Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYI5_LEIMU

TriTrypDb:

LmxM.26.2050

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.658
CLV_C14_Caspase3-7	31	35	PF00656	0.393
CLV_C14_Caspase3-7	406	410	PF00656	0.600
CLV_C14_Caspase3-7	690	694	PF00656	0.625
CLV_C14_Caspase3-7	709	713	PF00656	0.513
CLV_C14_Caspase3-7	762	766	PF00656	0.619
CLV_NRD_NRD_1	216	218	PF00675	0.581
CLV_NRD_NRD_1	229	231	PF00675	0.478
CLV_NRD_NRD_1	243	245	PF00675	0.476
CLV_NRD_NRD_1	325	327	PF00675	0.543
CLV_NRD_NRD_1	440	442	PF00675	0.689
CLV_NRD_NRD_1	460	462	PF00675	0.679
CLV_NRD_NRD_1	502	504	PF00675	0.649
CLV_NRD_NRD_1	644	646	PF00675	0.650
CLV_NRD_NRD_1	722	724	PF00675	0.593
CLV_PCSK_KEX2_1	216	218	PF00082	0.581
CLV_PCSK_KEX2_1	229	231	PF00082	0.478
CLV_PCSK_KEX2_1	243	245	PF00082	0.479
CLV_PCSK_KEX2_1	325	327	PF00082	0.543
CLV_PCSK_KEX2_1	440	442	PF00082	0.646
CLV_PCSK_KEX2_1	460	462	PF00082	0.683
CLV_PCSK_KEX2_1	502	504	PF00082	0.649
CLV_PCSK_KEX2_1	643	645	PF00082	0.679
CLV_PCSK_KEX2_1	722	724	PF00082	0.593
CLV_PCSK_PC1ET2_1	643	645	PF00082	0.679
CLV_PCSK_SKI1_1	13	17	PF00082	0.608
CLV_PCSK_SKI1_1	201	205	PF00082	0.581
CLV_PCSK_SKI1_1	224	228	PF00082	0.592
CLV_PCSK_SKI1_1	25	29	PF00082	0.469
CLV_PCSK_SKI1_1	30	34	PF00082	0.406
CLV_PCSK_SKI1_1	37	41	PF00082	0.456
CLV_PCSK_SKI1_1	503	507	PF00082	0.644
CLV_PCSK_SKI1_1	717	721	PF00082	0.571
CLV_PCSK_SKI1_1	761	765	PF00082	0.573
DEG_APCC_DBOX_1	12	20	PF00400	0.605
DEG_APCC_DBOX_1	760	768	PF00400	0.443
DEG_MDM2_SWIB_1	720	727	PF02201	0.576
DEG_Nend_UBRbox_2	1	3	PF02207	0.651
DEG_SCF_FBW7_1	57	63	PF00400	0.494
DEG_SCF_FBW7_1	792	797	PF00400	0.586
DEG_SPOP_SBC_1	144	148	PF00917	0.507
DEG_SPOP_SBC_1	81	85	PF00917	0.533
DOC_CDC14_PxL_1	627	635	PF14671	0.602
DOC_CKS1_1	386	391	PF01111	0.687
DOC_CKS1_1	557	562	PF01111	0.685
DOC_CKS1_1	57	62	PF01111	0.533
DOC_CKS1_1	789	794	PF01111	0.630
DOC_CYCLIN_RxL_1	717	730	PF00134	0.581
DOC_CYCLIN_RxL_1	755	768	PF00134	0.576
DOC_CYCLIN_yCln2_LP_2	465	471	PF00134	0.649
DOC_MAPK_gen_1	216	227	PF00069	0.588
DOC_MAPK_gen_1	325	333	PF00069	0.551
DOC_MAPK_MEF2A_6	42	50	PF00069	0.543
DOC_PP2B_LxvP_1	317	320	PF13499	0.663
DOC_PP2B_LxvP_1	381	384	PF13499	0.542
DOC_PP2B_LxvP_1	465	468	PF13499	0.700
DOC_PP2B_LxvP_1	736	739	PF13499	0.655
DOC_PP2B_LxvP_1	888	891	PF13499	0.655
DOC_USP7_MATH_1	133	137	PF00917	0.563
DOC_USP7_MATH_1	144	148	PF00917	0.566
DOC_USP7_MATH_1	336	340	PF00917	0.561
DOC_USP7_MATH_1	342	346	PF00917	0.546
DOC_USP7_MATH_1	471	475	PF00917	0.699
DOC_USP7_MATH_1	58	62	PF00917	0.728
DOC_USP7_MATH_1	648	652	PF00917	0.540
DOC_USP7_MATH_1	800	804	PF00917	0.681
DOC_WW_Pin1_4	237	242	PF00397	0.535
DOC_WW_Pin1_4	370	375	PF00397	0.704
DOC_WW_Pin1_4	385	390	PF00397	0.581
DOC_WW_Pin1_4	42	47	PF00397	0.609
DOC_WW_Pin1_4	516	521	PF00397	0.707
DOC_WW_Pin1_4	556	561	PF00397	0.682
DOC_WW_Pin1_4	56	61	PF00397	0.570
DOC_WW_Pin1_4	70	75	PF00397	0.559
DOC_WW_Pin1_4	734	739	PF00397	0.674
DOC_WW_Pin1_4	785	790	PF00397	0.707
DOC_WW_Pin1_4	828	833	PF00397	0.567
DOC_WW_Pin1_4	87	92	PF00397	0.569
DOC_WW_Pin1_4	889	894	PF00397	0.511
LIG_14-3-3_CanoR_1	18	26	PF00244	0.595
LIG_14-3-3_CanoR_1	325	333	PF00244	0.682
LIG_14-3-3_CanoR_1	387	393	PF00244	0.678
LIG_14-3-3_CanoR_1	502	511	PF00244	0.645
LIG_14-3-3_CanoR_1	512	520	PF00244	0.571
LIG_14-3-3_CanoR_1	603	610	PF00244	0.657
LIG_14-3-3_CanoR_1	722	728	PF00244	0.585
LIG_14-3-3_CanoR_1	815	823	PF00244	0.632
LIG_14-3-3_CanoR_1	839	844	PF00244	0.660
LIG_Actin_WH2_2	739	757	PF00022	0.655
LIG_Actin_WH2_2	860	875	PF00022	0.586
LIG_BIR_III_2	433	437	PF00653	0.617
LIG_BIR_III_4	429	433	PF00653	0.617
LIG_BIR_III_4	496	500	PF00653	0.660
LIG_deltaCOP1_diTrp_1	185	194	PF00928	0.407
LIG_DLG_GKlike_1	723	731	PF00625	0.589
LIG_DLG_GKlike_1	755	763	PF00625	0.575
LIG_FHA_1	107	113	PF00498	0.678
LIG_FHA_1	158	164	PF00498	0.603
LIG_FHA_1	325	331	PF00498	0.618
LIG_FHA_1	473	479	PF00498	0.729
LIG_FHA_1	504	510	PF00498	0.690
LIG_FHA_1	686	692	PF00498	0.590
LIG_FHA_1	731	737	PF00498	0.666
LIG_FHA_1	802	808	PF00498	0.595
LIG_FHA_1	822	828	PF00498	0.515
LIG_FHA_2	271	277	PF00498	0.561
LIG_FHA_2	402	408	PF00498	0.637
LIG_FHA_2	616	622	PF00498	0.470
LIG_FHA_2	669	675	PF00498	0.532
LIG_FHA_2	707	713	PF00498	0.645
LIG_LIR_Gen_1	202	211	PF02991	0.404
LIG_LIR_Nem_3	202	207	PF02991	0.400
LIG_LIR_Nem_3	282	288	PF02991	0.527
LIG_LIR_Nem_3	345	350	PF02991	0.664
LIG_LIR_Nem_3	758	763	PF02991	0.538
LIG_MYND_1	463	467	PF01753	0.575
LIG_Pex14_2	720	724	PF04695	0.636
LIG_Rb_LxCxE_1	581	596	PF01857	0.510
LIG_RPA_C_Fungi	860	872	PF08784	0.583
LIG_SH2_CRK	627	631	PF00017	0.605
LIG_SH2_PTP2	557	560	PF00017	0.634
LIG_SH2_SRC	232	235	PF00017	0.585
LIG_SH2_STAP1	153	157	PF00017	0.607
LIG_SH2_STAP1	750	754	PF00017	0.630
LIG_SH2_STAT3	260	263	PF00017	0.492
LIG_SH2_STAT5	232	235	PF00017	0.633
LIG_SH2_STAT5	350	353	PF00017	0.664
LIG_SH2_STAT5	557	560	PF00017	0.634
LIG_SH3_3	119	125	PF00018	0.632
LIG_SH3_3	351	357	PF00018	0.631
LIG_SH3_3	371	377	PF00018	0.532
LIG_SH3_3	464	470	PF00018	0.643
LIG_SH3_3	555	561	PF00018	0.630
LIG_SH3_3	591	597	PF00018	0.636
LIG_SH3_3	736	742	PF00018	0.652
LIG_SH3_3	783	789	PF00018	0.702
LIG_SUMO_SIM_anti_2	418	425	PF11976	0.618
LIG_SUMO_SIM_anti_2	45	52	PF11976	0.589
LIG_SUMO_SIM_anti_2	527	533	PF11976	0.420
LIG_SUMO_SIM_par_1	45	52	PF11976	0.429
LIG_SUMO_SIM_par_1	783	788	PF11976	0.525
LIG_SUMO_SIM_par_1	803	809	PF11976	0.546
LIG_TRAF2_1	367	370	PF00917	0.708
LIG_TRAF2_1	679	682	PF00917	0.579
LIG_WW_2	467	470	PF00397	0.572
MOD_CDK_SPK_2	385	390	PF00069	0.699
MOD_CDK_SPK_2	87	92	PF00069	0.702
MOD_CDK_SPxK_1	237	243	PF00069	0.476
MOD_CDK_SPxxK_3	237	244	PF00069	0.539
MOD_CDK_SPxxK_3	70	77	PF00069	0.632
MOD_CK1_1	279	285	PF00069	0.522
MOD_CK1_1	373	379	PF00069	0.730
MOD_CK1_1	514	520	PF00069	0.586
MOD_CK1_1	52	58	PF00069	0.495
MOD_CK1_1	527	533	PF00069	0.426
MOD_CK1_1	635	641	PF00069	0.510
MOD_CK1_1	726	732	PF00069	0.641
MOD_CK1_1	737	743	PF00069	0.585
MOD_CK1_1	788	794	PF00069	0.703
MOD_CK1_1	80	86	PF00069	0.607
MOD_CK1_1	856	862	PF00069	0.641
MOD_CK2_1	270	276	PF00069	0.559
MOD_CK2_1	364	370	PF00069	0.635
MOD_CK2_1	606	612	PF00069	0.524
MOD_CK2_1	615	621	PF00069	0.464
MOD_CK2_1	657	663	PF00069	0.629
MOD_CK2_1	668	674	PF00069	0.622
MOD_CK2_1	676	682	PF00069	0.617
MOD_Cter_Amidation	500	503	PF01082	0.644
MOD_DYRK1A_RPxSP_1	42	46	PF00069	0.527
MOD_DYRK1A_RPxSP_1	889	893	PF00069	0.506
MOD_GlcNHglycan	153	156	PF01048	0.608
MOD_GlcNHglycan	278	281	PF01048	0.565
MOD_GlcNHglycan	293	296	PF01048	0.714
MOD_GlcNHglycan	30	33	PF01048	0.655
MOD_GlcNHglycan	317	320	PF01048	0.711
MOD_GlcNHglycan	366	369	PF01048	0.635
MOD_GlcNHglycan	51	54	PF01048	0.612
MOD_GlcNHglycan	514	517	PF01048	0.547
MOD_GlcNHglycan	573	576	PF01048	0.645
MOD_GlcNHglycan	678	681	PF01048	0.695
MOD_GlcNHglycan	79	82	PF01048	0.643
MOD_GSK3_1	315	322	PF00069	0.666
MOD_GSK3_1	364	371	PF00069	0.644
MOD_GSK3_1	409	416	PF00069	0.695
MOD_GSK3_1	418	425	PF00069	0.704
MOD_GSK3_1	512	519	PF00069	0.634
MOD_GSK3_1	52	59	PF00069	0.623
MOD_GSK3_1	602	609	PF00069	0.664
MOD_GSK3_1	611	618	PF00069	0.531
MOD_GSK3_1	657	664	PF00069	0.636
MOD_GSK3_1	723	730	PF00069	0.586
MOD_GSK3_1	737	744	PF00069	0.537
MOD_GSK3_1	755	762	PF00069	0.475
MOD_GSK3_1	77	84	PF00069	0.558
MOD_GSK3_1	790	797	PF00069	0.599
MOD_GSK3_1	835	842	PF00069	0.656
MOD_GSK3_1	853	860	PF00069	0.454
MOD_N-GLC_1	815	820	PF02516	0.585
MOD_NEK2_1	706	711	PF00069	0.480
MOD_NEK2_1	727	732	PF00069	0.594
MOD_NEK2_1	759	764	PF00069	0.622
MOD_NEK2_1	857	862	PF00069	0.531
MOD_PIKK_1	157	163	PF00454	0.592
MOD_PIKK_1	25	31	PF00454	0.483
MOD_PIKK_1	263	269	PF00454	0.618
MOD_PIKK_1	302	308	PF00454	0.560
MOD_PIKK_1	319	325	PF00454	0.686
MOD_PIKK_1	352	358	PF00454	0.691
MOD_PIKK_1	632	638	PF00454	0.604
MOD_PKA_1	325	331	PF00069	0.548
MOD_PKA_2	17	23	PF00069	0.677
MOD_PKA_2	324	330	PF00069	0.670
MOD_PKA_2	364	370	PF00069	0.646
MOD_PKA_2	511	517	PF00069	0.592
MOD_PKA_2	602	608	PF00069	0.661
MOD_PKA_2	814	820	PF00069	0.652
MOD_PKA_2	821	827	PF00069	0.618
MOD_PKB_1	23	31	PF00069	0.595
MOD_Plk_1	1	7	PF00069	0.591
MOD_Plk_1	106	112	PF00069	0.679
MOD_Plk_1	312	318	PF00069	0.652
MOD_Plk_1	800	806	PF00069	0.615
MOD_Plk_1	857	863	PF00069	0.588
MOD_Plk_2-3	606	612	PF00069	0.488
MOD_Plk_4	106	112	PF00069	0.633
MOD_Plk_4	124	130	PF00069	0.643
MOD_Plk_4	342	348	PF00069	0.665
MOD_Plk_4	418	424	PF00069	0.667
MOD_Plk_4	527	533	PF00069	0.420
MOD_Plk_4	67	73	PF00069	0.642
MOD_Plk_4	745	751	PF00069	0.527
MOD_Plk_4	755	761	PF00069	0.520
MOD_Plk_4	771	777	PF00069	0.529
MOD_ProDKin_1	237	243	PF00069	0.536
MOD_ProDKin_1	370	376	PF00069	0.704
MOD_ProDKin_1	385	391	PF00069	0.574
MOD_ProDKin_1	42	48	PF00069	0.613
MOD_ProDKin_1	516	522	PF00069	0.705
MOD_ProDKin_1	556	562	PF00069	0.684
MOD_ProDKin_1	56	62	PF00069	0.575
MOD_ProDKin_1	70	76	PF00069	0.560
MOD_ProDKin_1	734	740	PF00069	0.675
MOD_ProDKin_1	785	791	PF00069	0.708
MOD_ProDKin_1	828	834	PF00069	0.566
MOD_ProDKin_1	87	93	PF00069	0.566
MOD_ProDKin_1	889	895	PF00069	0.511
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.675
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.582
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.630
TRG_ENDOCYTIC_2	153	156	PF00928	0.602
TRG_ENDOCYTIC_2	350	353	PF00928	0.664
TRG_ENDOCYTIC_2	627	630	PF00928	0.605
TRG_ER_diArg_1	216	218	PF00400	0.581
TRG_ER_diArg_1	23	26	PF00400	0.601
TRG_ER_diArg_1	242	244	PF00400	0.501
TRG_ER_diArg_1	440	442	PF00400	0.646
TRG_ER_diArg_1	459	461	PF00400	0.678
TRG_ER_diArg_1	721	723	PF00400	0.591
TRG_NES_CRM1_1	582	596	PF08389	0.644
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	761	765	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICB4	Leishmania donovani	80%	88%
A4HF49	Leishmania braziliensis	60%	100%
A4I2D3	Leishmania infantum	80%	100%
Q4Q8Y7	Leishmania major	80%	99%