Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYM2_LEIMU

TriTrypDb:

LmxM.26.2410

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.477
CLV_C14_Caspase3-7	195	199	PF00656	0.519
CLV_NRD_NRD_1	184	186	PF00675	0.465
CLV_NRD_NRD_1	207	209	PF00675	0.469
CLV_NRD_NRD_1	293	295	PF00675	0.350
CLV_NRD_NRD_1	308	310	PF00675	0.456
CLV_NRD_NRD_1	51	53	PF00675	0.514
CLV_NRD_NRD_1	65	67	PF00675	0.564
CLV_NRD_NRD_1	96	98	PF00675	0.435
CLV_PCSK_FUR_1	182	186	PF00082	0.499
CLV_PCSK_KEX2_1	142	144	PF00082	0.538
CLV_PCSK_KEX2_1	184	186	PF00082	0.465
CLV_PCSK_KEX2_1	308	310	PF00082	0.440
CLV_PCSK_KEX2_1	51	53	PF00082	0.514
CLV_PCSK_KEX2_1	65	67	PF00082	0.567
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.538
CLV_PCSK_PC7_1	180	186	PF00082	0.472
CLV_PCSK_SKI1_1	139	143	PF00082	0.502
CLV_PCSK_SKI1_1	308	312	PF00082	0.439
CLV_PCSK_SKI1_1	98	102	PF00082	0.451
DEG_APCC_DBOX_1	210	218	PF00400	0.499
DEG_APCC_KENBOX_2	18	22	PF00400	0.444
DEG_SPOP_SBC_1	375	379	PF00917	0.273
DOC_ANK_TNKS_1	145	152	PF00023	0.351
DOC_CYCLIN_RxL_1	305	314	PF00134	0.568
DOC_MAPK_gen_1	294	302	PF00069	0.254
DOC_MAPK_gen_1	409	418	PF00069	0.622
DOC_MAPK_gen_1	95	103	PF00069	0.505
DOC_MAPK_MEF2A_6	266	273	PF00069	0.367
DOC_PP4_FxxP_1	302	305	PF00568	0.343
DOC_USP7_MATH_1	134	138	PF00917	0.430
DOC_USP7_MATH_1	250	254	PF00917	0.517
DOC_USP7_MATH_1	319	323	PF00917	0.507
DOC_WW_Pin1_4	301	306	PF00397	0.488
LIG_14-3-3_CanoR_1	182	192	PF00244	0.501
LIG_14-3-3_CanoR_1	309	318	PF00244	0.510
LIG_Actin_WH2_2	248	264	PF00022	0.577
LIG_APCC_ABBA_1	361	366	PF00400	0.454
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_BRCT_BRCA1_1	188	192	PF00533	0.483
LIG_BRCT_BRCA1_2	188	194	PF00533	0.363
LIG_CaM_IQ_9	167	182	PF13499	0.521
LIG_Clathr_ClatBox_1	242	246	PF01394	0.435
LIG_deltaCOP1_diTrp_1	125	131	PF00928	0.470
LIG_deltaCOP1_diTrp_1	298	302	PF00928	0.245
LIG_FHA_1	155	161	PF00498	0.420
LIG_FHA_1	375	381	PF00498	0.496
LIG_FHA_1	423	429	PF00498	0.549
LIG_FHA_1	86	92	PF00498	0.445
LIG_FHA_2	217	223	PF00498	0.463
LIG_FHA_2	330	336	PF00498	0.396
LIG_FHA_2	353	359	PF00498	0.488
LIG_FHA_2	39	45	PF00498	0.538
LIG_Integrin_RGD_1	220	222	PF01839	0.279
LIG_LIR_Apic_2	11	17	PF02991	0.384
LIG_LIR_Apic_2	301	305	PF02991	0.281
LIG_LIR_Gen_1	125	134	PF02991	0.467
LIG_LIR_Gen_1	20	30	PF02991	0.385
LIG_LIR_Gen_1	229	237	PF02991	0.407
LIG_LIR_Gen_1	238	245	PF02991	0.354
LIG_LIR_Gen_1	267	276	PF02991	0.353
LIG_LIR_Gen_1	298	307	PF02991	0.294
LIG_LIR_Gen_1	414	422	PF02991	0.599
LIG_LIR_Gen_1	74	83	PF02991	0.507
LIG_LIR_Gen_1	86	94	PF02991	0.436
LIG_LIR_LC3C_4	28	33	PF02991	0.258
LIG_LIR_Nem_3	110	115	PF02991	0.498
LIG_LIR_Nem_3	125	130	PF02991	0.383
LIG_LIR_Nem_3	20	25	PF02991	0.412
LIG_LIR_Nem_3	229	234	PF02991	0.402
LIG_LIR_Nem_3	238	244	PF02991	0.342
LIG_LIR_Nem_3	267	271	PF02991	0.342
LIG_LIR_Nem_3	274	279	PF02991	0.375
LIG_LIR_Nem_3	298	302	PF02991	0.538
LIG_LIR_Nem_3	382	386	PF02991	0.528
LIG_LIR_Nem_3	404	408	PF02991	0.553
LIG_LIR_Nem_3	414	418	PF02991	0.507
LIG_LIR_Nem_3	74	78	PF02991	0.539
LIG_LIR_Nem_3	86	90	PF02991	0.473
LIG_NRBOX	100	106	PF00104	0.428
LIG_NRBOX	306	312	PF00104	0.418
LIG_Pex14_1	127	131	PF04695	0.509
LIG_Pex14_2	192	196	PF04695	0.436
LIG_Pex14_2	226	230	PF04695	0.386
LIG_PTB_Apo_2	225	232	PF02174	0.525
LIG_PTB_Phospho_1	225	231	PF10480	0.520
LIG_RPA_C_Fungi	46	58	PF08784	0.507
LIG_SH2_CRK	14	18	PF00017	0.504
LIG_SH2_CRK	231	235	PF00017	0.476
LIG_SH2_CRK	276	280	PF00017	0.474
LIG_SH2_GRB2like	231	234	PF00017	0.535
LIG_SH2_NCK_1	231	235	PF00017	0.539
LIG_SH2_PTP2	415	418	PF00017	0.486
LIG_SH2_SRC	231	234	PF00017	0.394
LIG_SH2_STAP1	22	26	PF00017	0.385
LIG_SH2_STAT5	354	357	PF00017	0.385
LIG_SH2_STAT5	415	418	PF00017	0.558
LIG_SH2_STAT5	84	87	PF00017	0.507
LIG_SH3_3	432	438	PF00018	0.640
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.262
LIG_SUMO_SIM_par_1	113	119	PF11976	0.576
LIG_SUMO_SIM_par_1	269	275	PF11976	0.460
LIG_SUMO_SIM_par_1	28	34	PF11976	0.483
LIG_TRAF2_1	188	191	PF00917	0.448
LIG_TRAF2_1	333	336	PF00917	0.269
LIG_TYR_ITIM	159	164	PF00017	0.388
LIG_UBA3_1	270	278	PF00899	0.496
LIG_UBA3_1	418	426	PF00899	0.591
LIG_WRC_WIRS_1	100	105	PF05994	0.501
MOD_CDK_SPxxK_3	301	308	PF00069	0.364
MOD_CK1_1	133	139	PF00069	0.445
MOD_CK1_1	186	192	PF00069	0.577
MOD_CK1_1	352	358	PF00069	0.432
MOD_CK1_1	374	380	PF00069	0.382
MOD_CK2_1	184	190	PF00069	0.519
MOD_CK2_1	280	286	PF00069	0.399
MOD_CK2_1	287	293	PF00069	0.379
MOD_CK2_1	329	335	PF00069	0.516
MOD_CK2_1	352	358	PF00069	0.445
MOD_CK2_1	38	44	PF00069	0.436
MOD_CK2_1	394	400	PF00069	0.549
MOD_GlcNHglycan	132	135	PF01048	0.377
MOD_GlcNHglycan	147	150	PF01048	0.568
MOD_GlcNHglycan	373	376	PF01048	0.454
MOD_GlcNHglycan	69	72	PF01048	0.643
MOD_GlcNHglycan	75	78	PF01048	0.511
MOD_GSK3_1	126	133	PF00069	0.481
MOD_GSK3_1	150	157	PF00069	0.529
MOD_GSK3_1	310	317	PF00069	0.523
MOD_GSK3_1	371	378	PF00069	0.449
MOD_GSK3_1	407	414	PF00069	0.568
MOD_GSK3_1	67	74	PF00069	0.515
MOD_GSK3_1	99	106	PF00069	0.381
MOD_N-GLC_1	226	231	PF02516	0.375
MOD_NEK2_1	103	108	PF00069	0.476
MOD_NEK2_1	196	201	PF00069	0.474
MOD_NEK2_1	226	231	PF00069	0.407
MOD_NEK2_1	310	315	PF00069	0.456
MOD_NEK2_1	329	334	PF00069	0.501
MOD_NEK2_1	376	381	PF00069	0.410
MOD_NEK2_1	422	427	PF00069	0.566
MOD_NEK2_2	134	139	PF00069	0.502
MOD_PIKK_1	196	202	PF00454	0.449
MOD_PIKK_1	311	317	PF00454	0.498
MOD_PIKK_1	407	413	PF00454	0.551
MOD_PKA_1	184	190	PF00069	0.476
MOD_PKA_1	65	71	PF00069	0.699
MOD_PKA_2	145	151	PF00069	0.517
MOD_PKA_2	183	189	PF00069	0.513
MOD_PKA_2	210	216	PF00069	0.496
MOD_PKA_2	45	51	PF00069	0.534
MOD_PKA_2	65	71	PF00069	0.548
MOD_PKB_1	182	190	PF00069	0.480
MOD_Plk_1	115	121	PF00069	0.503
MOD_Plk_1	134	140	PF00069	0.428
MOD_Plk_1	226	232	PF00069	0.546
MOD_Plk_1	352	358	PF00069	0.438
MOD_Plk_4	126	132	PF00069	0.421
MOD_Plk_4	226	232	PF00069	0.395
MOD_Plk_4	376	382	PF00069	0.374
MOD_Plk_4	411	417	PF00069	0.605
MOD_Plk_4	99	105	PF00069	0.412
MOD_ProDKin_1	301	307	PF00069	0.487
MOD_SUMO_for_1	368	371	PF00179	0.546
MOD_SUMO_rev_2	106	115	PF00179	0.553
MOD_SUMO_rev_2	289	297	PF00179	0.266
MOD_SUMO_rev_2	321	330	PF00179	0.574
MOD_SUMO_rev_2	34	41	PF00179	0.608
MOD_SUMO_rev_2	401	410	PF00179	0.486
TRG_DiLeu_BaEn_1	110	115	PF01217	0.413
TRG_DiLeu_BaEn_2	297	303	PF01217	0.246
TRG_DiLeu_BaEn_2	98	104	PF01217	0.504
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.283
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.575
TRG_ENDOCYTIC_2	161	164	PF00928	0.440
TRG_ENDOCYTIC_2	22	25	PF00928	0.423
TRG_ENDOCYTIC_2	231	234	PF00928	0.451
TRG_ENDOCYTIC_2	276	279	PF00928	0.417
TRG_ENDOCYTIC_2	415	418	PF00928	0.535
TRG_ER_diArg_1	183	185	PF00400	0.489
TRG_ER_diArg_1	307	309	PF00400	0.438
TRG_ER_diArg_1	64	66	PF00400	0.584
TRG_ER_diArg_1	94	97	PF00400	0.259
TRG_NES_CRM1_1	162	173	PF08389	0.499
TRG_NES_CRM1_1	301	315	PF08389	0.252
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM42	Leptomonas seymouri	63%	100%
A0A1X0P7I7	Trypanosomatidae	34%	92%
A0A1X0P7R8	Trypanosomatidae	27%	87%
A0A3Q8ID54	Leishmania donovani	91%	100%
A0A3R7LDN5	Trypanosoma rangeli	29%	95%
A0A422MV92	Trypanosoma rangeli	26%	92%
A4HF86	Leishmania braziliensis	75%	100%
A4I2G9	Leishmania infantum	92%	100%
C9ZX27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	95%
D0A343	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	91%
Q4Q8V0	Leishmania major	90%	100%
V5ATI0	Trypanosoma cruzi	30%	100%