DUF4460 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4460), putative

Species:

Leishmania mexicana

UniProt:

E9AYG8_LEIMU

TriTrypDb:

LmxM.26.1880

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.459
CLV_C14_Caspase3-7	245	249	PF00656	0.521
CLV_NRD_NRD_1	177	179	PF00675	0.368
CLV_NRD_NRD_1	199	201	PF00675	0.516
CLV_NRD_NRD_1	208	210	PF00675	0.507
CLV_NRD_NRD_1	428	430	PF00675	0.388
CLV_NRD_NRD_1	507	509	PF00675	0.537
CLV_NRD_NRD_1	547	549	PF00675	0.522
CLV_NRD_NRD_1	579	581	PF00675	0.774
CLV_NRD_NRD_1	64	66	PF00675	0.473
CLV_NRD_NRD_1	699	701	PF00675	0.582
CLV_PCSK_FUR_1	206	210	PF00082	0.578
CLV_PCSK_KEX2_1	109	111	PF00082	0.636
CLV_PCSK_KEX2_1	177	179	PF00082	0.382
CLV_PCSK_KEX2_1	199	201	PF00082	0.509
CLV_PCSK_KEX2_1	206	208	PF00082	0.505
CLV_PCSK_KEX2_1	507	509	PF00082	0.467
CLV_PCSK_KEX2_1	547	549	PF00082	0.517
CLV_PCSK_KEX2_1	579	581	PF00082	0.774
CLV_PCSK_KEX2_1	64	66	PF00082	0.498
CLV_PCSK_KEX2_1	699	701	PF00082	0.582
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.682
CLV_PCSK_PC7_1	173	179	PF00082	0.360
CLV_PCSK_SKI1_1	173	177	PF00082	0.339
CLV_PCSK_SKI1_1	200	204	PF00082	0.611
CLV_PCSK_SKI1_1	221	225	PF00082	0.399
CLV_PCSK_SKI1_1	3	7	PF00082	0.277
CLV_PCSK_SKI1_1	375	379	PF00082	0.361
CLV_PCSK_SKI1_1	393	397	PF00082	0.439
CLV_PCSK_SKI1_1	43	47	PF00082	0.303
CLV_PCSK_SKI1_1	436	440	PF00082	0.389
CLV_PCSK_SKI1_1	476	480	PF00082	0.333
CLV_PCSK_SKI1_1	508	512	PF00082	0.323
CLV_PCSK_SKI1_1	537	541	PF00082	0.573
CLV_PCSK_SKI1_1	684	688	PF00082	0.483
CLV_PCSK_SKI1_1	727	731	PF00082	0.633
DEG_APCC_DBOX_1	270	278	PF00400	0.397
DEG_APCC_DBOX_1	414	422	PF00400	0.382
DEG_Nend_Nbox_1	1	3	PF02207	0.367
DOC_CDC14_PxL_1	237	245	PF14671	0.459
DOC_CYCLIN_RxL_1	678	689	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.378
DOC_CYCLIN_yCln2_LP_2	583	589	PF00134	0.598
DOC_MAPK_MEF2A_6	397	406	PF00069	0.476
DOC_PP1_RVXF_1	469	475	PF00149	0.338
DOC_PP2B_LxvP_1	303	306	PF13499	0.363
DOC_PP2B_LxvP_1	50	53	PF13499	0.384
DOC_PP2B_LxvP_1	510	513	PF13499	0.429
DOC_PP4_FxxP_1	148	151	PF00568	0.405
DOC_USP7_MATH_1	102	106	PF00917	0.586
DOC_USP7_MATH_1	156	160	PF00917	0.570
DOC_USP7_MATH_1	54	58	PF00917	0.456
DOC_USP7_MATH_1	83	87	PF00917	0.748
DOC_USP7_MATH_1	88	92	PF00917	0.764
DOC_USP7_UBL2_3	217	221	PF12436	0.614
DOC_USP7_UBL2_3	533	537	PF12436	0.563
DOC_WW_Pin1_4	256	261	PF00397	0.375
DOC_WW_Pin1_4	495	500	PF00397	0.431
DOC_WW_Pin1_4	603	608	PF00397	0.537
LIG_14-3-3_CanoR_1	271	275	PF00244	0.522
LIG_14-3-3_CanoR_1	429	435	PF00244	0.244
LIG_14-3-3_CanoR_1	542	549	PF00244	0.591
LIG_14-3-3_CanoR_1	555	563	PF00244	0.604
LIG_14-3-3_CanoR_1	603	607	PF00244	0.571
LIG_14-3-3_CanoR_1	627	635	PF00244	0.582
LIG_APCC_ABBA_1	11	16	PF00400	0.274
LIG_BRCT_BRCA1_1	56	60	PF00533	0.451
LIG_BRCT_BRCA1_1	697	701	PF00533	0.579
LIG_deltaCOP1_diTrp_1	116	124	PF00928	0.643
LIG_deltaCOP1_diTrp_1	489	495	PF00928	0.404
LIG_FHA_1	139	145	PF00498	0.451
LIG_FHA_1	298	304	PF00498	0.353
LIG_FHA_1	385	391	PF00498	0.361
LIG_FHA_1	492	498	PF00498	0.344
LIG_FHA_1	558	564	PF00498	0.442
LIG_FHA_1	659	665	PF00498	0.586
LIG_FHA_1	668	674	PF00498	0.572
LIG_FHA_2	220	226	PF00498	0.537
LIG_FHA_2	240	246	PF00498	0.245
LIG_FHA_2	335	341	PF00498	0.433
LIG_FHA_2	346	352	PF00498	0.396
LIG_FHA_2	408	414	PF00498	0.368
LIG_FHA_2	612	618	PF00498	0.638
LIG_FHA_2	637	643	PF00498	0.597
LIG_LIR_Apic_2	146	151	PF02991	0.390
LIG_LIR_Apic_2	648	654	PF02991	0.554
LIG_LIR_Gen_1	280	289	PF02991	0.400
LIG_LIR_Gen_1	308	317	PF02991	0.477
LIG_LIR_Gen_1	489	497	PF02991	0.389
LIG_LIR_Gen_1	702	710	PF02991	0.556
LIG_LIR_Nem_3	308	312	PF02991	0.438
LIG_LIR_Nem_3	489	493	PF02991	0.382
LIG_LIR_Nem_3	57	63	PF02991	0.460
LIG_MYND_3	240	244	PF01753	0.458
LIG_NRBOX	171	177	PF00104	0.334
LIG_NRBOX	34	40	PF00104	0.274
LIG_Pex14_1	41	45	PF04695	0.274
LIG_Pex14_1	647	651	PF04695	0.506
LIG_REV1ctd_RIR_1	104	114	PF16727	0.455
LIG_REV1ctd_RIR_1	7	14	PF16727	0.274
LIG_SH2_SRC	651	654	PF00017	0.546
LIG_SH2_STAP1	468	472	PF00017	0.346
LIG_SH2_STAT3	655	658	PF00017	0.577
LIG_SH2_STAT5	524	527	PF00017	0.383
LIG_SH2_STAT5	655	658	PF00017	0.596
LIG_SH3_3	583	589	PF00018	0.670
LIG_SH3_3	622	628	PF00018	0.564
LIG_SUMO_SIM_par_1	138	147	PF11976	0.579
LIG_SUMO_SIM_par_1	283	291	PF11976	0.369
LIG_SUMO_SIM_par_1	400	405	PF11976	0.403
LIG_SUMO_SIM_par_1	621	626	PF11976	0.601
LIG_TRAF2_1	242	245	PF00917	0.441
LIG_TRAF2_1	410	413	PF00917	0.393
LIG_TRAF2_1	550	553	PF00917	0.568
LIG_TRFH_1	495	499	PF08558	0.341
LIG_WRC_WIRS_1	314	319	PF05994	0.349
MOD_CK1_1	239	245	PF00069	0.488
MOD_CK1_1	407	413	PF00069	0.460
MOD_CK2_1	143	149	PF00069	0.394
MOD_CK2_1	181	187	PF00069	0.413
MOD_CK2_1	239	245	PF00069	0.393
MOD_CK2_1	270	276	PF00069	0.515
MOD_CK2_1	334	340	PF00069	0.404
MOD_CK2_1	345	351	PF00069	0.395
MOD_CK2_1	357	363	PF00069	0.404
MOD_CK2_1	407	413	PF00069	0.378
MOD_CK2_1	448	454	PF00069	0.263
MOD_CK2_1	528	534	PF00069	0.557
MOD_CK2_1	547	553	PF00069	0.568
MOD_CK2_1	567	573	PF00069	0.610
MOD_CK2_1	611	617	PF00069	0.631
MOD_CK2_1	634	640	PF00069	0.535
MOD_CK2_1	88	94	PF00069	0.823
MOD_Cter_Amidation	694	697	PF01082	0.505
MOD_GlcNHglycan	125	129	PF01048	0.735
MOD_GlcNHglycan	217	220	PF01048	0.678
MOD_GlcNHglycan	263	266	PF01048	0.345
MOD_GlcNHglycan	530	533	PF01048	0.490
MOD_GlcNHglycan	543	546	PF01048	0.416
MOD_GlcNHglycan	81	84	PF01048	0.664
MOD_GlcNHglycan	90	93	PF01048	0.716
MOD_GSK3_1	181	188	PF00069	0.439
MOD_GSK3_1	215	222	PF00069	0.545
MOD_GSK3_1	225	232	PF00069	0.327
MOD_GSK3_1	235	242	PF00069	0.275
MOD_GSK3_1	266	273	PF00069	0.472
MOD_GSK3_1	297	304	PF00069	0.433
MOD_GSK3_1	444	451	PF00069	0.439
MOD_GSK3_1	491	498	PF00069	0.416
MOD_GSK3_1	567	574	PF00069	0.648
MOD_GSK3_1	627	634	PF00069	0.603
MOD_GSK3_1	667	674	PF00069	0.544
MOD_GSK3_1	75	82	PF00069	0.653
MOD_GSK3_1	83	90	PF00069	0.625
MOD_N-GLC_1	384	389	PF02516	0.378
MOD_N-GLC_2	464	466	PF02516	0.447
MOD_NEK2_1	124	129	PF00069	0.784
MOD_NEK2_1	143	148	PF00069	0.256
MOD_NEK2_1	233	238	PF00069	0.454
MOD_NEK2_1	254	259	PF00069	0.444
MOD_NEK2_1	261	266	PF00069	0.432
MOD_NEK2_1	270	275	PF00069	0.470
MOD_NEK2_1	438	443	PF00069	0.342
MOD_NEK2_1	541	546	PF00069	0.423
MOD_NEK2_1	667	672	PF00069	0.523
MOD_NEK2_1	690	695	PF00069	0.592
MOD_NEK2_2	102	107	PF00069	0.595
MOD_NEK2_2	131	136	PF00069	0.470
MOD_NEK2_2	266	271	PF00069	0.366
MOD_PIKK_1	136	142	PF00454	0.567
MOD_PIKK_1	76	82	PF00454	0.591
MOD_PK_1	430	436	PF00069	0.378
MOD_PKA_1	547	553	PF00069	0.582
MOD_PKA_2	136	142	PF00069	0.459
MOD_PKA_2	270	276	PF00069	0.518
MOD_PKA_2	541	547	PF00069	0.591
MOD_PKA_2	602	608	PF00069	0.550
MOD_PKA_2	671	677	PF00069	0.655
MOD_PKA_2	83	89	PF00069	0.779
MOD_Plk_1	164	170	PF00069	0.480
MOD_Plk_1	307	313	PF00069	0.514
MOD_Plk_1	384	390	PF00069	0.350
MOD_Plk_1	404	410	PF00069	0.486
MOD_Plk_1	439	445	PF00069	0.343
MOD_Plk_1	464	470	PF00069	0.379
MOD_Plk_1	491	497	PF00069	0.330
MOD_Plk_2-3	187	193	PF00069	0.434
MOD_Plk_2-3	448	454	PF00069	0.265
MOD_Plk_2-3	567	573	PF00069	0.596
MOD_Plk_2-3	621	627	PF00069	0.582
MOD_Plk_4	102	108	PF00069	0.710
MOD_Plk_4	138	144	PF00069	0.458
MOD_Plk_4	219	225	PF00069	0.417
MOD_Plk_4	313	319	PF00069	0.308
MOD_Plk_4	439	445	PF00069	0.343
MOD_ProDKin_1	256	262	PF00069	0.369
MOD_ProDKin_1	495	501	PF00069	0.438
MOD_ProDKin_1	603	609	PF00069	0.537
MOD_SUMO_for_1	645	648	PF00179	0.520
TRG_DiLeu_BaEn_1	338	343	PF01217	0.468
TRG_DiLeu_BaEn_1	492	497	PF01217	0.466
TRG_DiLeu_BaEn_1	536	541	PF01217	0.543
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.502
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.464
TRG_ENDOCYTIC_2	63	66	PF00928	0.519
TRG_ENDOCYTIC_2	703	706	PF00928	0.560
TRG_ER_diArg_1	176	178	PF00400	0.379
TRG_ER_diArg_1	205	208	PF00400	0.553
TRG_ER_diArg_1	546	548	PF00400	0.553
TRG_ER_diArg_1	578	580	PF00400	0.539
TRG_ER_diArg_1	63	65	PF00400	0.513
TRG_ER_diArg_1	699	701	PF00400	0.573
TRG_NES_CRM1_1	180	194	PF08389	0.487
TRG_NES_CRM1_1	340	354	PF08389	0.333
TRG_NES_CRM1_1	416	428	PF08389	0.476
TRG_NLS_Bipartite_1	684	700	PF00514	0.514
TRG_NLS_MonoExtC_3	695	700	PF00514	0.531
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB5	Leptomonas seymouri	78%	100%
A0A0S4IT81	Bodo saltans	50%	100%
A0A1X0P7G1	Trypanosomatidae	58%	100%
A0A3R7MTD0	Trypanosoma rangeli	58%	100%
A0A3S7WZZ9	Leishmania donovani	95%	100%
A4HF33	Leishmania braziliensis	87%	99%
A4I272	Leishmania infantum	95%	100%
C9ZX97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
Q4Q904	Leishmania major	95%	100%
V5DB85	Trypanosoma cruzi	58%	100%