Putative sec1 family transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sec1 family transport protein, putative

Species:

Leishmania mexicana

UniProt:

E9AYL7_LEIMU

TriTrypDb:

LmxM.26.2360

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYL7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0016192	vesicle-mediated transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.333
CLV_C14_Caspase3-7	374	378	PF00656	0.276
CLV_C14_Caspase3-7	597	601	PF00656	0.203
CLV_NRD_NRD_1	247	249	PF00675	0.257
CLV_NRD_NRD_1	351	353	PF00675	0.362
CLV_NRD_NRD_1	393	395	PF00675	0.379
CLV_NRD_NRD_1	606	608	PF00675	0.256
CLV_NRD_NRD_1	641	643	PF00675	0.274
CLV_NRD_NRD_1	644	646	PF00675	0.280
CLV_PCSK_KEX2_1	247	249	PF00082	0.257
CLV_PCSK_KEX2_1	351	353	PF00082	0.328
CLV_PCSK_KEX2_1	395	397	PF00082	0.257
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.257
CLV_PCSK_SKI1_1	260	264	PF00082	0.328
CLV_PCSK_SKI1_1	272	276	PF00082	0.250
CLV_PCSK_SKI1_1	295	299	PF00082	0.257
CLV_PCSK_SKI1_1	403	407	PF00082	0.290
DEG_APCC_DBOX_1	150	158	PF00400	0.280
DEG_APCC_DBOX_1	271	279	PF00400	0.281
DEG_APCC_DBOX_1	294	302	PF00400	0.257
DEG_APCC_DBOX_1	451	459	PF00400	0.257
DEG_SCF_FBW7_1	262	267	PF00400	0.333
DOC_ANK_TNKS_1	106	113	PF00023	0.257
DOC_CDC14_PxL_1	228	236	PF14671	0.333
DOC_CDC14_PxL_1	385	393	PF14671	0.257
DOC_CKS1_1	261	266	PF01111	0.333
DOC_CKS1_1	311	316	PF01111	0.333
DOC_CKS1_1	362	367	PF01111	0.357
DOC_CYCLIN_RxL_1	269	279	PF00134	0.257
DOC_CYCLIN_RxL_1	289	300	PF00134	0.128
DOC_CYCLIN_RxL_1	68	77	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	270	276	PF00134	0.257
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.257
DOC_MAPK_gen_1	247	253	PF00069	0.257
DOC_MAPK_gen_1	493	502	PF00069	0.218
DOC_MAPK_gen_1	605	612	PF00069	0.257
DOC_MAPK_JIP1_4	272	278	PF00069	0.257
DOC_MAPK_MEF2A_6	80	89	PF00069	0.257
DOC_MAPK_MEF2A_6	93	101	PF00069	0.257
DOC_PP1_RVXF_1	401	407	PF00149	0.389
DOC_PP1_RVXF_1	69	76	PF00149	0.389
DOC_PP4_FxxP_1	118	121	PF00568	0.257
DOC_USP7_MATH_1	165	169	PF00917	0.399
DOC_USP7_MATH_1	264	268	PF00917	0.305
DOC_USP7_MATH_1	510	514	PF00917	0.419
DOC_USP7_MATH_1	581	585	PF00917	0.343
DOC_USP7_MATH_1	59	63	PF00917	0.579
DOC_USP7_MATH_1	644	648	PF00917	0.353
DOC_USP7_UBL2_3	202	206	PF12436	0.364
DOC_WW_Pin1_4	161	166	PF00397	0.389
DOC_WW_Pin1_4	17	22	PF00397	0.487
DOC_WW_Pin1_4	260	265	PF00397	0.336
DOC_WW_Pin1_4	310	315	PF00397	0.333
DOC_WW_Pin1_4	361	366	PF00397	0.357
DOC_WW_Pin1_4	501	506	PF00397	0.367
DOC_WW_Pin1_4	572	577	PF00397	0.357
LIG_14-3-3_CanoR_1	177	182	PF00244	0.389
LIG_14-3-3_CanoR_1	247	252	PF00244	0.302
LIG_14-3-3_CanoR_1	280	288	PF00244	0.268
LIG_14-3-3_CanoR_1	470	479	PF00244	0.347
LIG_14-3-3_CanoR_1	496	501	PF00244	0.275
LIG_14-3-3_CanoR_1	645	649	PF00244	0.289
LIG_Actin_WH2_2	185	203	PF00022	0.386
LIG_APCC_ABBA_1	72	77	PF00400	0.257
LIG_APCC_ABBAyCdc20_2	327	333	PF00400	0.386
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.257
LIG_BIR_III_4	45	49	PF00653	0.495
LIG_BRCT_BRCA1_1	512	516	PF00533	0.333
LIG_Clathr_ClatBox_1	275	279	PF01394	0.257
LIG_Clathr_ClatBox_1	320	324	PF01394	0.152
LIG_Clathr_ClatBox_1	72	76	PF01394	0.389
LIG_CtBP_PxDLS_1	609	613	PF00389	0.278
LIG_deltaCOP1_diTrp_1	139	145	PF00928	0.257
LIG_DLG_GKlike_1	177	184	PF00625	0.389
LIG_eIF4E_1	456	462	PF01652	0.276
LIG_FHA_1	144	150	PF00498	0.301
LIG_FHA_1	541	547	PF00498	0.290
LIG_FHA_1	55	61	PF00498	0.529
LIG_FHA_1	575	581	PF00498	0.333
LIG_FHA_1	651	657	PF00498	0.297
LIG_FHA_1	67	73	PF00498	0.371
LIG_FHA_1	96	102	PF00498	0.389
LIG_FHA_2	103	109	PF00498	0.389
LIG_FHA_2	310	316	PF00498	0.357
LIG_FHA_2	446	452	PF00498	0.257
LIG_GBD_Chelix_1	245	253	PF00786	0.257
LIG_GBD_Chelix_1	524	532	PF00786	0.257
LIG_IRF3_LxIS_1	217	222	PF10401	0.336
LIG_LIR_Apic_2	572	576	PF02991	0.285
LIG_LIR_Gen_1	136	145	PF02991	0.258
LIG_LIR_Gen_1	178	189	PF02991	0.257
LIG_LIR_Gen_1	355	365	PF02991	0.363
LIG_LIR_Gen_1	435	446	PF02991	0.280
LIG_LIR_Gen_1	632	641	PF02991	0.274
LIG_LIR_Gen_1	98	104	PF02991	0.389
LIG_LIR_Nem_3	136	141	PF02991	0.266
LIG_LIR_Nem_3	178	184	PF02991	0.257
LIG_LIR_Nem_3	196	200	PF02991	0.343
LIG_LIR_Nem_3	293	297	PF02991	0.257
LIG_LIR_Nem_3	338	342	PF02991	0.278
LIG_LIR_Nem_3	355	360	PF02991	0.281
LIG_LIR_Nem_3	418	423	PF02991	0.267
LIG_LIR_Nem_3	435	441	PF02991	0.257
LIG_LIR_Nem_3	632	636	PF02991	0.274
LIG_LIR_Nem_3	68	73	PF02991	0.335
LIG_LIR_Nem_3	98	103	PF02991	0.301
LIG_Pex14_2	516	520	PF04695	0.389
LIG_PTB_Apo_2	183	190	PF02174	0.298
LIG_PTB_Apo_2	191	198	PF02174	0.333
LIG_SH2_CRK	294	298	PF00017	0.257
LIG_SH2_CRK	357	361	PF00017	0.307
LIG_SH2_CRK	573	577	PF00017	0.333
LIG_SH2_CRK	633	637	PF00017	0.389
LIG_SH2_GRB2like	142	145	PF00017	0.257
LIG_SH2_GRB2like	633	636	PF00017	0.389
LIG_SH2_NCK_1	55	59	PF00017	0.597
LIG_SH2_NCK_1	573	577	PF00017	0.285
LIG_SH2_PTP2	181	184	PF00017	0.257
LIG_SH2_SRC	100	103	PF00017	0.389
LIG_SH2_SRC	456	459	PF00017	0.276
LIG_SH2_STAP1	138	142	PF00017	0.257
LIG_SH2_STAP1	175	179	PF00017	0.333
LIG_SH2_STAP1	357	361	PF00017	0.389
LIG_SH2_STAP1	55	59	PF00017	0.597
LIG_SH2_STAT5	100	103	PF00017	0.354
LIG_SH2_STAT5	117	120	PF00017	0.161
LIG_SH2_STAT5	142	145	PF00017	0.266
LIG_SH2_STAT5	181	184	PF00017	0.257
LIG_SH2_STAT5	456	459	PF00017	0.290
LIG_SH2_STAT5	460	463	PF00017	0.296
LIG_SH2_STAT5	471	474	PF00017	0.316
LIG_SH2_STAT5	491	494	PF00017	0.257
LIG_SH3_3	108	114	PF00018	0.257
LIG_SH3_3	48	54	PF00018	0.500
LIG_SH3_3	499	505	PF00018	0.378
LIG_SH3_3	551	557	PF00018	0.152
LIG_SUMO_SIM_anti_2	424	429	PF11976	0.389
LIG_SUMO_SIM_par_1	231	237	PF11976	0.336
LIG_SUMO_SIM_par_1	273	279	PF11976	0.257
LIG_SUMO_SIM_par_1	318	324	PF11976	0.389
LIG_SUMO_SIM_par_1	608	614	PF11976	0.278
LIG_SxIP_EBH_1	142	151	PF03271	0.333
LIG_TRAF2_1	121	124	PF00917	0.336
LIG_TRAF2_1	464	467	PF00917	0.379
LIG_TYR_ITIM	179	184	PF00017	0.257
LIG_TYR_ITSM	96	103	PF00017	0.301
LIG_UBA3_1	297	305	PF00899	0.333
LIG_UBA3_1	539	544	PF00899	0.389
LIG_UBA3_1	82	88	PF00899	0.389
MOD_CDK_SPxxK_3	310	317	PF00069	0.333
MOD_CK1_1	407	413	PF00069	0.421
MOD_CK1_1	445	451	PF00069	0.285
MOD_CK1_1	531	537	PF00069	0.389
MOD_CK1_1	560	566	PF00069	0.303
MOD_CK1_1	572	578	PF00069	0.314
MOD_CK1_1	585	591	PF00069	0.413
MOD_CK1_1	654	660	PF00069	0.393
MOD_CK2_1	133	139	PF00069	0.325
MOD_CK2_1	161	167	PF00069	0.333
MOD_CK2_1	531	537	PF00069	0.391
MOD_CK2_1	626	632	PF00069	0.403
MOD_GlcNHglycan	161	164	PF01048	0.345
MOD_GlcNHglycan	238	241	PF01048	0.416
MOD_GlcNHglycan	505	508	PF01048	0.334
MOD_GlcNHglycan	559	562	PF01048	0.312
MOD_GlcNHglycan	566	569	PF01048	0.352
MOD_GlcNHglycan	577	580	PF01048	0.239
MOD_GlcNHglycan	584	587	PF01048	0.417
MOD_GlcNHglycan	61	64	PF01048	0.478
MOD_GlcNHglycan	656	659	PF01048	0.396
MOD_GSK3_1	161	168	PF00069	0.384
MOD_GSK3_1	260	267	PF00069	0.363
MOD_GSK3_1	279	286	PF00069	0.193
MOD_GSK3_1	407	414	PF00069	0.353
MOD_GSK3_1	442	449	PF00069	0.243
MOD_GSK3_1	527	534	PF00069	0.389
MOD_GSK3_1	560	567	PF00069	0.297
MOD_GSK3_1	571	578	PF00069	0.212
MOD_GSK3_1	581	588	PF00069	0.336
MOD_GSK3_1	650	657	PF00069	0.414
MOD_LATS_1	494	500	PF00433	0.257
MOD_N-GLC_1	124	129	PF02516	0.389
MOD_N-GLC_1	143	148	PF02516	0.142
MOD_N-GLC_1	193	198	PF02516	0.423
MOD_N-GLC_1	200	205	PF02516	0.344
MOD_N-GLC_1	496	501	PF02516	0.259
MOD_N-GLC_2	307	309	PF02516	0.389
MOD_NEK2_1	143	148	PF00069	0.389
MOD_NEK2_1	193	198	PF00069	0.404
MOD_NEK2_1	200	205	PF00069	0.403
MOD_NEK2_1	219	224	PF00069	0.276
MOD_NEK2_1	234	239	PF00069	0.247
MOD_NEK2_1	404	409	PF00069	0.257
MOD_NEK2_1	442	447	PF00069	0.221
MOD_NEK2_1	668	673	PF00069	0.517
MOD_NEK2_1	95	100	PF00069	0.257
MOD_NEK2_2	133	138	PF00069	0.341
MOD_NEK2_2	165	170	PF00069	0.391
MOD_PIKK_1	124	130	PF00454	0.152
MOD_PIKK_1	144	150	PF00454	0.276
MOD_PIKK_1	19	25	PF00454	0.530
MOD_PIKK_1	510	516	PF00454	0.416
MOD_PIKK_1	615	621	PF00454	0.257
MOD_PIKK_1	668	674	PF00454	0.539
MOD_PK_1	247	253	PF00069	0.276
MOD_PK_1	29	35	PF00069	0.211
MOD_PK_1	663	669	PF00069	0.234
MOD_PKA_1	247	253	PF00069	0.257
MOD_PKA_2	247	253	PF00069	0.258
MOD_PKA_2	279	285	PF00069	0.268
MOD_PKA_2	644	650	PF00069	0.336
MOD_PKB_1	27	35	PF00069	0.215
MOD_Plk_1	124	130	PF00069	0.389
MOD_Plk_1	175	181	PF00069	0.257
MOD_Plk_1	193	199	PF00069	0.301
MOD_Plk_1	496	502	PF00069	0.261
MOD_Plk_4	133	139	PF00069	0.352
MOD_Plk_4	177	183	PF00069	0.389
MOD_Plk_4	265	271	PF00069	0.295
MOD_Plk_4	29	35	PF00069	0.211
MOD_Plk_4	367	373	PF00069	0.152
MOD_Plk_4	535	541	PF00069	0.359
MOD_Plk_4	644	650	PF00069	0.389
MOD_Plk_4	651	657	PF00069	0.328
MOD_Plk_4	663	669	PF00069	0.324
MOD_Plk_4	95	101	PF00069	0.336
MOD_ProDKin_1	161	167	PF00069	0.389
MOD_ProDKin_1	17	23	PF00069	0.477
MOD_ProDKin_1	260	266	PF00069	0.336
MOD_ProDKin_1	310	316	PF00069	0.333
MOD_ProDKin_1	361	367	PF00069	0.357
MOD_ProDKin_1	501	507	PF00069	0.367
MOD_ProDKin_1	572	578	PF00069	0.357
MOD_SUMO_for_1	205	208	PF00179	0.271
TRG_DiLeu_BaEn_1	437	442	PF01217	0.301
TRG_DiLeu_BaEn_4	355	361	PF01217	0.236
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.333
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.257
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.316
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.257
TRG_ENDOCYTIC_2	100	103	PF00928	0.301
TRG_ENDOCYTIC_2	138	141	PF00928	0.264
TRG_ENDOCYTIC_2	142	145	PF00928	0.270
TRG_ENDOCYTIC_2	181	184	PF00928	0.257
TRG_ENDOCYTIC_2	294	297	PF00928	0.257
TRG_ENDOCYTIC_2	357	360	PF00928	0.309
TRG_ENDOCYTIC_2	420	423	PF00928	0.328
TRG_ENDOCYTIC_2	633	636	PF00928	0.257
TRG_ER_diArg_1	247	249	PF00400	0.257
TRG_ER_diArg_1	26	29	PF00400	0.320
TRG_ER_diArg_1	350	352	PF00400	0.362
TRG_ER_diArg_1	412	415	PF00400	0.466
TRG_ER_diArg_1	452	455	PF00400	0.289
TRG_ER_diArg_1	604	607	PF00400	0.281
TRG_NLS_MonoCore_2	641	646	PF00514	0.218
TRG_NLS_MonoExtC_3	641	646	PF00514	0.218
TRG_Pf-PMV_PEXEL_1	295	300	PF00026	0.257
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P0	Leptomonas seymouri	80%	98%
A0A1X0P7J8	Trypanosomatidae	59%	100%
A0A3Q8ICD5	Leishmania donovani	95%	99%
A0A3R7MBF0	Trypanosoma rangeli	57%	100%
A4HF81	Leishmania braziliensis	90%	100%
A4I2G4	Leishmania infantum	95%	99%
C9ZX33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
O18637	Drosophila virilis	30%	100%
O74534	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P22213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q24179	Drosophila melanogaster	30%	100%
Q4Q8V5	Leishmania major	94%	100%
Q54IJ1	Dictyostelium discoideum	28%	100%
Q5VNU3	Oryza sativa subsp. japonica	21%	100%
Q62991	Rattus norvegicus	28%	100%
Q851W1	Oryza sativa subsp. japonica	30%	100%
Q8BRF7	Mus musculus	28%	100%
Q8WVM8	Homo sapiens	28%	100%
Q9SL48	Arabidopsis thaliana	31%	100%
V5BI09	Trypanosoma cruzi	57%	100%