Putative peroxisomal membrane protein 4

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisomal membrane protein 4, putative

Species:

Leishmania mexicana

UniProt:

E9AYM1_LEIMU

TriTrypDb:

LmxM.26.2400

Length:

226

Annotations

LeishMANIAdb annotations

Similar to animal PXMP4 proteins. Presumed to have a 5TM topology in eukaryotes.. Localization: Peroxisomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005778	peroxisomal membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AYM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.316
CLV_PCSK_SKI1_1	104	108	PF00082	0.261
DEG_APCC_DBOX_1	103	111	PF00400	0.499
DEG_SCF_TRCP1_1	207	213	PF00400	0.496
DOC_MAPK_gen_1	57	66	PF00069	0.460
DOC_MAPK_MEF2A_6	59	68	PF00069	0.477
DOC_PP2B_LxvP_1	3	6	PF13499	0.504
DOC_PP4_FxxP_1	18	21	PF00568	0.713
DOC_USP7_MATH_1	74	78	PF00917	0.549
DOC_USP7_UBL2_3	206	210	PF12436	0.494
DOC_WW_Pin1_4	186	191	PF00397	0.458
DOC_WW_Pin1_4	70	75	PF00397	0.519
LIG_14-3-3_CanoR_1	11	16	PF00244	0.716
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BRCT_BRCA1_1	207	211	PF00533	0.445
LIG_BRCT_BRCA1_1	34	38	PF00533	0.667
LIG_BRCT_BRCA1_1	96	100	PF00533	0.549
LIG_FHA_1	12	18	PF00498	0.577
LIG_FHA_1	86	92	PF00498	0.468
LIG_FHA_1	97	103	PF00498	0.397
LIG_GBD_Chelix_1	102	110	PF00786	0.316
LIG_GBD_Chelix_1	150	158	PF00786	0.444
LIG_LIR_Gen_1	212	223	PF02991	0.392
LIG_LIR_Gen_1	35	45	PF02991	0.654
LIG_LIR_Gen_1	73	83	PF02991	0.488
LIG_LIR_Gen_1	97	107	PF02991	0.482
LIG_LIR_LC3C_4	216	219	PF02991	0.475
LIG_LIR_Nem_3	212	218	PF02991	0.395
LIG_LIR_Nem_3	35	41	PF02991	0.582
LIG_LIR_Nem_3	97	103	PF02991	0.482
LIG_NRBOX	153	159	PF00104	0.418
LIG_PDZ_Class_3	221	226	PF00595	0.425
LIG_Pex14_2	38	42	PF04695	0.615
LIG_SH2_CRK	155	159	PF00017	0.411
LIG_SH2_CRK	215	219	PF00017	0.437
LIG_SH2_CRK	95	99	PF00017	0.526
LIG_SH2_NCK_1	95	99	PF00017	0.549
LIG_SH2_STAP1	215	219	PF00017	0.410
LIG_SH2_STAT5	145	148	PF00017	0.223
LIG_SH2_STAT5	203	206	PF00017	0.389
LIG_SH3_3	55	61	PF00018	0.526
LIG_SH3_CIN85_PxpxPR_1	6	11	PF14604	0.652
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.467
LIG_SUMO_SIM_par_1	216	222	PF11976	0.418
LIG_TYR_ITIM	93	98	PF00017	0.490
LIG_UBA3_1	183	192	PF00899	0.625
MOD_CDC14_SPxK_1	189	192	PF00782	0.462
MOD_CDK_SPxK_1	186	192	PF00069	0.460
MOD_CK1_1	73	79	PF00069	0.486
MOD_CK1_1	96	102	PF00069	0.560
MOD_GlcNHglycan	135	138	PF01048	0.460
MOD_GlcNHglycan	18	21	PF01048	0.444
MOD_GlcNHglycan	207	210	PF01048	0.658
MOD_GlcNHglycan	34	37	PF01048	0.315
MOD_GSK3_1	193	200	PF00069	0.406
MOD_GSK3_1	205	212	PF00069	0.381
MOD_GSK3_1	70	77	PF00069	0.473
MOD_GSK3_1	81	88	PF00069	0.449
MOD_NEK2_1	110	115	PF00069	0.549
MOD_NEK2_1	157	162	PF00069	0.560
MOD_NEK2_1	205	210	PF00069	0.387
MOD_NEK2_1	68	73	PF00069	0.465
MOD_NEK2_1	83	88	PF00069	0.401
MOD_NEK2_1	93	98	PF00069	0.424
MOD_PK_1	81	87	PF00069	0.509
MOD_Plk_4	210	216	PF00069	0.427
MOD_ProDKin_1	186	192	PF00069	0.460
MOD_ProDKin_1	70	76	PF00069	0.519
TRG_AP2beta_CARGO_1	39	49	PF09066	0.526
TRG_ENDOCYTIC_2	155	158	PF00928	0.411
TRG_ENDOCYTIC_2	215	218	PF00928	0.404
TRG_ENDOCYTIC_2	75	78	PF00928	0.499
TRG_ENDOCYTIC_2	95	98	PF00928	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9U5	Leptomonas seymouri	74%	97%
A0A0S4JK51	Bodo saltans	34%	100%
A0A1X0P776	Trypanosomatidae	44%	100%
A0A3Q8IG25	Leishmania donovani	94%	100%
A0A3R7P3X1	Trypanosoma rangeli	49%	100%
A4HF85	Leishmania braziliensis	87%	100%
A5PJL1	Bos taurus	30%	100%
C9ZX28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	74%
P59382	Rattus norvegicus	31%	100%
Q4Q8V1	Leishmania major	93%	100%
Q9JJW0	Mus musculus	30%	100%
Q9Y6I8	Homo sapiens	32%	100%