ADP-ribosylation factor family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor family, putative

Species:

Leishmania mexicana

UniProt:

E9AYJ9_LEIMU

TriTrypDb:

LmxM.26.2190

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYJ9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006893	Golgi to plasma membrane transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034067	protein localization to Golgi apparatus	6	1
GO:0043001	Golgi to plasma membrane protein transport	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061951	establishment of protein localization to plasma membrane	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0072659	protein localization to plasma membrane	5	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1
GO:1990778	protein localization to cell periphery	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0003924	GTPase activity	7	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	120	126	PF00089	0.431
CLV_MEL_PAP_1	354	360	PF00089	0.594
CLV_NRD_NRD_1	86	88	PF00675	0.705
CLV_PCSK_KEX2_1	107	109	PF00082	0.475
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.475
CLV_PCSK_SKI1_1	176	180	PF00082	0.435
CLV_PCSK_SKI1_1	247	251	PF00082	0.386
DEG_APCC_DBOX_1	175	183	PF00400	0.360
DEG_APCC_DBOX_1	246	254	PF00400	0.440
DEG_Nend_Nbox_1	1	3	PF02207	0.498
DOC_CDC14_PxL_1	259	267	PF14671	0.366
DOC_CKS1_1	13	18	PF01111	0.489
DOC_CKS1_1	40	45	PF01111	0.486
DOC_CKS1_1	77	82	PF01111	0.813
DOC_CKS1_1	93	98	PF01111	0.425
DOC_CYCLIN_yCln2_LP_2	254	260	PF00134	0.468
DOC_MAPK_gen_1	107	115	PF00069	0.482
DOC_MAPK_gen_1	135	141	PF00069	0.596
DOC_MAPK_MEF2A_6	107	115	PF00069	0.482
DOC_MAPK_MEF2A_6	350	358	PF00069	0.544
DOC_PP4_FxxP_1	13	16	PF00568	0.519
DOC_USP7_MATH_1	126	130	PF00917	0.443
DOC_USP7_MATH_1	143	147	PF00917	0.641
DOC_USP7_MATH_1	217	221	PF00917	0.614
DOC_USP7_MATH_1	28	32	PF00917	0.377
DOC_USP7_MATH_1	371	375	PF00917	0.409
DOC_USP7_MATH_1	54	58	PF00917	0.568
DOC_USP7_UBL2_3	236	240	PF12436	0.497
DOC_WW_Pin1_4	12	17	PF00397	0.514
DOC_WW_Pin1_4	122	127	PF00397	0.448
DOC_WW_Pin1_4	146	151	PF00397	0.469
DOC_WW_Pin1_4	215	220	PF00397	0.574
DOC_WW_Pin1_4	335	340	PF00397	0.636
DOC_WW_Pin1_4	39	44	PF00397	0.479
DOC_WW_Pin1_4	76	81	PF00397	0.811
DOC_WW_Pin1_4	92	97	PF00397	0.448
LIG_14-3-3_CanoR_1	213	222	PF00244	0.476
LIG_14-3-3_CanoR_1	56	66	PF00244	0.613
LIG_EVH1_1	147	151	PF00568	0.542
LIG_FHA_1	110	116	PF00498	0.412
LIG_FHA_1	173	179	PF00498	0.416
LIG_FHA_1	269	275	PF00498	0.495
LIG_FHA_1	68	74	PF00498	0.726
LIG_FHA_2	233	239	PF00498	0.526
LIG_FHA_2	279	285	PF00498	0.451
LIG_FHA_2	30	36	PF00498	0.336
LIG_FHA_2	347	353	PF00498	0.659
LIG_FHA_2	70	76	PF00498	0.700
LIG_GBD_Chelix_1	202	210	PF00786	0.376
LIG_LIR_Apic_2	11	16	PF02991	0.529
LIG_LIR_Gen_1	17	23	PF02991	0.401
LIG_LIR_Gen_1	6	16	PF02991	0.536
LIG_LIR_Nem_3	15	21	PF02991	0.434
LIG_LIR_Nem_3	190	195	PF02991	0.360
LIG_LIR_Nem_3	294	300	PF02991	0.651
LIG_LIR_Nem_3	361	366	PF02991	0.601
LIG_LIR_Nem_3	6	12	PF02991	0.542
LIG_NRBOX	249	255	PF00104	0.443
LIG_PCNA_PIPBox_1	185	194	PF02747	0.360
LIG_PCNA_yPIPBox_3	180	192	PF02747	0.360
LIG_PDZ_Class_1	398	403	PF00595	0.553
LIG_Pex14_1	192	196	PF04695	0.300
LIG_PTB_Apo_2	7	14	PF02174	0.536
LIG_SH2_CRK	117	121	PF00017	0.454
LIG_SH2_CRK	18	22	PF00017	0.333
LIG_SH2_CRK	9	13	PF00017	0.503
LIG_SH2_NCK_1	117	121	PF00017	0.454
LIG_SH2_NCK_1	41	45	PF00017	0.392
LIG_SH2_STAT5	204	207	PF00017	0.360
LIG_SH2_STAT5	41	44	PF00017	0.479
LIG_SH3_1	87	93	PF00018	0.638
LIG_SH3_3	145	151	PF00018	0.658
LIG_SH3_3	216	222	PF00018	0.692
LIG_SH3_3	74	80	PF00018	0.774
LIG_SH3_3	87	93	PF00018	0.621
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.591
LIG_SUMO_SIM_par_1	262	268	PF11976	0.356
LIG_TRAF2_1	235	238	PF00917	0.501
LIG_TRAF2_1	281	284	PF00917	0.426
LIG_TRAF2_1	309	312	PF00917	0.686
LIG_TYR_ITIM	115	120	PF00017	0.454
LIG_UBA3_1	33	38	PF00899	0.398
LIG_WW_3	228	232	PF00397	0.567
MOD_CK1_1	11	17	PF00069	0.535
MOD_CK1_1	129	135	PF00069	0.700
MOD_CK1_1	146	152	PF00069	0.635
MOD_CK1_1	218	224	PF00069	0.630
MOD_CK1_1	268	274	PF00069	0.471
MOD_CK1_1	324	330	PF00069	0.788
MOD_CK1_1	57	63	PF00069	0.606
MOD_CK2_1	11	17	PF00069	0.519
MOD_CK2_1	221	227	PF00069	0.699
MOD_CK2_1	232	238	PF00069	0.500
MOD_CK2_1	278	284	PF00069	0.460
MOD_CK2_1	29	35	PF00069	0.338
MOD_CK2_1	346	352	PF00069	0.661
MOD_CK2_1	371	377	PF00069	0.270
MOD_CK2_1	57	63	PF00069	0.653
MOD_CK2_1	69	75	PF00069	0.691
MOD_GlcNHglycan	128	131	PF01048	0.578
MOD_GlcNHglycan	215	218	PF01048	0.412
MOD_GlcNHglycan	223	226	PF01048	0.792
MOD_GlcNHglycan	303	306	PF01048	0.512
MOD_GlcNHglycan	323	326	PF01048	0.717
MOD_GlcNHglycan	360	363	PF01048	0.544
MOD_GlcNHglycan	372	376	PF01048	0.406
MOD_GlcNHglycan	59	62	PF01048	0.622
MOD_GSK3_1	122	129	PF00069	0.510
MOD_GSK3_1	168	175	PF00069	0.579
MOD_GSK3_1	213	220	PF00069	0.293
MOD_GSK3_1	268	275	PF00069	0.473
MOD_GSK3_1	342	349	PF00069	0.648
MOD_GSK3_1	67	74	PF00069	0.766
MOD_GSK3_1	8	15	PF00069	0.534
MOD_N-GLC_1	268	273	PF02516	0.438
MOD_N-GLC_1	301	306	PF02516	0.601
MOD_NEK2_1	212	217	PF00069	0.446
MOD_NEK2_1	265	270	PF00069	0.369
MOD_NEK2_1	300	305	PF00069	0.525
MOD_NEK2_2	364	369	PF00069	0.502
MOD_PIKK_1	134	140	PF00454	0.633
MOD_PIKK_1	196	202	PF00454	0.360
MOD_PIKK_1	312	318	PF00454	0.660
MOD_PIKK_1	327	333	PF00454	0.498
MOD_PKA_2	109	115	PF00069	0.413
MOD_PKA_2	212	218	PF00069	0.354
MOD_PKA_2	55	61	PF00069	0.602
MOD_Plk_1	206	212	PF00069	0.303
MOD_Plk_1	272	278	PF00069	0.496
MOD_Plk_1	364	370	PF00069	0.442
MOD_Plk_1	371	377	PF00069	0.366
MOD_Plk_4	129	135	PF00069	0.591
MOD_Plk_4	29	35	PF00069	0.397
MOD_Plk_4	293	299	PF00069	0.665
MOD_Plk_4	48	54	PF00069	0.524
MOD_Plk_4	8	14	PF00069	0.478
MOD_ProDKin_1	12	18	PF00069	0.498
MOD_ProDKin_1	122	128	PF00069	0.465
MOD_ProDKin_1	146	152	PF00069	0.576
MOD_ProDKin_1	215	221	PF00069	0.579
MOD_ProDKin_1	335	341	PF00069	0.634
MOD_ProDKin_1	39	45	PF00069	0.480
MOD_ProDKin_1	76	82	PF00069	0.813
MOD_ProDKin_1	92	98	PF00069	0.440
MOD_SUMO_rev_2	232	242	PF00179	0.476
TRG_DiLeu_BaEn_1	17	22	PF01217	0.403
TRG_DiLeu_BaEn_2	34	40	PF01217	0.416
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.388
TRG_ENDOCYTIC_2	117	120	PF00928	0.451
TRG_ENDOCYTIC_2	18	21	PF00928	0.334
TRG_ENDOCYTIC_2	9	12	PF00928	0.485
TRG_ER_diArg_1	108	111	PF00400	0.487
TRG_NLS_MonoExtC_3	106	111	PF00514	0.426
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTD1	Leptomonas seymouri	58%	100%
A0A3Q8ICC5	Leishmania donovani	92%	100%
A4HF63	Leishmania braziliensis	71%	98%
A4I2E6	Leishmania infantum	92%	100%
C9ZX62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q8X3	Leishmania major	90%	100%