Serine/threonine protein phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase-like protein

Species:

Leishmania mexicana

UniProt:

E9AYJ0_LEIMU

TriTrypDb:

LmxM.26.2100

Length:

962

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYJ0

Function

Biological processes
Term	Name	Level	Count
GO:0000082	G1/S transition of mitotic cell cycle	5	1
GO:0009987	cellular process	1	1
GO:0022402	cell cycle process	2	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044843	cell cycle G1/S phase transition	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004722	protein serine/threonine phosphatase activity	4	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.784
CLV_C14_Caspase3-7	274	278	PF00656	0.627
CLV_C14_Caspase3-7	551	555	PF00656	0.513
CLV_C14_Caspase3-7	597	601	PF00656	0.637
CLV_NRD_NRD_1	262	264	PF00675	0.721
CLV_NRD_NRD_1	679	681	PF00675	0.524
CLV_NRD_NRD_1	694	696	PF00675	0.542
CLV_NRD_NRD_1	727	729	PF00675	0.684
CLV_NRD_NRD_1	810	812	PF00675	0.511
CLV_PCSK_FUR_1	532	536	PF00082	0.698
CLV_PCSK_KEX2_1	124	126	PF00082	0.630
CLV_PCSK_KEX2_1	393	395	PF00082	0.335
CLV_PCSK_KEX2_1	534	536	PF00082	0.705
CLV_PCSK_KEX2_1	679	681	PF00082	0.524
CLV_PCSK_KEX2_1	694	696	PF00082	0.542
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.630
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.335
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.705
CLV_PCSK_SKI1_1	353	357	PF00082	0.426
CLV_PCSK_SKI1_1	393	397	PF00082	0.335
CLV_PCSK_SKI1_1	481	485	PF00082	0.453
CLV_PCSK_SKI1_1	647	651	PF00082	0.540
CLV_PCSK_SKI1_1	925	929	PF00082	0.387
CLV_PCSK_SKI1_1	958	962	PF00082	0.607
DEG_Nend_UBRbox_3	1	3	PF02207	0.473
DEG_SCF_FBW7_1	270	275	PF00400	0.542
DEG_SCF_FBW7_1	498	505	PF00400	0.551
DEG_SPOP_SBC_1	537	541	PF00917	0.672
DEG_SPOP_SBC_1	706	710	PF00917	0.540
DOC_CKS1_1	102	107	PF01111	0.561
DOC_CKS1_1	210	215	PF01111	0.699
DOC_CKS1_1	332	337	PF01111	0.528
DOC_CKS1_1	34	39	PF01111	0.663
DOC_CKS1_1	499	504	PF01111	0.486
DOC_CYCLIN_RxL_1	347	360	PF00134	0.417
DOC_CYCLIN_RxL_1	390	400	PF00134	0.335
DOC_CYCLIN_RxL_1	485	495	PF00134	0.335
DOC_MAPK_gen_1	919	929	PF00069	0.424
DOC_MAPK_MEF2A_6	865	873	PF00069	0.550
DOC_PP1_RVXF_1	122	129	PF00149	0.697
DOC_PP1_RVXF_1	392	399	PF00149	0.335
DOC_PP1_RVXF_1	639	646	PF00149	0.530
DOC_PP2B_LxvP_1	496	499	PF13499	0.383
DOC_PP4_FxxP_1	137	140	PF00568	0.633
DOC_USP7_MATH_1	223	227	PF00917	0.726
DOC_USP7_MATH_1	272	276	PF00917	0.634
DOC_USP7_MATH_1	599	603	PF00917	0.762
DOC_USP7_MATH_1	704	708	PF00917	0.572
DOC_USP7_MATH_1	711	715	PF00917	0.675
DOC_USP7_MATH_1	735	739	PF00917	0.721
DOC_USP7_MATH_1	753	757	PF00917	0.508
DOC_USP7_MATH_1	764	768	PF00917	0.624
DOC_USP7_MATH_1	78	82	PF00917	0.551
DOC_USP7_MATH_1	851	855	PF00917	0.775
DOC_USP7_MATH_1	86	90	PF00917	0.644
DOC_USP7_MATH_1	864	868	PF00917	0.551
DOC_USP7_UBL2_3	725	729	PF12436	0.598
DOC_WW_Pin1_4	101	106	PF00397	0.577
DOC_WW_Pin1_4	209	214	PF00397	0.700
DOC_WW_Pin1_4	240	245	PF00397	0.550
DOC_WW_Pin1_4	255	260	PF00397	0.734
DOC_WW_Pin1_4	268	273	PF00397	0.607
DOC_WW_Pin1_4	276	281	PF00397	0.707
DOC_WW_Pin1_4	312	317	PF00397	0.448
DOC_WW_Pin1_4	33	38	PF00397	0.662
DOC_WW_Pin1_4	331	336	PF00397	0.407
DOC_WW_Pin1_4	359	364	PF00397	0.503
DOC_WW_Pin1_4	401	406	PF00397	0.335
DOC_WW_Pin1_4	498	503	PF00397	0.461
DOC_WW_Pin1_4	586	591	PF00397	0.648
DOC_WW_Pin1_4	628	633	PF00397	0.707
DOC_WW_Pin1_4	707	712	PF00397	0.624
DOC_WW_Pin1_4	788	793	PF00397	0.709
DOC_WW_Pin1_4	823	828	PF00397	0.451
DOC_WW_Pin1_4	865	870	PF00397	0.579
DOC_WW_Pin1_4	89	94	PF00397	0.804
LIG_14-3-3_CanoR_1	125	135	PF00244	0.627
LIG_14-3-3_CanoR_1	263	272	PF00244	0.629
LIG_14-3-3_CanoR_1	302	306	PF00244	0.653
LIG_14-3-3_CanoR_1	417	423	PF00244	0.335
LIG_14-3-3_CanoR_1	508	514	PF00244	0.569
LIG_14-3-3_CanoR_1	532	542	PF00244	0.763
LIG_14-3-3_CanoR_1	617	626	PF00244	0.511
LIG_14-3-3_CanoR_1	62	66	PF00244	0.756
LIG_14-3-3_CanoR_1	641	646	PF00244	0.563
LIG_14-3-3_CanoR_1	647	652	PF00244	0.506
LIG_14-3-3_CanoR_1	770	775	PF00244	0.549
LIG_14-3-3_CanoR_1	796	805	PF00244	0.631
LIG_14-3-3_CanoR_1	811	815	PF00244	0.521
LIG_14-3-3_CanoR_1	919	929	PF00244	0.478
LIG_Actin_WH2_2	112	129	PF00022	0.600
LIG_APCC_ABBA_1	395	400	PF00400	0.335
LIG_APCC_ABBAyCdc20_2	394	400	PF00400	0.335
LIG_BRCT_BRCA1_1	641	645	PF00533	0.520
LIG_BRCT_BRCA1_1	713	717	PF00533	0.511
LIG_BRCT_BRCA1_1	904	908	PF00533	0.385
LIG_CtBP_PxDLS_1	181	185	PF00389	0.602
LIG_deltaCOP1_diTrp_1	875	878	PF00928	0.502
LIG_eIF4E_1	815	821	PF01652	0.461
LIG_eIF4E_1	902	908	PF01652	0.522
LIG_FHA_1	121	127	PF00498	0.573
LIG_FHA_1	265	271	PF00498	0.647
LIG_FHA_1	34	40	PF00498	0.656
LIG_FHA_1	499	505	PF00498	0.492
LIG_FHA_1	537	543	PF00498	0.712
LIG_FHA_1	769	775	PF00498	0.596
LIG_FHA_1	866	872	PF00498	0.649
LIG_FHA_2	256	262	PF00498	0.738
LIG_FHA_2	269	275	PF00498	0.606
LIG_FHA_2	595	601	PF00498	0.634
LIG_FHA_2	804	810	PF00498	0.568
LIG_FHA_2	814	820	PF00498	0.468
LIG_FHA_2	824	830	PF00498	0.347
LIG_IBAR_NPY_1	2	4	PF08397	0.577
LIG_LIR_Apic_2	134	140	PF02991	0.624
LIG_LIR_Apic_2	303	308	PF02991	0.593
LIG_LIR_Apic_2	819	825	PF02991	0.449
LIG_LIR_Gen_1	107	116	PF02991	0.550
LIG_LIR_Gen_1	314	325	PF02991	0.398
LIG_LIR_Gen_1	339	349	PF02991	0.354
LIG_LIR_Gen_1	593	603	PF02991	0.753
LIG_LIR_Gen_1	813	821	PF02991	0.459
LIG_LIR_Nem_3	107	111	PF02991	0.550
LIG_LIR_Nem_3	314	320	PF02991	0.401
LIG_LIR_Nem_3	328	332	PF02991	0.389
LIG_LIR_Nem_3	339	344	PF02991	0.385
LIG_LIR_Nem_3	477	483	PF02991	0.373
LIG_LIR_Nem_3	484	490	PF02991	0.300
LIG_LIR_Nem_3	593	598	PF02991	0.745
LIG_LIR_Nem_3	675	681	PF02991	0.533
LIG_LIR_Nem_3	714	720	PF02991	0.508
LIG_LIR_Nem_3	813	818	PF02991	0.468
LIG_MYND_1	37	41	PF01753	0.669
LIG_NRBOX	18	24	PF00104	0.563
LIG_NRBOX	391	397	PF00104	0.335
LIG_OCRL_FandH_1	377	389	PF00620	0.335
LIG_Pex14_1	814	818	PF04695	0.474
LIG_Pex14_2	818	822	PF04695	0.471
LIG_REV1ctd_RIR_1	388	398	PF16727	0.335
LIG_RPA_C_Fungi	690	702	PF08784	0.541
LIG_SH2_CRK	317	321	PF00017	0.383
LIG_SH2_CRK	595	599	PF00017	0.633
LIG_SH2_CRK	904	908	PF00017	0.385
LIG_SH2_GRB2like	633	636	PF00017	0.461
LIG_SH2_NCK_1	332	336	PF00017	0.394
LIG_SH2_NCK_1	595	599	PF00017	0.633
LIG_SH2_SRC	633	636	PF00017	0.461
LIG_SH2_STAP1	633	637	PF00017	0.458
LIG_SH2_STAP1	904	908	PF00017	0.385
LIG_SH2_STAT3	519	522	PF00017	0.616
LIG_SH2_STAT3	801	804	PF00017	0.685
LIG_SH2_STAT5	285	288	PF00017	0.793
LIG_SH2_STAT5	319	322	PF00017	0.387
LIG_SH2_STAT5	324	327	PF00017	0.425
LIG_SH2_STAT5	340	343	PF00017	0.386
LIG_SH2_STAT5	4	7	PF00017	0.547
LIG_SH2_STAT5	414	417	PF00017	0.335
LIG_SH2_STAT5	473	476	PF00017	0.278
LIG_SH2_STAT5	489	492	PF00017	0.440
LIG_SH2_STAT5	519	522	PF00017	0.616
LIG_SH2_STAT5	668	671	PF00017	0.537
LIG_SH2_STAT5	801	804	PF00017	0.721
LIG_SH2_STAT5	815	818	PF00017	0.437
LIG_SH3_3	216	222	PF00018	0.603
LIG_SH3_3	238	244	PF00018	0.605
LIG_SH3_3	254	260	PF00018	0.584
LIG_SH3_3	277	283	PF00018	0.636
LIG_SH3_3	28	34	PF00018	0.655
LIG_SH3_3	496	502	PF00018	0.438
LIG_SH3_3	50	56	PF00018	0.603
LIG_SH3_3	510	516	PF00018	0.585
LIG_SH3_3	517	523	PF00018	0.612
LIG_SH3_3	650	656	PF00018	0.553
LIG_SH3_3	736	742	PF00018	0.513
LIG_SH3_3	99	105	PF00018	0.588
LIG_SUMO_SIM_anti_2	423	430	PF11976	0.335
LIG_SUMO_SIM_par_1	923	933	PF11976	0.406
LIG_TRAF2_1	18	21	PF00917	0.669
LIG_TRAF2_1	208	211	PF00917	0.706
LIG_TRAF2_1	613	616	PF00917	0.546
LIG_TRAF2_1	910	913	PF00917	0.406
LIG_TRFH_1	401	405	PF08558	0.335
LIG_TYR_ITSM	591	598	PF00017	0.745
LIG_UBA3_1	118	124	PF00899	0.667
LIG_UBA3_1	427	432	PF00899	0.334
LIG_ULM_U2AF65_1	124	129	PF00076	0.707
LIG_WRC_WIRS_1	717	722	PF05994	0.501
LIG_WRC_WIRS_1	887	892	PF05994	0.447
LIG_WRC_WIRS_1	895	900	PF05994	0.424
LIG_WRC_WIRS_1	94	99	PF05994	0.661
MOD_CDK_SPxxK_3	33	40	PF00069	0.669
MOD_CDK_SPxxK_3	331	338	PF00069	0.520
MOD_CK1_1	101	107	PF00069	0.711
MOD_CK1_1	120	126	PF00069	0.712
MOD_CK1_1	242	248	PF00069	0.528
MOD_CK1_1	275	281	PF00069	0.678
MOD_CK1_1	509	515	PF00069	0.576
MOD_CK1_1	538	544	PF00069	0.761
MOD_CK1_1	552	558	PF00069	0.703
MOD_CK1_1	579	585	PF00069	0.685
MOD_CK1_1	636	642	PF00069	0.438
MOD_CK1_1	707	713	PF00069	0.562
MOD_CK1_1	716	722	PF00069	0.569
MOD_CK1_1	731	737	PF00069	0.747
MOD_CK1_1	757	763	PF00069	0.697
MOD_CK1_1	766	772	PF00069	0.781
MOD_CK1_1	813	819	PF00069	0.485
MOD_CK1_1	823	829	PF00069	0.482
MOD_CK1_1	854	860	PF00069	0.706
MOD_CK1_1	867	873	PF00069	0.496
MOD_CK1_1	89	95	PF00069	0.620
MOD_CK1_1	921	927	PF00069	0.486
MOD_CK2_1	15	21	PF00069	0.553
MOD_CK2_1	330	336	PF00069	0.387
MOD_CK2_1	606	612	PF00069	0.642
MOD_CK2_1	628	634	PF00069	0.640
MOD_CK2_1	69	75	PF00069	0.646
MOD_CK2_1	737	743	PF00069	0.690
MOD_CK2_1	823	829	PF00069	0.605
MOD_Cter_Amidation	261	264	PF01082	0.718
MOD_GlcNHglycan	10	13	PF01048	0.576
MOD_GlcNHglycan	173	176	PF01048	0.643
MOD_GlcNHglycan	245	248	PF01048	0.637
MOD_GlcNHglycan	543	546	PF01048	0.659
MOD_GlcNHglycan	568	571	PF01048	0.649
MOD_GlcNHglycan	581	584	PF01048	0.649
MOD_GlcNHglycan	66	69	PF01048	0.685
MOD_GlcNHglycan	682	685	PF01048	0.645
MOD_GlcNHglycan	731	734	PF01048	0.791
MOD_GlcNHglycan	739	742	PF01048	0.642
MOD_GlcNHglycan	762	765	PF01048	0.710
MOD_GlcNHglycan	766	769	PF01048	0.662
MOD_GlcNHglycan	859	862	PF01048	0.593
MOD_GlcNHglycan	890	893	PF01048	0.441
MOD_GSK3_1	151	158	PF00069	0.760
MOD_GSK3_1	239	246	PF00069	0.587
MOD_GSK3_1	264	271	PF00069	0.650
MOD_GSK3_1	272	279	PF00069	0.683
MOD_GSK3_1	330	337	PF00069	0.382
MOD_GSK3_1	498	505	PF00069	0.602
MOD_GSK3_1	533	540	PF00069	0.693
MOD_GSK3_1	541	548	PF00069	0.640
MOD_GSK3_1	586	593	PF00069	0.812
MOD_GSK3_1	702	709	PF00069	0.564
MOD_GSK3_1	716	723	PF00069	0.708
MOD_GSK3_1	731	738	PF00069	0.640
MOD_GSK3_1	753	760	PF00069	0.691
MOD_GSK3_1	764	771	PF00069	0.586
MOD_GSK3_1	851	858	PF00069	0.758
MOD_GSK3_1	882	889	PF00069	0.509
MOD_GSK3_1	89	96	PF00069	0.790
MOD_GSK3_1	921	928	PF00069	0.440
MOD_N-GLC_1	401	406	PF02516	0.335
MOD_N-GLC_1	434	439	PF02516	0.335
MOD_N-GLC_1	502	507	PF02516	0.669
MOD_N-GLC_1	530	535	PF02516	0.595
MOD_N-GLC_2	227	229	PF02516	0.521
MOD_NEK2_1	301	306	PF00069	0.570
MOD_NEK2_1	330	335	PF00069	0.384
MOD_NEK2_1	427	432	PF00069	0.335
MOD_NEK2_1	434	439	PF00069	0.335
MOD_NEK2_1	471	476	PF00069	0.214
MOD_NEK2_1	506	511	PF00069	0.558
MOD_NEK2_1	518	523	PF00069	0.614
MOD_NEK2_1	720	725	PF00069	0.602
MOD_NEK2_1	918	923	PF00069	0.441
MOD_NEK2_1	930	935	PF00069	0.396
MOD_PIKK_1	21	27	PF00454	0.712
MOD_PIKK_1	506	512	PF00454	0.560
MOD_PIKK_1	518	524	PF00454	0.609
MOD_PIKK_1	552	558	PF00454	0.684
MOD_PKA_1	728	734	PF00069	0.689
MOD_PKA_2	120	126	PF00069	0.596
MOD_PKA_2	160	166	PF00069	0.719
MOD_PKA_2	265	271	PF00069	0.553
MOD_PKA_2	301	307	PF00069	0.583
MOD_PKA_2	39	45	PF00069	0.661
MOD_PKA_2	61	67	PF00069	0.641
MOD_PKA_2	757	763	PF00069	0.754
MOD_PKA_2	795	801	PF00069	0.647
MOD_PKA_2	810	816	PF00069	0.549
MOD_PKA_2	852	858	PF00069	0.728
MOD_PKA_2	864	870	PF00069	0.752
MOD_PKA_2	882	888	PF00069	0.395
MOD_PKA_2	918	924	PF00069	0.446
MOD_Plk_1	386	392	PF00069	0.335
MOD_Plk_1	481	487	PF00069	0.335
MOD_Plk_1	502	508	PF00069	0.668
MOD_Plk_1	574	580	PF00069	0.608
MOD_Plk_1	599	605	PF00069	0.646
MOD_Plk_1	633	639	PF00069	0.644
MOD_Plk_1	839	845	PF00069	0.672
MOD_Plk_2-3	155	161	PF00069	0.712
MOD_Plk_2-3	54	60	PF00069	0.747
MOD_Plk_4	325	331	PF00069	0.413
MOD_Plk_4	386	392	PF00069	0.335
MOD_Plk_4	466	472	PF00069	0.335
MOD_Plk_4	502	508	PF00069	0.588
MOD_Plk_4	509	515	PF00069	0.541
MOD_Plk_4	61	67	PF00069	0.546
MOD_Plk_4	647	653	PF00069	0.539
MOD_Plk_4	770	776	PF00069	0.597
MOD_Plk_4	810	816	PF00069	0.481
MOD_Plk_4	894	900	PF00069	0.422
MOD_Plk_4	902	908	PF00069	0.404
MOD_Plk_4	925	931	PF00069	0.384
MOD_ProDKin_1	101	107	PF00069	0.567
MOD_ProDKin_1	209	215	PF00069	0.700
MOD_ProDKin_1	240	246	PF00069	0.549
MOD_ProDKin_1	255	261	PF00069	0.740
MOD_ProDKin_1	268	274	PF00069	0.609
MOD_ProDKin_1	276	282	PF00069	0.710
MOD_ProDKin_1	312	318	PF00069	0.445
MOD_ProDKin_1	33	39	PF00069	0.663
MOD_ProDKin_1	331	337	PF00069	0.402
MOD_ProDKin_1	359	365	PF00069	0.504
MOD_ProDKin_1	401	407	PF00069	0.335
MOD_ProDKin_1	498	504	PF00069	0.466
MOD_ProDKin_1	586	592	PF00069	0.643
MOD_ProDKin_1	628	634	PF00069	0.704
MOD_ProDKin_1	707	713	PF00069	0.625
MOD_ProDKin_1	788	794	PF00069	0.706
MOD_ProDKin_1	823	829	PF00069	0.465
MOD_ProDKin_1	865	871	PF00069	0.566
MOD_ProDKin_1	89	95	PF00069	0.799
MOD_SUMO_for_1	670	673	PF00179	0.527
TRG_DiLeu_BaEn_1	423	428	PF01217	0.335
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.411
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.335
TRG_ENDOCYTIC_2	317	320	PF00928	0.385
TRG_ENDOCYTIC_2	489	492	PF00928	0.335
TRG_ENDOCYTIC_2	595	598	PF00928	0.631
TRG_ENDOCYTIC_2	815	818	PF00928	0.476
TRG_ENDOCYTIC_2	904	907	PF00928	0.391
TRG_ER_diArg_1	125	128	PF00400	0.598
TRG_ER_diArg_1	678	680	PF00400	0.516
TRG_NES_CRM1_1	386	400	PF08389	0.335
TRG_NLS_MonoExtN_4	121	128	PF00514	0.694
TRG_NLS_MonoExtN_4	260	267	PF00514	0.538
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	559	564	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II84	Leptomonas seymouri	57%	91%
A0A3Q8IG06	Leishmania donovani	89%	95%
A4HF54	Leishmania braziliensis	76%	100%
A4I2D8	Leishmania infantum	89%	95%
Q4Q8Y2	Leishmania major	88%	100%