Sedlin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Sedlin

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYG9_LEIMU

TriTrypDb:

LmxM.26.1890

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	159	163	PF00082	0.419
CLV_PCSK_SKI1_1	30	34	PF00082	0.471
DEG_SPOP_SBC_1	114	118	PF00917	0.437
DEG_SPOP_SBC_1	81	85	PF00917	0.480
DOC_CYCLIN_yCln2_LP_2	33	39	PF00134	0.546
DOC_PP1_RVXF_1	51	57	PF00149	0.371
DOC_PP4_FxxP_1	199	202	PF00568	0.456
DOC_USP7_MATH_1	228	232	PF00917	0.594
DOC_USP7_MATH_1	254	258	PF00917	0.628
DOC_USP7_MATH_1	73	77	PF00917	0.662
DOC_USP7_MATH_1	80	84	PF00917	0.696
DOC_WW_Pin1_4	133	138	PF00397	0.631
DOC_WW_Pin1_4	16	21	PF00397	0.384
DOC_WW_Pin1_4	198	203	PF00397	0.515
DOC_WW_Pin1_4	25	30	PF00397	0.383
DOC_WW_Pin1_4	277	282	PF00397	0.491
DOC_WW_Pin1_4	32	37	PF00397	0.392
LIG_14-3-3_CanoR_1	152	157	PF00244	0.438
LIG_14-3-3_CanoR_1	24	29	PF00244	0.394
LIG_14-3-3_CanoR_1	260	265	PF00244	0.561
LIG_14-3-3_CanoR_1	294	304	PF00244	0.517
LIG_BIR_II_1	1	5	PF00653	0.499
LIG_BRCT_BRCA1_1	154	158	PF00533	0.336
LIG_BRCT_BRCA1_1	292	296	PF00533	0.437
LIG_deltaCOP1_diTrp_1	270	273	PF00928	0.670
LIG_EH_1	196	200	PF12763	0.433
LIG_FHA_1	114	120	PF00498	0.568
LIG_FHA_1	129	135	PF00498	0.497
LIG_FHA_1	164	170	PF00498	0.450
LIG_FHA_1	17	23	PF00498	0.392
LIG_FHA_1	228	234	PF00498	0.595
LIG_FHA_1	287	293	PF00498	0.548
LIG_FHA_1	3	9	PF00498	0.389
LIG_FHA_2	296	302	PF00498	0.479
LIG_LIR_Apic_2	25	29	PF02991	0.385
LIG_LIR_Apic_2	270	276	PF02991	0.667
LIG_NRBOX	143	149	PF00104	0.476
LIG_NRBOX	299	305	PF00104	0.420
LIG_PCNA_yPIPBox_3	294	304	PF02747	0.498
LIG_SH2_CRK	26	30	PF00017	0.517
LIG_SH2_NCK_1	188	192	PF00017	0.346
LIG_SH2_PTP2	45	48	PF00017	0.473
LIG_SH2_STAT3	241	244	PF00017	0.581
LIG_SH2_STAT5	26	29	PF00017	0.503
LIG_SH2_STAT5	45	48	PF00017	0.415
LIG_SH3_1	275	281	PF00018	0.438
LIG_SH3_3	275	281	PF00018	0.438
LIG_SH3_3	33	39	PF00018	0.546
LIG_SH3_3	76	82	PF00018	0.427
LIG_SUMO_SIM_par_1	12	17	PF11976	0.381
LIG_SUMO_SIM_par_1	165	170	PF11976	0.449
LIG_SUMO_SIM_par_1	19	25	PF11976	0.372
LIG_SUMO_SIM_par_1	287	293	PF11976	0.573
LIG_WRC_WIRS_1	304	309	PF05994	0.519
MOD_CAAXbox	314	317	PF01239	0.643
MOD_CDK_SPK_2	25	30	PF00069	0.421
MOD_CK1_1	117	123	PF00069	0.571
MOD_CK1_1	136	142	PF00069	0.440
MOD_CK1_1	2	8	PF00069	0.485
MOD_CK1_1	263	269	PF00069	0.594
MOD_CK1_1	305	311	PF00069	0.550
MOD_CK2_1	102	108	PF00069	0.618
MOD_CK2_1	216	222	PF00069	0.622
MOD_CK2_1	295	301	PF00069	0.482
MOD_GlcNHglycan	103	107	PF01048	0.777
MOD_GlcNHglycan	126	129	PF01048	0.494
MOD_GlcNHglycan	159	162	PF01048	0.417
MOD_GlcNHglycan	191	194	PF01048	0.385
MOD_GlcNHglycan	218	221	PF01048	0.660
MOD_GlcNHglycan	256	259	PF01048	0.746
MOD_GlcNHglycan	265	268	PF01048	0.660
MOD_GSK3_1	113	120	PF00069	0.701
MOD_GSK3_1	124	131	PF00069	0.478
MOD_GSK3_1	159	166	PF00069	0.408
MOD_GSK3_1	222	229	PF00069	0.579
MOD_GSK3_1	259	266	PF00069	0.690
MOD_GSK3_1	282	289	PF00069	0.538
MOD_GSK3_1	303	310	PF00069	0.491
MOD_N-GLC_1	124	129	PF02516	0.609
MOD_NEK2_1	147	152	PF00069	0.415
MOD_NEK2_1	167	172	PF00069	0.472
MOD_NEK2_1	22	27	PF00069	0.433
MOD_NEK2_1	269	274	PF00069	0.616
MOD_NEK2_1	290	295	PF00069	0.476
MOD_NEK2_1	303	308	PF00069	0.446
MOD_PIKK_1	228	234	PF00454	0.734
MOD_PIKK_1	240	246	PF00454	0.515
MOD_PIKK_1	247	253	PF00454	0.437
MOD_PIKK_1	295	301	PF00454	0.522
MOD_PKA_2	259	265	PF00069	0.560
MOD_Plk_1	269	275	PF00069	0.772
MOD_Plk_1	92	98	PF00069	0.657
MOD_Plk_4	119	125	PF00069	0.523
MOD_Plk_4	163	169	PF00069	0.540
MOD_Plk_4	92	98	PF00069	0.777
MOD_ProDKin_1	133	139	PF00069	0.618
MOD_ProDKin_1	16	22	PF00069	0.380
MOD_ProDKin_1	198	204	PF00069	0.516
MOD_ProDKin_1	25	31	PF00069	0.391
MOD_ProDKin_1	277	283	PF00069	0.486
MOD_ProDKin_1	32	38	PF00069	0.388
TRG_DiLeu_BaEn_1	108	113	PF01217	0.513
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.605
TRG_DiLeu_LyEn_5	17	22	PF01217	0.486
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P7	Leptomonas seymouri	57%	94%
A0A1X0P7Q6	Trypanosomatidae	37%	100%
A0A3Q8ICA3	Leishmania donovani	91%	100%
A4HF34	Leishmania braziliensis	76%	100%
A4I2B8	Leishmania infantum	91%	100%
C9ZX95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q903	Leishmania major	91%	100%
V5AV59	Trypanosoma cruzi	36%	100%