Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYL6_LEIMU

TriTrypDb:

LmxM.26.2350

Length:

860

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.567
CLV_C14_Caspase3-7	516	520	PF00656	0.833
CLV_C14_Caspase3-7	560	564	PF00656	0.675
CLV_C14_Caspase3-7	592	596	PF00656	0.771
CLV_C14_Caspase3-7	770	774	PF00656	0.765
CLV_NRD_NRD_1	298	300	PF00675	0.729
CLV_NRD_NRD_1	350	352	PF00675	0.787
CLV_NRD_NRD_1	417	419	PF00675	0.616
CLV_NRD_NRD_1	537	539	PF00675	0.854
CLV_NRD_NRD_1	583	585	PF00675	0.851
CLV_NRD_NRD_1	687	689	PF00675	0.667
CLV_NRD_NRD_1	706	708	PF00675	0.699
CLV_NRD_NRD_1	762	764	PF00675	0.682
CLV_PCSK_FUR_1	348	352	PF00082	0.693
CLV_PCSK_FUR_1	760	764	PF00082	0.764
CLV_PCSK_KEX2_1	298	300	PF00082	0.729
CLV_PCSK_KEX2_1	350	352	PF00082	0.787
CLV_PCSK_KEX2_1	372	374	PF00082	0.745
CLV_PCSK_KEX2_1	417	419	PF00082	0.668
CLV_PCSK_KEX2_1	537	539	PF00082	0.854
CLV_PCSK_KEX2_1	582	584	PF00082	0.860
CLV_PCSK_KEX2_1	606	608	PF00082	0.776
CLV_PCSK_KEX2_1	670	672	PF00082	0.830
CLV_PCSK_KEX2_1	706	708	PF00082	0.843
CLV_PCSK_KEX2_1	762	764	PF00082	0.687
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.745
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.776
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.830
CLV_PCSK_PC7_1	702	708	PF00082	0.773
CLV_PCSK_SKI1_1	101	105	PF00082	0.599
CLV_PCSK_SKI1_1	108	112	PF00082	0.684
CLV_PCSK_SKI1_1	422	426	PF00082	0.541
CLV_PCSK_SKI1_1	584	588	PF00082	0.756
CLV_PCSK_SKI1_1	644	648	PF00082	0.614
CLV_PCSK_SKI1_1	670	674	PF00082	0.657
CLV_PCSK_SKI1_1	763	767	PF00082	0.747
CLV_PCSK_SKI1_1	777	781	PF00082	0.706
DEG_APCC_DBOX_1	100	108	PF00400	0.408
DEG_APCC_DBOX_1	152	160	PF00400	0.806
DEG_APCC_KENBOX_2	4	8	PF00400	0.658
DEG_COP1_1	41	49	PF00400	0.797
DEG_SCF_FBW7_1	428	434	PF00400	0.600
DEG_SCF_FBW7_1	509	516	PF00400	0.751
DEG_SPOP_SBC_1	18	22	PF00917	0.616
DEG_SPOP_SBC_1	262	266	PF00917	0.693
DEG_SPOP_SBC_1	611	615	PF00917	0.758
DEG_SPOP_SBC_1	660	664	PF00917	0.733
DEG_SPOP_SBC_1	818	822	PF00917	0.623
DOC_ANK_TNKS_1	408	415	PF00023	0.775
DOC_ANK_TNKS_1	480	487	PF00023	0.552
DOC_CDC14_PxL_1	730	738	PF14671	0.799
DOC_CDC14_PxL_1	80	88	PF14671	0.585
DOC_CKS1_1	428	433	PF01111	0.528
DOC_CKS1_1	848	853	PF01111	0.815
DOC_CYCLIN_RxL_1	580	590	PF00134	0.773
DOC_CYCLIN_yCln2_LP_2	505	511	PF00134	0.748
DOC_MAPK_gen_1	372	380	PF00069	0.630
DOC_MAPK_HePTP_8	369	384	PF00069	0.649
DOC_MAPK_MEF2A_6	373	382	PF00069	0.630
DOC_PP1_RVXF_1	581	588	PF00149	0.775
DOC_PP1_RVXF_1	99	106	PF00149	0.411
DOC_PP2B_LxvP_1	658	661	PF13499	0.592
DOC_PP4_FxxP_1	211	214	PF00568	0.715
DOC_PP4_FxxP_1	527	530	PF00568	0.825
DOC_USP7_MATH_1	134	138	PF00917	0.736
DOC_USP7_MATH_1	262	266	PF00917	0.651
DOC_USP7_MATH_1	280	284	PF00917	0.712
DOC_USP7_MATH_1	286	290	PF00917	0.672
DOC_USP7_MATH_1	314	318	PF00917	0.857
DOC_USP7_MATH_1	45	49	PF00917	0.810
DOC_USP7_MATH_1	475	479	PF00917	0.771
DOC_USP7_MATH_1	574	578	PF00917	0.704
DOC_USP7_MATH_1	611	615	PF00917	0.758
DOC_USP7_MATH_1	661	665	PF00917	0.728
DOC_USP7_MATH_1	819	823	PF00917	0.785
DOC_USP7_MATH_1	99	103	PF00917	0.413
DOC_USP7_MATH_2	694	700	PF00917	0.559
DOC_WW_Pin1_4	229	234	PF00397	0.869
DOC_WW_Pin1_4	247	252	PF00397	0.543
DOC_WW_Pin1_4	266	271	PF00397	0.612
DOC_WW_Pin1_4	309	314	PF00397	0.784
DOC_WW_Pin1_4	316	321	PF00397	0.786
DOC_WW_Pin1_4	352	357	PF00397	0.848
DOC_WW_Pin1_4	39	44	PF00397	0.782
DOC_WW_Pin1_4	427	432	PF00397	0.814
DOC_WW_Pin1_4	443	448	PF00397	0.530
DOC_WW_Pin1_4	453	458	PF00397	0.648
DOC_WW_Pin1_4	489	494	PF00397	0.853
DOC_WW_Pin1_4	498	503	PF00397	0.637
DOC_WW_Pin1_4	509	514	PF00397	0.669
DOC_WW_Pin1_4	570	575	PF00397	0.646
DOC_WW_Pin1_4	636	641	PF00397	0.825
DOC_WW_Pin1_4	690	695	PF00397	0.771
DOC_WW_Pin1_4	71	76	PF00397	0.733
DOC_WW_Pin1_4	821	826	PF00397	0.728
DOC_WW_Pin1_4	838	843	PF00397	0.540
DOC_WW_Pin1_4	847	852	PF00397	0.656
LIG_14-3-3_CanoR_1	108	117	PF00244	0.714
LIG_14-3-3_CanoR_1	153	157	PF00244	0.591
LIG_14-3-3_CanoR_1	301	310	PF00244	0.772
LIG_14-3-3_CanoR_1	469	476	PF00244	0.840
LIG_14-3-3_CanoR_1	503	508	PF00244	0.760
LIG_14-3-3_CanoR_1	600	610	PF00244	0.726
LIG_14-3-3_CanoR_1	644	652	PF00244	0.627
LIG_14-3-3_CanoR_1	671	675	PF00244	0.599
LIG_14-3-3_CanoR_1	69	75	PF00244	0.565
LIG_14-3-3_CanoR_1	87	93	PF00244	0.697
LIG_ActinCP_TwfCPI_2	527	537	PF01115	0.639
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BIR_III_2	81	85	PF00653	0.588
LIG_BRCT_BRCA1_1	101	105	PF00533	0.623
LIG_BRCT_BRCA1_1	433	437	PF00533	0.730
LIG_EVH1_1	527	531	PF00568	0.822
LIG_FHA_1	109	115	PF00498	0.707
LIG_FHA_1	248	254	PF00498	0.778
LIG_FHA_1	256	262	PF00498	0.756
LIG_FHA_1	270	276	PF00498	0.628
LIG_FHA_1	334	340	PF00498	0.609
LIG_FHA_1	379	385	PF00498	0.743
LIG_FHA_1	423	429	PF00498	0.700
LIG_FHA_1	468	474	PF00498	0.756
LIG_FHA_1	495	501	PF00498	0.568
LIG_FHA_1	641	647	PF00498	0.791
LIG_FHA_1	685	691	PF00498	0.763
LIG_FHA_1	801	807	PF00498	0.560
LIG_FHA_2	164	170	PF00498	0.741
LIG_FHA_2	326	332	PF00498	0.572
LIG_FHA_2	472	478	PF00498	0.771
LIG_FHA_2	514	520	PF00498	0.835
LIG_FHA_2	558	564	PF00498	0.770
LIG_FHA_2	645	651	PF00498	0.792
LIG_FHA_2	768	774	PF00498	0.651
LIG_FHA_2	776	782	PF00498	0.725
LIG_FHA_2	831	837	PF00498	0.730
LIG_LIR_Apic_2	305	311	PF02991	0.809
LIG_LIR_Gen_1	198	208	PF02991	0.507
LIG_LIR_Gen_1	300	311	PF02991	0.749
LIG_LIR_Gen_1	434	445	PF02991	0.643
LIG_LIR_Gen_1	566	576	PF02991	0.666
LIG_LIR_Nem_3	198	203	PF02991	0.505
LIG_LIR_Nem_3	300	306	PF02991	0.750
LIG_LIR_Nem_3	434	440	PF02991	0.611
LIG_MAD2	37	45	PF02301	0.521
LIG_Pex14_1	855	859	PF04695	0.800
LIG_SH2_CRK	308	312	PF00017	0.745
LIG_SH2_PTP2	200	203	PF00017	0.419
LIG_SH2_STAT5	200	203	PF00017	0.496
LIG_SH2_STAT5	308	311	PF00017	0.745
LIG_SH2_STAT5	391	394	PF00017	0.742
LIG_SH2_STAT5	429	432	PF00017	0.626
LIG_SH2_STAT5	526	529	PF00017	0.833
LIG_SH2_STAT5	789	792	PF00017	0.668
LIG_SH3_1	307	313	PF00018	0.739
LIG_SH3_1	350	356	PF00018	0.780
LIG_SH3_1	451	457	PF00018	0.637
LIG_SH3_1	634	640	PF00018	0.674
LIG_SH3_2	311	316	PF14604	0.757
LIG_SH3_3	12	18	PF00018	0.639
LIG_SH3_3	182	188	PF00018	0.777
LIG_SH3_3	307	313	PF00018	0.739
LIG_SH3_3	350	356	PF00018	0.847
LIG_SH3_3	451	457	PF00018	0.783
LIG_SH3_3	490	496	PF00018	0.777
LIG_SH3_3	525	531	PF00018	0.825
LIG_SH3_3	632	638	PF00018	0.745
LIG_SH3_3	813	819	PF00018	0.514
LIG_SH3_3	839	845	PF00018	0.743
LIG_SUMO_SIM_par_1	423	430	PF11976	0.537
LIG_TRAF2_1	520	523	PF00917	0.821
LIG_TRAF2_2	851	856	PF00917	0.812
MOD_CDK_SPK_2	316	321	PF00069	0.790
MOD_CDK_SPK_2	498	503	PF00069	0.560
MOD_CDK_SPK_2	847	852	PF00069	0.813
MOD_CDK_SPxK_1	638	644	PF00069	0.647
MOD_CDK_SPxK_1	821	827	PF00069	0.827
MOD_CDK_SPxxK_3	309	316	PF00069	0.733
MOD_CK1_1	22	28	PF00069	0.793
MOD_CK1_1	234	240	PF00069	0.748
MOD_CK1_1	256	262	PF00069	0.783
MOD_CK1_1	265	271	PF00069	0.665
MOD_CK1_1	289	295	PF00069	0.560
MOD_CK1_1	326	332	PF00069	0.785
MOD_CK1_1	355	361	PF00069	0.738
MOD_CK1_1	436	442	PF00069	0.799
MOD_CK1_1	456	462	PF00069	0.485
MOD_CK1_1	471	477	PF00069	0.651
MOD_CK1_1	494	500	PF00069	0.718
MOD_CK1_1	557	563	PF00069	0.771
MOD_CK1_1	566	572	PF00069	0.655
MOD_CK1_1	577	583	PF00069	0.513
MOD_CK1_1	662	668	PF00069	0.830
MOD_CK1_1	70	76	PF00069	0.606
MOD_CK1_1	821	827	PF00069	0.827
MOD_CK1_1	847	853	PF00069	0.812
MOD_CK2_1	289	295	PF00069	0.677
MOD_CK2_1	392	398	PF00069	0.824
MOD_CK2_1	471	477	PF00069	0.768
MOD_CK2_1	591	597	PF00069	0.658
MOD_CK2_1	690	696	PF00069	0.793
MOD_CK2_1	748	754	PF00069	0.533
MOD_CK2_1	775	781	PF00069	0.829
MOD_Cter_Amidation	348	351	PF01082	0.794
MOD_DYRK1A_RPxSP_1	316	320	PF00069	0.787
MOD_GlcNHglycan	136	139	PF01048	0.757
MOD_GlcNHglycan	141	146	PF01048	0.693
MOD_GlcNHglycan	192	195	PF01048	0.726
MOD_GlcNHglycan	26	29	PF01048	0.741
MOD_GlcNHglycan	291	294	PF01048	0.721
MOD_GlcNHglycan	344	347	PF01048	0.818
MOD_GlcNHglycan	398	401	PF01048	0.706
MOD_GlcNHglycan	465	468	PF01048	0.737
MOD_GlcNHglycan	47	50	PF01048	0.761
MOD_GlcNHglycan	470	473	PF01048	0.692
MOD_GlcNHglycan	509	512	PF01048	0.851
MOD_GlcNHglycan	556	559	PF01048	0.840
MOD_GlcNHglycan	576	579	PF01048	0.535
MOD_GlcNHglycan	597	600	PF01048	0.791
MOD_GlcNHglycan	630	633	PF01048	0.859
MOD_GlcNHglycan	69	72	PF01048	0.824
MOD_GlcNHglycan	742	745	PF01048	0.779
MOD_GSK3_1	148	155	PF00069	0.661
MOD_GSK3_1	18	25	PF00069	0.746
MOD_GSK3_1	261	268	PF00069	0.656
MOD_GSK3_1	297	304	PF00069	0.734
MOD_GSK3_1	352	359	PF00069	0.643
MOD_GSK3_1	392	399	PF00069	0.630
MOD_GSK3_1	41	48	PF00069	0.744
MOD_GSK3_1	427	434	PF00069	0.800
MOD_GSK3_1	439	446	PF00069	0.590
MOD_GSK3_1	463	470	PF00069	0.700
MOD_GSK3_1	471	478	PF00069	0.626
MOD_GSK3_1	494	501	PF00069	0.832
MOD_GSK3_1	503	510	PF00069	0.649
MOD_GSK3_1	563	570	PF00069	0.831
MOD_GSK3_1	591	598	PF00069	0.572
MOD_GSK3_1	636	643	PF00069	0.790
MOD_GSK3_1	659	666	PF00069	0.651
MOD_GSK3_1	67	74	PF00069	0.752
MOD_GSK3_1	763	770	PF00069	0.810
MOD_GSK3_1	817	824	PF00069	0.693
MOD_GSK3_1	840	847	PF00069	0.800
MOD_LATS_1	67	73	PF00433	0.539
MOD_LATS_1	761	767	PF00433	0.769
MOD_N-GLC_1	342	347	PF02516	0.569
MOD_N-GLC_1	51	56	PF02516	0.774
MOD_N-GLC_1	690	695	PF02516	0.771
MOD_NEK2_1	152	157	PF00069	0.593
MOD_NEK2_1	19	24	PF00069	0.657
MOD_NEK2_1	368	373	PF00069	0.751
MOD_NEK2_1	380	385	PF00069	0.592
MOD_NEK2_1	748	753	PF00069	0.590
MOD_NEK2_2	148	153	PF00069	0.526
MOD_NEK2_2	612	617	PF00069	0.639
MOD_PIKK_1	503	509	PF00454	0.848
MOD_PIKK_1	819	825	PF00454	0.747
MOD_PIKK_1	844	850	PF00454	0.813
MOD_PKA_1	670	676	PF00069	0.749
MOD_PKA_2	152	158	PF00069	0.591
MOD_PKA_2	297	303	PF00069	0.789
MOD_PKA_2	468	474	PF00069	0.756
MOD_PKA_2	670	676	PF00069	0.661
MOD_PKA_2	767	773	PF00069	0.655
MOD_PKA_2	86	92	PF00069	0.737
MOD_PKB_1	106	114	PF00069	0.701
MOD_PKB_1	299	307	PF00069	0.749
MOD_Plk_1	141	147	PF00069	0.656
MOD_Plk_1	422	428	PF00069	0.540
MOD_Plk_1	99	105	PF00069	0.609
MOD_Plk_4	19	25	PF00069	0.720
MOD_Plk_4	436	442	PF00069	0.612
MOD_Plk_4	563	569	PF00069	0.771
MOD_Plk_4	663	669	PF00069	0.650
MOD_ProDKin_1	229	235	PF00069	0.869
MOD_ProDKin_1	247	253	PF00069	0.542
MOD_ProDKin_1	266	272	PF00069	0.611
MOD_ProDKin_1	309	315	PF00069	0.790
MOD_ProDKin_1	316	322	PF00069	0.785
MOD_ProDKin_1	352	358	PF00069	0.850
MOD_ProDKin_1	39	45	PF00069	0.782
MOD_ProDKin_1	427	433	PF00069	0.813
MOD_ProDKin_1	443	449	PF00069	0.532
MOD_ProDKin_1	453	459	PF00069	0.648
MOD_ProDKin_1	489	495	PF00069	0.848
MOD_ProDKin_1	498	504	PF00069	0.637
MOD_ProDKin_1	509	515	PF00069	0.667
MOD_ProDKin_1	570	576	PF00069	0.644
MOD_ProDKin_1	636	642	PF00069	0.824
MOD_ProDKin_1	690	696	PF00069	0.774
MOD_ProDKin_1	71	77	PF00069	0.734
MOD_ProDKin_1	821	827	PF00069	0.731
MOD_ProDKin_1	838	844	PF00069	0.540
MOD_ProDKin_1	847	853	PF00069	0.656
MOD_SUMO_for_1	401	404	PF00179	0.669
MOD_SUMO_for_1	450	453	PF00179	0.642
MOD_SUMO_rev_2	419	424	PF00179	0.540
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.619
TRG_ENDOCYTIC_2	200	203	PF00928	0.710
TRG_ER_diArg_1	105	108	PF00400	0.697
TRG_ER_diArg_1	298	301	PF00400	0.721
TRG_ER_diArg_1	348	351	PF00400	0.784
TRG_ER_diArg_1	537	539	PF00400	0.757
TRG_ER_diArg_1	581	584	PF00400	0.854
TRG_ER_diArg_1	607	610	PF00400	0.661
TRG_ER_diArg_1	706	709	PF00400	0.757
TRG_ER_diArg_1	715	718	PF00400	0.649
TRG_ER_diArg_1	760	763	PF00400	0.665
TRG_ER_diArg_1	790	793	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.698
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	777	781	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	827	832	PF00026	0.742

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X067	Leishmania donovani	80%	100%
A4HF80	Leishmania braziliensis	53%	98%
A4I2G3	Leishmania infantum	80%	100%
Q4Q8V6	Leishmania major	78%	100%