM48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZX13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D0A358	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A366	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	79%
E9ANT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AQ21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ASX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B262	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
O42773	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	43%	79%
P14747	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	83%
P16298	Homo sapiens	48%	96%
P20651	Rattus norvegicus	48%	96%
P23287	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	91%
P48452	Bos taurus	48%	97%
P48453	Mus musculus	48%	96%
P48454	Homo sapiens	47%	98%
P48455	Mus musculus	45%	98%
P48456	Drosophila melanogaster	46%	81%
P48457	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	46%	92%
P63328	Mus musculus	48%	97%
P63329	Rattus norvegicus	48%	97%
Q05681	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	48%	90%
Q08209	Homo sapiens	46%	97%
Q0G819	Caenorhabditis elegans	48%	93%
Q12705	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	91%
Q27889	Drosophila melanogaster	46%	88%
Q4Q1M5	Leishmania major	36%	100%
Q4Q5Z8	Leishmania major	36%	100%
Q4Q8T8	Leishmania major	89%	99%
Q4QFG0	Leishmania major	35%	100%
Q4QG03	Leishmania major	31%	100%
Q4QGT8	Leishmania major	25%	100%
Q4WUR1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	48%	94%
Q7YSW8	Dictyostelium discoideum	44%	81%
Q84XU2	Arabidopsis thaliana	35%	93%
Q9FN02	Arabidopsis thaliana	34%	100%
Q9VXF1	Drosophila melanogaster	45%	86%
V5B3V2	Trypanosoma cruzi	52%	100%
V5BBR3	Trypanosoma cruzi	46%	100%
V5BBS3	Trypanosoma cruzi	26%	84%