Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYI3_LEIMU

TriTrypDb:

LmxM.26.2030

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	496	500	PF00656	0.461
CLV_C14_Caspase3-7	517	521	PF00656	0.739
CLV_C14_Caspase3-7	664	668	PF00656	0.562
CLV_NRD_NRD_1	221	223	PF00675	0.253
CLV_NRD_NRD_1	358	360	PF00675	0.519
CLV_NRD_NRD_1	491	493	PF00675	0.508
CLV_NRD_NRD_1	565	567	PF00675	0.569
CLV_NRD_NRD_1	585	587	PF00675	0.621
CLV_PCSK_KEX2_1	221	223	PF00082	0.253
CLV_PCSK_KEX2_1	357	359	PF00082	0.525
CLV_PCSK_KEX2_1	565	567	PF00082	0.569
CLV_PCSK_KEX2_1	585	587	PF00082	0.553
CLV_PCSK_SKI1_1	123	127	PF00082	0.690
CLV_PCSK_SKI1_1	331	335	PF00082	0.403
CLV_PCSK_SKI1_1	493	497	PF00082	0.566
CLV_PCSK_SKI1_1	595	599	PF00082	0.452
CLV_PCSK_SKI1_1	768	772	PF00082	0.432
CLV_PCSK_SKI1_1	91	95	PF00082	0.393
CLV_Separin_Metazoa	148	152	PF03568	0.503
DEG_APCC_DBOX_1	40	48	PF00400	0.614
DEG_APCC_DBOX_1	67	75	PF00400	0.416
DEG_Nend_Nbox_1	1	3	PF02207	0.403
DEG_SPOP_SBC_1	177	181	PF00917	0.519
DEG_SPOP_SBC_1	524	528	PF00917	0.474
DOC_CKS1_1	154	159	PF01111	0.413
DOC_CKS1_1	588	593	PF01111	0.398
DOC_CYCLIN_RxL_1	765	775	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.515
DOC_MAPK_gen_1	226	235	PF00069	0.259
DOC_MAPK_gen_1	357	364	PF00069	0.468
DOC_MAPK_gen_1	469	479	PF00069	0.312
DOC_MAPK_MEF2A_6	472	481	PF00069	0.291
DOC_PP1_RVXF_1	329	336	PF00149	0.344
DOC_PP1_RVXF_1	674	680	PF00149	0.484
DOC_PP2B_LxvP_1	115	118	PF13499	0.538
DOC_USP7_MATH_1	118	122	PF00917	0.560
DOC_USP7_MATH_1	178	182	PF00917	0.672
DOC_USP7_MATH_1	388	392	PF00917	0.390
DOC_USP7_MATH_1	4	8	PF00917	0.399
DOC_USP7_MATH_1	501	505	PF00917	0.756
DOC_USP7_MATH_1	524	528	PF00917	0.606
DOC_USP7_MATH_1	534	538	PF00917	0.311
DOC_USP7_MATH_1	617	621	PF00917	0.382
DOC_USP7_MATH_1	655	659	PF00917	0.590
DOC_USP7_MATH_1	704	708	PF00917	0.538
DOC_USP7_MATH_1	753	757	PF00917	0.563
DOC_WW_Pin1_4	153	158	PF00397	0.361
DOC_WW_Pin1_4	587	592	PF00397	0.411
DOC_WW_Pin1_4	748	753	PF00397	0.472
LIG_14-3-3_CanoR_1	221	230	PF00244	0.378
LIG_14-3-3_CanoR_1	248	255	PF00244	0.485
LIG_14-3-3_CanoR_1	45	50	PF00244	0.431
LIG_14-3-3_CanoR_1	578	588	PF00244	0.435
LIG_14-3-3_CanoR_1	676	680	PF00244	0.475
LIG_14-3-3_CterR_2	789	792	PF00244	0.452
LIG_Actin_WH2_2	29	47	PF00022	0.579
LIG_Actin_WH2_2	682	700	PF00022	0.464
LIG_APCC_ABBA_1	556	561	PF00400	0.501
LIG_BIR_III_4	58	62	PF00653	0.536
LIG_BRCT_BRCA1_1	331	335	PF00533	0.381
LIG_Clathr_ClatBox_1	263	267	PF01394	0.452
LIG_DLG_GKlike_1	45	53	PF00625	0.401
LIG_FHA_1	105	111	PF00498	0.468
LIG_FHA_1	145	151	PF00498	0.439
LIG_FHA_1	154	160	PF00498	0.421
LIG_FHA_1	18	24	PF00498	0.705
LIG_FHA_1	195	201	PF00498	0.462
LIG_FHA_1	214	220	PF00498	0.327
LIG_FHA_1	287	293	PF00498	0.409
LIG_FHA_1	298	304	PF00498	0.343
LIG_FHA_1	371	377	PF00498	0.379
LIG_FHA_1	425	431	PF00498	0.600
LIG_FHA_1	454	460	PF00498	0.457
LIG_FHA_1	524	530	PF00498	0.706
LIG_FHA_1	537	543	PF00498	0.320
LIG_FHA_1	765	771	PF00498	0.527
LIG_FHA_2	410	416	PF00498	0.353
LIG_FHA_2	455	461	PF00498	0.435
LIG_FHA_2	494	500	PF00498	0.475
LIG_FHA_2	591	597	PF00498	0.374
LIG_FHA_2	759	765	PF00498	0.529
LIG_LIR_Gen_1	260	269	PF02991	0.454
LIG_LIR_Gen_1	320	330	PF02991	0.381
LIG_LIR_Gen_1	42	49	PF02991	0.461
LIG_LIR_Gen_1	596	605	PF02991	0.237
LIG_LIR_Nem_3	260	264	PF02991	0.444
LIG_LIR_Nem_3	320	326	PF02991	0.359
LIG_LIR_Nem_3	42	46	PF02991	0.558
LIG_LIR_Nem_3	596	600	PF02991	0.246
LIG_MYND_2	142	146	PF01753	0.443
LIG_PDZ_Class_1	787	792	PF00595	0.606
LIG_SH2_NCK_1	318	322	PF00017	0.389
LIG_SH2_NCK_1	407	411	PF00017	0.519
LIG_SH2_PTP2	323	326	PF00017	0.423
LIG_SH2_SRC	726	729	PF00017	0.435
LIG_SH2_STAP1	350	354	PF00017	0.611
LIG_SH2_STAP1	690	694	PF00017	0.327
LIG_SH2_STAT5	323	326	PF00017	0.387
LIG_SH2_STAT5	441	444	PF00017	0.523
LIG_SH2_STAT5	480	483	PF00017	0.392
LIG_SH2_STAT5	5	8	PF00017	0.394
LIG_SH2_STAT5	592	595	PF00017	0.388
LIG_SH2_STAT5	726	729	PF00017	0.435
LIG_SH3_1	151	157	PF00018	0.434
LIG_SH3_3	136	142	PF00018	0.642
LIG_SH3_3	151	157	PF00018	0.291
LIG_SH3_3	374	380	PF00018	0.486
LIG_SH3_3	585	591	PF00018	0.555
LIG_SH3_3	64	70	PF00018	0.498
LIG_SUMO_SIM_anti_2	260	267	PF11976	0.277
LIG_SUMO_SIM_anti_2	373	379	PF11976	0.425
LIG_SUMO_SIM_anti_2	603	608	PF11976	0.419
LIG_SUMO_SIM_par_1	260	267	PF11976	0.277
LIG_SUMO_SIM_par_1	286	293	PF11976	0.349
LIG_SUMO_SIM_par_1	45	51	PF11976	0.413
LIG_TRAF2_1	412	415	PF00917	0.608
LIG_TRAF2_1	514	517	PF00917	0.690
LIG_TRAF2_1	745	748	PF00917	0.581
LIG_TRAF2_1	761	764	PF00917	0.569
LIG_UBA3_1	378	384	PF00899	0.382
MOD_CDK_SPxxK_3	153	160	PF00069	0.407
MOD_CK1_1	247	253	PF00069	0.453
MOD_CK1_1	270	276	PF00069	0.635
MOD_CK1_1	312	318	PF00069	0.449
MOD_CK1_1	353	359	PF00069	0.643
MOD_CK1_1	365	371	PF00069	0.343
MOD_CK1_1	391	397	PF00069	0.391
MOD_CK1_1	579	585	PF00069	0.602
MOD_CK1_1	640	646	PF00069	0.255
MOD_CK1_1	707	713	PF00069	0.540
MOD_CK1_1	751	757	PF00069	0.406
MOD_CK1_1	784	790	PF00069	0.610
MOD_CK2_1	409	415	PF00069	0.338
MOD_CK2_1	45	51	PF00069	0.453
MOD_CK2_1	454	460	PF00069	0.427
MOD_CK2_1	718	724	PF00069	0.404
MOD_CK2_1	758	764	PF00069	0.544
MOD_GlcNHglycan	13	16	PF01048	0.479
MOD_GlcNHglycan	29	32	PF01048	0.547
MOD_GlcNHglycan	311	314	PF01048	0.496
MOD_GlcNHglycan	336	339	PF01048	0.363
MOD_GlcNHglycan	365	368	PF01048	0.493
MOD_GlcNHglycan	503	506	PF01048	0.736
MOD_GlcNHglycan	520	523	PF01048	0.646
MOD_GlcNHglycan	566	569	PF01048	0.690
MOD_GlcNHglycan	578	581	PF01048	0.576
MOD_GlcNHglycan	619	622	PF01048	0.488
MOD_GlcNHglycan	642	645	PF01048	0.298
MOD_GlcNHglycan	657	660	PF01048	0.742
MOD_GSK3_1	100	107	PF00069	0.417
MOD_GSK3_1	13	20	PF00069	0.609
MOD_GSK3_1	22	29	PF00069	0.692
MOD_GSK3_1	270	277	PF00069	0.550
MOD_GSK3_1	363	370	PF00069	0.421
MOD_GSK3_1	409	416	PF00069	0.578
MOD_GSK3_1	520	527	PF00069	0.720
MOD_GSK3_1	530	537	PF00069	0.472
MOD_GSK3_1	692	699	PF00069	0.432
MOD_GSK3_1	707	714	PF00069	0.397
MOD_GSK3_1	718	725	PF00069	0.361
MOD_GSK3_1	758	765	PF00069	0.562
MOD_GSK3_1	784	791	PF00069	0.541
MOD_N-GLC_1	189	194	PF02516	0.535
MOD_N-GLC_1	267	272	PF02516	0.277
MOD_N-GLC_1	309	314	PF02516	0.491
MOD_N-GLC_2	169	171	PF02516	0.300
MOD_NEK2_1	334	339	PF00069	0.322
MOD_NEK2_1	39	44	PF00069	0.546
MOD_NEK2_1	431	436	PF00069	0.649
MOD_NEK2_1	488	493	PF00069	0.420
MOD_NEK2_1	600	605	PF00069	0.360
MOD_NEK2_1	693	698	PF00069	0.470
MOD_NEK2_1	722	727	PF00069	0.410
MOD_NEK2_2	5	10	PF00069	0.640
MOD_OFUCOSY	188	193	PF10250	0.452
MOD_PIKK_1	178	184	PF00454	0.665
MOD_PIKK_1	194	200	PF00454	0.507
MOD_PIKK_1	367	373	PF00454	0.358
MOD_PIKK_1	515	521	PF00454	0.503
MOD_PIKK_1	579	585	PF00454	0.591
MOD_PIKK_1	704	710	PF00454	0.525
MOD_PIKK_1	784	790	PF00454	0.609
MOD_PKA_1	221	227	PF00069	0.243
MOD_PKA_2	11	17	PF00069	0.503
MOD_PKA_2	221	227	PF00069	0.389
MOD_PKA_2	247	253	PF00069	0.481
MOD_PKA_2	270	276	PF00069	0.470
MOD_PKA_2	564	570	PF00069	0.649
MOD_PKA_2	653	659	PF00069	0.633
MOD_PKA_2	675	681	PF00069	0.470
MOD_PKA_2	722	728	PF00069	0.484
MOD_PKA_2	781	787	PF00069	0.568
MOD_Plk_1	286	292	PF00069	0.461
MOD_Plk_1	34	40	PF00069	0.442
MOD_Plk_1	350	356	PF00069	0.634
MOD_Plk_1	524	530	PF00069	0.523
MOD_Plk_1	595	601	PF00069	0.417
MOD_Plk_1	762	768	PF00069	0.491
MOD_Plk_2-3	424	430	PF00069	0.576
MOD_Plk_4	319	325	PF00069	0.438
MOD_Plk_4	34	40	PF00069	0.524
MOD_Plk_4	350	356	PF00069	0.565
MOD_Plk_4	413	419	PF00069	0.626
MOD_Plk_4	525	531	PF00069	0.439
MOD_Plk_4	675	681	PF00069	0.470
MOD_Plk_4	707	713	PF00069	0.526
MOD_Plk_4	722	728	PF00069	0.304
MOD_Plk_4	753	759	PF00069	0.646
MOD_ProDKin_1	153	159	PF00069	0.353
MOD_ProDKin_1	587	593	PF00069	0.412
MOD_ProDKin_1	748	754	PF00069	0.472
TRG_DiLeu_BaEn_1	260	265	PF01217	0.207
TRG_DiLeu_BaEn_1	51	56	PF01217	0.443
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.433
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.482
TRG_DiLeu_BaLyEn_6	765	770	PF01217	0.433
TRG_ENDOCYTIC_2	323	326	PF00928	0.313
TRG_ENDOCYTIC_2	690	693	PF00928	0.318
TRG_ER_diArg_1	221	223	PF00400	0.287
TRG_ER_diArg_1	357	359	PF00400	0.441
TRG_NES_CRM1_1	256	267	PF08389	0.382
TRG_NES_CRM1_1	468	483	PF08389	0.300
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P479	Leptomonas seymouri	60%	100%
A0A1X0P8E3	Trypanosomatidae	32%	100%
A0A3Q8IDS4	Leishmania donovani	89%	100%
A0A3R7LMQ0	Trypanosoma rangeli	34%	100%
A4HF47	Leishmania braziliensis	79%	100%
A4I2D1	Leishmania infantum	87%	100%
C9ZX77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	96%
Q4Q8Y9	Leishmania major	87%	100%
V5BJ35	Trypanosoma cruzi	33%	100%