PQ-loop repeat-containing protein 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PQ loop repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AYI4_LEIMU

TriTrypDb:

LmxM.26.2040

Length:

358

Annotations

LeishMANIAdb annotations

Shows homology to LAAT transporters found in mammals (SLC66 family).. Localization: Lysosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005768	endosome	7	1
GO:0005802	trans-Golgi network	4	1
GO:0005829	cytosol	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0031984	organelle subcompartment	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

E9AYI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYI4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006869	lipid transport	5	1
GO:0009987	cellular process	1	1
GO:0015748	organophosphate ester transport	5	1
GO:0015914	phospholipid transport	6	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0034204	lipid translocation	4	1
GO:0042147	retrograde transport, endosome to Golgi	5	1
GO:0045332	phospholipid translocation	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071702	organic substance transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097035	regulation of membrane lipid distribution	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.591
CLV_NRD_NRD_1	237	239	PF00675	0.500
CLV_NRD_NRD_1	269	271	PF00675	0.303
CLV_PCSK_KEX2_1	237	239	PF00082	0.500
CLV_PCSK_KEX2_1	268	270	PF00082	0.301
CLV_PCSK_KEX2_1	329	331	PF00082	0.405
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.478
CLV_PCSK_PC7_1	265	271	PF00082	0.360
CLV_PCSK_PC7_1	325	331	PF00082	0.422
CLV_PCSK_SKI1_1	193	197	PF00082	0.328
CLV_PCSK_SKI1_1	298	302	PF00082	0.560
CLV_PCSK_SKI1_1	59	63	PF00082	0.445
CLV_Separin_Metazoa	2	6	PF03568	0.190
DEG_APCC_DBOX_1	58	66	PF00400	0.190
DEG_Nend_UBRbox_2	1	3	PF02207	0.485
DEG_SPOP_SBC_1	158	162	PF00917	0.792
DOC_CYCLIN_RxL_1	190	200	PF00134	0.452
DOC_MAPK_gen_1	329	336	PF00069	0.678
DOC_MAPK_MEF2A_6	59	66	PF00069	0.190
DOC_MAPK_NFAT4_5	59	67	PF00069	0.190
DOC_MAPK_RevD_3	316	330	PF00069	0.565
DOC_PP1_RVXF_1	191	197	PF00149	0.512
DOC_PP1_RVXF_1	288	295	PF00149	0.438
DOC_PP1_RVXF_1	3	9	PF00149	0.398
DOC_PP2B_LxvP_1	258	261	PF13499	0.357
DOC_USP7_MATH_1	158	162	PF00917	0.759
DOC_USP7_MATH_1	38	42	PF00917	0.351
DOC_WW_Pin1_4	141	146	PF00397	0.734
DOC_WW_Pin1_4	149	154	PF00397	0.725
DOC_WW_Pin1_4	207	212	PF00397	0.561
DOC_WW_Pin1_4	34	39	PF00397	0.391
LIG_14-3-3_CanoR_1	268	278	PF00244	0.483
LIG_14-3-3_CanoR_1	29	34	PF00244	0.493
LIG_Actin_WH2_2	195	210	PF00022	0.580
LIG_Actin_WH2_2	250	267	PF00022	0.438
LIG_APCC_ABBA_1	309	314	PF00400	0.415
LIG_BIR_III_2	173	177	PF00653	0.654
LIG_Clathr_ClatBox_1	195	199	PF01394	0.590
LIG_CtBP_PxDLS_1	175	179	PF00389	0.747
LIG_FHA_1	142	148	PF00498	0.750
LIG_FHA_1	221	227	PF00498	0.304
LIG_FHA_1	270	276	PF00498	0.496
LIG_FHA_1	348	354	PF00498	0.594
LIG_FHA_1	47	53	PF00498	0.438
LIG_FHA_2	134	140	PF00498	0.679
LIG_FHA_2	162	168	PF00498	0.682
LIG_FHA_2	96	102	PF00498	0.553
LIG_HP1_1	38	42	PF01393	0.391
LIG_LIR_Gen_1	189	198	PF02991	0.605
LIG_LIR_Nem_3	189	194	PF02991	0.623
LIG_LIR_Nem_3	30	36	PF02991	0.542
LIG_MYND_1	176	180	PF01753	0.676
LIG_NRBOX	274	280	PF00104	0.598
LIG_NRBOX	60	66	PF00104	0.391
LIG_SH2_CRK	216	220	PF00017	0.389
LIG_SH2_CRK	233	237	PF00017	0.380
LIG_SH2_CRK	249	253	PF00017	0.399
LIG_SH2_CRK	324	328	PF00017	0.659
LIG_SH2_CRK	36	40	PF00017	0.357
LIG_SH2_SRC	218	221	PF00017	0.395
LIG_SH2_STAP1	296	300	PF00017	0.336
LIG_SH2_STAT3	20	23	PF00017	0.357
LIG_SH2_STAT3	296	299	PF00017	0.360
LIG_SH2_STAT5	20	23	PF00017	0.381
LIG_SH2_STAT5	218	221	PF00017	0.374
LIG_SH2_STAT5	249	252	PF00017	0.368
LIG_SH2_STAT5	293	296	PF00017	0.358
LIG_SH2_STAT5	55	58	PF00017	0.379
LIG_SH3_3	10	16	PF00018	0.371
LIG_SH3_3	114	120	PF00018	0.587
LIG_SUMO_SIM_anti_2	255	261	PF11976	0.385
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.401
LIG_SUMO_SIM_anti_2	314	319	PF11976	0.332
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.357
LIG_SUMO_SIM_par_1	276	282	PF11976	0.391
LIG_SUMO_SIM_par_1	41	47	PF11976	0.357
LIG_TYR_ITIM	231	236	PF00017	0.427
LIG_TYR_ITIM	247	252	PF00017	0.364
LIG_TYR_ITIM	321	326	PF00017	0.513
MOD_CK1_1	146	152	PF00069	0.769
MOD_CK1_1	161	167	PF00069	0.710
MOD_CK1_1	95	101	PF00069	0.717
MOD_CK2_1	161	167	PF00069	0.654
MOD_CK2_1	95	101	PF00069	0.545
MOD_GlcNHglycan	100	105	PF01048	0.526
MOD_GlcNHglycan	121	124	PF01048	0.515
MOD_GlcNHglycan	161	164	PF01048	0.564
MOD_GlcNHglycan	169	173	PF01048	0.585
MOD_GlcNHglycan	180	183	PF01048	0.389
MOD_GlcNHglycan	339	343	PF01048	0.357
MOD_GSK3_1	119	126	PF00069	0.782
MOD_GSK3_1	157	164	PF00069	0.687
MOD_GSK3_1	174	181	PF00069	0.756
MOD_GSK3_1	269	276	PF00069	0.496
MOD_GSK3_1	34	41	PF00069	0.378
MOD_N-GLC_1	133	138	PF02516	0.574
MOD_NEK2_1	279	284	PF00069	0.348
MOD_NEK2_1	44	49	PF00069	0.391
MOD_NEK2_2	232	237	PF00069	0.407
MOD_PIKK_1	27	33	PF00454	0.591
MOD_PKA_1	268	274	PF00069	0.502
MOD_PKA_1	329	335	PF00069	0.588
MOD_PKA_2	268	274	PF00069	0.502
MOD_PKA_2	329	335	PF00069	0.588
MOD_Plk_1	95	101	PF00069	0.514
MOD_Plk_2-3	92	98	PF00069	0.492
MOD_Plk_4	273	279	PF00069	0.517
MOD_Plk_4	38	44	PF00069	0.356
MOD_ProDKin_1	141	147	PF00069	0.735
MOD_ProDKin_1	149	155	PF00069	0.725
MOD_ProDKin_1	207	213	PF00069	0.563
MOD_ProDKin_1	34	40	PF00069	0.391
MOD_SUMO_for_1	328	331	PF00179	0.678
TRG_DiLeu_BaEn_1	331	336	PF01217	0.622
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.488
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.497
TRG_ENDOCYTIC_2	216	219	PF00928	0.357
TRG_ENDOCYTIC_2	233	236	PF00928	0.414
TRG_ENDOCYTIC_2	249	252	PF00928	0.296
TRG_ENDOCYTIC_2	323	326	PF00928	0.585
TRG_ENDOCYTIC_2	36	39	PF00928	0.363
TRG_ENDOCYTIC_2	53	56	PF00928	0.403
TRG_ER_diArg_1	236	238	PF00400	0.289
TRG_ER_diArg_1	268	270	PF00400	0.560
TRG_NES_CRM1_1	299	314	PF08389	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVE3	Leptomonas seymouri	50%	100%
A0A3Q8IDX3	Leishmania donovani	83%	97%
A0A422N3F4	Trypanosoma rangeli	38%	100%
A4HF48	Leishmania braziliensis	65%	100%
A4I2D2	Leishmania infantum	83%	97%
C9ZX76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	90%
Q4Q8Y8	Leishmania major	79%	100%