LeishMANIAdb
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Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secreted protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AYL1_LEIMU
TriTrypDb:
LmxM.26.2305
Length:
120

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYL1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYL1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 4 6 PF00675 0.512
CLV_PCSK_KEX2_1 4 6 PF00082 0.512
CLV_PCSK_SKI1_1 4 8 PF00082 0.470
CLV_PCSK_SKI1_1 75 79 PF00082 0.584
DEG_Nend_Nbox_1 1 3 PF02207 0.512
DEG_SCF_FBW7_1 36 43 PF00400 0.523
DOC_CKS1_1 37 42 PF01111 0.523
DOC_MAPK_MEF2A_6 30 38 PF00069 0.604
DOC_USP7_MATH_1 54 58 PF00917 0.666
DOC_WW_Pin1_4 21 26 PF00397 0.548
DOC_WW_Pin1_4 36 41 PF00397 0.617
DOC_WW_Pin1_4 79 84 PF00397 0.563
LIG_14-3-3_CanoR_1 19 25 PF00244 0.549
LIG_14-3-3_CanoR_1 5 15 PF00244 0.472
LIG_14-3-3_CanoR_1 99 105 PF00244 0.415
LIG_BRCT_BRCA1_1 88 92 PF00533 0.552
LIG_deltaCOP1_diTrp_1 93 98 PF00928 0.477
LIG_FHA_1 37 43 PF00498 0.540
LIG_FHA_1 61 67 PF00498 0.589
LIG_LIR_Nem_3 93 98 PF02991 0.587
LIG_MYND_1 33 37 PF01753 0.471
LIG_MYND_3 61 65 PF01753 0.605
LIG_NRBOX 73 79 PF00104 0.575
LIG_PCNA_PIPBox_1 85 94 PF02747 0.415
LIG_PCNA_yPIPBox_3 85 99 PF02747 0.473
LIG_SH2_CRK 17 21 PF00017 0.398
LIG_SH2_STAT5 17 20 PF00017 0.453
LIG_SH3_3 31 37 PF00018 0.476
LIG_SUMO_SIM_par_1 62 68 PF11976 0.626
LIG_SxIP_EBH_1 4 18 PF03271 0.464
MOD_CK1_1 57 63 PF00069 0.683
MOD_Cter_Amidation 2 5 PF01082 0.526
MOD_GlcNHglycan 110 113 PF01048 0.643
MOD_GSK3_1 36 43 PF00069 0.504
MOD_N-GLC_1 100 105 PF02516 0.452
MOD_NEK2_1 108 113 PF00069 0.556
MOD_NEK2_1 15 20 PF00069 0.457
MOD_NEK2_1 42 47 PF00069 0.511
MOD_NEK2_1 7 12 PF00069 0.521
MOD_NEK2_1 77 82 PF00069 0.537
MOD_NEK2_1 86 91 PF00069 0.527
MOD_Plk_1 100 106 PF00069 0.452
MOD_Plk_4 103 109 PF00069 0.608
MOD_ProDKin_1 21 27 PF00069 0.546
MOD_ProDKin_1 36 42 PF00069 0.615
MOD_ProDKin_1 79 85 PF00069 0.563
TRG_ENDOCYTIC_2 17 20 PF00928 0.393
TRG_ER_diArg_1 4 6 PF00400 0.511
TRG_Pf-PMV_PEXEL_1 75 79 PF00026 0.622

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3I1 Leptomonas seymouri 33% 100%
A0A0N1I021 Leptomonas seymouri 76% 100%
A0A0S4J296 Bodo saltans 40% 99%
A0A0S4KKW4 Bodo saltans 42% 100%
A0A1X0P697 Trypanosomatidae 36% 96%
A0A1X0P784 Trypanosomatidae 56% 100%
A0A3Q8IE17 Leishmania donovani 96% 100%
A0A3R7RT45 Trypanosoma rangeli 51% 100%
A4HA86 Leishmania braziliensis 34% 100%
A4HF75 Leishmania braziliensis 90% 100%
A4I2F8 Leishmania infantum 96% 100%
C9ZX39 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
Q4Q8W1 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS