Putative syntaxin binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

syntaxin binding protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9AYK6_LEIMU

TriTrypDb:

LmxM.26.2260

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0020016	ciliary pocket	2	1
GO:0030141	secretory granule	8	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0099503	secretory vesicle	7	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYK6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0006886	intracellular protein transport	4	1
GO:0006904	vesicle docking involved in exocytosis	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0140029	exocytic process	2	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	541	545	PF00656	0.379
CLV_NRD_NRD_1	143	145	PF00675	0.413
CLV_NRD_NRD_1	2	4	PF00675	0.496
CLV_NRD_NRD_1	649	651	PF00675	0.383
CLV_NRD_NRD_1	690	692	PF00675	0.458
CLV_PCSK_KEX2_1	143	145	PF00082	0.413
CLV_PCSK_KEX2_1	2	4	PF00082	0.496
CLV_PCSK_KEX2_1	393	395	PF00082	0.374
CLV_PCSK_KEX2_1	649	651	PF00082	0.365
CLV_PCSK_KEX2_1	689	691	PF00082	0.461
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.160
CLV_PCSK_SKI1_1	185	189	PF00082	0.385
CLV_PCSK_SKI1_1	459	463	PF00082	0.346
CLV_PCSK_SKI1_1	503	507	PF00082	0.405
CLV_PCSK_SKI1_1	58	62	PF00082	0.623
CLV_PCSK_SKI1_1	643	647	PF00082	0.436
CLV_PCSK_SKI1_1	649	653	PF00082	0.392
CLV_PCSK_SKI1_1	691	695	PF00082	0.300
DEG_APCC_DBOX_1	481	489	PF00400	0.339
DEG_APCC_DBOX_1	690	698	PF00400	0.362
DEG_Nend_UBRbox_1	1	4	PF02207	0.705
DEG_SPOP_SBC_1	30	34	PF00917	0.589
DOC_CKS1_1	726	731	PF01111	0.425
DOC_MAPK_DCC_7	212	220	PF00069	0.425
DOC_MAPK_gen_1	185	194	PF00069	0.350
DOC_MAPK_gen_1	363	371	PF00069	0.463
DOC_MAPK_gen_1	482	490	PF00069	0.317
DOC_MAPK_gen_1	687	696	PF00069	0.392
DOC_MAPK_MEF2A_6	185	194	PF00069	0.362
DOC_MAPK_MEF2A_6	212	220	PF00069	0.425
DOC_MAPK_MEF2A_6	424	431	PF00069	0.314
DOC_MAPK_MEF2A_6	470	479	PF00069	0.355
DOC_MAPK_MEF2A_6	482	489	PF00069	0.241
DOC_MAPK_MEF2A_6	687	696	PF00069	0.390
DOC_MAPK_NFAT4_5	482	490	PF00069	0.305
DOC_MAPK_NFAT4_5	689	697	PF00069	0.452
DOC_PP1_RVXF_1	689	696	PF00149	0.305
DOC_PP2B_LxvP_1	119	122	PF13499	0.425
DOC_PP2B_LxvP_1	213	216	PF13499	0.367
DOC_PP4_FxxP_1	194	197	PF00568	0.305
DOC_USP7_MATH_1	21	25	PF00917	0.597
DOC_USP7_MATH_1	270	274	PF00917	0.434
DOC_USP7_MATH_1	346	350	PF00917	0.277
DOC_USP7_MATH_1	473	477	PF00917	0.410
DOC_USP7_MATH_1	564	568	PF00917	0.345
DOC_WW_Pin1_4	14	19	PF00397	0.696
DOC_WW_Pin1_4	2	7	PF00397	0.783
DOC_WW_Pin1_4	284	289	PF00397	0.321
DOC_WW_Pin1_4	294	299	PF00397	0.379
DOC_WW_Pin1_4	578	583	PF00397	0.444
DOC_WW_Pin1_4	597	602	PF00397	0.454
DOC_WW_Pin1_4	725	730	PF00397	0.425
LIG_14-3-3_CanoR_1	281	288	PF00244	0.418
LIG_14-3-3_CanoR_1	482	488	PF00244	0.371
LIG_14-3-3_CanoR_1	518	523	PF00244	0.321
LIG_14-3-3_CanoR_1	631	635	PF00244	0.413
LIG_14-3-3_CanoR_1	731	737	PF00244	0.452
LIG_Actin_WH2_2	639	655	PF00022	0.425
LIG_APCC_ABBA_1	204	209	PF00400	0.452
LIG_APCC_ABBA_1	425	430	PF00400	0.305
LIG_APCC_ABBAyCdc20_2	424	430	PF00400	0.305
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.488
LIG_BRCT_BRCA1_1	198	202	PF00533	0.393
LIG_BRCT_BRCA1_1	236	240	PF00533	0.425
LIG_Clathr_ClatBox_1	300	304	PF01394	0.339
LIG_Clathr_ClatBox_1	326	330	PF01394	0.321
LIG_deltaCOP1_diTrp_1	356	366	PF00928	0.309
LIG_DLG_GKlike_1	638	646	PF00625	0.374
LIG_FHA_1	231	237	PF00498	0.432
LIG_FHA_1	484	490	PF00498	0.415
LIG_FHA_1	527	533	PF00498	0.327
LIG_FHA_1	558	564	PF00498	0.160
LIG_FHA_1	673	679	PF00498	0.370
LIG_FHA_1	712	718	PF00498	0.352
LIG_FHA_1	722	728	PF00498	0.254
LIG_FHA_2	112	118	PF00498	0.305
LIG_FHA_2	184	190	PF00498	0.425
LIG_FHA_2	539	545	PF00498	0.421
LIG_FHA_2	699	705	PF00498	0.305
LIG_LIR_Apic_2	193	197	PF02991	0.316
LIG_LIR_Gen_1	304	314	PF02991	0.321
LIG_LIR_Gen_1	316	327	PF02991	0.321
LIG_LIR_Gen_1	463	473	PF02991	0.339
LIG_LIR_Gen_1	521	526	PF02991	0.396
LIG_LIR_Gen_1	83	90	PF02991	0.494
LIG_LIR_Nem_3	237	242	PF02991	0.390
LIG_LIR_Nem_3	304	310	PF02991	0.321
LIG_LIR_Nem_3	316	322	PF02991	0.321
LIG_LIR_Nem_3	356	362	PF02991	0.305
LIG_LIR_Nem_3	463	468	PF02991	0.344
LIG_LIR_Nem_3	521	525	PF02991	0.396
LIG_LIR_Nem_3	625	630	PF02991	0.337
LIG_LIR_Nem_3	663	667	PF02991	0.374
LIG_LIR_Nem_3	701	705	PF02991	0.371
LIG_LIR_Nem_3	83	89	PF02991	0.416
LIG_MLH1_MIPbox_1	236	240	PF16413	0.425
LIG_NRBOX	484	490	PF00104	0.326
LIG_PCNA_yPIPBox_3	317	327	PF02747	0.321
LIG_Pex14_2	630	634	PF04695	0.374
LIG_PTB_Apo_2	328	335	PF02174	0.321
LIG_PTB_Apo_2	605	612	PF02174	0.362
LIG_PTB_Phospho_1	328	334	PF10480	0.321
LIG_PTB_Phospho_1	605	611	PF10480	0.362
LIG_SH2_CRK	319	323	PF00017	0.321
LIG_SH2_CRK	465	469	PF00017	0.425
LIG_SH2_CRK	86	90	PF00017	0.381
LIG_SH2_GRB2like	465	468	PF00017	0.374
LIG_SH2_NCK_1	709	713	PF00017	0.374
LIG_SH2_SRC	465	468	PF00017	0.374
LIG_SH2_SRC	709	712	PF00017	0.339
LIG_SH2_STAP1	334	338	PF00017	0.390
LIG_SH2_STAT3	358	361	PF00017	0.362
LIG_SH2_STAT3	439	442	PF00017	0.339
LIG_SH2_STAT3	606	609	PF00017	0.425
LIG_SH2_STAT5	133	136	PF00017	0.305
LIG_SH2_STAT5	611	614	PF00017	0.366
LIG_SH3_3	119	125	PF00018	0.297
LIG_SH3_3	472	478	PF00018	0.390
LIG_SUMO_SIM_anti_2	295	304	PF11976	0.421
LIG_SUMO_SIM_anti_2	486	491	PF11976	0.226
LIG_SUMO_SIM_par_1	295	304	PF11976	0.316
LIG_SUMO_SIM_par_1	403	410	PF11976	0.160
LIG_TRAF2_1	137	140	PF00917	0.425
LIG_TRAF2_1	342	345	PF00917	0.452
LIG_TYR_ITIM	700	705	PF00017	0.440
MOD_CDK_SPxK_1	725	731	PF00069	0.425
MOD_CK1_1	164	170	PF00069	0.452
MOD_CK1_1	28	34	PF00069	0.739
MOD_CK1_1	284	290	PF00069	0.363
MOD_CK1_1	725	731	PF00069	0.425
MOD_CK2_1	111	117	PF00069	0.321
MOD_CK2_1	162	168	PF00069	0.407
MOD_CK2_1	192	198	PF00069	0.178
MOD_CK2_1	339	345	PF00069	0.406
MOD_CK2_1	698	704	PF00069	0.321
MOD_Cter_Amidation	55	58	PF01082	0.691
MOD_GlcNHglycan	128	131	PF01048	0.421
MOD_GlcNHglycan	220	223	PF01048	0.425
MOD_GlcNHglycan	23	26	PF01048	0.774
MOD_GlcNHglycan	28	31	PF01048	0.749
MOD_GlcNHglycan	283	286	PF01048	0.450
MOD_GlcNHglycan	33	36	PF01048	0.713
MOD_GlcNHglycan	341	344	PF01048	0.390
MOD_GlcNHglycan	396	399	PF01048	0.432
MOD_GlcNHglycan	409	412	PF01048	0.340
MOD_GlcNHglycan	41	44	PF01048	0.631
MOD_GlcNHglycan	577	581	PF01048	0.437
MOD_GSK3_1	160	167	PF00069	0.421
MOD_GSK3_1	192	199	PF00069	0.180
MOD_GSK3_1	21	28	PF00069	0.735
MOD_GSK3_1	226	233	PF00069	0.360
MOD_GSK3_1	234	241	PF00069	0.301
MOD_GSK3_1	280	287	PF00069	0.400
MOD_GSK3_1	492	499	PF00069	0.338
MOD_GSK3_1	507	514	PF00069	0.321
MOD_GSK3_1	520	527	PF00069	0.455
MOD_GSK3_1	534	541	PF00069	0.346
MOD_GSK3_1	618	625	PF00069	0.323
MOD_GSK3_1	721	728	PF00069	0.425
MOD_GSK3_1	731	738	PF00069	0.425
MOD_N-GLC_1	570	575	PF02516	0.423
MOD_N-GLC_1	596	601	PF02516	0.465
MOD_N-GLC_1	618	623	PF02516	0.274
MOD_N-GLC_2	203	205	PF02516	0.374
MOD_N-GLC_2	517	519	PF02516	0.160
MOD_NEK2_1	161	166	PF00069	0.402
MOD_NEK2_1	192	197	PF00069	0.185
MOD_NEK2_1	280	285	PF00069	0.414
MOD_NEK2_1	507	512	PF00069	0.397
MOD_NEK2_1	524	529	PF00069	0.382
MOD_NEK2_1	630	635	PF00069	0.416
MOD_NEK2_1	732	737	PF00069	0.374
MOD_NEK2_2	183	188	PF00069	0.452
MOD_NEK2_2	423	428	PF00069	0.305
MOD_NEK2_2	564	569	PF00069	0.374
MOD_PIKK_1	230	236	PF00454	0.219
MOD_PIKK_1	252	258	PF00454	0.464
MOD_PKA_2	280	286	PF00069	0.442
MOD_PKA_2	483	489	PF00069	0.318
MOD_PKA_2	630	636	PF00069	0.326
MOD_Plk_1	138	144	PF00069	0.298
MOD_Plk_1	192	198	PF00069	0.246
MOD_Plk_1	303	309	PF00069	0.321
MOD_Plk_1	315	321	PF00069	0.321
MOD_Plk_1	334	340	PF00069	0.356
MOD_Plk_1	473	479	PF00069	0.348
MOD_Plk_1	618	624	PF00069	0.274
MOD_Plk_4	111	117	PF00069	0.353
MOD_Plk_4	196	202	PF00069	0.344
MOD_Plk_4	234	240	PF00069	0.353
MOD_Plk_4	377	383	PF00069	0.425
MOD_Plk_4	483	489	PF00069	0.249
MOD_Plk_4	722	728	PF00069	0.305
MOD_ProDKin_1	14	20	PF00069	0.696
MOD_ProDKin_1	2	8	PF00069	0.784
MOD_ProDKin_1	284	290	PF00069	0.321
MOD_ProDKin_1	294	300	PF00069	0.379
MOD_ProDKin_1	578	584	PF00069	0.444
MOD_ProDKin_1	597	603	PF00069	0.454
MOD_ProDKin_1	725	731	PF00069	0.425
MOD_SUMO_rev_2	497	504	PF00179	0.406
TRG_DiLeu_BaEn_1	296	301	PF01217	0.425
TRG_DiLeu_BaEn_1	500	505	PF01217	0.425
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.374
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.408
TRG_ENDOCYTIC_2	319	322	PF00928	0.305
TRG_ENDOCYTIC_2	465	468	PF00928	0.390
TRG_ENDOCYTIC_2	611	614	PF00928	0.321
TRG_ENDOCYTIC_2	702	705	PF00928	0.401
TRG_ENDOCYTIC_2	86	89	PF00928	0.444
TRG_ER_diArg_1	1	3	PF00400	0.502
TRG_ER_diArg_1	142	144	PF00400	0.413
TRG_ER_diArg_1	481	484	PF00400	0.348
TRG_ER_diArg_1	689	691	PF00400	0.425
TRG_ER_diArg_1	70	73	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUY7	Leptomonas seymouri	63%	100%
A0A0S4J1J9	Bodo saltans	38%	100%
A0A1X0P7K8	Trypanosomatidae	40%	100%
A0A3Q8ID43	Leishmania donovani	92%	100%
A0A3Q8IG36	Leishmania donovani	20%	100%
A0A3R7MWF2	Trypanosoma rangeli	40%	100%
A4HF70	Leishmania braziliensis	75%	100%
A4I2F3	Leishmania infantum	92%	100%
A4IDJ7	Leishmania infantum	20%	100%
C9ZX51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AT00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	100%
Q4Q8W6	Leishmania major	90%	100%
Q54QC8	Dictyostelium discoideum	24%	100%
Q5VNU3	Oryza sativa subsp. japonica	26%	100%
Q9C5P7	Arabidopsis thaliana	24%	100%
V5AUI0	Trypanosoma cruzi	39%	100%