Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYH6_LEIMU

TriTrypDb:

LmxM.26.1960

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0005875	microtubule associated complex	2	3
GO:0030286	dynein complex	3	3
GO:0032991	protein-containing complex	1	3
GO:1902494	catalytic complex	2	3

Expansion

Sequence features

E9AYH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYH6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	3
GO:0003777	microtubule motor activity	2	3
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0008569	minus-end-directed microtubule motor activity	3	3
GO:0045505	dynein intermediate chain binding	3	3
GO:0051959	dynein light intermediate chain binding	3	3
GO:0140657	ATP-dependent activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.508
CLV_C14_Caspase3-7	732	736	PF00656	0.593
CLV_C14_Caspase3-7	784	788	PF00656	0.548
CLV_NRD_NRD_1	156	158	PF00675	0.546
CLV_NRD_NRD_1	170	172	PF00675	0.550
CLV_NRD_NRD_1	229	231	PF00675	0.455
CLV_NRD_NRD_1	433	435	PF00675	0.611
CLV_NRD_NRD_1	478	480	PF00675	0.516
CLV_NRD_NRD_1	662	664	PF00675	0.650
CLV_NRD_NRD_1	780	782	PF00675	0.843
CLV_NRD_NRD_1	91	93	PF00675	0.611
CLV_PCSK_FUR_1	229	233	PF00082	0.533
CLV_PCSK_KEX2_1	156	158	PF00082	0.547
CLV_PCSK_KEX2_1	229	231	PF00082	0.516
CLV_PCSK_KEX2_1	249	251	PF00082	0.703
CLV_PCSK_KEX2_1	366	368	PF00082	0.568
CLV_PCSK_KEX2_1	478	480	PF00082	0.496
CLV_PCSK_KEX2_1	505	507	PF00082	0.613
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.604
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.742
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.599
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.673
CLV_PCSK_SKI1_1	106	110	PF00082	0.576
CLV_PCSK_SKI1_1	121	125	PF00082	0.450
CLV_PCSK_SKI1_1	315	319	PF00082	0.612
CLV_PCSK_SKI1_1	498	502	PF00082	0.641
CLV_PCSK_SKI1_1	663	667	PF00082	0.666
DEG_APCC_DBOX_1	109	117	PF00400	0.409
DEG_APCC_DBOX_1	314	322	PF00400	0.601
DOC_CDC14_PxL_1	666	674	PF14671	0.651
DOC_CYCLIN_yCln2_LP_2	547	553	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	623	629	PF00134	0.583
DOC_MAPK_DCC_7	171	180	PF00069	0.346
DOC_MAPK_gen_1	229	236	PF00069	0.502
DOC_MAPK_gen_1	495	504	PF00069	0.611
DOC_MAPK_gen_1	663	669	PF00069	0.651
DOC_MAPK_HePTP_8	316	328	PF00069	0.414
DOC_MAPK_MEF2A_6	171	180	PF00069	0.470
DOC_MAPK_MEF2A_6	319	328	PF00069	0.644
DOC_MAPK_MEF2A_6	495	504	PF00069	0.672
DOC_PP1_RVXF_1	212	219	PF00149	0.539
DOC_PP1_RVXF_1	597	603	PF00149	0.536
DOC_PP2B_LxvP_1	547	550	PF13499	0.440
DOC_USP7_MATH_1	15	19	PF00917	0.638
DOC_USP7_MATH_1	20	24	PF00917	0.622
DOC_USP7_MATH_1	267	271	PF00917	0.696
DOC_USP7_MATH_1	769	773	PF00917	0.782
DOC_USP7_UBL2_3	599	603	PF12436	0.528
DOC_WW_Pin1_4	18	23	PF00397	0.652
DOC_WW_Pin1_4	220	225	PF00397	0.515
DOC_WW_Pin1_4	256	261	PF00397	0.773
DOC_WW_Pin1_4	43	48	PF00397	0.629
DOC_WW_Pin1_4	603	608	PF00397	0.558
LIG_14-3-3_CanoR_1	121	128	PF00244	0.417
LIG_14-3-3_CanoR_1	171	175	PF00244	0.650
LIG_14-3-3_CanoR_1	214	219	PF00244	0.521
LIG_14-3-3_CanoR_1	325	335	PF00244	0.594
LIG_14-3-3_CanoR_1	453	459	PF00244	0.597
LIG_14-3-3_CanoR_1	479	485	PF00244	0.592
LIG_14-3-3_CanoR_1	531	539	PF00244	0.513
LIG_14-3-3_CanoR_1	781	791	PF00244	0.847
LIG_Actin_WH2_2	145	162	PF00022	0.586
LIG_Actin_WH2_2	21	37	PF00022	0.549
LIG_Actin_WH2_2	324	341	PF00022	0.541
LIG_Actin_WH2_2	52	70	PF00022	0.555
LIG_APCC_ABBA_1	189	194	PF00400	0.558
LIG_APCC_ABBA_1	593	598	PF00400	0.518
LIG_BIR_II_1	1	5	PF00653	0.770
LIG_BIR_III_2	356	360	PF00653	0.695
LIG_BIR_III_4	397	401	PF00653	0.570
LIG_CtBP_PxDLS_1	224	228	PF00389	0.547
LIG_FHA_1	122	128	PF00498	0.552
LIG_FHA_1	144	150	PF00498	0.621
LIG_FHA_1	358	364	PF00498	0.585
LIG_FHA_1	499	505	PF00498	0.647
LIG_FHA_1	603	609	PF00498	0.519
LIG_FHA_1	64	70	PF00498	0.616
LIG_FHA_1	744	750	PF00498	0.546
LIG_FHA_1	755	761	PF00498	0.567
LIG_FHA_2	195	201	PF00498	0.562
LIG_FHA_2	457	463	PF00498	0.515
LIG_FHA_2	465	471	PF00498	0.489
LIG_FHA_2	645	651	PF00498	0.648
LIG_LIR_Gen_1	166	175	PF02991	0.619
LIG_LIR_Gen_1	197	206	PF02991	0.456
LIG_LIR_Gen_1	3	14	PF02991	0.654
LIG_LIR_Gen_1	399	409	PF02991	0.567
LIG_LIR_Gen_1	508	518	PF02991	0.500
LIG_LIR_Gen_1	519	526	PF02991	0.500
LIG_LIR_Gen_1	529	539	PF02991	0.516
LIG_LIR_Nem_3	166	170	PF02991	0.515
LIG_LIR_Nem_3	197	202	PF02991	0.640
LIG_LIR_Nem_3	3	9	PF02991	0.578
LIG_LIR_Nem_3	38	42	PF02991	0.440
LIG_LIR_Nem_3	399	404	PF02991	0.566
LIG_LIR_Nem_3	508	514	PF02991	0.497
LIG_LIR_Nem_3	519	525	PF02991	0.418
LIG_NRBOX	468	474	PF00104	0.565
LIG_PTB_Apo_2	302	309	PF02174	0.600
LIG_SH2_CRK	511	515	PF00017	0.582
LIG_SH2_GRB2like	641	644	PF00017	0.687
LIG_SH2_NCK_1	597	601	PF00017	0.487
LIG_SH2_PTP2	401	404	PF00017	0.553
LIG_SH2_SRC	174	177	PF00017	0.457
LIG_SH2_SRC	192	195	PF00017	0.455
LIG_SH2_SRC	676	679	PF00017	0.699
LIG_SH2_STAP1	192	196	PF00017	0.589
LIG_SH2_STAP1	532	536	PF00017	0.517
LIG_SH2_STAP1	676	680	PF00017	0.550
LIG_SH2_STAP1	685	689	PF00017	0.514
LIG_SH2_STAT5	174	177	PF00017	0.442
LIG_SH2_STAT5	39	42	PF00017	0.379
LIG_SH2_STAT5	401	404	PF00017	0.519
LIG_SH2_STAT5	511	514	PF00017	0.579
LIG_SH2_STAT5	553	556	PF00017	0.541
LIG_SH3_3	348	354	PF00018	0.697
LIG_SH3_3	56	62	PF00018	0.574
LIG_SH3_3	678	684	PF00018	0.739
LIG_SH3_3	768	774	PF00018	0.758
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.530
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.693
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.507
LIG_SUMO_SIM_par_1	186	195	PF11976	0.429
LIG_SUMO_SIM_par_1	552	558	PF11976	0.584
LIG_SUMO_SIM_par_1	57	63	PF11976	0.501
LIG_TRAF2_1	459	462	PF00917	0.608
LIG_TRAF2_1	94	97	PF00917	0.481
LIG_UBA3_1	335	339	PF00899	0.591
LIG_UBA3_1	342	350	PF00899	0.679
LIG_UBA3_1	52	57	PF00899	0.324
MOD_CDC14_SPxK_1	46	49	PF00782	0.674
MOD_CDK_SPxK_1	43	49	PF00069	0.643
MOD_CDK_SPxxK_3	256	263	PF00069	0.495
MOD_CK1_1	18	24	PF00069	0.731
MOD_CK1_1	2	8	PF00069	0.789
MOD_CK1_1	274	280	PF00069	0.599
MOD_CK1_1	743	749	PF00069	0.819
MOD_CK1_1	792	798	PF00069	0.816
MOD_CK2_1	114	120	PF00069	0.608
MOD_CK2_1	194	200	PF00069	0.554
MOD_CK2_1	2	8	PF00069	0.644
MOD_CK2_1	326	332	PF00069	0.589
MOD_CK2_1	456	462	PF00069	0.572
MOD_CK2_1	464	470	PF00069	0.557
MOD_CK2_1	524	530	PF00069	0.590
MOD_CK2_1	644	650	PF00069	0.643
MOD_DYRK1A_RPxSP_1	256	260	PF00069	0.668
MOD_GlcNHglycan	166	170	PF01048	0.559
MOD_GlcNHglycan	17	20	PF01048	0.614
MOD_GlcNHglycan	252	255	PF01048	0.773
MOD_GlcNHglycan	269	272	PF01048	0.663
MOD_GlcNHglycan	328	331	PF01048	0.450
MOD_GlcNHglycan	393	396	PF01048	0.571
MOD_GlcNHglycan	417	420	PF01048	0.495
MOD_GlcNHglycan	518	521	PF01048	0.477
MOD_GlcNHglycan	590	593	PF01048	0.457
MOD_GlcNHglycan	629	632	PF01048	0.701
MOD_GlcNHglycan	742	745	PF01048	0.784
MOD_GlcNHglycan	771	774	PF01048	0.777
MOD_GSK3_1	14	21	PF00069	0.616
MOD_GSK3_1	170	177	PF00069	0.627
MOD_GSK3_1	194	201	PF00069	0.443
MOD_GSK3_1	214	221	PF00069	0.518
MOD_GSK3_1	250	257	PF00069	0.771
MOD_GSK3_1	267	274	PF00069	0.649
MOD_GSK3_1	526	533	PF00069	0.451
MOD_GSK3_1	598	605	PF00069	0.460
MOD_GSK3_1	717	724	PF00069	0.805
MOD_GSK3_1	740	747	PF00069	0.771
MOD_GSK3_1	791	798	PF00069	0.766
MOD_N-GLC_1	250	255	PF02516	0.538
MOD_N-GLC_1	274	279	PF02516	0.580
MOD_N-GLC_1	608	613	PF02516	0.577
MOD_N-GLC_1	75	80	PF02516	0.694
MOD_N-GLC_1	754	759	PF02516	0.773
MOD_N-GLC_2	305	307	PF02516	0.605
MOD_NEK2_1	170	175	PF00069	0.606
MOD_NEK2_1	198	203	PF00069	0.520
MOD_NEK2_1	225	230	PF00069	0.549
MOD_NEK2_1	279	284	PF00069	0.463
MOD_NEK2_1	324	329	PF00069	0.404
MOD_NEK2_1	509	514	PF00069	0.541
MOD_NEK2_1	602	607	PF00069	0.545
MOD_NEK2_1	608	613	PF00069	0.532
MOD_NEK2_1	740	745	PF00069	0.838
MOD_NEK2_2	359	364	PF00069	0.624
MOD_PIKK_1	121	127	PF00454	0.559
MOD_PIKK_1	404	410	PF00454	0.601
MOD_PIKK_1	464	470	PF00454	0.520
MOD_PIKK_1	608	614	PF00454	0.559
MOD_PIKK_1	721	727	PF00454	0.713
MOD_PIKK_1	78	84	PF00454	0.756
MOD_PKA_1	781	787	PF00069	0.746
MOD_PKA_2	170	176	PF00069	0.594
MOD_PKA_2	324	330	PF00069	0.571
MOD_PKA_2	530	536	PF00069	0.543
MOD_PKA_2	789	795	PF00069	0.614
MOD_PKB_1	250	258	PF00069	0.790
MOD_Plk_1	131	137	PF00069	0.573
MOD_Plk_1	165	171	PF00069	0.523
MOD_Plk_1	192	198	PF00069	0.599
MOD_Plk_1	2	8	PF00069	0.644
MOD_Plk_1	218	224	PF00069	0.397
MOD_Plk_1	274	280	PF00069	0.529
MOD_Plk_1	464	470	PF00069	0.555
MOD_Plk_1	498	504	PF00069	0.639
MOD_Plk_1	541	547	PF00069	0.542
MOD_Plk_1	566	572	PF00069	0.513
MOD_Plk_1	75	81	PF00069	0.675
MOD_Plk_1	795	801	PF00069	0.819
MOD_Plk_2-3	194	200	PF00069	0.333
MOD_Plk_2-3	650	656	PF00069	0.702
MOD_Plk_4	170	176	PF00069	0.552
MOD_Plk_4	194	200	PF00069	0.498
MOD_Plk_4	21	27	PF00069	0.617
MOD_Plk_4	274	280	PF00069	0.351
MOD_Plk_4	359	365	PF00069	0.630
MOD_Plk_4	542	548	PF00069	0.567
MOD_Plk_4	549	555	PF00069	0.546
MOD_Plk_4	560	566	PF00069	0.401
MOD_ProDKin_1	18	24	PF00069	0.651
MOD_ProDKin_1	220	226	PF00069	0.517
MOD_ProDKin_1	256	262	PF00069	0.768
MOD_ProDKin_1	43	49	PF00069	0.637
MOD_ProDKin_1	603	609	PF00069	0.558
MOD_SUMO_rev_2	332	341	PF00179	0.499
MOD_SUMO_rev_2	776	784	PF00179	0.807
MOD_SUMO_rev_2	95	101	PF00179	0.490
TRG_DiLeu_BaEn_1	313	318	PF01217	0.526
TRG_DiLeu_BaEn_1	427	432	PF01217	0.554
TRG_DiLeu_BaEn_4	461	467	PF01217	0.503
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.521
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.446
TRG_ENDOCYTIC_2	39	42	PF00928	0.384
TRG_ENDOCYTIC_2	401	404	PF00928	0.553
TRG_ENDOCYTIC_2	511	514	PF00928	0.510
TRG_ENDOCYTIC_2	532	535	PF00928	0.574
TRG_ENDOCYTIC_2	597	600	PF00928	0.416
TRG_ER_diArg_1	103	106	PF00400	0.347
TRG_ER_diArg_1	229	232	PF00400	0.520
TRG_ER_diArg_1	445	448	PF00400	0.465
TRG_NES_CRM1_1	179	194	PF08389	0.461
TRG_NES_CRM1_1	323	337	PF08389	0.532
TRG_NLS_Bipartite_1	230	252	PF00514	0.632
TRG_NLS_MonoExtC_3	247	252	PF00514	0.789
TRG_NLS_MonoExtN_4	229	234	PF00514	0.473
TRG_NLS_MonoExtN_4	247	253	PF00514	0.741
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHD7	Leptomonas seymouri	69%	97%
A0A0N1ILZ8	Leptomonas seymouri	24%	86%
A0A1X0P7D5	Trypanosomatidae	20%	76%
A0A1X0P8A9	Trypanosomatidae	36%	96%
A0A3S7X009	Leishmania donovani	82%	100%
A0A422N0G0	Trypanosoma rangeli	33%	100%
A0A422NQU4	Trypanosoma rangeli	23%	97%
A4HF40	Leishmania braziliensis	65%	100%
A4I2C4	Leishmania infantum	82%	100%
C9ZX89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZX90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q8Z6	Leishmania major	79%	100%