MATH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYM3_LEIMU

TriTrypDb:

LmxM.26.2420

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYM3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	240	242	PF00675	0.693
CLV_NRD_NRD_1	438	440	PF00675	0.363
CLV_NRD_NRD_1	539	541	PF00675	0.504
CLV_PCSK_KEX2_1	240	242	PF00082	0.693
CLV_PCSK_KEX2_1	438	440	PF00082	0.363
CLV_PCSK_KEX2_1	539	541	PF00082	0.511
CLV_PCSK_KEX2_1	570	572	PF00082	0.467
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.467
CLV_PCSK_SKI1_1	158	162	PF00082	0.754
CLV_PCSK_SKI1_1	385	389	PF00082	0.395
CLV_PCSK_SKI1_1	493	497	PF00082	0.331
CLV_PCSK_SKI1_1	499	503	PF00082	0.366
CLV_PCSK_SKI1_1	636	640	PF00082	0.525
DEG_Nend_UBRbox_2	1	3	PF02207	0.402
DEG_SCF_FBW7_1	164	169	PF00400	0.726
DOC_CKS1_1	387	392	PF01111	0.479
DOC_CYCLIN_RxL_1	382	391	PF00134	0.377
DOC_CYCLIN_RxL_1	435	446	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.385
DOC_MAPK_DCC_7	187	196	PF00069	0.489
DOC_MAPK_gen_1	16	25	PF00069	0.351
DOC_MAPK_gen_1	438	444	PF00069	0.385
DOC_MAPK_MEF2A_6	16	25	PF00069	0.465
DOC_PP1_RVXF_1	133	140	PF00149	0.489
DOC_PP1_RVXF_1	462	469	PF00149	0.355
DOC_PP1_RVXF_1	497	504	PF00149	0.342
DOC_SPAK_OSR1_1	48	52	PF12202	0.427
DOC_USP7_MATH_1	156	160	PF00917	0.714
DOC_USP7_MATH_1	166	170	PF00917	0.612
DOC_USP7_MATH_1	231	235	PF00917	0.675
DOC_USP7_MATH_1	514	518	PF00917	0.411
DOC_USP7_MATH_1	630	634	PF00917	0.490
DOC_USP7_MATH_1	88	92	PF00917	0.380
DOC_WW_Pin1_4	162	167	PF00397	0.666
DOC_WW_Pin1_4	181	186	PF00397	0.509
DOC_WW_Pin1_4	198	203	PF00397	0.722
DOC_WW_Pin1_4	209	214	PF00397	0.623
DOC_WW_Pin1_4	386	391	PF00397	0.488
DOC_WW_Pin1_4	508	513	PF00397	0.544
DOC_WW_Pin1_4	67	72	PF00397	0.427
LIG_14-3-3_CanoR_1	20	26	PF00244	0.365
LIG_14-3-3_CanoR_1	205	213	PF00244	0.671
LIG_14-3-3_CanoR_1	215	224	PF00244	0.662
LIG_14-3-3_CanoR_1	230	239	PF00244	0.570
LIG_14-3-3_CanoR_1	241	247	PF00244	0.481
LIG_14-3-3_CanoR_1	276	282	PF00244	0.372
LIG_14-3-3_CanoR_1	343	351	PF00244	0.358
LIG_14-3-3_CanoR_1	35	42	PF00244	0.306
LIG_14-3-3_CanoR_1	438	443	PF00244	0.362
LIG_14-3-3_CanoR_1	600	605	PF00244	0.405
LIG_14-3-3_CanoR_1	607	612	PF00244	0.425
LIG_14-3-3_CanoR_1	636	644	PF00244	0.549
LIG_14-3-3_CanoR_1	92	97	PF00244	0.340
LIG_Actin_WH2_2	330	345	PF00022	0.367
LIG_APCC_ABBA_1	7	12	PF00400	0.521
LIG_BRCT_BRCA1_1	36	40	PF00533	0.302
LIG_BRCT_BRCA1_1	74	78	PF00533	0.474
LIG_BRCT_BRCA1_1	92	96	PF00533	0.189
LIG_Clathr_ClatBox_1	221	225	PF01394	0.738
LIG_Clathr_ClatBox_1	252	256	PF01394	0.543
LIG_FHA_1	132	138	PF00498	0.499
LIG_FHA_1	159	165	PF00498	0.730
LIG_FHA_1	216	222	PF00498	0.664
LIG_FHA_1	337	343	PF00498	0.401
LIG_FHA_1	578	584	PF00498	0.499
LIG_FHA_1	627	633	PF00498	0.454
LIG_FHA_2	126	132	PF00498	0.510
LIG_FHA_2	517	523	PF00498	0.364
LIG_FHA_2	542	548	PF00498	0.570
LIG_FHA_2	635	641	PF00498	0.419
LIG_Integrin_isoDGR_2	151	153	PF01839	0.722
LIG_LIR_Gen_1	138	145	PF02991	0.535
LIG_LIR_Gen_1	280	289	PF02991	0.425
LIG_LIR_Gen_1	336	346	PF02991	0.329
LIG_LIR_Gen_1	409	420	PF02991	0.391
LIG_LIR_Gen_1	426	437	PF02991	0.306
LIG_LIR_Gen_1	476	484	PF02991	0.381
LIG_LIR_Gen_1	529	538	PF02991	0.354
LIG_LIR_Gen_1	617	627	PF02991	0.456
LIG_LIR_Nem_3	138	142	PF02991	0.536
LIG_LIR_Nem_3	280	286	PF02991	0.427
LIG_LIR_Nem_3	336	341	PF02991	0.332
LIG_LIR_Nem_3	372	376	PF02991	0.347
LIG_LIR_Nem_3	409	415	PF02991	0.382
LIG_LIR_Nem_3	418	423	PF02991	0.343
LIG_LIR_Nem_3	426	432	PF02991	0.310
LIG_LIR_Nem_3	472	478	PF02991	0.448
LIG_LIR_Nem_3	529	533	PF02991	0.357
LIG_LIR_Nem_3	617	623	PF02991	0.461
LIG_LIR_Nem_3	633	638	PF02991	0.355
LIG_MYND_1	386	390	PF01753	0.480
LIG_NRBOX	412	418	PF00104	0.335
LIG_PCNA_PIPBox_1	628	637	PF02747	0.382
LIG_PCNA_yPIPBox_3	528	538	PF02747	0.465
LIG_PCNA_yPIPBox_3	628	636	PF02747	0.384
LIG_Pex14_1	45	49	PF04695	0.427
LIG_Pex14_2	96	100	PF04695	0.302
LIG_SH2_CRK	19	23	PF00017	0.322
LIG_SH2_CRK	420	424	PF00017	0.381
LIG_SH2_NCK_1	244	248	PF00017	0.706
LIG_SH2_NCK_1	401	405	PF00017	0.512
LIG_SH2_PTP2	383	386	PF00017	0.431
LIG_SH2_SRC	412	415	PF00017	0.447
LIG_SH2_STAP1	346	350	PF00017	0.361
LIG_SH2_STAP1	36	40	PF00017	0.399
LIG_SH2_STAP1	374	378	PF00017	0.389
LIG_SH2_STAP1	420	424	PF00017	0.369
LIG_SH2_STAP1	478	482	PF00017	0.482
LIG_SH2_STAP1	487	491	PF00017	0.473
LIG_SH2_STAT3	127	130	PF00017	0.532
LIG_SH2_STAT5	127	130	PF00017	0.424
LIG_SH2_STAT5	344	347	PF00017	0.316
LIG_SH2_STAT5	365	368	PF00017	0.328
LIG_SH2_STAT5	383	386	PF00017	0.353
LIG_SH2_STAT5	412	415	PF00017	0.344
LIG_SH2_STAT5	494	497	PF00017	0.343
LIG_SH2_STAT5	604	607	PF00017	0.333
LIG_SH3_1	311	317	PF00018	0.368
LIG_SH3_2	454	459	PF14604	0.405
LIG_SH3_3	225	231	PF00018	0.727
LIG_SH3_3	272	278	PF00018	0.589
LIG_SH3_3	311	317	PF00018	0.369
LIG_SH3_3	352	358	PF00018	0.431
LIG_SH3_3	448	454	PF00018	0.410
LIG_SH3_3	478	484	PF00018	0.397
LIG_SH3_3	506	512	PF00018	0.479
LIG_SUMO_SIM_anti_2	551	557	PF11976	0.299
LIG_SUMO_SIM_par_1	251	256	PF11976	0.519
LIG_SUMO_SIM_par_1	333	340	PF11976	0.427
LIG_SUMO_SIM_par_1	394	399	PF11976	0.435
LIG_TRAF2_1	128	131	PF00917	0.526
LIG_WRC_WIRS_1	338	343	PF05994	0.426
LIG_WRC_WIRS_1	515	520	PF05994	0.504
MOD_CDC14_SPxK_1	184	187	PF00782	0.644
MOD_CDC14_SPxK_1	212	215	PF00782	0.727
MOD_CDK_SPxK_1	162	168	PF00069	0.734
MOD_CDK_SPxK_1	181	187	PF00069	0.737
MOD_CDK_SPxK_1	209	215	PF00069	0.733
MOD_CDK_SPxxK_3	198	205	PF00069	0.672
MOD_CK1_1	11	17	PF00069	0.412
MOD_CK1_1	206	212	PF00069	0.640
MOD_CK1_1	34	40	PF00069	0.324
MOD_CK1_1	446	452	PF00069	0.488
MOD_CK1_1	517	523	PF00069	0.406
MOD_CK1_1	526	532	PF00069	0.343
MOD_CK2_1	125	131	PF00069	0.501
MOD_CK2_1	473	479	PF00069	0.439
MOD_CK2_1	516	522	PF00069	0.377
MOD_CK2_1	634	640	PF00069	0.410
MOD_DYRK1A_RPxSP_1	162	166	PF00069	0.671
MOD_GlcNHglycan	104	107	PF01048	0.307
MOD_GlcNHglycan	12	16	PF01048	0.431
MOD_GlcNHglycan	148	151	PF01048	0.708
MOD_GlcNHglycan	158	161	PF01048	0.668
MOD_GlcNHglycan	205	208	PF01048	0.757
MOD_GlcNHglycan	218	221	PF01048	0.743
MOD_GlcNHglycan	233	236	PF01048	0.645
MOD_GlcNHglycan	271	274	PF01048	0.599
MOD_GlcNHglycan	352	355	PF01048	0.506
MOD_GlcNHglycan	36	39	PF01048	0.427
MOD_GlcNHglycan	375	379	PF01048	0.355
MOD_GlcNHglycan	471	474	PF01048	0.375
MOD_GlcNHglycan	53	57	PF01048	0.286
MOD_GlcNHglycan	547	551	PF01048	0.383
MOD_GSK3_1	125	132	PF00069	0.470
MOD_GSK3_1	156	163	PF00069	0.671
MOD_GSK3_1	183	190	PF00069	0.745
MOD_GSK3_1	203	210	PF00069	0.472
MOD_GSK3_1	469	476	PF00069	0.391
MOD_GSK3_1	626	633	PF00069	0.440
MOD_GSK3_1	88	95	PF00069	0.309
MOD_LATS_1	598	604	PF00433	0.376
MOD_N-GLC_1	146	151	PF02516	0.648
MOD_N-GLC_1	256	261	PF02516	0.667
MOD_N-GLC_1	607	612	PF02516	0.447
MOD_N-GLC_1	614	619	PF02516	0.471
MOD_N-GLC_1	96	101	PF02516	0.388
MOD_NEK2_1	125	130	PF00069	0.493
MOD_NEK2_1	458	463	PF00069	0.510
MOD_NEK2_1	523	528	PF00069	0.365
MOD_NEK2_1	577	582	PF00069	0.528
MOD_NEK2_1	634	639	PF00069	0.420
MOD_NEK2_1	78	83	PF00069	0.372
MOD_NEK2_1	96	101	PF00069	0.204
MOD_NEK2_2	630	635	PF00069	0.447
MOD_NEK2_2	72	77	PF00069	0.439
MOD_PIKK_1	501	507	PF00454	0.378
MOD_PIKK_1	614	620	PF00454	0.487
MOD_PK_1	187	193	PF00069	0.764
MOD_PK_1	607	613	PF00069	0.246
MOD_PKA_1	438	444	PF00069	0.365
MOD_PKA_2	207	213	PF00069	0.718
MOD_PKA_2	34	40	PF00069	0.396
MOD_PKA_2	438	444	PF00069	0.365
MOD_Plk_1	256	262	PF00069	0.601
MOD_Plk_1	290	296	PF00069	0.335
MOD_Plk_1	374	380	PF00069	0.433
MOD_Plk_1	523	529	PF00069	0.474
MOD_Plk_1	607	613	PF00069	0.445
MOD_Plk_1	96	102	PF00069	0.427
MOD_Plk_4	21	27	PF00069	0.467
MOD_Plk_4	256	262	PF00069	0.628
MOD_Plk_4	337	343	PF00069	0.422
MOD_Plk_4	357	363	PF00069	0.247
MOD_Plk_4	407	413	PF00069	0.448
MOD_Plk_4	438	444	PF00069	0.384
MOD_Plk_4	630	636	PF00069	0.439
MOD_ProDKin_1	162	168	PF00069	0.667
MOD_ProDKin_1	181	187	PF00069	0.511
MOD_ProDKin_1	198	204	PF00069	0.721
MOD_ProDKin_1	209	215	PF00069	0.623
MOD_ProDKin_1	386	392	PF00069	0.485
MOD_ProDKin_1	508	514	PF00069	0.549
MOD_ProDKin_1	67	73	PF00069	0.427
MOD_SUMO_for_1	569	572	PF00179	0.417
TRG_DiLeu_BaEn_2	56	62	PF01217	0.420
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.383
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.349
TRG_DiLeu_BaLyEn_6	581	586	PF01217	0.351
TRG_ENDOCYTIC_2	412	415	PF00928	0.359
TRG_ENDOCYTIC_2	420	423	PF00928	0.364
TRG_ENDOCYTIC_2	478	481	PF00928	0.392
TRG_ER_diArg_1	239	241	PF00400	0.634
TRG_ER_diArg_1	437	439	PF00400	0.383
TRG_ER_diArg_1	538	540	PF00400	0.487
TRG_NES_CRM1_1	406	421	PF08389	0.401
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K5	Leptomonas seymouri	77%	97%
A0A1X0P796	Trypanosomatidae	57%	100%
A0A3Q8IPI1	Leishmania donovani	97%	100%
A0A3R7KRV6	Trypanosoma rangeli	56%	100%
A4HF87	Leishmania braziliensis	87%	100%
A4I2H0	Leishmania infantum	97%	100%
C9ZX25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4Q8U9	Leishmania major	95%	100%
V5B8Y7	Trypanosoma cruzi	57%	100%