Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYM7_LEIMU

TriTrypDb:

LmxM.26.2460

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AYM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.496
CLV_NRD_NRD_1	173	175	PF00675	0.588
CLV_NRD_NRD_1	209	211	PF00675	0.666
CLV_NRD_NRD_1	283	285	PF00675	0.721
CLV_NRD_NRD_1	381	383	PF00675	0.625
CLV_NRD_NRD_1	5	7	PF00675	0.520
CLV_PCSK_KEX2_1	16	18	PF00082	0.496
CLV_PCSK_KEX2_1	170	172	PF00082	0.631
CLV_PCSK_KEX2_1	175	177	PF00082	0.647
CLV_PCSK_KEX2_1	209	211	PF00082	0.619
CLV_PCSK_KEX2_1	283	285	PF00082	0.716
CLV_PCSK_KEX2_1	5	7	PF00082	0.520
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.591
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.628
CLV_PCSK_PC7_1	171	177	PF00082	0.593
CLV_PCSK_SKI1_1	170	174	PF00082	0.479
CLV_PCSK_SKI1_1	209	213	PF00082	0.568
CLV_PCSK_SKI1_1	219	223	PF00082	0.635
CLV_PCSK_SKI1_1	326	330	PF00082	0.627
CLV_PCSK_SKI1_1	6	10	PF00082	0.528
DEG_COP1_1	401	409	PF00400	0.392
DEG_Nend_Nbox_1	1	3	PF02207	0.658
DEG_SPOP_SBC_1	22	26	PF00917	0.773
DOC_CKS1_1	40	45	PF01111	0.591
DOC_MAPK_FxFP_2	159	162	PF00069	0.483
DOC_MAPK_gen_1	16	22	PF00069	0.740
DOC_MAPK_gen_1	170	181	PF00069	0.417
DOC_MAPK_gen_1	253	261	PF00069	0.547
DOC_MAPK_gen_1	421	430	PF00069	0.315
DOC_MAPK_gen_1	5	11	PF00069	0.700
DOC_MAPK_MEF2A_6	116	125	PF00069	0.542
DOC_MAPK_MEF2A_6	253	261	PF00069	0.377
DOC_PP4_FxxP_1	159	162	PF00568	0.483
DOC_PP4_FxxP_1	199	202	PF00568	0.440
DOC_PP4_FxxP_1	37	40	PF00568	0.599
DOC_USP7_MATH_1	376	380	PF00917	0.357
DOC_USP7_MATH_1	55	59	PF00917	0.742
DOC_WW_Pin1_4	148	153	PF00397	0.507
DOC_WW_Pin1_4	297	302	PF00397	0.451
DOC_WW_Pin1_4	317	322	PF00397	0.550
DOC_WW_Pin1_4	36	41	PF00397	0.752
LIG_14-3-3_CanoR_1	116	122	PF00244	0.643
LIG_14-3-3_CanoR_1	154	158	PF00244	0.477
LIG_14-3-3_CanoR_1	16	22	PF00244	0.712
LIG_14-3-3_CanoR_1	174	180	PF00244	0.256
LIG_14-3-3_CanoR_1	291	301	PF00244	0.546
LIG_14-3-3_CanoR_1	330	334	PF00244	0.403
LIG_14-3-3_CanoR_1	47	56	PF00244	0.733
LIG_Actin_WH2_2	320	338	PF00022	0.279
LIG_Actin_WH2_2	368	384	PF00022	0.446
LIG_ActinCP_TwfCPI_2	199	209	PF01115	0.400
LIG_BRCT_BRCA1_1	155	159	PF00533	0.525
LIG_BRCT_BRCA1_1	23	27	PF00533	0.674
LIG_BRCT_BRCA1_1	49	53	PF00533	0.591
LIG_Clathr_ClatBox_1	230	234	PF01394	0.463
LIG_EVH1_2	257	261	PF00568	0.380
LIG_FHA_1	120	126	PF00498	0.399
LIG_FHA_1	141	147	PF00498	0.400
LIG_FHA_1	176	182	PF00498	0.471
LIG_FHA_1	225	231	PF00498	0.425
LIG_FHA_1	323	329	PF00498	0.487
LIG_FHA_1	401	407	PF00498	0.426
LIG_FHA_1	59	65	PF00498	0.700
LIG_FHA_2	311	317	PF00498	0.563
LIG_FHA_2	399	405	PF00498	0.477
LIG_LIR_Apic_2	156	162	PF02991	0.503
LIG_LIR_Apic_2	197	202	PF02991	0.374
LIG_LIR_Apic_2	36	40	PF02991	0.601
LIG_LIR_Gen_1	140	150	PF02991	0.445
LIG_LIR_Gen_1	349	358	PF02991	0.456
LIG_LIR_Gen_1	414	424	PF02991	0.401
LIG_LIR_Gen_1	97	107	PF02991	0.657
LIG_LIR_Nem_3	140	145	PF02991	0.439
LIG_LIR_Nem_3	156	161	PF02991	0.390
LIG_LIR_Nem_3	349	353	PF02991	0.439
LIG_LIR_Nem_3	414	420	PF02991	0.394
LIG_LIR_Nem_3	97	102	PF02991	0.629
LIG_MLH1_MIPbox_1	155	159	PF16413	0.525
LIG_PCNA_yPIPBox_3	209	221	PF02747	0.424
LIG_PCNA_yPIPBox_3	373	385	PF02747	0.359
LIG_PDZ_Class_1	433	438	PF00595	0.296
LIG_SH2_CRK	142	146	PF00017	0.449
LIG_SH2_CRK	99	103	PF00017	0.656
LIG_SH2_NCK_1	99	103	PF00017	0.597
LIG_SH2_STAP1	142	146	PF00017	0.406
LIG_SH2_STAP1	177	181	PF00017	0.335
LIG_SH2_STAP1	350	354	PF00017	0.364
LIG_SH2_STAP1	367	371	PF00017	0.454
LIG_SH2_STAP1	385	389	PF00017	0.299
LIG_SH2_STAP1	431	435	PF00017	0.418
LIG_SH2_STAT5	124	127	PF00017	0.448
LIG_SH2_STAT5	134	137	PF00017	0.318
LIG_SH2_STAT5	138	141	PF00017	0.363
LIG_SH2_STAT5	142	145	PF00017	0.264
LIG_SH2_STAT5	177	180	PF00017	0.338
LIG_SH2_STAT5	223	226	PF00017	0.363
LIG_SH2_STAT5	433	436	PF00017	0.448
LIG_SH3_2	321	326	PF14604	0.518
LIG_SH3_3	179	185	PF00018	0.315
LIG_SH3_3	318	324	PF00018	0.551
LIG_SH3_3	37	43	PF00018	0.652
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.456
LIG_SUMO_SIM_par_1	227	234	PF11976	0.390
LIG_TYR_ITSM	138	145	PF00017	0.508
MOD_CDC14_SPxK_1	151	154	PF00782	0.521
MOD_CDK_SPK_2	297	302	PF00069	0.398
MOD_CDK_SPxK_1	148	154	PF00069	0.512
MOD_CK1_1	21	27	PF00069	0.714
MOD_CK1_1	277	283	PF00069	0.561
MOD_CK1_1	300	306	PF00069	0.542
MOD_CK1_1	38	44	PF00069	0.689
MOD_CK1_1	58	64	PF00069	0.549
MOD_CK2_1	310	316	PF00069	0.538
MOD_CK2_1	398	404	PF00069	0.485
MOD_CMANNOS	286	289	PF00535	0.716
MOD_GlcNHglycan	107	110	PF01048	0.552
MOD_GlcNHglycan	27	30	PF01048	0.501
MOD_GlcNHglycan	304	307	PF01048	0.697
MOD_GlcNHglycan	378	381	PF01048	0.686
MOD_GlcNHglycan	395	398	PF01048	0.529
MOD_GSK3_1	140	147	PF00069	0.361
MOD_GSK3_1	18	25	PF00069	0.766
MOD_GSK3_1	274	281	PF00069	0.533
MOD_GSK3_1	300	307	PF00069	0.543
MOD_GSK3_1	35	42	PF00069	0.650
MOD_N-GLC_1	148	153	PF02516	0.707
MOD_N-GLC_1	47	52	PF02516	0.393
MOD_N-GLC_1	77	82	PF02516	0.412
MOD_NEK2_1	105	110	PF00069	0.702
MOD_NEK2_1	126	131	PF00069	0.367
MOD_NEK2_1	329	334	PF00069	0.383
MOD_NEK2_1	335	340	PF00069	0.435
MOD_NEK2_2	119	124	PF00069	0.447
MOD_NEK2_2	89	94	PF00069	0.728
MOD_PIKK_1	278	284	PF00454	0.580
MOD_PKA_1	170	176	PF00069	0.475
MOD_PKA_2	15	21	PF00069	0.745
MOD_PKA_2	153	159	PF00069	0.492
MOD_PKA_2	170	176	PF00069	0.325
MOD_PKA_2	329	335	PF00069	0.430
MOD_Plk_1	89	95	PF00069	0.585
MOD_Plk_2-3	398	404	PF00069	0.415
MOD_Plk_4	119	125	PF00069	0.485
MOD_Plk_4	140	146	PF00069	0.381
MOD_Plk_4	153	159	PF00069	0.456
MOD_Plk_4	226	232	PF00069	0.350
MOD_Plk_4	97	103	PF00069	0.593
MOD_ProDKin_1	148	154	PF00069	0.512
MOD_ProDKin_1	297	303	PF00069	0.452
MOD_ProDKin_1	317	323	PF00069	0.542
MOD_ProDKin_1	36	42	PF00069	0.751
TRG_DiLeu_BaEn_1	208	213	PF01217	0.268
TRG_DiLeu_BaEn_1	97	102	PF01217	0.546
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.277
TRG_ENDOCYTIC_2	142	145	PF00928	0.452
TRG_ENDOCYTIC_2	242	245	PF00928	0.453
TRG_ENDOCYTIC_2	350	353	PF00928	0.467
TRG_ENDOCYTIC_2	367	370	PF00928	0.411
TRG_ENDOCYTIC_2	99	102	PF00928	0.647
TRG_ER_diArg_1	174	177	PF00400	0.345
TRG_ER_diArg_1	209	211	PF00400	0.466
TRG_ER_diArg_1	283	285	PF00400	0.521
TRG_ER_diArg_1	333	336	PF00400	0.382
TRG_NLS_MonoExtN_4	171	178	PF00514	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV3	Leptomonas seymouri	50%	100%
A0A1X0P8N3	Trypanosomatidae	26%	100%
A0A3S7X083	Leishmania donovani	83%	99%
A4HF91	Leishmania braziliensis	68%	100%
A4I2H3	Leishmania infantum	82%	99%
C9ZX21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q8U5	Leishmania major	80%	100%