Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYL3_LEIMU

TriTrypDb:

LmxM.26.2320

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AYL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYL3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	3
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	2
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016310	phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0030515	snoRNA binding	5	1
GO:0034511	U3 snoRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0003824	catalytic activity	1	1
GO:0004672	protein kinase activity	3	1
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.685
CLV_C14_Caspase3-7	41	45	PF00656	0.549
CLV_C14_Caspase3-7	437	441	PF00656	0.661
CLV_C14_Caspase3-7	492	496	PF00656	0.559
CLV_NRD_NRD_1	151	153	PF00675	0.519
CLV_NRD_NRD_1	303	305	PF00675	0.655
CLV_NRD_NRD_1	314	316	PF00675	0.609
CLV_NRD_NRD_1	411	413	PF00675	0.575
CLV_NRD_NRD_1	541	543	PF00675	0.624
CLV_NRD_NRD_1	545	547	PF00675	0.640
CLV_NRD_NRD_1	58	60	PF00675	0.513
CLV_NRD_NRD_1	626	628	PF00675	0.684
CLV_PCSK_FUR_1	222	226	PF00082	0.598
CLV_PCSK_KEX2_1	151	153	PF00082	0.519
CLV_PCSK_KEX2_1	224	226	PF00082	0.617
CLV_PCSK_KEX2_1	303	305	PF00082	0.640
CLV_PCSK_KEX2_1	314	316	PF00082	0.769
CLV_PCSK_KEX2_1	411	413	PF00082	0.575
CLV_PCSK_KEX2_1	541	543	PF00082	0.626
CLV_PCSK_KEX2_1	545	547	PF00082	0.623
CLV_PCSK_KEX2_1	58	60	PF00082	0.503
CLV_PCSK_KEX2_1	626	628	PF00082	0.687
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.617
CLV_PCSK_PC7_1	541	547	PF00082	0.680
CLV_PCSK_SKI1_1	134	138	PF00082	0.507
CLV_PCSK_SKI1_1	246	250	PF00082	0.585
CLV_PCSK_SKI1_1	403	407	PF00082	0.763
CLV_PCSK_SKI1_1	491	495	PF00082	0.534
CLV_PCSK_SKI1_1	514	518	PF00082	0.638
CLV_PCSK_SKI1_1	531	535	PF00082	0.609
CLV_PCSK_SKI1_1	59	63	PF00082	0.403
CLV_PCSK_SKI1_1	632	636	PF00082	0.610
DEG_SPOP_SBC_1	108	112	PF00917	0.531
DEG_SPOP_SBC_1	376	380	PF00917	0.604
DEG_SPOP_SBC_1	690	694	PF00917	0.538
DOC_CKS1_1	426	431	PF01111	0.533
DOC_MAPK_gen_1	312	321	PF00069	0.750
DOC_MAPK_gen_1	491	499	PF00069	0.631
DOC_MAPK_gen_1	681	689	PF00069	0.540
DOC_MAPK_MEF2A_6	312	321	PF00069	0.750
DOC_MAPK_RevD_3	209	225	PF00069	0.604
DOC_PP2B_LxvP_1	406	409	PF13499	0.773
DOC_PP2B_LxvP_1	47	50	PF13499	0.553
DOC_PP4_FxxP_1	210	213	PF00568	0.508
DOC_SPAK_OSR1_1	100	104	PF12202	0.496
DOC_USP7_MATH_1	213	217	PF00917	0.588
DOC_USP7_MATH_1	307	311	PF00917	0.467
DOC_USP7_MATH_1	376	380	PF00917	0.721
DOC_USP7_MATH_1	485	489	PF00917	0.611
DOC_USP7_MATH_1	50	54	PF00917	0.584
DOC_USP7_MATH_1	597	601	PF00917	0.528
DOC_USP7_MATH_1	702	706	PF00917	0.576
DOC_USP7_MATH_1	720	724	PF00917	0.324
DOC_USP7_UBL2_3	403	407	PF12436	0.678
DOC_USP7_UBL2_3	494	498	PF12436	0.586
DOC_USP7_UBL2_3	517	521	PF12436	0.651
DOC_USP7_UBL2_3	531	535	PF12436	0.487
DOC_WW_Pin1_4	223	228	PF00397	0.382
DOC_WW_Pin1_4	370	375	PF00397	0.808
DOC_WW_Pin1_4	377	382	PF00397	0.674
DOC_WW_Pin1_4	425	430	PF00397	0.538
DOC_WW_Pin1_4	674	679	PF00397	0.578
DOC_WW_Pin1_4	92	97	PF00397	0.642
LIG_14-3-3_CanoR_1	102	108	PF00244	0.512
LIG_14-3-3_CanoR_1	151	156	PF00244	0.505
LIG_14-3-3_CanoR_1	314	318	PF00244	0.616
LIG_14-3-3_CanoR_1	473	479	PF00244	0.554
LIG_14-3-3_CanoR_1	58	67	PF00244	0.556
LIG_14-3-3_CanoR_1	639	643	PF00244	0.594
LIG_Actin_WH2_2	479	496	PF00022	0.560
LIG_Actin_WH2_2	504	519	PF00022	0.636
LIG_APCC_ABBA_1	248	253	PF00400	0.665
LIG_BIR_III_4	348	352	PF00653	0.718
LIG_BRCT_BRCA1_1	382	386	PF00533	0.676
LIG_BRCT_BRCA1_1	447	451	PF00533	0.524
LIG_CaM_IQ_9	390	405	PF13499	0.663
LIG_EH1_1	114	122	PF00400	0.534
LIG_FHA_1	108	114	PF00498	0.560
LIG_FHA_1	179	185	PF00498	0.506
LIG_FHA_1	201	207	PF00498	0.506
LIG_FHA_1	272	278	PF00498	0.426
LIG_FHA_1	325	331	PF00498	0.634
LIG_FHA_1	336	342	PF00498	0.756
LIG_FHA_1	420	426	PF00498	0.449
LIG_FHA_1	692	698	PF00498	0.637
LIG_FHA_1	72	78	PF00498	0.441
LIG_FHA_2	143	149	PF00498	0.506
LIG_FHA_2	490	496	PF00498	0.522
LIG_FHA_2	83	89	PF00498	0.448
LIG_LIR_Apic_2	207	213	PF02991	0.499
LIG_LIR_Gen_1	37	47	PF02991	0.557
LIG_LIR_Gen_1	684	691	PF02991	0.633
LIG_LIR_Nem_3	630	634	PF02991	0.632
LIG_LIR_Nem_3	684	689	PF02991	0.583
LIG_LIR_Nem_3	80	86	PF02991	0.563
LIG_PCNA_TLS_4	639	646	PF02747	0.641
LIG_PDZ_Class_3	733	738	PF00595	0.420
LIG_PTB_Apo_2	685	692	PF02174	0.569
LIG_PTB_Phospho_1	685	691	PF10480	0.574
LIG_SH2_CRK	715	719	PF00017	0.551
LIG_SH2_NCK_1	251	255	PF00017	0.713
LIG_SH2_NCK_1	500	504	PF00017	0.573
LIG_SH2_NCK_1	715	719	PF00017	0.551
LIG_SH2_SRC	251	254	PF00017	0.701
LIG_SH2_STAP1	715	719	PF00017	0.551
LIG_SH2_STAT3	719	722	PF00017	0.504
LIG_SH2_STAT5	13	16	PF00017	0.586
LIG_SH2_STAT5	186	189	PF00017	0.542
LIG_SH2_STAT5	500	503	PF00017	0.543
LIG_SH2_STAT5	691	694	PF00017	0.550
LIG_SH3_1	224	230	PF00018	0.692
LIG_SH3_2	622	627	PF14604	0.661
LIG_SH3_3	209	215	PF00018	0.525
LIG_SH3_3	224	230	PF00018	0.638
LIG_SH3_3	420	426	PF00018	0.495
LIG_SH3_3	619	625	PF00018	0.708
LIG_SH3_3	684	690	PF00018	0.349
LIG_SUMO_SIM_anti_2	143	148	PF11976	0.524
LIG_SUMO_SIM_par_1	164	169	PF11976	0.445
LIG_SxIP_EBH_1	211	225	PF03271	0.610
LIG_TRAF2_1	362	365	PF00917	0.766
LIG_TRAF2_1	537	540	PF00917	0.653
LIG_TRAF2_1	549	552	PF00917	0.560
LIG_TRAF2_1	567	570	PF00917	0.680
LIG_TRAF2_1	573	576	PF00917	0.660
LIG_TRAF2_1	586	589	PF00917	0.521
LIG_TRAF2_1	641	644	PF00917	0.575
LIG_TRAF2_1	647	650	PF00917	0.592
LIG_TRAF2_1	85	88	PF00917	0.557
LIG_WW_3	623	627	PF00397	0.585
MOD_CDK_SPxxK_3	674	681	PF00069	0.629
MOD_CK1_1	124	130	PF00069	0.401
MOD_CK1_1	223	229	PF00069	0.503
MOD_CK1_1	232	238	PF00069	0.660
MOD_CK1_1	3	9	PF00069	0.546
MOD_CK1_1	306	312	PF00069	0.538
MOD_CK1_1	372	378	PF00069	0.728
MOD_CK1_1	433	439	PF00069	0.656
MOD_CK1_1	504	510	PF00069	0.449
MOD_CK1_1	705	711	PF00069	0.524
MOD_CK1_1	95	101	PF00069	0.702
MOD_CK2_1	142	148	PF00069	0.504
MOD_CK2_1	265	271	PF00069	0.549
MOD_CK2_1	598	604	PF00069	0.649
MOD_CK2_1	638	644	PF00069	0.446
MOD_CK2_1	65	71	PF00069	0.447
MOD_CK2_1	82	88	PF00069	0.464
MOD_GlcNHglycan	123	126	PF01048	0.466
MOD_GlcNHglycan	172	175	PF01048	0.350
MOD_GlcNHglycan	191	194	PF01048	0.528
MOD_GlcNHglycan	258	261	PF01048	0.698
MOD_GlcNHglycan	305	308	PF01048	0.410
MOD_GlcNHglycan	309	312	PF01048	0.421
MOD_GlcNHglycan	403	406	PF01048	0.647
MOD_GlcNHglycan	432	435	PF01048	0.428
MOD_GlcNHglycan	436	439	PF01048	0.456
MOD_GlcNHglycan	503	506	PF01048	0.334
MOD_GlcNHglycan	67	70	PF01048	0.518
MOD_GlcNHglycan	700	703	PF01048	0.574
MOD_GlcNHglycan	707	710	PF01048	0.538
MOD_GSK3_1	103	110	PF00069	0.408
MOD_GSK3_1	200	207	PF00069	0.577
MOD_GSK3_1	229	236	PF00069	0.663
MOD_GSK3_1	261	268	PF00069	0.565
MOD_GSK3_1	303	310	PF00069	0.625
MOD_GSK3_1	372	379	PF00069	0.761
MOD_GSK3_1	397	404	PF00069	0.662
MOD_GSK3_1	430	437	PF00069	0.518
MOD_GSK3_1	485	492	PF00069	0.619
MOD_GSK3_1	698	705	PF00069	0.636
MOD_GSK3_1	73	80	PF00069	0.484
MOD_GSK3_1	91	98	PF00069	0.517
MOD_LATS_1	57	63	PF00433	0.394
MOD_N-GLC_1	140	145	PF02516	0.581
MOD_N-GLC_1	170	175	PF02516	0.398
MOD_NEK2_1	107	112	PF00069	0.486
MOD_NEK2_1	233	238	PF00069	0.759
MOD_NEK2_1	335	340	PF00069	0.710
MOD_NEK2_1	430	435	PF00069	0.637
MOD_NEK2_1	65	70	PF00069	0.424
MOD_NEK2_1	77	82	PF00069	0.423
MOD_NEK2_2	50	55	PF00069	0.533
MOD_PKA_1	151	157	PF00069	0.357
MOD_PKA_1	303	309	PF00069	0.630
MOD_PKA_1	632	638	PF00069	0.592
MOD_PKA_2	103	109	PF00069	0.534
MOD_PKA_2	150	156	PF00069	0.513
MOD_PKA_2	3	9	PF00069	0.584
MOD_PKA_2	303	309	PF00069	0.669
MOD_PKA_2	313	319	PF00069	0.671
MOD_PKA_2	472	478	PF00069	0.515
MOD_PKA_2	638	644	PF00069	0.587
MOD_Plk_1	271	277	PF00069	0.358
MOD_Plk_1	324	330	PF00069	0.571
MOD_Plk_1	335	341	PF00069	0.749
MOD_Plk_2-3	32	38	PF00069	0.472
MOD_Plk_2-3	551	557	PF00069	0.780
MOD_Plk_4	103	109	PF00069	0.590
MOD_Plk_4	142	148	PF00069	0.521
MOD_Plk_4	161	167	PF00069	0.560
MOD_Plk_4	172	178	PF00069	0.578
MOD_Plk_4	445	451	PF00069	0.521
MOD_Plk_4	50	56	PF00069	0.482
MOD_Plk_4	707	713	PF00069	0.590
MOD_ProDKin_1	223	229	PF00069	0.386
MOD_ProDKin_1	370	376	PF00069	0.808
MOD_ProDKin_1	377	383	PF00069	0.668
MOD_ProDKin_1	425	431	PF00069	0.538
MOD_ProDKin_1	674	680	PF00069	0.578
MOD_ProDKin_1	92	98	PF00069	0.639
MOD_SUMO_rev_2	243	248	PF00179	0.658
MOD_SUMO_rev_2	37	45	PF00179	0.530
MOD_SUMO_rev_2	383	390	PF00179	0.651
MOD_SUMO_rev_2	512	519	PF00179	0.641
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.540
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.531
TRG_ENDOCYTIC_2	39	42	PF00928	0.565
TRG_ENDOCYTIC_2	715	718	PF00928	0.566
TRG_ER_diArg_1	101	104	PF00400	0.657
TRG_ER_diArg_1	411	413	PF00400	0.558
TRG_ER_diArg_1	625	627	PF00400	0.692
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	465	470	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTI6	Leptomonas seymouri	51%	100%
A0A3Q8IDU6	Leishmania donovani	93%	100%
A0A422P3R9	Trypanosoma rangeli	25%	100%
A4HF77	Leishmania braziliensis	77%	100%
A4I2G0	Leishmania infantum	93%	100%
Q4Q8V9	Leishmania major	90%	100%
V5ATI5	Trypanosoma cruzi	26%	100%