Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYK5_LEIMU

TriTrypDb:

LmxM.26.2250

Length:

823

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.476
CLV_NRD_NRD_1	29	31	PF00675	0.506
CLV_NRD_NRD_1	345	347	PF00675	0.720
CLV_NRD_NRD_1	350	352	PF00675	0.714
CLV_NRD_NRD_1	503	505	PF00675	0.599
CLV_NRD_NRD_1	661	663	PF00675	0.690
CLV_NRD_NRD_1	71	73	PF00675	0.605
CLV_NRD_NRD_1	95	97	PF00675	0.524
CLV_PCSK_FUR_1	628	632	PF00082	0.643
CLV_PCSK_KEX2_1	29	31	PF00082	0.506
CLV_PCSK_KEX2_1	344	346	PF00082	0.666
CLV_PCSK_KEX2_1	350	352	PF00082	0.593
CLV_PCSK_KEX2_1	487	489	PF00082	0.528
CLV_PCSK_KEX2_1	502	504	PF00082	0.599
CLV_PCSK_KEX2_1	630	632	PF00082	0.620
CLV_PCSK_KEX2_1	661	663	PF00082	0.709
CLV_PCSK_KEX2_1	97	99	PF00082	0.496
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.528
CLV_PCSK_PC1ET2_1	630	632	PF00082	0.650
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.448
CLV_PCSK_PC7_1	346	352	PF00082	0.474
CLV_PCSK_PC7_1	483	489	PF00082	0.524
CLV_PCSK_SKI1_1	30	34	PF00082	0.569
CLV_PCSK_SKI1_1	449	453	PF00082	0.762
CLV_PCSK_SKI1_1	463	467	PF00082	0.589
CLV_PCSK_SKI1_1	528	532	PF00082	0.668
CLV_PCSK_SKI1_1	569	573	PF00082	0.583
CLV_PCSK_SKI1_1	631	635	PF00082	0.626
CLV_PCSK_SKI1_1	784	788	PF00082	0.549
DEG_COP1_1	684	692	PF00400	0.615
DEG_SCF_FBW7_1	677	684	PF00400	0.498
DEG_SPOP_SBC_1	16	20	PF00917	0.657
DOC_CDC14_PxL_1	686	694	PF14671	0.560
DOC_CKS1_1	678	683	PF01111	0.501
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.694
DOC_CYCLIN_yCln2_LP_2	551	557	PF00134	0.569
DOC_MAPK_gen_1	449	458	PF00069	0.612
DOC_MAPK_gen_1	487	495	PF00069	0.553
DOC_MAPK_gen_1	70	78	PF00069	0.487
DOC_PP1_RVXF_1	536	543	PF00149	0.423
DOC_PP2B_LxvP_1	138	141	PF13499	0.582
DOC_PP4_FxxP_1	475	478	PF00568	0.677
DOC_PP4_FxxP_1	678	681	PF00568	0.440
DOC_USP7_MATH_1	133	137	PF00917	0.614
DOC_USP7_MATH_1	263	267	PF00917	0.608
DOC_USP7_MATH_1	276	280	PF00917	0.691
DOC_USP7_MATH_1	325	329	PF00917	0.540
DOC_USP7_MATH_1	506	510	PF00917	0.718
DOC_USP7_MATH_1	577	581	PF00917	0.722
DOC_USP7_MATH_1	589	593	PF00917	0.456
DOC_USP7_UBL2_3	784	788	PF12436	0.567
DOC_WW_Pin1_4	288	293	PF00397	0.759
DOC_WW_Pin1_4	458	463	PF00397	0.701
DOC_WW_Pin1_4	543	548	PF00397	0.677
DOC_WW_Pin1_4	677	682	PF00397	0.545
DOC_WW_Pin1_4	736	741	PF00397	0.700
LIG_14-3-3_CanoR_1	171	177	PF00244	0.610
LIG_14-3-3_CanoR_1	361	365	PF00244	0.571
LIG_14-3-3_CanoR_1	442	451	PF00244	0.732
LIG_14-3-3_CanoR_1	483	487	PF00244	0.525
LIG_14-3-3_CanoR_1	528	533	PF00244	0.663
LIG_14-3-3_CanoR_1	569	574	PF00244	0.623
LIG_14-3-3_CanoR_1	661	670	PF00244	0.580
LIG_14-3-3_CanoR_1	796	805	PF00244	0.606
LIG_BIR_II_1	1	5	PF00653	0.690
LIG_BRCT_BRCA1_1	135	139	PF00533	0.635
LIG_BRCT_BRCA1_1	453	457	PF00533	0.588
LIG_Clathr_ClatBox_1	492	496	PF01394	0.625
LIG_eIF4E_1	183	189	PF01652	0.559
LIG_FHA_1	17	23	PF00498	0.617
LIG_FHA_1	183	189	PF00498	0.619
LIG_FHA_1	202	208	PF00498	0.574
LIG_FHA_1	395	401	PF00498	0.567
LIG_FHA_1	700	706	PF00498	0.693
LIG_FHA_1	711	717	PF00498	0.518
LIG_FHA_1	737	743	PF00498	0.725
LIG_FHA_1	767	773	PF00498	0.669
LIG_FHA_1	8	14	PF00498	0.628
LIG_FHA_2	19	25	PF00498	0.592
LIG_FHA_2	361	367	PF00498	0.626
LIG_FHA_2	416	422	PF00498	0.669
LIG_FHA_2	534	540	PF00498	0.634
LIG_FHA_2	612	618	PF00498	0.658
LIG_LIR_Apic_2	473	478	PF02991	0.678
LIG_LIR_Apic_2	769	774	PF02991	0.672
LIG_LIR_Gen_1	170	181	PF02991	0.624
LIG_LIR_Gen_1	190	201	PF02991	0.373
LIG_LIR_Gen_1	799	810	PF02991	0.563
LIG_LIR_Nem_3	170	176	PF02991	0.610
LIG_LIR_Nem_3	190	196	PF02991	0.375
LIG_LIR_Nem_3	197	202	PF02991	0.474
LIG_LIR_Nem_3	473	479	PF02991	0.523
LIG_LIR_Nem_3	621	625	PF02991	0.640
LIG_LIR_Nem_3	799	805	PF02991	0.618
LIG_LIR_Nem_3	816	822	PF02991	0.564
LIG_LYPXL_yS_3	479	482	PF13949	0.659
LIG_MAD2	368	376	PF02301	0.711
LIG_PTB_Apo_2	49	56	PF02174	0.556
LIG_SH2_NCK_1	193	197	PF00017	0.635
LIG_SH2_NCK_1	362	366	PF00017	0.624
LIG_SH2_PTP2	173	176	PF00017	0.598
LIG_SH2_PTP2	373	376	PF00017	0.672
LIG_SH2_STAP1	815	819	PF00017	0.615
LIG_SH2_STAT5	173	176	PF00017	0.598
LIG_SH2_STAT5	260	263	PF00017	0.527
LIG_SH2_STAT5	362	365	PF00017	0.591
LIG_SH2_STAT5	373	376	PF00017	0.598
LIG_SH2_STAT5	4	7	PF00017	0.633
LIG_SH2_STAT5	417	420	PF00017	0.708
LIG_SH2_STAT5	729	732	PF00017	0.719
LIG_SH2_STAT5	771	774	PF00017	0.686
LIG_SH2_STAT5	802	805	PF00017	0.676
LIG_SH2_STAT5	815	818	PF00017	0.585
LIG_SH3_1	373	379	PF00018	0.672
LIG_SH3_3	138	144	PF00018	0.694
LIG_SH3_3	215	221	PF00018	0.676
LIG_SH3_3	289	295	PF00018	0.782
LIG_SH3_3	361	367	PF00018	0.681
LIG_SH3_3	373	379	PF00018	0.728
LIG_SH3_3	667	673	PF00018	0.562
LIG_SH3_3	804	810	PF00018	0.511
LIG_SUMO_SIM_par_1	553	559	PF11976	0.686
LIG_TRAF2_1	747	750	PF00917	0.469
LIG_TYR_ITIM	360	365	PF00017	0.631
LIG_TYR_ITIM	817	822	PF00017	0.584
LIG_UBA3_1	27	36	PF00899	0.620
LIG_WRC_WIRS_1	196	201	PF05994	0.515
LIG_WW_3	573	577	PF00397	0.568
MOD_CDK_SPK_2	291	296	PF00069	0.766
MOD_CDK_SPK_2	458	463	PF00069	0.710
MOD_CDK_SPxK_1	543	549	PF00069	0.510
MOD_CK1_1	120	126	PF00069	0.694
MOD_CK1_1	18	24	PF00069	0.712
MOD_CK1_1	266	272	PF00069	0.577
MOD_CK1_1	291	297	PF00069	0.732
MOD_CK1_1	34	40	PF00069	0.550
MOD_CK1_1	432	438	PF00069	0.598
MOD_CK1_1	580	586	PF00069	0.526
MOD_CK1_1	592	598	PF00069	0.442
MOD_CK1_1	63	69	PF00069	0.636
MOD_CK1_1	699	705	PF00069	0.692
MOD_CK2_1	265	271	PF00069	0.466
MOD_CK2_1	360	366	PF00069	0.570
MOD_CK2_1	415	421	PF00069	0.636
MOD_CK2_1	511	517	PF00069	0.661
MOD_CK2_1	611	617	PF00069	0.652
MOD_Cter_Amidation	348	351	PF01082	0.475
MOD_Cter_Amidation	94	97	PF01082	0.416
MOD_GlcNHglycan	107	110	PF01048	0.740
MOD_GlcNHglycan	122	125	PF01048	0.747
MOD_GlcNHglycan	217	221	PF01048	0.562
MOD_GlcNHglycan	278	281	PF01048	0.589
MOD_GlcNHglycan	327	330	PF01048	0.790
MOD_GlcNHglycan	33	36	PF01048	0.573
MOD_GlcNHglycan	405	408	PF01048	0.757
MOD_GlcNHglycan	508	511	PF01048	0.624
MOD_GlcNHglycan	61	65	PF01048	0.602
MOD_GlcNHglycan	640	643	PF01048	0.626
MOD_GlcNHglycan	664	667	PF01048	0.677
MOD_GlcNHglycan	698	701	PF01048	0.638
MOD_GSK3_1	105	112	PF00069	0.566
MOD_GSK3_1	114	121	PF00069	0.574
MOD_GSK3_1	129	136	PF00069	0.586
MOD_GSK3_1	142	149	PF00069	0.494
MOD_GSK3_1	179	186	PF00069	0.575
MOD_GSK3_1	263	270	PF00069	0.642
MOD_GSK3_1	298	305	PF00069	0.630
MOD_GSK3_1	308	315	PF00069	0.615
MOD_GSK3_1	34	41	PF00069	0.627
MOD_GSK3_1	394	401	PF00069	0.530
MOD_GSK3_1	411	418	PF00069	0.494
MOD_GSK3_1	429	436	PF00069	0.634
MOD_GSK3_1	452	459	PF00069	0.637
MOD_GSK3_1	528	535	PF00069	0.677
MOD_GSK3_1	577	584	PF00069	0.782
MOD_GSK3_1	589	596	PF00069	0.561
MOD_GSK3_1	656	663	PF00069	0.711
MOD_GSK3_1	677	684	PF00069	0.619
MOD_GSK3_1	688	695	PF00069	0.655
MOD_GSK3_1	696	703	PF00069	0.611
MOD_GSK3_1	706	713	PF00069	0.527
MOD_GSK3_1	738	745	PF00069	0.791
MOD_N-GLC_1	183	188	PF02516	0.563
MOD_N-GLC_1	48	53	PF02516	0.588
MOD_N-GLC_1	543	548	PF02516	0.532
MOD_N-GLC_1	681	686	PF02516	0.610
MOD_N-GLC_2	411	413	PF02516	0.470
MOD_NEK2_1	105	110	PF00069	0.602
MOD_NEK2_1	161	166	PF00069	0.510
MOD_NEK2_1	195	200	PF00069	0.508
MOD_NEK2_1	31	36	PF00069	0.576
MOD_NEK2_1	415	420	PF00069	0.625
MOD_NEK2_1	424	429	PF00069	0.655
MOD_NEK2_1	482	487	PF00069	0.498
MOD_NEK2_1	532	537	PF00069	0.650
MOD_NEK2_1	561	566	PF00069	0.699
MOD_NEK2_1	692	697	PF00069	0.713
MOD_NEK2_1	91	96	PF00069	0.644
MOD_PIKK_1	133	139	PF00454	0.630
MOD_PIKK_1	258	264	PF00454	0.720
MOD_PIKK_1	415	421	PF00454	0.636
MOD_PIKK_1	611	617	PF00454	0.644
MOD_PIKK_1	656	662	PF00454	0.569
MOD_PKA_2	258	264	PF00069	0.567
MOD_PKA_2	318	324	PF00069	0.673
MOD_PKA_2	360	366	PF00069	0.558
MOD_PKA_2	482	488	PF00069	0.523
MOD_PKA_2	561	567	PF00069	0.698
MOD_PKA_2	660	666	PF00069	0.617
MOD_PKA_2	710	716	PF00069	0.598
MOD_PKA_2	91	97	PF00069	0.692
MOD_Plk_1	133	139	PF00069	0.630
MOD_Plk_1	183	189	PF00069	0.559
MOD_Plk_1	593	599	PF00069	0.554
MOD_Plk_1	719	725	PF00069	0.628
MOD_Plk_4	172	178	PF00069	0.513
MOD_Plk_4	360	366	PF00069	0.627
MOD_Plk_4	452	458	PF00069	0.631
MOD_Plk_4	511	517	PF00069	0.668
MOD_Plk_4	605	611	PF00069	0.646
MOD_ProDKin_1	288	294	PF00069	0.759
MOD_ProDKin_1	458	464	PF00069	0.702
MOD_ProDKin_1	543	549	PF00069	0.678
MOD_ProDKin_1	677	683	PF00069	0.546
MOD_ProDKin_1	736	742	PF00069	0.702
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.559
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.381
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.615
TRG_ENDOCYTIC_2	173	176	PF00928	0.467
TRG_ENDOCYTIC_2	193	196	PF00928	0.369
TRG_ENDOCYTIC_2	362	365	PF00928	0.571
TRG_ENDOCYTIC_2	479	482	PF00928	0.527
TRG_ENDOCYTIC_2	802	805	PF00928	0.624
TRG_ENDOCYTIC_2	819	822	PF00928	0.584
TRG_ER_diArg_1	256	259	PF00400	0.559
TRG_ER_diArg_1	28	30	PF00400	0.505
TRG_ER_diArg_1	343	346	PF00400	0.661
TRG_ER_diArg_1	502	504	PF00400	0.678
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z2	Leptomonas seymouri	55%	99%
A0A1X0P794	Trypanosomatidae	32%	100%
A0A3Q8IG16	Leishmania donovani	90%	100%
A0A3R7KYT8	Trypanosoma rangeli	35%	100%
A4HF69	Leishmania braziliensis	77%	98%
A4I2F2	Leishmania infantum	90%	100%
C9ZX52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q8W7	Leishmania major	89%	100%
V5AUK1	Trypanosoma cruzi	35%	100%