Yip1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYK0_LEIMU

TriTrypDb:

LmxM.26.2200

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005802	trans-Golgi network	4	1
GO:0031984	organelle subcompartment	2	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

E9AYK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYK0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	7
GO:0009987	cellular process	1	7
GO:0016192	vesicle-mediated transport	4	7
GO:0046907	intracellular transport	3	7
GO:0048193	Golgi vesicle transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	7
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048280	vesicle fusion with Golgi apparatus	6	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	232	234	PF00675	0.532
CLV_NRD_NRD_1	308	310	PF00675	0.373
CLV_NRD_NRD_1	56	58	PF00675	0.483
CLV_NRD_NRD_1	8	10	PF00675	0.531
CLV_PCSK_KEX2_1	232	234	PF00082	0.532
CLV_PCSK_KEX2_1	308	310	PF00082	0.373
CLV_PCSK_KEX2_1	56	58	PF00082	0.483
CLV_PCSK_KEX2_1	8	10	PF00082	0.531
CLV_PCSK_SKI1_1	379	383	PF00082	0.413
CLV_PCSK_SKI1_1	435	439	PF00082	0.304
CLV_PCSK_SKI1_1	480	484	PF00082	0.469
DEG_SPOP_SBC_1	103	107	PF00917	0.737
DEG_SPOP_SBC_1	123	127	PF00917	0.618
DOC_CDC14_PxL_1	513	521	PF14671	0.304
DOC_CKS1_1	20	25	PF01111	0.610
DOC_CYCLIN_RxL_1	432	439	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.657
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.304
DOC_MAPK_MEF2A_6	444	451	PF00069	0.596
DOC_MAPK_MEF2A_6	480	489	PF00069	0.272
DOC_MAPK_NFAT4_5	480	488	PF00069	0.269
DOC_PIKK_1	359	367	PF02985	0.608
DOC_PP1_RVXF_1	415	421	PF00149	0.364
DOC_PP4_FxxP_1	354	357	PF00568	0.604
DOC_USP7_MATH_1	103	107	PF00917	0.737
DOC_USP7_MATH_1	123	127	PF00917	0.669
DOC_USP7_MATH_1	136	140	PF00917	0.677
DOC_USP7_MATH_1	141	145	PF00917	0.636
DOC_USP7_MATH_1	23	27	PF00917	0.683
DOC_USP7_MATH_1	41	45	PF00917	0.624
DOC_USP7_MATH_1	68	72	PF00917	0.703
DOC_USP7_MATH_2	16	22	PF00917	0.686
DOC_WW_Pin1_4	149	154	PF00397	0.702
DOC_WW_Pin1_4	163	168	PF00397	0.608
DOC_WW_Pin1_4	19	24	PF00397	0.733
DOC_WW_Pin1_4	245	250	PF00397	0.618
DOC_WW_Pin1_4	275	280	PF00397	0.723
DOC_WW_Pin1_4	293	298	PF00397	0.729
DOC_WW_Pin1_4	39	44	PF00397	0.648
LIG_14-3-3_CanoR_1	170	179	PF00244	0.658
LIG_14-3-3_CanoR_1	308	314	PF00244	0.557
LIG_14-3-3_CanoR_1	56	60	PF00244	0.695
LIG_Actin_WH2_2	465	482	PF00022	0.466
LIG_BIR_II_1	1	5	PF00653	0.696
LIG_EH_1	382	386	PF12763	0.602
LIG_FHA_1	461	467	PF00498	0.304
LIG_FHA_1	496	502	PF00498	0.425
LIG_FHA_1	50	56	PF00498	0.676
LIG_FHA_1	522	528	PF00498	0.325
LIG_GBD_Chelix_1	452	460	PF00786	0.437
LIG_LIR_Apic_2	11	16	PF02991	0.686
LIG_LIR_Apic_2	118	123	PF02991	0.697
LIG_LIR_Gen_1	509	520	PF02991	0.472
LIG_LIR_Gen_1	523	531	PF02991	0.343
LIG_LIR_Nem_3	421	427	PF02991	0.346
LIG_LIR_Nem_3	455	461	PF02991	0.284
LIG_LIR_Nem_3	509	515	PF02991	0.472
LIG_LIR_Nem_3	523	528	PF02991	0.343
LIG_LIR_Nem_3	82	86	PF02991	0.671
LIG_LYPXL_S_1	515	519	PF13949	0.304
LIG_LYPXL_yS_3	516	519	PF13949	0.304
LIG_MYND_3	361	365	PF01753	0.605
LIG_NRBOX	407	413	PF00104	0.304
LIG_Pex14_2	313	317	PF04695	0.569
LIG_Pex14_2	521	525	PF04695	0.304
LIG_PTB_Apo_2	106	113	PF02174	0.736
LIG_PTB_Phospho_1	106	112	PF10480	0.737
LIG_REV1ctd_RIR_1	431	439	PF16727	0.304
LIG_SH2_CRK	458	462	PF00017	0.304
LIG_SH2_PTP2	120	123	PF00017	0.699
LIG_SH2_PTP2	13	16	PF00017	0.617
LIG_SH2_SRC	13	16	PF00017	0.703
LIG_SH2_STAP1	291	295	PF00017	0.705
LIG_SH2_STAT3	236	239	PF00017	0.711
LIG_SH2_STAT5	120	123	PF00017	0.699
LIG_SH2_STAT5	13	16	PF00017	0.617
LIG_SH2_STAT5	241	244	PF00017	0.706
LIG_SH2_STAT5	34	37	PF00017	0.694
LIG_SH2_STAT5	512	515	PF00017	0.304
LIG_SH2_STAT5	85	88	PF00017	0.669
LIG_SH3_3	213	219	PF00018	0.742
LIG_SH3_3	240	246	PF00018	0.690
LIG_SH3_3	282	288	PF00018	0.671
LIG_SH3_3	378	384	PF00018	0.617
LIG_SH3_3	511	517	PF00018	0.304
LIG_SUMO_SIM_anti_2	407	413	PF11976	0.304
LIG_SUMO_SIM_par_1	386	391	PF11976	0.581
LIG_SUMO_SIM_par_1	462	468	PF11976	0.205
LIG_TRFH_1	458	462	PF08558	0.304
LIG_TYR_ITIM	456	461	PF00017	0.304
LIG_TYR_ITIM	514	519	PF00017	0.304
LIG_UBA3_1	411	417	PF00899	0.308
LIG_WRC_WIRS_1	522	527	PF05994	0.325
LIG_WW_3	175	179	PF00397	0.698
MOD_CDK_SPxxK_3	163	170	PF00069	0.622
MOD_CK1_1	105	111	PF00069	0.690
MOD_CK1_1	137	143	PF00069	0.693
MOD_CK1_1	189	195	PF00069	0.716
MOD_CK1_1	21	27	PF00069	0.709
MOD_CK1_1	244	250	PF00069	0.729
MOD_CK1_1	296	302	PF00069	0.650
MOD_CK1_1	44	50	PF00069	0.699
MOD_CK1_1	468	474	PF00069	0.293
MOD_CMANNOS	492	495	PF00535	0.304
MOD_GlcNHglycan	117	120	PF01048	0.515
MOD_GlcNHglycan	139	142	PF01048	0.525
MOD_GlcNHglycan	143	146	PF01048	0.630
MOD_GlcNHglycan	167	170	PF01048	0.525
MOD_GlcNHglycan	190	194	PF01048	0.506
MOD_GlcNHglycan	204	207	PF01048	0.439
MOD_GlcNHglycan	258	261	PF01048	0.494
MOD_GlcNHglycan	271	274	PF01048	0.558
MOD_GlcNHglycan	28	31	PF01048	0.491
MOD_GlcNHglycan	282	285	PF01048	0.554
MOD_GlcNHglycan	292	296	PF01048	0.428
MOD_GlcNHglycan	310	313	PF01048	0.482
MOD_GlcNHglycan	326	330	PF01048	0.575
MOD_GlcNHglycan	333	336	PF01048	0.503
MOD_GlcNHglycan	339	342	PF01048	0.452
MOD_GlcNHglycan	420	423	PF01048	0.493
MOD_GlcNHglycan	43	46	PF01048	0.436
MOD_GlcNHglycan	48	51	PF01048	0.422
MOD_GlcNHglycan	492	495	PF01048	0.272
MOD_GlcNHglycan	96	99	PF01048	0.473
MOD_GSK3_1	137	144	PF00069	0.686
MOD_GSK3_1	14	21	PF00069	0.665
MOD_GSK3_1	145	152	PF00069	0.667
MOD_GSK3_1	161	168	PF00069	0.617
MOD_GSK3_1	185	192	PF00069	0.704
MOD_GSK3_1	196	203	PF00069	0.662
MOD_GSK3_1	241	248	PF00069	0.737
MOD_GSK3_1	271	278	PF00069	0.704
MOD_GSK3_1	55	62	PF00069	0.775
MOD_GSK3_1	89	96	PF00069	0.664
MOD_GSK3_1	98	105	PF00069	0.680
MOD_N-GLC_1	123	128	PF02516	0.530
MOD_N-GLC_1	146	151	PF02516	0.494
MOD_N-GLC_1	197	202	PF02516	0.501
MOD_N-GLC_1	74	79	PF02516	0.585
MOD_NEK2_1	226	231	PF00069	0.674
MOD_NEK2_1	325	330	PF00069	0.663
MOD_NEK2_1	404	409	PF00069	0.338
MOD_NEK2_1	436	441	PF00069	0.322
MOD_NEK2_1	451	456	PF00069	0.256
MOD_NEK2_1	465	470	PF00069	0.304
MOD_NEK2_1	520	525	PF00069	0.369
MOD_PIKK_1	124	130	PF00454	0.701
MOD_PIKK_1	170	176	PF00454	0.662
MOD_PIKK_1	226	232	PF00454	0.632
MOD_PK_1	386	392	PF00069	0.625
MOD_PKA_1	308	314	PF00069	0.557
MOD_PKA_2	137	143	PF00069	0.713
MOD_PKA_2	254	260	PF00069	0.715
MOD_PKA_2	26	32	PF00069	0.707
MOD_PKA_2	307	313	PF00069	0.643
MOD_PKA_2	55	61	PF00069	0.679
MOD_Plk_1	197	203	PF00069	0.716
MOD_Plk_4	436	442	PF00069	0.304
MOD_Plk_4	460	466	PF00069	0.296
MOD_Plk_4	471	477	PF00069	0.340
MOD_Plk_4	483	489	PF00069	0.304
MOD_Plk_4	496	502	PF00069	0.304
MOD_ProDKin_1	149	155	PF00069	0.702
MOD_ProDKin_1	163	169	PF00069	0.608
MOD_ProDKin_1	19	25	PF00069	0.734
MOD_ProDKin_1	245	251	PF00069	0.618
MOD_ProDKin_1	275	281	PF00069	0.725
MOD_ProDKin_1	293	299	PF00069	0.729
MOD_ProDKin_1	39	45	PF00069	0.650
TRG_DiLeu_BaEn_1	509	514	PF01217	0.469
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.609
TRG_ENDOCYTIC_2	424	427	PF00928	0.304
TRG_ENDOCYTIC_2	458	461	PF00928	0.304
TRG_ENDOCYTIC_2	512	515	PF00928	0.304
TRG_ENDOCYTIC_2	516	519	PF00928	0.304
TRG_ENDOCYTIC_2	522	525	PF00928	0.304
TRG_ENDOCYTIC_2	83	86	PF00928	0.673
TRG_ER_diArg_1	55	57	PF00400	0.729
TRG_ER_diArg_1	8	10	PF00400	0.731
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAG4	Leptomonas seymouri	50%	95%
A0A3S7X055	Leishmania donovani	92%	100%
A4HF64	Leishmania braziliensis	78%	100%
A4I2E7	Leishmania infantum	92%	100%
Q4Q8X2	Leishmania major	91%	100%