Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYI8_LEIMU

TriTrypDb:

LmxM.26.2080

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.474
CLV_NRD_NRD_1	19	21	PF00675	0.624
CLV_PCSK_KEX2_1	21	23	PF00082	0.593
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.597
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.442
DOC_MAPK_MEF2A_6	181	189	PF00069	0.661
DOC_PP2B_LxvP_1	187	190	PF13499	0.610
DOC_PP2B_LxvP_1	284	287	PF13499	0.458
DOC_PP2B_LxvP_1	296	299	PF13499	0.392
DOC_USP7_MATH_1	118	122	PF00917	0.531
DOC_USP7_MATH_1	201	205	PF00917	0.695
DOC_USP7_MATH_1	245	249	PF00917	0.583
DOC_USP7_UBL2_3	215	219	PF12436	0.597
DOC_WW_Pin1_4	126	131	PF00397	0.698
DOC_WW_Pin1_4	144	149	PF00397	0.594
DOC_WW_Pin1_4	155	160	PF00397	0.704
DOC_WW_Pin1_4	161	166	PF00397	0.552
DOC_WW_Pin1_4	207	212	PF00397	0.645
DOC_WW_Pin1_4	226	231	PF00397	0.568
DOC_WW_Pin1_4	282	287	PF00397	0.451
DOC_WW_Pin1_4	57	62	PF00397	0.558
DOC_WW_Pin1_4	64	69	PF00397	0.547
LIG_14-3-3_CanoR_1	200	208	PF00244	0.616
LIG_BRCT_BRCA1_1	146	150	PF00533	0.625
LIG_FHA_1	184	190	PF00498	0.633
LIG_FHA_1	203	209	PF00498	0.504
LIG_FHA_1	233	239	PF00498	0.448
LIG_FHA_1	41	47	PF00498	0.622
LIG_FHA_1	78	84	PF00498	0.556
LIG_FHA_2	114	120	PF00498	0.697
LIG_LIR_Apic_2	154	159	PF02991	0.641
LIG_LIR_LC3C_4	229	233	PF02991	0.637
LIG_LIR_Nem_3	147	153	PF02991	0.628
LIG_LIR_Nem_3	241	246	PF02991	0.479
LIG_LIR_Nem_3	49	53	PF02991	0.528
LIG_Pex14_2	297	301	PF04695	0.401
LIG_SH2_PTP2	56	59	PF00017	0.556
LIG_SH2_SRC	56	59	PF00017	0.556
LIG_SH2_STAT5	242	245	PF00017	0.523
LIG_SH2_STAT5	56	59	PF00017	0.591
LIG_SH3_3	145	151	PF00018	0.488
LIG_SH3_3	208	214	PF00018	0.659
LIG_SH3_3	273	279	PF00018	0.484
LIG_SH3_3	280	286	PF00018	0.551
LIG_SH3_3	55	61	PF00018	0.579
LIG_SH3_3	62	68	PF00018	0.602
LIG_SH3_3	97	103	PF00018	0.500
LIG_SUMO_SIM_par_1	229	235	PF11976	0.534
LIG_TRAF2_1	117	120	PF00917	0.657
LIG_TRAF2_1	262	265	PF00917	0.498
MOD_CDK_SPK_2	207	212	PF00069	0.676
MOD_CK1_1	101	107	PF00069	0.494
MOD_CK1_1	121	127	PF00069	0.726
MOD_CK1_1	129	135	PF00069	0.668
MOD_CK1_1	139	145	PF00069	0.651
MOD_CK1_1	146	152	PF00069	0.762
MOD_CK1_1	199	205	PF00069	0.684
MOD_CK1_1	210	216	PF00069	0.648
MOD_CK1_1	33	39	PF00069	0.634
MOD_CK1_1	40	46	PF00069	0.709
MOD_CK1_1	6	12	PF00069	0.627
MOD_CK2_1	113	119	PF00069	0.598
MOD_CK2_1	35	41	PF00069	0.640
MOD_GlcNHglycan	100	103	PF01048	0.567
MOD_GlcNHglycan	131	134	PF01048	0.660
MOD_GlcNHglycan	153	156	PF01048	0.687
MOD_GlcNHglycan	165	168	PF01048	0.733
MOD_GlcNHglycan	71	74	PF01048	0.642
MOD_GSK3_1	121	128	PF00069	0.716
MOD_GSK3_1	129	136	PF00069	0.621
MOD_GSK3_1	139	146	PF00069	0.720
MOD_GSK3_1	151	158	PF00069	0.561
MOD_GSK3_1	171	178	PF00069	0.581
MOD_GSK3_1	179	186	PF00069	0.587
MOD_GSK3_1	191	198	PF00069	0.742
MOD_GSK3_1	2	9	PF00069	0.594
MOD_GSK3_1	33	40	PF00069	0.570
MOD_GSK3_1	71	78	PF00069	0.585
MOD_LATS_1	161	167	PF00433	0.640
MOD_N-GLC_1	139	144	PF02516	0.509
MOD_N-GLC_1	267	272	PF02516	0.440
MOD_NEK2_1	231	236	PF00069	0.638
MOD_NEK2_1	267	272	PF00069	0.461
MOD_NMyristoyl	1	7	PF02799	0.587
MOD_PIKK_1	191	197	PF00454	0.589
MOD_PKA_2	113	119	PF00069	0.606
MOD_PKA_2	180	186	PF00069	0.592
MOD_PKA_2	199	205	PF00069	0.627
MOD_Plk_1	118	124	PF00069	0.808
MOD_Plk_1	267	273	PF00069	0.441
MOD_Plk_4	267	273	PF00069	0.462
MOD_Plk_4	77	83	PF00069	0.708
MOD_ProDKin_1	126	132	PF00069	0.699
MOD_ProDKin_1	144	150	PF00069	0.594
MOD_ProDKin_1	155	161	PF00069	0.704
MOD_ProDKin_1	207	213	PF00069	0.645
MOD_ProDKin_1	226	232	PF00069	0.563
MOD_ProDKin_1	282	288	PF00069	0.441
MOD_ProDKin_1	57	63	PF00069	0.564
MOD_ProDKin_1	64	70	PF00069	0.546
TRG_ENDOCYTIC_2	50	53	PF00928	0.524
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU5	Leptomonas seymouri	46%	97%
A0A3S7X039	Leishmania donovani	87%	100%
A4HF52	Leishmania braziliensis	66%	100%
A4I2D6	Leishmania infantum	87%	100%
Q4Q8Y4	Leishmania major	84%	100%