Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYK9_LEIMU

TriTrypDb:

LmxM.26.2290

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.622
CLV_NRD_NRD_1	114	116	PF00675	0.597
CLV_NRD_NRD_1	135	137	PF00675	0.530
CLV_NRD_NRD_1	17	19	PF00675	0.764
CLV_NRD_NRD_1	3	5	PF00675	0.569
CLV_NRD_NRD_1	339	341	PF00675	0.499
CLV_NRD_NRD_1	390	392	PF00675	0.458
CLV_NRD_NRD_1	83	85	PF00675	0.609
CLV_PCSK_FUR_1	112	116	PF00082	0.609
CLV_PCSK_KEX2_1	113	115	PF00082	0.626
CLV_PCSK_KEX2_1	135	137	PF00082	0.511
CLV_PCSK_KEX2_1	17	19	PF00082	0.705
CLV_PCSK_KEX2_1	3	5	PF00082	0.596
CLV_PCSK_KEX2_1	75	77	PF00082	0.674
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.672
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.674
CLV_PCSK_SKI1_1	290	294	PF00082	0.508
CLV_PCSK_SKI1_1	349	353	PF00082	0.473
CLV_PCSK_SKI1_1	396	400	PF00082	0.541
CLV_PCSK_SKI1_1	7	11	PF00082	0.568
CLV_Separin_Metazoa	45	49	PF03568	0.472
DEG_APCC_DBOX_1	357	365	PF00400	0.483
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DEG_SPOP_SBC_1	154	158	PF00917	0.645
DOC_CDC14_PxL_1	332	340	PF14671	0.434
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.692
DOC_MAPK_gen_1	112	120	PF00069	0.630
DOC_MAPK_gen_1	17	25	PF00069	0.769
DOC_MAPK_gen_1	3	10	PF00069	0.608
DOC_MAPK_gen_1	75	83	PF00069	0.658
DOC_MAPK_MEF2A_6	247	254	PF00069	0.599
DOC_PP1_RVXF_1	360	367	PF00149	0.439
DOC_PP4_FxxP_1	223	226	PF00568	0.427
DOC_WW_Pin1_4	102	107	PF00397	0.736
DOC_WW_Pin1_4	178	183	PF00397	0.546
DOC_WW_Pin1_4	238	243	PF00397	0.397
DOC_WW_Pin1_4	308	313	PF00397	0.483
LIG_14-3-3_CanoR_1	17	25	PF00244	0.751
LIG_14-3-3_CanoR_1	33	41	PF00244	0.741
LIG_14-3-3_CanoR_1	396	405	PF00244	0.678
LIG_Actin_WH2_2	144	162	PF00022	0.612
LIG_Actin_WH2_2	347	364	PF00022	0.477
LIG_deltaCOP1_diTrp_1	263	269	PF00928	0.422
LIG_deltaCOP1_diTrp_1	343	350	PF00928	0.456
LIG_deltaCOP1_diTrp_1	382	390	PF00928	0.378
LIG_FHA_1	18	24	PF00498	0.698
LIG_FHA_1	301	307	PF00498	0.393
LIG_FHA_2	289	295	PF00498	0.417
LIG_Integrin_isoDGR_2	273	275	PF01839	0.287
LIG_LIR_Gen_1	198	206	PF02991	0.401
LIG_LIR_Gen_1	214	223	PF02991	0.362
LIG_LIR_Gen_1	227	233	PF02991	0.390
LIG_LIR_Gen_1	382	390	PF02991	0.378
LIG_LIR_Nem_3	131	137	PF02991	0.505
LIG_LIR_Nem_3	198	204	PF02991	0.401
LIG_LIR_Nem_3	214	218	PF02991	0.369
LIG_LIR_Nem_3	311	316	PF02991	0.508
LIG_LIR_Nem_3	343	348	PF02991	0.414
LIG_LYPXL_yS_3	199	202	PF13949	0.417
LIG_PDZ_Class_2	400	405	PF00595	0.676
LIG_Pex14_1	344	348	PF04695	0.473
LIG_PTB_Apo_2	360	367	PF02174	0.439
LIG_Rb_LxCxE_1	74	93	PF01857	0.651
LIG_REV1ctd_RIR_1	220	225	PF16727	0.414
LIG_RPA_C_Fungi	28	40	PF08784	0.487
LIG_SH2_CRK	185	189	PF00017	0.427
LIG_SH2_CRK	201	205	PF00017	0.325
LIG_SH2_CRK	326	330	PF00017	0.523
LIG_SH2_NCK_1	185	189	PF00017	0.454
LIG_SH2_PTP2	141	144	PF00017	0.599
LIG_SH2_PTP2	286	289	PF00017	0.400
LIG_SH2_SRC	334	337	PF00017	0.510
LIG_SH2_STAP1	185	189	PF00017	0.510
LIG_SH2_STAP1	229	233	PF00017	0.552
LIG_SH2_STAT5	141	144	PF00017	0.574
LIG_SH2_STAT5	286	289	PF00017	0.400
LIG_SH2_STAT5	334	337	PF00017	0.472
LIG_SH2_STAT5	389	392	PF00017	0.424
LIG_SH3_3	115	121	PF00018	0.586
LIG_SH3_3	148	154	PF00018	0.604
LIG_SH3_3	200	206	PF00018	0.386
LIG_SH3_3	309	315	PF00018	0.483
LIG_SH3_3	330	336	PF00018	0.382
LIG_SH3_3	354	360	PF00018	0.545
LIG_SUMO_SIM_par_1	201	207	PF11976	0.387
LIG_TYR_ITIM	183	188	PF00017	0.489
LIG_WRPW_2	313	316	PF00400	0.319
MOD_CDC14_SPxK_1	311	314	PF00782	0.549
MOD_CDK_SPxK_1	308	314	PF00069	0.487
MOD_CK2_1	224	230	PF00069	0.477
MOD_CK2_1	288	294	PF00069	0.409
MOD_CK2_1	51	57	PF00069	0.676
MOD_DYRK1A_RPxSP_1	308	312	PF00069	0.488
MOD_GlcNHglycan	170	174	PF01048	0.523
MOD_GlcNHglycan	27	30	PF01048	0.783
MOD_GlcNHglycan	308	311	PF01048	0.495
MOD_GlcNHglycan	400	403	PF01048	0.596
MOD_GSK3_1	47	54	PF00069	0.757
MOD_GSK3_1	8	15	PF00069	0.724
MOD_GSK3_1	98	105	PF00069	0.742
MOD_N-GLC_1	129	134	PF02516	0.582
MOD_N-GLC_1	23	28	PF02516	0.603
MOD_N-GLC_1	31	36	PF02516	0.659
MOD_N-GLC_1	61	66	PF02516	0.748
MOD_NEK2_1	155	160	PF00069	0.626
MOD_NEK2_1	300	305	PF00069	0.400
MOD_NEK2_1	306	311	PF00069	0.460
MOD_NEK2_1	31	36	PF00069	0.669
MOD_NEK2_1	60	65	PF00069	0.735
MOD_NEK2_1	8	13	PF00069	0.703
MOD_NEK2_1	96	101	PF00069	0.680
MOD_PIKK_1	31	37	PF00454	0.682
MOD_PIKK_1	88	94	PF00454	0.574
MOD_PK_1	61	67	PF00069	0.713
MOD_PKA_1	17	23	PF00069	0.765
MOD_PKA_2	16	22	PF00069	0.751
MOD_PKA_2	224	230	PF00069	0.477
MOD_PKA_2	47	53	PF00069	0.725
MOD_Plk_1	129	135	PF00069	0.541
MOD_Plk_1	169	175	PF00069	0.520
MOD_Plk_1	61	67	PF00069	0.746
MOD_Plk_4	183	189	PF00069	0.438
MOD_Plk_4	328	334	PF00069	0.384
MOD_ProDKin_1	102	108	PF00069	0.728
MOD_ProDKin_1	178	184	PF00069	0.541
MOD_ProDKin_1	238	244	PF00069	0.400
MOD_ProDKin_1	308	314	PF00069	0.487
MOD_SUMO_rev_2	158	166	PF00179	0.578
MOD_SUMO_rev_2	186	195	PF00179	0.527
TRG_ENDOCYTIC_2	185	188	PF00928	0.421
TRG_ENDOCYTIC_2	199	202	PF00928	0.347
TRG_ENDOCYTIC_2	229	232	PF00928	0.550
TRG_ENDOCYTIC_2	286	289	PF00928	0.400
TRG_ENDOCYTIC_2	326	329	PF00928	0.549
TRG_ENDOCYTIC_2	345	348	PF00928	0.285
TRG_ENDOCYTIC_2	375	378	PF00928	0.389
TRG_ER_diArg_1	111	114	PF00400	0.619
TRG_ER_diArg_1	134	136	PF00400	0.509
TRG_ER_diArg_1	2	4	PF00400	0.595
TRG_ER_diArg_1	356	359	PF00400	0.452
TRG_NLS_MonoCore_2	111	116	PF00514	0.654
TRG_NLS_MonoExtN_4	112	117	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P2	Leptomonas seymouri	85%	100%
A0A0S4JRL5	Bodo saltans	62%	100%
A0A1X0P7G6	Trypanosomatidae	66%	100%
A0A3S7X061	Leishmania donovani	92%	100%
A4HF73	Leishmania braziliensis	86%	100%
A4I2F6	Leishmania infantum	92%	100%
C9ZX41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
Q4Q8W3	Leishmania major	94%	100%
V5BI14	Trypanosoma cruzi	66%	100%