Protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AYN2_LEIMU

TriTrypDb:

LmxM.26.2510

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYN2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	14
GO:0006793	phosphorus metabolic process	3	14
GO:0006796	phosphate-containing compound metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016310	phosphorylation	5	14
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004672	protein kinase activity	3	14
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0016301	kinase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140096	catalytic activity, acting on a protein	2	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	228	230	PF00675	0.325
CLV_NRD_NRD_1	29	31	PF00675	0.315
CLV_NRD_NRD_1	33	35	PF00675	0.312
CLV_NRD_NRD_1	370	372	PF00675	0.324
CLV_NRD_NRD_1	68	70	PF00675	0.238
CLV_PCSK_FUR_1	30	34	PF00082	0.209
CLV_PCSK_KEX2_1	166	168	PF00082	0.313
CLV_PCSK_KEX2_1	228	230	PF00082	0.317
CLV_PCSK_KEX2_1	29	31	PF00082	0.356
CLV_PCSK_KEX2_1	32	34	PF00082	0.362
CLV_PCSK_KEX2_1	370	372	PF00082	0.285
CLV_PCSK_KEX2_1	64	66	PF00082	0.338
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.308
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.255
CLV_PCSK_PC7_1	29	35	PF00082	0.381
CLV_PCSK_SKI1_1	106	110	PF00082	0.431
CLV_PCSK_SKI1_1	167	171	PF00082	0.303
CLV_PCSK_SKI1_1	269	273	PF00082	0.254
CLV_PCSK_SKI1_1	431	435	PF00082	0.542
CLV_PCSK_SKI1_1	65	69	PF00082	0.234
DEG_APCC_DBOX_1	166	174	PF00400	0.248
DEG_APCC_DBOX_1	211	219	PF00400	0.381
DEG_APCC_DBOX_1	72	80	PF00400	0.351
DEG_APCC_KENBOX_2	408	412	PF00400	0.263
DEG_Nend_UBRbox_2	1	3	PF02207	0.645
DOC_CKS1_1	10	15	PF01111	0.511
DOC_CKS1_1	102	107	PF01111	0.494
DOC_CKS1_1	282	287	PF01111	0.381
DOC_CKS1_1	466	471	PF01111	0.560
DOC_MAPK_gen_1	269	278	PF00069	0.268
DOC_MAPK_gen_1	69	80	PF00069	0.180
DOC_MAPK_MEF2A_6	212	219	PF00069	0.381
DOC_MAPK_MEF2A_6	73	80	PF00069	0.301
DOC_USP7_MATH_1	320	324	PF00917	0.262
DOC_USP7_MATH_1	356	360	PF00917	0.263
DOC_USP7_UBL2_3	171	175	PF12436	0.270
DOC_WW_Pin1_4	101	106	PF00397	0.512
DOC_WW_Pin1_4	281	286	PF00397	0.381
DOC_WW_Pin1_4	465	470	PF00397	0.508
DOC_WW_Pin1_4	9	14	PF00397	0.516
DOC_WW_Pin1_4	91	96	PF00397	0.466
LIG_14-3-3_CanoR_1	479	483	PF00244	0.561
LIG_14-3-3_CanoR_1	81	85	PF00244	0.533
LIG_APCC_ABBAyCdc20_2	264	270	PF00400	0.223
LIG_BRCT_BRCA1_1	20	24	PF00533	0.198
LIG_BRCT_BRCA1_1	358	362	PF00533	0.267
LIG_BRCT_BRCA1_2	358	364	PF00533	0.263
LIG_EH_1	410	414	PF12763	0.230
LIG_FHA_1	107	113	PF00498	0.473
LIG_FHA_1	282	288	PF00498	0.360
LIG_FHA_1	374	380	PF00498	0.453
LIG_FHA_1	416	422	PF00498	0.371
LIG_FHA_1	5	11	PF00498	0.706
LIG_FHA_2	209	215	PF00498	0.372
LIG_FHA_2	437	443	PF00498	0.607
LIG_Integrin_isoDGR_2	85	87	PF01839	0.321
LIG_LIR_Apic_2	101	105	PF02991	0.474
LIG_LIR_Apic_2	279	285	PF02991	0.381
LIG_LIR_Apic_2	309	315	PF02991	0.268
LIG_LIR_Gen_1	359	369	PF02991	0.366
LIG_LIR_Gen_1	404	413	PF02991	0.429
LIG_LIR_Gen_1	442	451	PF02991	0.494
LIG_LIR_Gen_1	94	103	PF02991	0.375
LIG_LIR_Nem_3	150	154	PF02991	0.390
LIG_LIR_Nem_3	300	306	PF02991	0.398
LIG_LIR_Nem_3	404	408	PF02991	0.433
LIG_LIR_Nem_3	442	446	PF02991	0.482
LIG_LIR_Nem_3	94	99	PF02991	0.388
LIG_MAD2	192	200	PF02301	0.255
LIG_PDZ_Class_2	480	485	PF00595	0.656
LIG_Pex14_1	472	476	PF04695	0.579
LIG_Pex14_2	151	155	PF04695	0.351
LIG_Pex14_2	35	39	PF04695	0.292
LIG_Pex14_2	80	84	PF04695	0.490
LIG_SH2_CRK	130	134	PF00017	0.461
LIG_SH2_CRK	282	286	PF00017	0.327
LIG_SH2_CRK	405	409	PF00017	0.263
LIG_SH2_NCK_1	130	134	PF00017	0.435
LIG_SH2_NCK_1	312	316	PF00017	0.327
LIG_SH2_NCK_1	397	401	PF00017	0.263
LIG_SH2_SRC	397	400	PF00017	0.253
LIG_SH2_STAP1	181	185	PF00017	0.302
LIG_SH2_STAT3	63	66	PF00017	0.263
LIG_SH2_STAT5	102	105	PF00017	0.526
LIG_SH2_STAT5	181	184	PF00017	0.381
LIG_SH2_STAT5	259	262	PF00017	0.268
LIG_SH2_STAT5	304	307	PF00017	0.317
LIG_SH2_STAT5	349	352	PF00017	0.350
LIG_SH2_STAT5	476	479	PF00017	0.566
LIG_SH2_STAT5	52	55	PF00017	0.368
LIG_SH3_3	194	200	PF00018	0.263
LIG_SH3_3	459	465	PF00018	0.711
LIG_SUMO_SIM_anti_2	213	220	PF11976	0.292
LIG_SUMO_SIM_par_1	213	220	PF11976	0.237
LIG_TRAF2_1	240	243	PF00917	0.230
LIG_TRAF2_2	399	404	PF00917	0.263
LIG_TYR_ITIM	346	351	PF00017	0.281
LIG_UBA3_1	169	175	PF00899	0.263
LIG_WRC_WIRS_1	137	142	PF05994	0.356
MOD_CDK_SPK_2	101	106	PF00069	0.499
MOD_CDK_SPxK_1	465	471	PF00069	0.601
MOD_CK1_1	101	107	PF00069	0.400
MOD_CK1_1	114	120	PF00069	0.327
MOD_CK1_1	174	180	PF00069	0.311
MOD_CK1_1	3	9	PF00069	0.467
MOD_CK2_1	436	442	PF00069	0.561
MOD_Cter_Amidation	27	30	PF01082	0.381
MOD_GlcNHglycan	158	163	PF01048	0.396
MOD_GlcNHglycan	26	29	PF01048	0.320
MOD_GlcNHglycan	278	281	PF01048	0.405
MOD_GlcNHglycan	322	325	PF01048	0.193
MOD_GlcNHglycan	351	354	PF01048	0.267
MOD_GSK3_1	276	283	PF00069	0.248
MOD_GSK3_1	442	449	PF00069	0.621
MOD_GSK3_1	87	94	PF00069	0.312
MOD_N-GLC_1	177	182	PF02516	0.381
MOD_N-GLC_2	72	74	PF02516	0.234
MOD_NEK2_1	1	6	PF00069	0.720
MOD_NEK2_1	111	116	PF00069	0.389
MOD_NEK2_1	129	134	PF00069	0.293
MOD_NEK2_1	179	184	PF00069	0.299
MOD_NEK2_1	24	29	PF00069	0.316
MOD_NEK2_1	415	420	PF00069	0.486
MOD_NEK2_1	80	85	PF00069	0.523
MOD_NEK2_2	331	336	PF00069	0.381
MOD_NEK2_2	58	63	PF00069	0.361
MOD_PKA_2	147	153	PF00069	0.381
MOD_PKA_2	4	10	PF00069	0.436
MOD_PKA_2	478	484	PF00069	0.629
MOD_PKA_2	80	86	PF00069	0.584
MOD_Plk_1	177	183	PF00069	0.398
MOD_Plk_2-3	442	448	PF00069	0.503
MOD_Plk_4	114	120	PF00069	0.514
MOD_Plk_4	136	142	PF00069	0.309
MOD_Plk_4	150	156	PF00069	0.223
MOD_Plk_4	58	64	PF00069	0.361
MOD_ProDKin_1	101	107	PF00069	0.509
MOD_ProDKin_1	281	287	PF00069	0.381
MOD_ProDKin_1	465	471	PF00069	0.508
MOD_ProDKin_1	9	15	PF00069	0.512
MOD_ProDKin_1	91	97	PF00069	0.468
MOD_SUMO_for_1	155	158	PF00179	0.263
MOD_SUMO_rev_2	158	168	PF00179	0.230
MOD_SUMO_rev_2	323	331	PF00179	0.138
TRG_DiLeu_BaEn_1	459	464	PF01217	0.543
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.516
TRG_ENDOCYTIC_2	130	133	PF00928	0.314
TRG_ENDOCYTIC_2	348	351	PF00928	0.303
TRG_ENDOCYTIC_2	405	408	PF00928	0.263
TRG_ER_diArg_1	29	32	PF00400	0.367
TRG_ER_diArg_1	33	35	PF00400	0.393
TRG_ER_diArg_1	369	371	PF00400	0.320
TRG_ER_diArg_1	73	76	PF00400	0.271
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K3	Leptomonas seymouri	66%	100%
A0A0N1PEW4	Leptomonas seymouri	28%	79%
A0A0S4JH92	Bodo saltans	39%	98%
A0A0S4JPZ7	Bodo saltans	26%	100%
A0A0S4JQP0	Bodo saltans	43%	99%
A0A0S4KKJ1	Bodo saltans	23%	77%
A0A1X0P834	Trypanosomatidae	46%	100%
A0A3Q8IHA5	Leishmania donovani	96%	100%
A0A3R7MPF2	Trypanosoma rangeli	25%	75%
A0A3S5H5G0	Leishmania donovani	27%	100%
A0A422N3U8	Trypanosoma rangeli	27%	67%
A0A422NYI3	Trypanosoma rangeli	27%	76%
A0A422P3P9	Trypanosoma rangeli	49%	98%
A0AAR7	Lotus japonicus	25%	94%
A4H459	Leishmania braziliensis	28%	100%
A4H8C4	Leishmania braziliensis	28%	100%
A4HCE6	Leishmania braziliensis	24%	100%
A4HF96	Leishmania braziliensis	90%	100%
A4HP12	Leishmania braziliensis	27%	95%
A4HSE2	Leishmania infantum	27%	100%
A4I2I8	Leishmania infantum	96%	100%
C9ZPX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZQL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	76%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZUU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	74%
C9ZX15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O94547	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	84%
O96017	Homo sapiens	28%	89%
P28867	Mus musculus	26%	72%
Q0VD22	Bos taurus	28%	100%
Q4Q5T9	Leishmania major	28%	100%
Q4Q8U0	Leishmania major	95%	100%
Q4QBQ2	Leishmania major	25%	100%
Q4QJJ0	Leishmania major	27%	100%
Q60823	Mus musculus	27%	100%
Q6IP76	Xenopus laevis	26%	100%
Q8MYF1	Dictyostelium discoideum	26%	100%
Q9CAH1	Arabidopsis thaliana	26%	100%
Q9FZ36	Arabidopsis thaliana	25%	75%
Q9SIQ7	Arabidopsis thaliana	27%	83%
Q9SN43	Arabidopsis thaliana	26%	99%
Q9ZSA2	Arabidopsis thaliana	27%	91%
V5B871	Trypanosoma cruzi	27%	100%
V5BC57	Trypanosoma cruzi	48%	98%
V5BHW8	Trypanosoma cruzi	26%	76%