Putative GDP-mannose 4,6 dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GDP-mannose 4,6 dehydratase, putative

Species:

Leishmania mexicana

UniProt:

E9AYK3_LEIMU

TriTrypDb:

LmxM.26.2230

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYK3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009225	nucleotide-sugar metabolic process	4	9
GO:0009987	cellular process	1	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044281	small molecule metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0055086	nucleobase-containing small molecule metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:1901135	carbohydrate derivative metabolic process	3	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008460	dTDP-glucose 4,6-dehydratase activity	5	9
GO:0016829	lyase activity	2	9
GO:0016835	carbon-oxygen lyase activity	3	9
GO:0016836	hydro-lyase activity	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.418
CLV_NRD_NRD_1	413	415	PF00675	0.431
CLV_NRD_NRD_1	419	421	PF00675	0.547
CLV_PCSK_KEX2_1	340	342	PF00082	0.306
CLV_PCSK_KEX2_1	413	415	PF00082	0.431
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.180
CLV_PCSK_SKI1_1	186	190	PF00082	0.458
CLV_PCSK_SKI1_1	310	314	PF00082	0.319
CLV_PCSK_SKI1_1	49	53	PF00082	0.459
CLV_PCSK_SKI1_1	75	79	PF00082	0.411
DEG_APCC_DBOX_1	48	56	PF00400	0.484
DOC_MAPK_MEF2A_6	164	172	PF00069	0.418
DOC_PP1_RVXF_1	184	191	PF00149	0.472
DOC_PP1_RVXF_1	412	419	PF00149	0.534
DOC_PP4_FxxP_1	264	267	PF00568	0.337
DOC_USP7_MATH_1	116	120	PF00917	0.688
DOC_USP7_MATH_1	121	125	PF00917	0.731
DOC_USP7_MATH_1	132	136	PF00917	0.440
DOC_USP7_MATH_1	37	41	PF00917	0.505
DOC_USP7_MATH_1	404	408	PF00917	0.180
DOC_WW_Pin1_4	138	143	PF00397	0.609
DOC_WW_Pin1_4	223	228	PF00397	0.451
LIG_14-3-3_CanoR_1	27	33	PF00244	0.679
LIG_14-3-3_CanoR_1	389	397	PF00244	0.459
LIG_14-3-3_CanoR_1	413	417	PF00244	0.417
LIG_APCC_ABBA_1	300	305	PF00400	0.394
LIG_APCC_ABBAyCdc20_2	299	305	PF00400	0.449
LIG_APCC_ABBAyCdc20_2	310	316	PF00400	0.382
LIG_BRCT_BRCA1_1	186	190	PF00533	0.337
LIG_EH1_1	165	173	PF00400	0.370
LIG_FHA_1	155	161	PF00498	0.472
LIG_FHA_1	163	169	PF00498	0.290
LIG_FHA_1	196	202	PF00498	0.337
LIG_FHA_1	210	216	PF00498	0.337
LIG_FHA_1	217	223	PF00498	0.268
LIG_FHA_1	28	34	PF00498	0.740
LIG_FHA_1	322	328	PF00498	0.418
LIG_FHA_2	107	113	PF00498	0.599
LIG_FHA_2	176	182	PF00498	0.376
LIG_FHA_2	198	204	PF00498	0.472
LIG_FHA_2	390	396	PF00498	0.394
LIG_GBD_Chelix_1	318	326	PF00786	0.472
LIG_IBAR_NPY_1	244	246	PF08397	0.337
LIG_LIR_Apic_2	263	267	PF02991	0.337
LIG_LIR_Gen_1	144	154	PF02991	0.342
LIG_LIR_Gen_1	187	196	PF02991	0.379
LIG_LIR_Gen_1	212	222	PF02991	0.370
LIG_LIR_Gen_1	258	269	PF02991	0.394
LIG_LIR_Gen_1	311	319	PF02991	0.346
LIG_LIR_Nem_3	144	149	PF02991	0.342
LIG_LIR_Nem_3	187	193	PF02991	0.379
LIG_LIR_Nem_3	207	211	PF02991	0.142
LIG_LIR_Nem_3	212	217	PF02991	0.307
LIG_LIR_Nem_3	258	264	PF02991	0.394
LIG_LIR_Nem_3	311	315	PF02991	0.346
LIG_LIR_Nem_3	373	379	PF02991	0.412
LIG_LIR_Nem_3	71	76	PF02991	0.197
LIG_SH2_CRK	146	150	PF00017	0.337
LIG_SH2_CRK	208	212	PF00017	0.397
LIG_SH2_NCK_1	80	84	PF00017	0.507
LIG_SH2_SRC	80	83	PF00017	0.502
LIG_SH2_STAT5	314	317	PF00017	0.418
LIG_SH2_STAT5	376	379	PF00017	0.390
LIG_SH2_STAT5	390	393	PF00017	0.410
LIG_SH2_STAT5	76	79	PF00017	0.282
LIG_SH2_STAT5	95	98	PF00017	0.374
LIG_SH3_3	236	242	PF00018	0.346
LIG_SH3_3	99	105	PF00018	0.453
LIG_SUMO_SIM_par_1	155	161	PF11976	0.355
LIG_SUMO_SIM_par_1	266	271	PF11976	0.390
LIG_TRAF2_1	407	410	PF00917	0.394
LIG_WRC_WIRS_1	261	266	PF05994	0.401
LIG_WRC_WIRS_1	287	292	PF05994	0.394
MOD_CDK_SPxxK_3	138	145	PF00069	0.589
MOD_CK1_1	119	125	PF00069	0.641
MOD_CK1_1	141	147	PF00069	0.425
MOD_CK2_1	119	125	PF00069	0.631
MOD_CK2_1	197	203	PF00069	0.472
MOD_CK2_1	215	221	PF00069	0.312
MOD_CK2_1	336	342	PF00069	0.356
MOD_CK2_1	389	395	PF00069	0.472
MOD_CK2_1	404	410	PF00069	0.472
MOD_GlcNHglycan	121	124	PF01048	0.561
MOD_GlcNHglycan	14	17	PF01048	0.714
MOD_GlcNHglycan	257	260	PF01048	0.394
MOD_GlcNHglycan	319	322	PF01048	0.226
MOD_GlcNHglycan	70	73	PF01048	0.423
MOD_GSK3_1	180	187	PF00069	0.337
MOD_GSK3_1	19	26	PF00069	0.718
MOD_GSK3_1	27	34	PF00069	0.608
MOD_GSK3_1	317	324	PF00069	0.239
MOD_GSK3_1	436	443	PF00069	0.754
MOD_N-GLC_1	27	32	PF02516	0.679
MOD_N-GLC_1	3	8	PF02516	0.747
MOD_N-GLC_1	335	340	PF02516	0.403
MOD_NEK2_1	154	159	PF00069	0.443
MOD_NEK2_1	184	189	PF00069	0.337
MOD_NEK2_1	3	8	PF00069	0.712
MOD_NEK2_1	372	377	PF00069	0.472
MOD_NEK2_1	412	417	PF00069	0.413
MOD_NEK2_1	68	73	PF00069	0.390
MOD_NEK2_2	260	265	PF00069	0.418
MOD_PIKK_1	188	194	PF00454	0.401
MOD_PK_1	341	347	PF00069	0.394
MOD_PKA_2	26	32	PF00069	0.703
MOD_PKA_2	412	418	PF00069	0.401
MOD_Plk_1	154	160	PF00069	0.472
MOD_Plk_1	180	186	PF00069	0.337
MOD_Plk_1	234	240	PF00069	0.472
MOD_Plk_1	341	347	PF00069	0.324
MOD_Plk_1	372	378	PF00069	0.462
MOD_Plk_1	404	410	PF00069	0.474
MOD_Plk_4	149	155	PF00069	0.418
MOD_Plk_4	197	203	PF00069	0.421
MOD_Plk_4	286	292	PF00069	0.394
MOD_Plk_4	321	327	PF00069	0.418
MOD_Plk_4	372	378	PF00069	0.472
MOD_ProDKin_1	138	144	PF00069	0.603
MOD_ProDKin_1	223	229	PF00069	0.451
TRG_ENDOCYTIC_2	146	149	PF00928	0.337
TRG_ENDOCYTIC_2	208	211	PF00928	0.397
TRG_ENDOCYTIC_2	261	264	PF00928	0.394
TRG_ENDOCYTIC_2	76	79	PF00928	0.213
TRG_ER_diArg_1	412	414	PF00400	0.394
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L5	Leptomonas seymouri	59%	100%
A0A0S4JG28	Bodo saltans	25%	100%
A0A0S4KEP1	Bodo saltans	25%	100%
A0A1X0NTG2	Trypanosomatidae	25%	100%
A0A1X0P4J8	Trypanosomatidae	26%	100%
A0A1X0P7H6	Trypanosomatidae	38%	100%
A0A3Q8IH81	Leishmania donovani	89%	99%
A0A3R7NVB4	Trypanosoma rangeli	42%	100%
A0QSK6	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	35%	100%
A0R5C5	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	29%	100%
A4HF67	Leishmania braziliensis	76%	100%
A4I2F0	Leishmania infantum	90%	99%
A6QLW2	Bos taurus	37%	100%
B0RVL0	Xanthomonas campestris pv. campestris (strain B100)	37%	100%
B9J8R3	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)	25%	100%
D4GU72	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	39%	100%
F8C4X8	Thermodesulfobacterium geofontis (strain OPF15)	26%	100%
O34886	Bacillus subtilis (strain 168)	29%	100%
O81312	Arabidopsis thaliana	22%	100%
O95455	Homo sapiens	37%	100%
P0C7J0	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	37%	100%
P13226	Streptomyces lividans	26%	100%
P14169	Salmonella typhi	21%	100%
P24325	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
P26391	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	100%
P27830	Escherichia coli (strain K12)	35%	100%
P29782	Streptomyces griseus	35%	100%
P33119	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)	26%	100%
P35673	Erwinia amylovora	24%	100%
P37759	Escherichia coli (strain K12)	34%	100%
P37761	Neisseria gonorrhoeae	35%	100%
P37777	Shigella flexneri	34%	100%
P39630	Bacillus subtilis (strain 168)	32%	100%
P39858	Staphylococcus aureus	20%	100%
P44914	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	35%	100%
P55293	Escherichia coli	33%	100%
P55294	Neisseria meningitidis serogroup B (strain MC58)	33%	100%
P55462	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	36%	100%
P75517	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	23%	100%
P95780	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	33%	100%
P9WN64	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	33%	100%
P9WN65	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	100%
P9WN66	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WN67	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q04973	Salmonella typhi	24%	100%
Q05026	Neisseria gonorrhoeae	24%	100%
Q2SYH7	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	28%	100%
Q331Q7	Streptomyces sp.	25%	100%
Q4Q8W9	Leishmania major	90%	100%
Q54WS6	Dictyostelium discoideum	35%	100%
Q57301	Yersinia enterocolitica	24%	100%
Q57664	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	100%
Q58455	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	23%	100%
Q59083	Azospirillum brasilense	27%	100%
Q59745	Rhizobium leguminosarum bv. trifolii	27%	100%
Q5SFA6	Streptomyces bikiniensis	26%	100%
Q5UR12	Acanthamoeba polyphaga mimivirus	39%	100%
Q67ZE1	Arabidopsis thaliana	25%	79%
Q6E7F4	Escherichia coli	31%	100%
Q6K2E1	Oryza sativa subsp. japonica	26%	100%
Q6ZDJ7	Oryza sativa subsp. japonica	24%	100%
Q8VDR7	Mus musculus	39%	100%
Q8VZC0	Arabidopsis thaliana	25%	100%
Q9CNY5	Pasteurella multocida (strain Pm70)	23%	100%
Q9F7D4	Yersinia pestis	27%	100%
Q9FIE8	Arabidopsis thaliana	24%	100%
Q9HDU4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9KDV3	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	28%	100%
Q9L9E8	Streptomyces niveus	36%	100%
Q9LH76	Arabidopsis thaliana	41%	67%
Q9LPC1	Arabidopsis thaliana	23%	100%
Q9LPG6	Arabidopsis thaliana	40%	67%
Q9LZI2	Arabidopsis thaliana	25%	100%
Q9RR28	Streptomyces antibioticus	34%	100%
Q9S642	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	35%	100%
Q9SN95	Arabidopsis thaliana	25%	100%
Q9SYM5	Arabidopsis thaliana	41%	66%
Q9ZAE8	Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)	34%	100%
Q9ZV36	Arabidopsis thaliana	26%	100%
V5BEL1	Trypanosoma cruzi	43%	78%