Stc1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYM8_LEIMU

TriTrypDb:

LmxM.26.2470

Length:

122

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYM8

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	1
GO:0005198	structural molecule activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.502
CLV_PCSK_KEX2_1	11	13	PF00082	0.627
CLV_PCSK_KEX2_1	32	34	PF00082	0.592
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.646
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.642
DEG_APCC_KENBOX_2	79	83	PF00400	0.289
DEG_Nend_Nbox_1	1	3	PF02207	0.607
DOC_CDC14_PxL_1	84	92	PF14671	0.478
DOC_MAPK_FxFP_2	85	88	PF00069	0.456
DOC_PP1_RVXF_1	10	17	PF00149	0.417
DOC_PP4_FxxP_1	85	88	PF00568	0.456
DOC_USP7_MATH_1	57	61	PF00917	0.544
LIG_14-3-3_CanoR_1	15	25	PF00244	0.307
LIG_14-3-3_CanoR_1	58	68	PF00244	0.530
LIG_BRCT_BRCA1_1	26	30	PF00533	0.546
LIG_BRCT_BRCA1_2	26	32	PF00533	0.609
LIG_FHA_1	2	8	PF00498	0.549
LIG_FHA_1	20	26	PF00498	0.531
LIG_LIR_Nem_3	81	87	PF02991	0.446
LIG_LYPXL_yS_3	87	90	PF13949	0.464
LIG_PCNA_yPIPBox_3	32	41	PF02747	0.544
LIG_Pex14_2	2	6	PF04695	0.646
LIG_SH2_STAT5	84	87	PF00017	0.445
LIG_SH3_3	51	57	PF00018	0.279
MOD_CK1_1	19	25	PF00069	0.485
MOD_CK1_1	59	65	PF00069	0.563
MOD_CK2_1	95	101	PF00069	0.565
MOD_GSK3_1	57	64	PF00069	0.551
MOD_N-GLC_2	67	69	PF02516	0.567
MOD_NEK2_1	1	6	PF00069	0.559
MOD_NEK2_1	16	21	PF00069	0.354
MOD_NEK2_1	61	66	PF00069	0.522
MOD_NEK2_1	7	12	PF00069	0.533
MOD_PIKK_1	16	22	PF00454	0.273
MOD_PKA_2	16	22	PF00069	0.410
MOD_PKA_2	57	63	PF00069	0.569
MOD_Plk_4	36	42	PF00069	0.447
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.433
TRG_ENDOCYTIC_2	87	90	PF00928	0.442
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZX2	Leptomonas seymouri	75%	90%
A0A1X0P889	Trypanosomatidae	56%	100%
A0A3S5H7G9	Leishmania donovani	85%	100%
A0A422P3V1	Trypanosoma rangeli	55%	100%
A4HF92	Leishmania braziliensis	80%	100%
A4I2H4	Leishmania infantum	84%	100%
C9ZX20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	94%
Q4Q8U4	Leishmania major	87%	100%