Methyltransf_11 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AYI0_LEIMU

TriTrypDb:

LmxM.26.2000

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AYI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYI0

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.548
CLV_NRD_NRD_1	297	299	PF00675	0.453
CLV_NRD_NRD_1	346	348	PF00675	0.556
CLV_NRD_NRD_1	49	51	PF00675	0.752
CLV_PCSK_KEX2_1	191	193	PF00082	0.537
CLV_PCSK_KEX2_1	346	348	PF00082	0.577
CLV_PCSK_KEX2_1	49	51	PF00082	0.723
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.537
CLV_PCSK_SKI1_1	261	265	PF00082	0.370
CLV_PCSK_SKI1_1	309	313	PF00082	0.500
CLV_Separin_Metazoa	195	199	PF03568	0.322
DEG_Nend_UBRbox_3	1	3	PF02207	0.694
DOC_MAPK_gen_1	125	133	PF00069	0.274
DOC_MAPK_gen_1	24	32	PF00069	0.522
DOC_MAPK_gen_1	261	269	PF00069	0.177
DOC_PP2B_LxvP_1	194	197	PF13499	0.336
DOC_WW_Pin1_4	87	92	PF00397	0.348
LIG_14-3-3_CanoR_1	261	267	PF00244	0.262
LIG_14-3-3_CanoR_1	7	15	PF00244	0.698
LIG_14-3-3_CanoR_1	99	104	PF00244	0.371
LIG_APCC_ABBA_1	213	218	PF00400	0.298
LIG_BRCT_BRCA1_1	144	148	PF00533	0.242
LIG_BRCT_BRCA1_1	157	161	PF00533	0.242
LIG_FHA_1	179	185	PF00498	0.301
LIG_FHA_1	224	230	PF00498	0.262
LIG_FHA_1	31	37	PF00498	0.351
LIG_FHA_1	95	101	PF00498	0.445
LIG_LIR_Apic_2	104	110	PF02991	0.308
LIG_LIR_Apic_2	119	123	PF02991	0.240
LIG_LIR_Gen_1	156	165	PF02991	0.268
LIG_LIR_Gen_1	265	271	PF02991	0.199
LIG_LIR_Nem_3	156	160	PF02991	0.277
LIG_LIR_Nem_3	227	233	PF02991	0.254
LIG_LIR_Nem_3	242	247	PF02991	0.225
LIG_LIR_Nem_3	265	269	PF02991	0.214
LIG_LYPXL_S_1	229	233	PF13949	0.496
LIG_LYPXL_yS_3	230	233	PF13949	0.336
LIG_PCNA_yPIPBox_3	255	267	PF02747	0.262
LIG_Pex14_2	157	161	PF04695	0.336
LIG_Rb_pABgroove_1	142	150	PF01858	0.166
LIG_SH2_CRK	107	111	PF00017	0.355
LIG_SH2_CRK	180	184	PF00017	0.336
LIG_SH2_CRK	27	31	PF00017	0.410
LIG_SH2_STAP1	75	79	PF00017	0.367
LIG_SH2_STAP1	96	100	PF00017	0.384
LIG_SH2_STAT5	120	123	PF00017	0.318
LIG_SH2_STAT5	180	183	PF00017	0.298
LIG_SH2_STAT5	89	92	PF00017	0.332
LIG_SH2_STAT5	96	99	PF00017	0.359
LIG_SH3_3	166	172	PF00018	0.262
LIG_SH3_3	253	259	PF00018	0.242
LIG_SUMO_SIM_anti_2	273	280	PF11976	0.297
LIG_SUMO_SIM_par_1	273	280	PF11976	0.247
LIG_WRC_WIRS_1	263	268	PF05994	0.277
MOD_CDK_SPxK_1	87	93	PF00069	0.310
MOD_CK1_1	220	226	PF00069	0.218
MOD_CK1_1	340	346	PF00069	0.278
MOD_CK1_1	38	44	PF00069	0.230
MOD_CK1_1	69	75	PF00069	0.465
MOD_CK1_1	77	83	PF00069	0.332
MOD_CK1_1	92	98	PF00069	0.379
MOD_CK2_1	137	143	PF00069	0.253
MOD_CK2_1	280	286	PF00069	0.258
MOD_CK2_1	99	105	PF00069	0.360
MOD_Cter_Amidation	174	177	PF01082	0.496
MOD_Cter_Amidation	296	299	PF01082	0.453
MOD_GlcNHglycan	173	176	PF01048	0.513
MOD_GlcNHglycan	37	40	PF01048	0.330
MOD_GlcNHglycan	52	55	PF01048	0.607
MOD_GlcNHglycan	78	82	PF01048	0.565
MOD_GSK3_1	13	20	PF00069	0.710
MOD_GSK3_1	217	224	PF00069	0.330
MOD_GSK3_1	62	69	PF00069	0.547
MOD_NEK2_1	142	147	PF00069	0.242
MOD_NEK2_1	262	267	PF00069	0.302
MOD_NEK2_1	337	342	PF00069	0.308
MOD_NEK2_1	64	69	PF00069	0.511
MOD_PIKK_1	94	100	PF00454	0.402
MOD_PK_1	99	105	PF00069	0.395
MOD_PKA_2	6	12	PF00069	0.666
MOD_PKA_2	92	98	PF00069	0.320
MOD_PKB_1	99	107	PF00069	0.346
MOD_Plk_2-3	280	286	PF00069	0.336
MOD_Plk_2-3	317	323	PF00069	0.292
MOD_Plk_4	137	143	PF00069	0.255
MOD_Plk_4	262	268	PF00069	0.371
MOD_Plk_4	280	286	PF00069	0.201
MOD_Plk_4	340	346	PF00069	0.254
MOD_Plk_4	38	44	PF00069	0.342
MOD_ProDKin_1	87	93	PF00069	0.351
MOD_SUMO_rev_2	217	223	PF00179	0.343
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.266
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.242
TRG_ENDOCYTIC_2	230	233	PF00928	0.255
TRG_ENDOCYTIC_2	27	30	PF00928	0.364
TRG_ENDOCYTIC_2	84	87	PF00928	0.335
TRG_ER_diArg_1	345	347	PF00400	0.327
TRG_ER_diArg_1	48	50	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D1	Leptomonas seymouri	71%	100%
A0A1X0P7E4	Trypanosomatidae	52%	96%
A0A3S7X035	Leishmania donovani	93%	100%
A0A422N3J7	Trypanosoma rangeli	56%	100%
A4HF44	Leishmania braziliensis	83%	100%
A4I2C8	Leishmania infantum	94%	100%
C9ZX82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	95%
Q4Q8Z2	Leishmania major	92%	99%
V5AUM3	Trypanosoma cruzi	54%	84%