FtsJ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYJ5_LEIMU

TriTrypDb:

LmxM.26.2150

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYJ5

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0032259	methylation	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.412
CLV_C14_Caspase3-7	438	442	PF00656	0.580
CLV_NRD_NRD_1	121	123	PF00675	0.484
CLV_NRD_NRD_1	291	293	PF00675	0.584
CLV_NRD_NRD_1	426	428	PF00675	0.588
CLV_NRD_NRD_1	43	45	PF00675	0.519
CLV_NRD_NRD_1	523	525	PF00675	0.398
CLV_NRD_NRD_1	539	541	PF00675	0.698
CLV_NRD_NRD_1	542	544	PF00675	0.677
CLV_NRD_NRD_1	64	66	PF00675	0.511
CLV_PCSK_FUR_1	289	293	PF00082	0.487
CLV_PCSK_FUR_1	521	525	PF00082	0.386
CLV_PCSK_FUR_1	540	544	PF00082	0.700
CLV_PCSK_KEX2_1	121	123	PF00082	0.425
CLV_PCSK_KEX2_1	291	293	PF00082	0.588
CLV_PCSK_KEX2_1	43	45	PF00082	0.551
CLV_PCSK_KEX2_1	523	525	PF00082	0.388
CLV_PCSK_KEX2_1	539	541	PF00082	0.574
CLV_PCSK_KEX2_1	542	544	PF00082	0.566
CLV_PCSK_KEX2_1	551	553	PF00082	0.541
CLV_PCSK_KEX2_1	64	66	PF00082	0.511
CLV_PCSK_PC1ET2_1	551	553	PF00082	0.590
CLV_PCSK_PC7_1	117	123	PF00082	0.464
CLV_PCSK_SKI1_1	121	125	PF00082	0.385
CLV_PCSK_SKI1_1	133	137	PF00082	0.419
CLV_PCSK_SKI1_1	235	239	PF00082	0.377
CLV_PCSK_SKI1_1	353	357	PF00082	0.460
CLV_PCSK_SKI1_1	477	481	PF00082	0.512
DEG_COP1_1	142	154	PF00400	0.399
DEG_SCF_FBW7_1	466	471	PF00400	0.401
DEG_SPOP_SBC_1	449	453	PF00917	0.423
DOC_ANK_TNKS_1	291	298	PF00023	0.379
DOC_MAPK_gen_1	481	488	PF00069	0.376
DOC_MAPK_gen_1	49	58	PF00069	0.283
DOC_PP2B_LxvP_1	347	350	PF13499	0.417
DOC_PP2B_LxvP_1	5	8	PF13499	0.628
DOC_USP7_MATH_1	150	154	PF00917	0.645
DOC_USP7_MATH_1	299	303	PF00917	0.631
DOC_USP7_MATH_1	80	84	PF00917	0.718
DOC_WW_Pin1_4	255	260	PF00397	0.516
DOC_WW_Pin1_4	391	396	PF00397	0.535
DOC_WW_Pin1_4	451	456	PF00397	0.509
DOC_WW_Pin1_4	462	467	PF00397	0.634
DOC_WW_Pin1_4	78	83	PF00397	0.746
LIG_14-3-3_CanoR_1	30	35	PF00244	0.530
LIG_14-3-3_CanoR_1	461	466	PF00244	0.510
LIG_14-3-3_CanoR_1	51	57	PF00244	0.500
LIG_14-3-3_CanoR_1	542	550	PF00244	0.746
LIG_14-3-3_CanoR_1	71	79	PF00244	0.419
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_BRCT_BRCA1_1	38	42	PF00533	0.418
LIG_deltaCOP1_diTrp_1	510	519	PF00928	0.342
LIG_FHA_1	100	106	PF00498	0.634
LIG_FHA_1	21	27	PF00498	0.575
LIG_FHA_1	252	258	PF00498	0.521
LIG_FHA_1	406	412	PF00498	0.376
LIG_FHA_1	442	448	PF00498	0.397
LIG_FHA_1	465	471	PF00498	0.520
LIG_FHA_1	545	551	PF00498	0.619
LIG_FHA_2	200	206	PF00498	0.559
LIG_LIR_Gen_1	205	215	PF02991	0.421
LIG_LIR_Gen_1	376	384	PF02991	0.378
LIG_LIR_Nem_3	174	180	PF02991	0.442
LIG_LIR_Nem_3	205	211	PF02991	0.468
LIG_LIR_Nem_3	39	45	PF02991	0.355
LIG_LIR_Nem_3	50	56	PF02991	0.391
LIG_PALB2_WD40_1	340	348	PF16756	0.324
LIG_PTAP_UEV_1	151	156	PF05743	0.347
LIG_REV1ctd_RIR_1	129	137	PF16727	0.514
LIG_SH2_STAT5	170	173	PF00017	0.405
LIG_SH2_STAT5	25	28	PF00017	0.464
LIG_SH2_STAT5	322	325	PF00017	0.505
LIG_SH2_STAT5	34	37	PF00017	0.348
LIG_SH2_STAT5	358	361	PF00017	0.471
LIG_SH2_STAT5	417	420	PF00017	0.315
LIG_SH2_STAT5	462	465	PF00017	0.449
LIG_SH3_3	149	155	PF00018	0.445
LIG_SH3_3	212	218	PF00018	0.509
LIG_SH3_3	337	343	PF00018	0.389
LIG_SH3_3	4	10	PF00018	0.579
LIG_SH3_3	420	426	PF00018	0.437
LIG_SH3_3	76	82	PF00018	0.739
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.477
LIG_WW_3	424	428	PF00397	0.513
MOD_CDK_SPK_2	451	456	PF00069	0.509
MOD_CK1_1	140	146	PF00069	0.664
MOD_CK1_1	204	210	PF00069	0.456
MOD_CK1_1	258	264	PF00069	0.525
MOD_CK1_1	304	310	PF00069	0.497
MOD_CK1_1	330	336	PF00069	0.616
MOD_CK1_1	396	402	PF00069	0.440
MOD_CK1_1	451	457	PF00069	0.595
MOD_CK1_1	72	78	PF00069	0.642
MOD_GlcNHglycan	1	4	PF01048	0.677
MOD_GlcNHglycan	152	155	PF01048	0.451
MOD_GlcNHglycan	185	188	PF01048	0.422
MOD_GlcNHglycan	19	23	PF01048	0.524
MOD_GlcNHglycan	224	227	PF01048	0.554
MOD_GlcNHglycan	260	263	PF01048	0.388
MOD_GlcNHglycan	268	271	PF01048	0.370
MOD_GlcNHglycan	301	304	PF01048	0.592
MOD_GlcNHglycan	306	309	PF01048	0.635
MOD_GlcNHglycan	396	399	PF01048	0.655
MOD_GlcNHglycan	532	535	PF01048	0.597
MOD_GlcNHglycan	72	75	PF01048	0.683
MOD_GSK3_1	133	140	PF00069	0.606
MOD_GSK3_1	20	27	PF00069	0.530
MOD_GSK3_1	213	220	PF00069	0.513
MOD_GSK3_1	247	254	PF00069	0.553
MOD_GSK3_1	325	332	PF00069	0.633
MOD_GSK3_1	354	361	PF00069	0.392
MOD_GSK3_1	405	412	PF00069	0.266
MOD_GSK3_1	460	467	PF00069	0.669
MOD_GSK3_1	66	73	PF00069	0.586
MOD_GSK3_1	80	87	PF00069	0.570
MOD_LATS_1	119	125	PF00433	0.461
MOD_N-GLC_1	138	143	PF02516	0.533
MOD_N-GLC_1	222	227	PF02516	0.441
MOD_NEK2_1	24	29	PF00069	0.510
MOD_NEK2_1	260	265	PF00069	0.440
MOD_NEK2_1	327	332	PF00069	0.558
MOD_NEK2_1	36	41	PF00069	0.313
MOD_NEK2_1	409	414	PF00069	0.346
MOD_NEK2_1	450	455	PF00069	0.503
MOD_NEK2_1	460	465	PF00069	0.604
MOD_PIKK_1	121	127	PF00454	0.475
MOD_PIKK_1	213	219	PF00454	0.506
MOD_PIKK_1	80	86	PF00454	0.594
MOD_PKA_1	121	127	PF00069	0.475
MOD_PKA_2	121	127	PF00069	0.481
MOD_PKA_2	460	466	PF00069	0.493
MOD_PKA_2	70	76	PF00069	0.470
MOD_Plk_1	107	113	PF00069	0.393
MOD_Plk_1	204	210	PF00069	0.430
MOD_Plk_1	36	42	PF00069	0.423
MOD_Plk_2-3	435	441	PF00069	0.405
MOD_Plk_4	107	113	PF00069	0.516
MOD_Plk_4	20	26	PF00069	0.641
MOD_Plk_4	204	210	PF00069	0.459
MOD_Plk_4	260	266	PF00069	0.483
MOD_Plk_4	322	328	PF00069	0.674
MOD_Plk_4	354	360	PF00069	0.521
MOD_Plk_4	36	42	PF00069	0.327
MOD_Plk_4	373	379	PF00069	0.196
MOD_ProDKin_1	255	261	PF00069	0.512
MOD_ProDKin_1	391	397	PF00069	0.533
MOD_ProDKin_1	451	457	PF00069	0.505
MOD_ProDKin_1	462	468	PF00069	0.636
MOD_ProDKin_1	78	84	PF00069	0.746
TRG_DiLeu_LyEn_5	192	197	PF01217	0.392
TRG_ENDOCYTIC_2	505	508	PF00928	0.462
TRG_ER_diArg_1	121	123	PF00400	0.484
TRG_ER_diArg_1	289	292	PF00400	0.592
TRG_ER_diArg_1	400	403	PF00400	0.437
TRG_ER_diArg_1	42	44	PF00400	0.550
TRG_ER_diArg_1	520	523	PF00400	0.393
TRG_ER_diArg_1	538	540	PF00400	0.531
TRG_NLS_Bipartite_1	539	555	PF00514	0.574
TRG_NLS_MonoExtC_3	550	556	PF00514	0.678
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	477	482	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL5	Leptomonas seymouri	48%	97%
A0A1X0P8D1	Trypanosomatidae	31%	100%
A0A3S7X044	Leishmania donovani	89%	100%
A0A422N0J7	Trypanosoma rangeli	32%	100%
A4HF59	Leishmania braziliensis	75%	100%
A4I2E3	Leishmania infantum	89%	100%
C9ZX64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q8X7	Leishmania major	87%	100%
V5BJ25	Trypanosoma cruzi	31%	100%