J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYN3_LEIMU

TriTrypDb:

LmxM.26.2520

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	469	473	PF00656	0.648
CLV_NRD_NRD_1	105	107	PF00675	0.656
CLV_NRD_NRD_1	139	141	PF00675	0.644
CLV_NRD_NRD_1	382	384	PF00675	0.613
CLV_NRD_NRD_1	40	42	PF00675	0.388
CLV_NRD_NRD_1	411	413	PF00675	0.558
CLV_NRD_NRD_1	449	451	PF00675	0.602
CLV_NRD_NRD_1	81	83	PF00675	0.392
CLV_PCSK_FUR_1	275	279	PF00082	0.393
CLV_PCSK_KEX2_1	277	279	PF00082	0.462
CLV_PCSK_KEX2_1	353	355	PF00082	0.495
CLV_PCSK_KEX2_1	40	42	PF00082	0.388
CLV_PCSK_KEX2_1	411	413	PF00082	0.521
CLV_PCSK_KEX2_1	421	423	PF00082	0.610
CLV_PCSK_KEX2_1	449	451	PF00082	0.617
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.462
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.495
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.521
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.610
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.664
CLV_PCSK_SKI1_1	106	110	PF00082	0.654
CLV_PCSK_SKI1_1	124	128	PF00082	0.641
CLV_PCSK_SKI1_1	353	357	PF00082	0.504
CLV_PCSK_SKI1_1	394	398	PF00082	0.677
CLV_PCSK_SKI1_1	402	406	PF00082	0.698
CLV_PCSK_SKI1_1	413	417	PF00082	0.458
CLV_PCSK_SKI1_1	8	12	PF00082	0.490
DEG_MDM2_SWIB_1	227	235	PF02201	0.412
DEG_Nend_UBRbox_2	1	3	PF02207	0.398
DOC_ANK_TNKS_1	142	149	PF00023	0.537
DOC_ANK_TNKS_1	359	366	PF00023	0.351
DOC_CKS1_1	29	34	PF01111	0.462
DOC_CKS1_1	426	431	PF01111	0.535
DOC_MAPK_FxFP_2	280	283	PF00069	0.337
DOC_MAPK_gen_1	233	241	PF00069	0.414
DOC_MAPK_gen_1	40	46	PF00069	0.384
DOC_PP4_FxxP_1	280	283	PF00568	0.337
DOC_PP4_FxxP_1	76	79	PF00568	0.439
DOC_USP7_MATH_1	120	124	PF00917	0.750
DOC_USP7_MATH_1	184	188	PF00917	0.458
DOC_USP7_MATH_1	254	258	PF00917	0.416
DOC_USP7_MATH_1	39	43	PF00917	0.423
DOC_USP7_MATH_1	398	402	PF00917	0.538
DOC_USP7_MATH_1	473	477	PF00917	0.679
DOC_USP7_UBL2_3	124	128	PF12436	0.641
DOC_USP7_UBL2_3	405	409	PF12436	0.760
DOC_WW_Pin1_4	112	117	PF00397	0.563
DOC_WW_Pin1_4	188	193	PF00397	0.575
DOC_WW_Pin1_4	28	33	PF00397	0.452
DOC_WW_Pin1_4	367	372	PF00397	0.538
DOC_WW_Pin1_4	404	409	PF00397	0.658
DOC_WW_Pin1_4	413	418	PF00397	0.673
DOC_WW_Pin1_4	425	430	PF00397	0.572
LIG_14-3-3_CanoR_1	221	227	PF00244	0.498
LIG_14-3-3_CanoR_1	383	391	PF00244	0.616
LIG_14-3-3_CanoR_1	40	44	PF00244	0.594
LIG_14-3-3_CanoR_1	402	408	PF00244	0.469
LIG_14-3-3_CanoR_1	412	420	PF00244	0.536
LIG_14-3-3_CanoR_1	452	459	PF00244	0.619
LIG_BRCT_BRCA1_1	256	260	PF00533	0.427
LIG_FHA_1	414	420	PF00498	0.689
LIG_FHA_2	156	162	PF00498	0.603
LIG_FHA_2	180	186	PF00498	0.459
LIG_LIR_Apic_2	74	79	PF02991	0.439
LIG_LIR_Gen_1	171	180	PF02991	0.489
LIG_LIR_Gen_1	42	50	PF02991	0.433
LIG_LIR_Gen_1	63	73	PF02991	0.350
LIG_LIR_Nem_3	171	177	PF02991	0.491
LIG_LIR_Nem_3	265	270	PF02991	0.430
LIG_LIR_Nem_3	42	46	PF02991	0.437
LIG_LIR_Nem_3	63	69	PF02991	0.351
LIG_LIR_Nem_3	71	76	PF02991	0.352
LIG_LYPXL_SIV_4	283	291	PF13949	0.332
LIG_Pex14_2	227	231	PF04695	0.416
LIG_SH2_CRK	267	271	PF00017	0.448
LIG_SH2_CRK	43	47	PF00017	0.408
LIG_SH2_NCK_1	267	271	PF00017	0.419
LIG_SH2_SRC	485	488	PF00017	0.609
LIG_SH2_STAP1	224	228	PF00017	0.347
LIG_SH2_STAP1	262	266	PF00017	0.353
LIG_SH3_3	110	116	PF00018	0.516
LIG_SH3_3	204	210	PF00018	0.383
LIG_SH3_3	26	32	PF00018	0.419
LIG_SH3_3	280	286	PF00018	0.315
LIG_SH3_4	409	416	PF00018	0.536
LIG_TRAF2_1	330	333	PF00917	0.435
LIG_TRAF2_1	460	463	PF00917	0.563
LIG_WW_3	389	393	PF00397	0.483
MOD_CDK_SPK_2	112	117	PF00069	0.473
MOD_CDK_SPK_2	404	409	PF00069	0.608
MOD_CDK_SPK_2	425	430	PF00069	0.534
MOD_CDK_SPxxK_3	112	119	PF00069	0.478
MOD_CDK_SPxxK_3	404	411	PF00069	0.601
MOD_CDK_SPxxK_3	425	432	PF00069	0.492
MOD_CK1_1	115	121	PF00069	0.590
MOD_CK1_1	131	137	PF00069	0.680
MOD_CK1_1	142	148	PF00069	0.470
MOD_CK1_1	164	170	PF00069	0.568
MOD_CK1_1	457	463	PF00069	0.632
MOD_CK1_1	476	482	PF00069	0.472
MOD_CK2_1	149	155	PF00069	0.656
MOD_CK2_1	179	185	PF00069	0.464
MOD_CK2_1	211	217	PF00069	0.507
MOD_CK2_1	307	313	PF00069	0.551
MOD_CK2_1	457	463	PF00069	0.596
MOD_CK2_1	464	470	PF00069	0.589
MOD_CK2_1	476	482	PF00069	0.495
MOD_CK2_1	68	74	PF00069	0.311
MOD_CK2_1	90	96	PF00069	0.497
MOD_Cter_Amidation	104	107	PF01082	0.608
MOD_Cter_Amidation	231	234	PF01082	0.356
MOD_Cter_Amidation	440	443	PF01082	0.721
MOD_GlcNHglycan	120	123	PF01048	0.720
MOD_GlcNHglycan	133	136	PF01048	0.510
MOD_GlcNHglycan	165	169	PF01048	0.668
MOD_GlcNHglycan	256	259	PF01048	0.432
MOD_GlcNHglycan	422	425	PF01048	0.768
MOD_GlcNHglycan	444	447	PF01048	0.587
MOD_GlcNHglycan	466	469	PF01048	0.531
MOD_GlcNHglycan	70	73	PF01048	0.320
MOD_GSK3_1	111	118	PF00069	0.715
MOD_GSK3_1	149	156	PF00069	0.626
MOD_GSK3_1	184	191	PF00069	0.497
MOD_GSK3_1	262	269	PF00069	0.387
MOD_GSK3_1	375	382	PF00069	0.524
MOD_GSK3_1	462	469	PF00069	0.622
MOD_GSK3_1	472	479	PF00069	0.678
MOD_GSK3_1	90	97	PF00069	0.501
MOD_LATS_1	352	358	PF00433	0.482
MOD_N-GLC_1	188	193	PF02516	0.636
MOD_NEK2_1	266	271	PF00069	0.446
MOD_NEK2_1	338	343	PF00069	0.449
MOD_NEK2_1	374	379	PF00069	0.588
MOD_NEK2_2	222	227	PF00069	0.444
MOD_NEK2_2	262	267	PF00069	0.346
MOD_PIKK_1	285	291	PF00454	0.359
MOD_PKA_1	383	389	PF00069	0.611
MOD_PKA_1	411	417	PF00069	0.584
MOD_PKA_1	442	448	PF00069	0.675
MOD_PKA_1	91	97	PF00069	0.439
MOD_PKA_2	118	124	PF00069	0.677
MOD_PKA_2	139	145	PF00069	0.525
MOD_PKA_2	379	385	PF00069	0.658
MOD_PKA_2	39	45	PF00069	0.449
MOD_PKA_2	411	417	PF00069	0.612
MOD_PKB_1	450	458	PF00069	0.629
MOD_Plk_1	262	268	PF00069	0.351
MOD_Plk_1	462	468	PF00069	0.653
MOD_Plk_1	476	482	PF00069	0.692
MOD_Plk_2-3	149	155	PF00069	0.611
MOD_Plk_4	222	228	PF00069	0.357
MOD_Plk_4	262	268	PF00069	0.351
MOD_Plk_4	6	12	PF00069	0.380
MOD_ProDKin_1	112	118	PF00069	0.566
MOD_ProDKin_1	188	194	PF00069	0.574
MOD_ProDKin_1	28	34	PF00069	0.447
MOD_ProDKin_1	367	373	PF00069	0.542
MOD_ProDKin_1	404	410	PF00069	0.655
MOD_ProDKin_1	413	419	PF00069	0.670
MOD_ProDKin_1	425	431	PF00069	0.573
MOD_SUMO_rev_2	164	173	PF00179	0.512
MOD_SUMO_rev_2	74	81	PF00179	0.466
TRG_DiLeu_BaEn_1	333	338	PF01217	0.400
TRG_DiLeu_BaEn_4	345	351	PF01217	0.432
TRG_DiLeu_BaEn_4	461	467	PF01217	0.479
TRG_ENDOCYTIC_2	224	227	PF00928	0.346
TRG_ENDOCYTIC_2	267	270	PF00928	0.428
TRG_ENDOCYTIC_2	284	287	PF00928	0.239
TRG_ENDOCYTIC_2	43	46	PF00928	0.381
TRG_NLS_Bipartite_1	127	144	PF00514	0.579
TRG_NLS_Bipartite_1	91	110	PF00514	0.550
TRG_NLS_MonoCore_2	448	453	PF00514	0.630
TRG_NLS_MonoExtC_3	449	454	PF00514	0.643
TRG_NLS_MonoExtN_4	137	144	PF00514	0.701
TRG_NLS_MonoExtN_4	408	415	PF00514	0.519
TRG_NLS_MonoExtN_4	447	454	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P789	Trypanosomatidae	42%	100%
A0A3R7KYR3	Trypanosoma rangeli	41%	100%
A0A3S7X087	Leishmania donovani	87%	100%
A4HF97	Leishmania braziliensis	69%	95%
A4I2I9	Leishmania infantum	87%	100%
C9ZX14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q8T9	Leishmania major	88%	100%