PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYH8_LEIMU

TriTrypDb:

LmxM.26.1980

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.508
CLV_C14_Caspase3-7	174	178	PF00656	0.297
CLV_NRD_NRD_1	131	133	PF00675	0.521
CLV_NRD_NRD_1	17	19	PF00675	0.498
CLV_NRD_NRD_1	24	26	PF00675	0.579
CLV_NRD_NRD_1	3	5	PF00675	0.648
CLV_NRD_NRD_1	32	34	PF00675	0.589
CLV_PCSK_KEX2_1	158	160	PF00082	0.548
CLV_PCSK_KEX2_1	17	19	PF00082	0.495
CLV_PCSK_KEX2_1	24	26	PF00082	0.582
CLV_PCSK_KEX2_1	3	5	PF00082	0.645
CLV_PCSK_KEX2_1	32	34	PF00082	0.597
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.522
CLV_PCSK_SKI1_1	103	107	PF00082	0.486
CLV_PCSK_SKI1_1	126	130	PF00082	0.463
CLV_PCSK_SKI1_1	158	162	PF00082	0.548
DOC_CKS1_1	48	53	PF01111	0.671
DOC_MAPK_gen_1	103	113	PF00069	0.612
DOC_MAPK_gen_1	115	122	PF00069	0.446
DOC_MAPK_gen_1	161	170	PF00069	0.490
DOC_MAPK_gen_1	179	187	PF00069	0.614
DOC_MAPK_gen_1	32	38	PF00069	0.616
DOC_MAPK_HePTP_8	160	172	PF00069	0.494
DOC_MAPK_MEF2A_6	163	172	PF00069	0.523
DOC_PP1_RVXF_1	181	188	PF00149	0.309
DOC_USP7_MATH_1	65	69	PF00917	0.800
DOC_USP7_UBL2_3	129	133	PF12436	0.464
DOC_WW_Pin1_4	47	52	PF00397	0.640
LIG_14-3-3_CanoR_1	115	121	PF00244	0.492
LIG_14-3-3_CanoR_1	17	22	PF00244	0.695
LIG_14-3-3_CanoR_1	200	205	PF00244	0.531
LIG_14-3-3_CanoR_1	24	29	PF00244	0.649
LIG_14-3-3_CanoR_1	32	37	PF00244	0.546
LIG_BIR_II_1	1	5	PF00653	0.707
LIG_CSL_BTD_1	8	11	PF09270	0.628
LIG_FHA_2	172	178	PF00498	0.372
LIG_FHA_2	65	71	PF00498	0.729
LIG_LIR_Gen_1	125	131	PF02991	0.419
LIG_LIR_Nem_3	125	130	PF02991	0.455
LIG_LIR_Nem_3	169	175	PF02991	0.571
LIG_LIR_Nem_3	50	56	PF02991	0.613
LIG_PAM2_1	34	46	PF00658	0.444
LIG_PDZ_Class_2	201	206	PF00595	0.492
LIG_PTB_Apo_2	188	195	PF02174	0.384
LIG_SH2_CRK	192	196	PF00017	0.455
LIG_SH2_STAT5	201	204	PF00017	0.503
LIG_SH3_3	35	41	PF00018	0.743
LIG_SH3_3	42	48	PF00018	0.609
LIG_SH3_3	68	74	PF00018	0.611
LIG_SUMO_SIM_par_1	97	102	PF11976	0.602
LIG_WRC_WIRS_1	201	206	PF05994	0.553
MOD_CK1_1	20	26	PF00069	0.644
MOD_CK1_1	76	82	PF00069	0.768
MOD_CK2_1	64	70	PF00069	0.670
MOD_Cter_Amidation	30	33	PF01082	0.664
MOD_GlcNHglycan	55	59	PF01048	0.775
MOD_GSK3_1	16	23	PF00069	0.615
MOD_GSK3_1	171	178	PF00069	0.568
MOD_GSK3_1	190	197	PF00069	0.518
MOD_N-GLC_1	190	195	PF02516	0.389
MOD_NEK2_1	111	116	PF00069	0.610
MOD_NEK2_1	168	173	PF00069	0.408
MOD_PK_1	17	23	PF00069	0.635
MOD_PKA_1	17	23	PF00069	0.490
MOD_PKA_1	24	30	PF00069	0.562
MOD_PKA_1	32	38	PF00069	0.567
MOD_PKA_2	111	117	PF00069	0.528
MOD_PKA_2	16	22	PF00069	0.495
MOD_PKA_2	162	168	PF00069	0.383
MOD_PKA_2	199	205	PF00069	0.532
MOD_PKA_2	24	30	PF00069	0.555
MOD_PKA_2	32	38	PF00069	0.548
MOD_Plk_1	168	174	PF00069	0.548
MOD_Plk_1	190	196	PF00069	0.387
MOD_Plk_4	168	174	PF00069	0.422
MOD_ProDKin_1	47	53	PF00069	0.640
MOD_SUMO_for_1	105	108	PF00179	0.443
MOD_SUMO_rev_2	155	160	PF00179	0.497
TRG_ENDOCYTIC_2	201	204	PF00928	0.571
TRG_ER_diArg_1	16	18	PF00400	0.546
TRG_NLS_MonoExtC_3	131	137	PF00514	0.440
TRG_NLS_MonoExtN_4	129	136	PF00514	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P8F5	Trypanosomatidae	22%	91%
A0A1X0P8T2	Trypanosomatidae	23%	91%
A0A3Q8IPD3	Leishmania donovani	85%	100%
A4HF42	Leishmania braziliensis	67%	100%
A4I2C6	Leishmania infantum	85%	100%
C9ZX85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
Q4Q8Z4	Leishmania major	81%	100%