Putative 60S ribosomal protein L35

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L35, putative

Species:

Leishmania mexicana

UniProt:

E9AYL4_LEIMU

TriTrypDb:

LmxM.26.2330 , LmxM.26.2340

Length:

127

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	10
GO:0022625	cytosolic large ribosomal subunit	5	10
GO:0032991	protein-containing complex	1	10
GO:0044391	ribosomal subunit	3	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYL4

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	10
GO:0000470	maturation of LSU-rRNA	9	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006364	rRNA processing	8	10
GO:0006396	RNA processing	6	10
GO:0006412	translation	4	10
GO:0006518	peptide metabolic process	4	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016072	rRNA metabolic process	7	10
GO:0019538	protein metabolic process	3	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043043	peptide biosynthetic process	5	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0043604	amide biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	10
GO:0005198	structural molecule activity	1	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.532
CLV_NRD_NRD_1	51	53	PF00675	0.295
CLV_NRD_NRD_1	95	97	PF00675	0.516
CLV_PCSK_KEX2_1	120	122	PF00082	0.537
CLV_PCSK_KEX2_1	94	96	PF00082	0.518
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.613
CLV_PCSK_SKI1_1	20	24	PF00082	0.376
CLV_PCSK_SKI1_1	57	61	PF00082	0.293
CLV_PCSK_SKI1_1	96	100	PF00082	0.519
DEG_APCC_KENBOX_2	99	103	PF00400	0.582
DOC_CYCLIN_RxL_1	90	103	PF00134	0.515
DOC_MAPK_gen_1	117	127	PF00069	0.516
DOC_MAPK_gen_1	26	34	PF00069	0.505
DOC_USP7_UBL2_3	100	104	PF12436	0.538
DOC_USP7_UBL2_3	78	82	PF12436	0.650
DOC_WW_Pin1_4	80	85	PF00397	0.546
LIG_14-3-3_CanoR_1	106	112	PF00244	0.631
LIG_14-3-3_CanoR_1	57	62	PF00244	0.499
LIG_14-3-3_CanoR_1	88	97	PF00244	0.609
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_FHA_1	81	87	PF00498	0.618
LIG_FHA_2	19	25	PF00498	0.592
LIG_PDZ_Class_2	122	127	PF00595	0.518
LIG_SH2_STAP1	123	127	PF00017	0.575
LIG_UBA3_1	18	27	PF00899	0.505
MOD_CDK_SPK_2	80	85	PF00069	0.546
MOD_CK2_1	18	24	PF00069	0.581
MOD_NEK2_1	18	23	PF00069	0.551
MOD_PIKK_1	27	33	PF00454	0.505
MOD_PKA_1	106	112	PF00069	0.588
MOD_PKA_2	105	111	PF00069	0.532
MOD_PKA_2	51	57	PF00069	0.511
MOD_Plk_1	27	33	PF00069	0.492
MOD_Plk_4	57	63	PF00069	0.505
MOD_ProDKin_1	80	86	PF00069	0.548
TRG_ER_diArg_1	47	50	PF00400	0.576
TRG_ER_diArg_1	94	96	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J165	Bodo saltans	72%	100%
A0A1D8PK30	Candida albicans (strain SC5314 / ATCC MYA-2876)	41%	100%
A0A1X0P858	Trypanosomatidae	76%	100%
A0A3Q8IDZ4	Leishmania donovani	98%	100%
A0A3R7N3R9	Trypanosoma rangeli	75%	100%
A4HF78	Leishmania braziliensis	89%	100%
A4I2G1	Leishmania infantum	98%	100%
C9ZX35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
O74904	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O80626	Arabidopsis thaliana	43%	100%
P0CX84	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P0CX85	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P0DJ51	Tetrahymena thermophila (strain SB210)	35%	100%
P17078	Rattus norvegicus	48%	100%
P34662	Caenorhabditis elegans	42%	100%
P42766	Homo sapiens	49%	100%
P52817	Babesia bovis	36%	100%
Q29361	Sus scrofa	48%	100%
Q2VA69	Theileria lestoquardi	38%	100%
Q3MHM7	Bos taurus	49%	100%
Q4N756	Theileria parva	38%	100%
Q4Q8V7	Leishmania major	98%	100%
Q4UIF8	Theileria annulata	37%	89%
Q54J23	Dictyostelium discoideum	41%	100%
Q5DVH6	Platichthys flesus	43%	100%
Q69CJ9	Ophiophagus hannah	48%	100%
Q6PBC1	Xenopus tropicalis	47%	100%
Q6UZF7	Hippocampus comes	45%	100%
Q6ZWV7	Mus musculus	48%	100%
Q8JHJ1	Danio rerio	46%	100%
Q8L805	Triticum aestivum	43%	100%
Q90YT4	Ictalurus punctatus	43%	100%
Q98TF7	Gallus gallus	48%	100%
Q9LZ41	Arabidopsis thaliana	42%	100%
Q9M3D2	Arabidopsis thaliana	42%	100%
Q9M5L0	Euphorbia esula	38%	100%
Q9SF53	Arabidopsis thaliana	43%	100%