Integrase catalytic domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 2

Species:

Leishmania mexicana

UniProt:

E9AYG6_LEIMU

TriTrypDb:

LmxM.26.1860

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AYG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.601
CLV_MEL_PAP_1	253	259	PF00089	0.596
CLV_NRD_NRD_1	158	160	PF00675	0.758
CLV_NRD_NRD_1	335	337	PF00675	0.620
CLV_NRD_NRD_1	389	391	PF00675	0.536
CLV_PCSK_KEX2_1	321	323	PF00082	0.551
CLV_PCSK_KEX2_1	370	372	PF00082	0.676
CLV_PCSK_KEX2_1	388	390	PF00082	0.440
CLV_PCSK_KEX2_1	500	502	PF00082	0.814
CLV_PCSK_KEX2_1	542	544	PF00082	0.390
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.552
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.682
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.814
CLV_PCSK_PC1ET2_1	542	544	PF00082	0.432
CLV_PCSK_SKI1_1	152	156	PF00082	0.714
CLV_PCSK_SKI1_1	160	164	PF00082	0.769
CLV_PCSK_SKI1_1	205	209	PF00082	0.695
CLV_PCSK_SKI1_1	219	223	PF00082	0.564
CLV_PCSK_SKI1_1	337	341	PF00082	0.616
CLV_PCSK_SKI1_1	362	366	PF00082	0.520
CLV_PCSK_SKI1_1	484	488	PF00082	0.706
DEG_APCC_DBOX_1	389	397	PF00400	0.317
DEG_Kelch_actinfilin_1	522	526	PF01344	0.285
DOC_CKS1_1	32	37	PF01111	0.548
DOC_CKS1_1	487	492	PF01111	0.473
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.474
DOC_MAPK_DCC_7	243	253	PF00069	0.384
DOC_MAPK_gen_1	159	166	PF00069	0.567
DOC_MAPK_gen_1	333	342	PF00069	0.346
DOC_MAPK_JIP1_4	160	166	PF00069	0.566
DOC_MAPK_MEF2A_6	245	253	PF00069	0.384
DOC_MAPK_RevD_3	526	542	PF00069	0.419
DOC_PP2B_LxvP_1	271	274	PF13499	0.425
DOC_PP2B_LxvP_1	4	7	PF13499	0.584
DOC_PP2B_PxIxI_1	248	254	PF00149	0.383
DOC_PP4_FxxP_1	236	239	PF00568	0.354
DOC_SPAK_OSR1_1	423	427	PF12202	0.300
DOC_USP7_MATH_1	102	106	PF00917	0.585
DOC_USP7_MATH_1	150	154	PF00917	0.476
DOC_USP7_MATH_1	17	21	PF00917	0.614
DOC_USP7_MATH_1	22	26	PF00917	0.615
DOC_USP7_MATH_1	305	309	PF00917	0.397
DOC_USP7_MATH_1	36	40	PF00917	0.596
DOC_USP7_MATH_1	452	456	PF00917	0.373
DOC_USP7_MATH_1	509	513	PF00917	0.571
DOC_USP7_MATH_1	529	533	PF00917	0.483
DOC_USP7_UBL2_3	201	205	PF12436	0.517
DOC_WW_Pin1_4	132	137	PF00397	0.563
DOC_WW_Pin1_4	138	143	PF00397	0.493
DOC_WW_Pin1_4	231	236	PF00397	0.380
DOC_WW_Pin1_4	27	32	PF00397	0.561
DOC_WW_Pin1_4	417	422	PF00397	0.400
DOC_WW_Pin1_4	486	491	PF00397	0.475
LIG_14-3-3_CanoR_1	159	165	PF00244	0.565
LIG_Actin_WH2_2	357	372	PF00022	0.421
LIG_deltaCOP1_diTrp_1	73	78	PF00928	0.459
LIG_FHA_1	138	144	PF00498	0.382
LIG_FHA_1	161	167	PF00498	0.534
LIG_FHA_1	363	369	PF00498	0.323
LIG_FHA_1	378	384	PF00498	0.328
LIG_FHA_1	475	481	PF00498	0.538
LIG_FHA_1	532	538	PF00498	0.346
LIG_FHA_2	57	63	PF00498	0.521
LIG_GBD_Chelix_1	360	368	PF00786	0.598
LIG_LIR_Apic_2	234	239	PF02991	0.361
LIG_LIR_Gen_1	298	307	PF02991	0.324
LIG_LIR_Gen_1	398	407	PF02991	0.327
LIG_LIR_Gen_1	445	454	PF02991	0.447
LIG_LIR_Gen_1	516	526	PF02991	0.381
LIG_LIR_Nem_3	298	302	PF02991	0.314
LIG_LIR_Nem_3	319	323	PF02991	0.405
LIG_LIR_Nem_3	392	397	PF02991	0.322
LIG_LIR_Nem_3	398	403	PF02991	0.302
LIG_LIR_Nem_3	445	451	PF02991	0.394
LIG_LIR_Nem_3	516	521	PF02991	0.527
LIG_LIR_Nem_3	75	81	PF02991	0.414
LIG_Pex14_1	74	78	PF04695	0.415
LIG_Pex14_2	295	299	PF04695	0.321
LIG_Pex14_2	400	404	PF04695	0.315
LIG_Rb_pABgroove_1	391	399	PF01858	0.311
LIG_SH2_CRK	323	327	PF00017	0.317
LIG_SH2_GRB2like	147	150	PF00017	0.513
LIG_SH2_NCK_1	323	327	PF00017	0.323
LIG_SH2_SRC	147	150	PF00017	0.513
LIG_SH2_SRC	53	56	PF00017	0.525
LIG_SH2_STAP1	147	151	PF00017	0.526
LIG_SH2_STAP1	297	301	PF00017	0.391
LIG_SH2_STAP1	356	360	PF00017	0.378
LIG_SH2_STAP1	397	401	PF00017	0.389
LIG_SH2_STAT5	327	330	PF00017	0.302
LIG_SH2_STAT5	53	56	PF00017	0.494
LIG_SH3_3	10	16	PF00018	0.580
LIG_SUMO_SIM_anti_2	534	539	PF11976	0.451
LIG_SUMO_SIM_par_1	438	445	PF11976	0.445
LIG_TYR_ITIM	325	330	PF00017	0.346
MOD_CDK_SPxK_1	417	423	PF00069	0.236
MOD_CK1_1	168	174	PF00069	0.533
MOD_CK1_1	39	45	PF00069	0.542
MOD_CK1_1	419	425	PF00069	0.367
MOD_CK1_1	517	523	PF00069	0.316
MOD_CK1_1	56	62	PF00069	0.526
MOD_CK2_1	22	28	PF00069	0.611
MOD_CK2_1	347	353	PF00069	0.454
MOD_CK2_1	379	385	PF00069	0.432
MOD_GlcNHglycan	105	108	PF01048	0.770
MOD_GlcNHglycan	109	112	PF01048	0.773
MOD_GlcNHglycan	152	155	PF01048	0.688
MOD_GlcNHglycan	19	22	PF01048	0.754
MOD_GlcNHglycan	24	27	PF01048	0.751
MOD_GlcNHglycan	259	262	PF01048	0.685
MOD_GlcNHglycan	307	310	PF01048	0.523
MOD_GlcNHglycan	465	468	PF01048	0.743
MOD_GlcNHglycan	506	509	PF01048	0.729
MOD_GlcNHglycan	511	514	PF01048	0.736
MOD_GlcNHglycan	531	534	PF01048	0.150
MOD_GSK3_1	103	110	PF00069	0.561
MOD_GSK3_1	128	135	PF00069	0.556
MOD_GSK3_1	185	192	PF00069	0.545
MOD_GSK3_1	27	34	PF00069	0.551
MOD_GSK3_1	399	406	PF00069	0.394
MOD_GSK3_1	412	419	PF00069	0.374
MOD_GSK3_1	49	56	PF00069	0.534
MOD_GSK3_1	491	498	PF00069	0.481
MOD_GSK3_1	500	507	PF00069	0.453
MOD_GSK3_1	509	516	PF00069	0.546
MOD_LATS_1	203	209	PF00433	0.553
MOD_NEK2_1	126	131	PF00069	0.549
MOD_NEK2_1	229	234	PF00069	0.386
MOD_NEK2_1	257	262	PF00069	0.470
MOD_NEK2_1	377	382	PF00069	0.417
MOD_NEK2_1	82	87	PF00069	0.505
MOD_NEK2_2	399	404	PF00069	0.366
MOD_PIKK_1	214	220	PF00454	0.503
MOD_PKA_1	205	211	PF00069	0.476
MOD_PKA_1	500	506	PF00069	0.607
MOD_PKA_2	100	106	PF00069	0.495
MOD_PKA_2	500	506	PF00069	0.607
MOD_Plk_1	185	191	PF00069	0.540
MOD_Plk_1	452	458	PF00069	0.452
MOD_Plk_2-3	379	385	PF00069	0.434
MOD_Plk_4	379	385	PF00069	0.356
MOD_Plk_4	399	405	PF00069	0.189
MOD_Plk_4	49	55	PF00069	0.503
MOD_ProDKin_1	132	138	PF00069	0.562
MOD_ProDKin_1	231	237	PF00069	0.373
MOD_ProDKin_1	27	33	PF00069	0.561
MOD_ProDKin_1	417	423	PF00069	0.401
MOD_ProDKin_1	486	492	PF00069	0.473
MOD_SUMO_rev_2	73	81	PF00179	0.472
TRG_DiLeu_BaEn_1	77	82	PF01217	0.482
TRG_ENDOCYTIC_2	327	330	PF00928	0.349
TRG_ENDOCYTIC_2	397	400	PF00928	0.337
TRG_ER_diArg_1	279	282	PF00400	0.368
TRG_ER_diArg_1	387	390	PF00400	0.352
TRG_ER_diLys_1	541	544	PF00400	0.711
TRG_NES_CRM1_1	291	304	PF08389	0.396
TRG_NES_CRM1_1	373	385	PF08389	0.400
TRG_NES_CRM1_1	449	460	PF08389	0.477
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.767
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.724
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG5	Leptomonas seymouri	64%	95%
A0A0S4IT25	Bodo saltans	44%	79%
A0A1X0P7G8	Trypanosomatidae	43%	88%
A0A3Q8IDW3	Leishmania donovani	94%	99%
A0A422NQN2	Trypanosoma rangeli	42%	90%
A4HF31	Leishmania braziliensis	88%	100%
A4I274	Leishmania infantum	94%	99%
C9ZX99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	90%
Q4Q906	Leishmania major	93%	100%