4HBT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioesterase-like superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9AYH4_LEIMU

TriTrypDb:

LmxM.26.1940

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	203	205	PF00675	0.261
CLV_NRD_NRD_1	228	230	PF00675	0.621
CLV_NRD_NRD_1	274	276	PF00675	0.496
CLV_PCSK_KEX2_1	190	192	PF00082	0.296
CLV_PCSK_KEX2_1	228	230	PF00082	0.627
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.296
CLV_PCSK_SKI1_1	135	139	PF00082	0.362
CLV_PCSK_SKI1_1	162	166	PF00082	0.299
CLV_PCSK_SKI1_1	275	279	PF00082	0.396
DEG_SPOP_SBC_1	166	170	PF00917	0.362
DEG_SPOP_SBC_1	175	179	PF00917	0.324
DOC_CKS1_1	284	289	PF01111	0.511
DOC_CKS1_1	56	61	PF01111	0.542
DOC_CYCLIN_RxL_1	159	169	PF00134	0.208
DOC_CYCLIN_yCln2_LP_2	164	167	PF00134	0.362
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.431
DOC_MAPK_gen_1	118	127	PF00069	0.362
DOC_MAPK_gen_1	149	159	PF00069	0.362
DOC_MAPK_gen_1	8	17	PF00069	0.422
DOC_PP1_RVXF_1	118	125	PF00149	0.401
DOC_PP1_RVXF_1	133	139	PF00149	0.221
DOC_PP2B_LxvP_1	164	167	PF13499	0.362
DOC_PP2B_LxvP_1	31	34	PF13499	0.454
DOC_PP4_FxxP_1	172	175	PF00568	0.349
DOC_PP4_FxxP_1	66	69	PF00568	0.464
DOC_USP7_MATH_1	176	180	PF00917	0.306
DOC_USP7_MATH_1	183	187	PF00917	0.398
DOC_USP7_MATH_1	232	236	PF00917	0.524
DOC_USP7_MATH_1	299	303	PF00917	0.568
DOC_USP7_MATH_1	38	42	PF00917	0.574
DOC_USP7_UBL2_3	201	205	PF12436	0.362
DOC_USP7_UBL2_3	351	355	PF12436	0.455
DOC_WW_Pin1_4	283	288	PF00397	0.512
DOC_WW_Pin1_4	336	341	PF00397	0.606
DOC_WW_Pin1_4	55	60	PF00397	0.562
LIG_14-3-3_CanoR_1	120	125	PF00244	0.436
LIG_14-3-3_CanoR_1	152	158	PF00244	0.331
LIG_14-3-3_CanoR_1	251	257	PF00244	0.420
LIG_14-3-3_CanoR_1	332	337	PF00244	0.603
LIG_APCC_ABBAyCdc20_2	189	195	PF00400	0.362
LIG_BIR_II_1	1	5	PF00653	0.470
LIG_BRCT_BRCA1_1	168	172	PF00533	0.362
LIG_eIF4E_1	93	99	PF01652	0.423
LIG_FHA_1	154	160	PF00498	0.303
LIG_FHA_1	207	213	PF00498	0.246
LIG_FHA_1	284	290	PF00498	0.651
LIG_FHA_1	38	44	PF00498	0.417
LIG_LIR_Apic_2	169	175	PF02991	0.342
LIG_LIR_LC3C_4	335	338	PF02991	0.446
LIG_LIR_Nem_3	100	105	PF02991	0.362
LIG_LIR_Nem_3	123	127	PF02991	0.362
LIG_LIR_Nem_3	77	83	PF02991	0.366
LIG_Pex14_2	66	70	PF04695	0.472
LIG_PTB_Apo_2	104	111	PF02174	0.299
LIG_PTB_Phospho_1	104	110	PF10480	0.299
LIG_SH2_CRK	93	97	PF00017	0.432
LIG_SH2_SRC	193	196	PF00017	0.362
LIG_SH2_STAP1	222	226	PF00017	0.382
LIG_SH2_STAT5	110	113	PF00017	0.333
LIG_SH2_STAT5	193	196	PF00017	0.362
LIG_SH2_STAT5	93	96	PF00017	0.405
LIG_SH3_1	72	78	PF00018	0.435
LIG_SH3_3	281	287	PF00018	0.391
LIG_SH3_3	334	340	PF00018	0.719
LIG_SH3_3	56	62	PF00018	0.519
LIG_SH3_3	72	78	PF00018	0.435
LIG_SH3_3	81	87	PF00018	0.343
LIG_WW_2	61	64	PF00397	0.463
MOD_CDK_SPK_2	55	60	PF00069	0.531
MOD_CK1_1	141	147	PF00069	0.299
MOD_CK1_1	178	184	PF00069	0.424
MOD_CK1_1	343	349	PF00069	0.557
MOD_CK2_1	267	273	PF00069	0.388
MOD_Cter_Amidation	202	205	PF01082	0.362
MOD_GlcNHglycan	180	183	PF01048	0.218
MOD_GlcNHglycan	234	237	PF01048	0.386
MOD_GlcNHglycan	27	30	PF01048	0.462
MOD_GlcNHglycan	279	282	PF01048	0.635
MOD_GlcNHglycan	301	304	PF01048	0.636
MOD_GlcNHglycan	309	312	PF01048	0.516
MOD_GSK3_1	174	181	PF00069	0.418
MOD_GSK3_1	21	28	PF00069	0.433
MOD_GSK3_1	230	237	PF00069	0.492
MOD_GSK3_1	332	339	PF00069	0.645
MOD_GSK3_1	340	347	PF00069	0.494
MOD_NEK2_1	206	211	PF00069	0.221
MOD_NEK2_1	266	271	PF00069	0.437
MOD_PKA_2	21	27	PF00069	0.428
MOD_PKA_2	252	258	PF00069	0.462
MOD_PKB_1	118	126	PF00069	0.439
MOD_PKB_1	249	257	PF00069	0.501
MOD_Plk_1	141	147	PF00069	0.347
MOD_Plk_4	120	126	PF00069	0.397
MOD_Plk_4	153	159	PF00069	0.264
MOD_Plk_4	332	338	PF00069	0.525
MOD_Plk_4	38	44	PF00069	0.419
MOD_ProDKin_1	283	289	PF00069	0.512
MOD_ProDKin_1	336	342	PF00069	0.605
MOD_ProDKin_1	55	61	PF00069	0.562
MOD_SUMO_for_1	220	223	PF00179	0.444
MOD_SUMO_rev_2	186	192	PF00179	0.208
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.419
TRG_ENDOCYTIC_2	110	113	PF00928	0.299
TRG_ENDOCYTIC_2	93	96	PF00928	0.359
TRG_ER_diArg_1	133	136	PF00400	0.420
TRG_ER_diArg_1	20	23	PF00400	0.419
TRG_ER_diArg_1	228	230	PF00400	0.613
TRG_ER_diArg_1	250	253	PF00400	0.440
TRG_NES_CRM1_1	86	101	PF08389	0.351
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.299
TRG_PTS1	353	356	PF00515	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E3	Leptomonas seymouri	46%	100%
A0A3Q8ICX4	Leishmania donovani	83%	100%
A4I2C2	Leishmania infantum	84%	100%
Q4Q8Z8	Leishmania major	82%	99%