PHD-finger domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYI1_LEIMU

TriTrypDb:

LmxM.26.2010

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYI1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.425
CLV_C14_Caspase3-7	424	428	PF00656	0.584
CLV_C14_Caspase3-7	437	441	PF00656	0.551
CLV_C14_Caspase3-7	580	584	PF00656	0.644
CLV_NRD_NRD_1	130	132	PF00675	0.542
CLV_NRD_NRD_1	147	149	PF00675	0.362
CLV_NRD_NRD_1	157	159	PF00675	0.421
CLV_NRD_NRD_1	450	452	PF00675	0.628
CLV_NRD_NRD_1	464	466	PF00675	0.704
CLV_NRD_NRD_1	473	475	PF00675	0.715
CLV_NRD_NRD_1	476	478	PF00675	0.682
CLV_NRD_NRD_1	554	556	PF00675	0.698
CLV_NRD_NRD_1	558	560	PF00675	0.673
CLV_NRD_NRD_1	569	571	PF00675	0.556
CLV_NRD_NRD_1	575	577	PF00675	0.547
CLV_NRD_NRD_1	634	636	PF00675	0.718
CLV_NRD_NRD_1	653	655	PF00675	0.579
CLV_NRD_NRD_1	663	665	PF00675	0.609
CLV_NRD_NRD_1	698	700	PF00675	0.702
CLV_NRD_NRD_1	711	713	PF00675	0.613
CLV_PCSK_FUR_1	474	478	PF00082	0.619
CLV_PCSK_FUR_1	554	558	PF00082	0.716
CLV_PCSK_KEX2_1	130	132	PF00082	0.542
CLV_PCSK_KEX2_1	147	149	PF00082	0.362
CLV_PCSK_KEX2_1	371	373	PF00082	0.510
CLV_PCSK_KEX2_1	450	452	PF00082	0.627
CLV_PCSK_KEX2_1	475	477	PF00082	0.660
CLV_PCSK_KEX2_1	554	556	PF00082	0.709
CLV_PCSK_KEX2_1	557	559	PF00082	0.698
CLV_PCSK_KEX2_1	569	571	PF00082	0.567
CLV_PCSK_KEX2_1	573	575	PF00082	0.540
CLV_PCSK_KEX2_1	634	636	PF00082	0.692
CLV_PCSK_KEX2_1	652	654	PF00082	0.599
CLV_PCSK_KEX2_1	663	665	PF00082	0.602
CLV_PCSK_KEX2_1	697	699	PF00082	0.693
CLV_PCSK_KEX2_1	710	712	PF00082	0.578
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.466
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.660
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.722
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.559
CLV_PCSK_PC7_1	554	560	PF00082	0.708
CLV_PCSK_PC7_1	569	575	PF00082	0.563
CLV_PCSK_PC7_1	706	712	PF00082	0.553
CLV_PCSK_SKI1_1	268	272	PF00082	0.600
CLV_PCSK_SKI1_1	372	376	PF00082	0.473
CLV_PCSK_SKI1_1	64	68	PF00082	0.463
DEG_SPOP_SBC_1	249	253	PF00917	0.670
DEG_SPOP_SBC_1	269	273	PF00917	0.458
DEG_SPOP_SBC_1	717	721	PF00917	0.700
DOC_CKS1_1	141	146	PF01111	0.475
DOC_CYCLIN_RxL_1	371	383	PF00134	0.446
DOC_MAPK_gen_1	147	155	PF00069	0.511
DOC_MAPK_gen_1	362	369	PF00069	0.584
DOC_MAPK_gen_1	371	379	PF00069	0.472
DOC_PP2B_LxvP_1	46	49	PF13499	0.569
DOC_PP2B_LxvP_1	689	692	PF13499	0.663
DOC_USP7_MATH_1	132	136	PF00917	0.472
DOC_USP7_MATH_1	206	210	PF00917	0.625
DOC_USP7_MATH_1	235	239	PF00917	0.656
DOC_USP7_MATH_1	249	253	PF00917	0.540
DOC_USP7_MATH_1	256	260	PF00917	0.613
DOC_USP7_MATH_1	269	273	PF00917	0.473
DOC_USP7_MATH_1	278	282	PF00917	0.574
DOC_USP7_MATH_1	294	298	PF00917	0.559
DOC_USP7_MATH_1	49	53	PF00917	0.525
DOC_USP7_MATH_1	496	500	PF00917	0.658
DOC_USP7_MATH_1	540	544	PF00917	0.673
DOC_USP7_MATH_1	579	583	PF00917	0.695
DOC_USP7_MATH_1	680	684	PF00917	0.713
DOC_USP7_MATH_1	693	697	PF00917	0.612
DOC_USP7_MATH_1	704	708	PF00917	0.615
DOC_USP7_MATH_1	717	721	PF00917	0.614
DOC_USP7_UBL2_3	371	375	PF12436	0.358
DOC_USP7_UBL2_3	443	447	PF12436	0.677
DOC_USP7_UBL2_3	519	523	PF12436	0.693
DOC_WW_Pin1_4	140	145	PF00397	0.537
DOC_WW_Pin1_4	283	288	PF00397	0.672
DOC_WW_Pin1_4	31	36	PF00397	0.671
DOC_WW_Pin1_4	47	52	PF00397	0.470
DOC_WW_Pin1_4	623	628	PF00397	0.684
DOC_WW_Pin1_4	645	650	PF00397	0.712
DOC_WW_Pin1_4	684	689	PF00397	0.620
LIG_14-3-3_CanoR_1	131	141	PF00244	0.506
LIG_14-3-3_CanoR_1	268	278	PF00244	0.614
LIG_14-3-3_CanoR_1	506	511	PF00244	0.642
LIG_14-3-3_CanoR_1	96	101	PF00244	0.482
LIG_BIR_II_1	1	5	PF00653	0.437
LIG_BRCT_BRCA1_1	134	138	PF00533	0.442
LIG_BRCT_BRCA1_1	216	220	PF00533	0.621
LIG_BRCT_BRCA1_1	266	270	PF00533	0.600
LIG_BRCT_BRCA1_1	53	57	PF00533	0.519
LIG_CSL_BTD_1	228	231	PF09270	0.608
LIG_DLG_GKlike_1	506	514	PF00625	0.643
LIG_FAT_LD_1	106	114	PF03623	0.421
LIG_FHA_1	116	122	PF00498	0.504
LIG_FHA_1	162	168	PF00498	0.514
LIG_FHA_1	269	275	PF00498	0.649
LIG_FHA_1	284	290	PF00498	0.558
LIG_FHA_1	313	319	PF00498	0.609
LIG_FHA_1	598	604	PF00498	0.668
LIG_FHA_2	300	306	PF00498	0.682
LIG_FHA_2	337	343	PF00498	0.460
LIG_FHA_2	40	46	PF00498	0.692
LIG_FHA_2	416	422	PF00498	0.671
LIG_LIR_Apic_2	302	306	PF02991	0.520
LIG_LIR_Gen_1	161	167	PF02991	0.508
LIG_LIR_Nem_3	135	141	PF02991	0.500
LIG_LIR_Nem_3	161	166	PF02991	0.512
LIG_LIR_Nem_3	227	232	PF02991	0.659
LIG_LIR_Nem_3	54	60	PF02991	0.514
LIG_PCNA_TLS_4	395	402	PF02747	0.611
LIG_PTB_Apo_2	273	280	PF02174	0.674
LIG_PTB_Phospho_1	273	279	PF10480	0.673
LIG_SH2_CRK	163	167	PF00017	0.648
LIG_SH2_PTP2	60	63	PF00017	0.480
LIG_SH2_STAP1	163	167	PF00017	0.519
LIG_SH2_STAT5	112	115	PF00017	0.444
LIG_SH2_STAT5	163	166	PF00017	0.525
LIG_SH2_STAT5	19	22	PF00017	0.505
LIG_SH2_STAT5	401	404	PF00017	0.651
LIG_SH2_STAT5	60	63	PF00017	0.471
LIG_SH3_1	602	608	PF00018	0.552
LIG_SH3_2	605	610	PF14604	0.559
LIG_SH3_3	184	190	PF00018	0.458
LIG_SH3_3	215	221	PF00018	0.621
LIG_SH3_3	23	29	PF00018	0.579
LIG_SH3_3	349	355	PF00018	0.637
LIG_SH3_3	602	608	PF00018	0.560
LIG_SH3_3	621	627	PF00018	0.693
LIG_SH3_3	685	691	PF00018	0.710
LIG_SH3_3	83	89	PF00018	0.648
LIG_SUMO_SIM_par_1	313	321	PF11976	0.479
LIG_TRAF2_1	53	56	PF00917	0.437
LIG_TRAF2_1	629	632	PF00917	0.677
LIG_UBA3_1	152	159	PF00899	0.510
MOD_CDC14_SPxK_1	34	37	PF00782	0.660
MOD_CDK_SPxK_1	31	37	PF00069	0.658
MOD_CDK_SPxxK_3	140	147	PF00069	0.490
MOD_CDK_SPxxK_3	645	652	PF00069	0.715
MOD_CK1_1	119	125	PF00069	0.558
MOD_CK1_1	31	37	PF00069	0.659
MOD_CK1_1	380	386	PF00069	0.645
MOD_CK1_1	388	394	PF00069	0.635
MOD_CK1_1	409	415	PF00069	0.659
MOD_CK1_1	487	493	PF00069	0.690
MOD_CK1_1	494	500	PF00069	0.659
MOD_CK1_1	50	56	PF00069	0.474
MOD_CK1_1	582	588	PF00069	0.708
MOD_CK1_1	589	595	PF00069	0.641
MOD_CK1_1	597	603	PF00069	0.579
MOD_CK1_1	682	688	PF00069	0.716
MOD_CK1_1	718	724	PF00069	0.704
MOD_CK1_1	98	104	PF00069	0.596
MOD_CK2_1	143	149	PF00069	0.601
MOD_CK2_1	210	216	PF00069	0.546
MOD_CK2_1	336	342	PF00069	0.458
MOD_CK2_1	388	394	PF00069	0.666
MOD_CK2_1	39	45	PF00069	0.662
MOD_CK2_1	49	55	PF00069	0.487
MOD_CK2_1	98	104	PF00069	0.545
MOD_Cter_Amidation	448	451	PF01082	0.548
MOD_Cter_Amidation	567	570	PF01082	0.666
MOD_Cter_Amidation	708	711	PF01082	0.650
MOD_GlcNHglycan	100	103	PF01048	0.397
MOD_GlcNHglycan	118	121	PF01048	0.436
MOD_GlcNHglycan	134	137	PF01048	0.353
MOD_GlcNHglycan	187	190	PF01048	0.433
MOD_GlcNHglycan	199	202	PF01048	0.458
MOD_GlcNHglycan	226	229	PF01048	0.581
MOD_GlcNHglycan	237	240	PF01048	0.645
MOD_GlcNHglycan	258	261	PF01048	0.537
MOD_GlcNHglycan	411	414	PF01048	0.665
MOD_GlcNHglycan	429	432	PF01048	0.527
MOD_GlcNHglycan	440	443	PF01048	0.573
MOD_GlcNHglycan	460	463	PF01048	0.610
MOD_GlcNHglycan	477	480	PF01048	0.603
MOD_GlcNHglycan	493	496	PF01048	0.586
MOD_GlcNHglycan	506	509	PF01048	0.564
MOD_GlcNHglycan	526	529	PF01048	0.532
MOD_GlcNHglycan	542	545	PF01048	0.594
MOD_GlcNHglycan	576	579	PF01048	0.625
MOD_GlcNHglycan	592	595	PF01048	0.595
MOD_GlcNHglycan	619	622	PF01048	0.676
MOD_GlcNHglycan	638	641	PF01048	0.544
MOD_GlcNHglycan	658	661	PF01048	0.666
MOD_GlcNHglycan	671	677	PF01048	0.561
MOD_GlcNHglycan	682	685	PF01048	0.640
MOD_GlcNHglycan	702	705	PF01048	0.535
MOD_GlcNHglycan	706	709	PF01048	0.689
MOD_GSK3_1	115	122	PF00069	0.393
MOD_GSK3_1	161	168	PF00069	0.517
MOD_GSK3_1	206	213	PF00069	0.547
MOD_GSK3_1	235	242	PF00069	0.519
MOD_GSK3_1	256	263	PF00069	0.615
MOD_GSK3_1	264	271	PF00069	0.584
MOD_GSK3_1	295	302	PF00069	0.648
MOD_GSK3_1	377	384	PF00069	0.677
MOD_GSK3_1	385	392	PF00069	0.677
MOD_GSK3_1	421	428	PF00069	0.553
MOD_GSK3_1	434	441	PF00069	0.557
MOD_GSK3_1	454	461	PF00069	0.605
MOD_GSK3_1	47	54	PF00069	0.560
MOD_GSK3_1	480	487	PF00069	0.707
MOD_GSK3_1	490	497	PF00069	0.596
MOD_GSK3_1	498	505	PF00069	0.532
MOD_GSK3_1	574	581	PF00069	0.667
MOD_GSK3_1	582	589	PF00069	0.673
MOD_GSK3_1	590	597	PF00069	0.600
MOD_GSK3_1	641	648	PF00069	0.642
MOD_GSK3_1	678	685	PF00069	0.708
MOD_GSK3_1	700	707	PF00069	0.677
MOD_GSK3_1	715	722	PF00069	0.575
MOD_LATS_1	310	316	PF00433	0.567
MOD_LATS_1	572	578	PF00433	0.613
MOD_N-GLC_1	114	119	PF02516	0.321
MOD_N-GLC_1	31	36	PF02516	0.536
MOD_N-GLC_1	377	382	PF02516	0.594
MOD_N-GLC_1	416	421	PF02516	0.671
MOD_N-GLC_1	700	705	PF02516	0.687
MOD_N-GLC_2	262	264	PF02516	0.621
MOD_N-GLC_2	368	370	PF02516	0.428
MOD_NEK2_1	114	119	PF00069	0.489
MOD_NEK2_1	174	179	PF00069	0.491
MOD_NEK2_1	199	204	PF00069	0.519
MOD_NEK2_1	210	215	PF00069	0.549
MOD_NEK2_1	270	275	PF00069	0.500
MOD_NEK2_1	336	341	PF00069	0.523
MOD_NEK2_1	377	382	PF00069	0.594
MOD_NEK2_1	386	391	PF00069	0.596
MOD_NEK2_1	587	592	PF00069	0.659
MOD_PIKK_1	166	172	PF00454	0.486
MOD_PIKK_1	174	180	PF00454	0.417
MOD_PIKK_1	199	205	PF00454	0.619
MOD_PIKK_1	336	342	PF00454	0.532
MOD_PIKK_1	425	431	PF00454	0.543
MOD_PIKK_1	612	618	PF00454	0.656
MOD_PKA_1	475	481	PF00069	0.593
MOD_PKA_1	574	580	PF00069	0.611
MOD_PKA_2	122	128	PF00069	0.497
MOD_PKA_2	214	220	PF00069	0.621
MOD_PKA_2	386	392	PF00069	0.677
MOD_PKA_2	475	481	PF00069	0.593
MOD_PKA_2	574	580	PF00069	0.545
MOD_PKA_2	95	101	PF00069	0.495
MOD_PKB_1	195	203	PF00069	0.456
MOD_Plk_1	206	212	PF00069	0.613
MOD_Plk_1	406	412	PF00069	0.649
MOD_Plk_1	487	493	PF00069	0.535
MOD_Plk_1	582	588	PF00069	0.664
MOD_Plk_1	672	678	PF00069	0.651
MOD_Plk_2-3	421	427	PF00069	0.553
MOD_Plk_2-3	434	440	PF00069	0.572
MOD_Plk_4	161	167	PF00069	0.508
MOD_Plk_4	214	220	PF00069	0.621
MOD_ProDKin_1	140	146	PF00069	0.538
MOD_ProDKin_1	283	289	PF00069	0.673
MOD_ProDKin_1	31	37	PF00069	0.673
MOD_ProDKin_1	47	53	PF00069	0.459
MOD_ProDKin_1	623	629	PF00069	0.683
MOD_ProDKin_1	645	651	PF00069	0.713
MOD_ProDKin_1	684	690	PF00069	0.621
TRG_DiLeu_BaEn_4	672	678	PF01217	0.695
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.427
TRG_ENDOCYTIC_2	163	166	PF00928	0.511
TRG_ER_diArg_1	130	132	PF00400	0.498
TRG_ER_diArg_1	194	197	PF00400	0.453
TRG_ER_diArg_1	474	477	PF00400	0.622
TRG_ER_diArg_1	554	557	PF00400	0.713
TRG_ER_diArg_1	558	561	PF00400	0.683
TRG_ER_diArg_1	569	571	PF00400	0.567
TRG_ER_diArg_1	574	576	PF00400	0.530
TRG_ER_diArg_1	634	636	PF00400	0.688
TRG_ER_diArg_1	652	654	PF00400	0.555
TRG_ER_diArg_1	662	664	PF00400	0.579
TRG_ER_diArg_1	697	699	PF00400	0.592
TRG_ER_diArg_1	710	712	PF00400	0.590
TRG_NLS_Bipartite_1	465	479	PF00514	0.615
TRG_NLS_Bipartite_1	555	577	PF00514	0.669
TRG_NLS_MonoCore_2	473	478	PF00514	0.619
TRG_NLS_MonoCore_2	554	559	PF00514	0.717
TRG_NLS_MonoCore_2	572	577	PF00514	0.544
TRG_NLS_MonoExtC_3	126	131	PF00514	0.423
TRG_NLS_MonoExtC_3	554	559	PF00514	0.717
TRG_NLS_MonoExtC_3	600	605	PF00514	0.555
TRG_NLS_MonoExtN_4	472	479	PF00514	0.671
TRG_NLS_MonoExtN_4	554	560	PF00514	0.716
TRG_NLS_MonoExtN_4	570	577	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	711	716	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7G6	Leishmania donovani	84%	100%
A4HF45	Leishmania braziliensis	61%	100%
A4I2C9	Leishmania infantum	84%	100%
Q4Q8Z1	Leishmania major	80%	100%