ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Engulfment and cell motility domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9AYG5_LEIMU

TriTrypDb:

LmxM.26.1850

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005741	mitochondrial outer membrane	5	1
GO:0005794	Golgi apparatus	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AYG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.451
CLV_NRD_NRD_1	332	334	PF00675	0.346
CLV_NRD_NRD_1	57	59	PF00675	0.627
CLV_PCSK_KEX2_1	150	152	PF00082	0.451
CLV_PCSK_KEX2_1	332	334	PF00082	0.346
CLV_PCSK_KEX2_1	57	59	PF00082	0.626
CLV_PCSK_SKI1_1	217	221	PF00082	0.266
CLV_PCSK_SKI1_1	266	270	PF00082	0.333
CLV_PCSK_SKI1_1	57	61	PF00082	0.691
DEG_SPOP_SBC_1	16	20	PF00917	0.635
DEG_SPOP_SBC_1	4	8	PF00917	0.704
DOC_CKS1_1	164	169	PF01111	0.538
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.615
DOC_PP2B_LxvP_1	131	134	PF13499	0.615
DOC_PP2B_LxvP_1	415	418	PF13499	0.632
DOC_USP7_MATH_1	16	20	PF00917	0.635
DOC_USP7_MATH_1	287	291	PF00917	0.467
DOC_USP7_MATH_1	4	8	PF00917	0.704
DOC_USP7_MATH_1	43	47	PF00917	0.622
DOC_USP7_MATH_1	59	63	PF00917	0.459
DOC_USP7_UBL2_3	409	413	PF12436	0.651
DOC_WW_Pin1_4	160	165	PF00397	0.696
DOC_WW_Pin1_4	19	24	PF00397	0.673
DOC_WW_Pin1_4	192	197	PF00397	0.533
DOC_WW_Pin1_4	220	225	PF00397	0.518
DOC_WW_Pin1_4	98	103	PF00397	0.467
LIG_14-3-3_CanoR_1	132	138	PF00244	0.653
LIG_14-3-3_CanoR_1	58	66	PF00244	0.387
LIG_Actin_WH2_2	303	320	PF00022	0.486
LIG_BIR_II_1	1	5	PF00653	0.784
LIG_BIR_III_1	1	5	PF00653	0.703
LIG_BIR_III_3	1	5	PF00653	0.703
LIG_BRCT_BRCA1_1	230	234	PF00533	0.557
LIG_BRCT_BRCA1_1	402	406	PF00533	0.588
LIG_FHA_1	164	170	PF00498	0.641
LIG_FHA_1	20	26	PF00498	0.726
LIG_FHA_1	203	209	PF00498	0.395
LIG_FHA_1	292	298	PF00498	0.492
LIG_FHA_1	314	320	PF00498	0.544
LIG_FHA_2	116	122	PF00498	0.710
LIG_FHA_2	193	199	PF00498	0.510
LIG_FHA_2	382	388	PF00498	0.473
LIG_LIR_Gen_1	172	181	PF02991	0.559
LIG_LIR_Gen_1	311	322	PF02991	0.485
LIG_LIR_Nem_3	172	176	PF02991	0.557
LIG_LIR_Nem_3	220	225	PF02991	0.481
LIG_LIR_Nem_3	282	286	PF02991	0.489
LIG_LIR_Nem_3	311	317	PF02991	0.480
LIG_LIR_Nem_3	351	357	PF02991	0.538
LIG_LIR_Nem_3	392	396	PF02991	0.467
LIG_MLH1_MIPbox_1	402	406	PF16413	0.590
LIG_Pex14_2	379	383	PF04695	0.496
LIG_Pex14_2	402	406	PF04695	0.516
LIG_REV1ctd_RIR_1	403	413	PF16727	0.616
LIG_SH2_CRK	222	226	PF00017	0.546
LIG_SH2_CRK	314	318	PF00017	0.467
LIG_SH2_NCK_1	222	226	PF00017	0.379
LIG_SH2_SRC	145	148	PF00017	0.595
LIG_SH2_STAT5	140	143	PF00017	0.627
LIG_SH2_STAT5	145	148	PF00017	0.635
LIG_SH2_STAT5	284	287	PF00017	0.467
LIG_SH3_1	96	102	PF00018	0.449
LIG_SH3_3	161	167	PF00018	0.641
LIG_SH3_3	96	102	PF00018	0.449
LIG_SUMO_SIM_par_1	284	290	PF11976	0.467
LIG_TRAF2_1	65	68	PF00917	0.411
LIG_TYR_ITSM	218	225	PF00017	0.379
LIG_WRC_WIRS_1	402	407	PF05994	0.501
LIG_WRC_WIRS_1	91	96	PF05994	0.231
MOD_CDK_SPxxK_3	192	199	PF00069	0.510
MOD_CK1_1	101	107	PF00069	0.326
MOD_CK1_1	163	169	PF00069	0.651
MOD_CK1_1	19	25	PF00069	0.658
MOD_CK1_1	360	366	PF00069	0.503
MOD_CK1_1	46	52	PF00069	0.525
MOD_CK1_1	6	12	PF00069	0.732
MOD_CK2_1	115	121	PF00069	0.709
MOD_CK2_1	381	387	PF00069	0.516
MOD_GlcNHglycan	359	362	PF01048	0.326
MOD_GlcNHglycan	397	400	PF01048	0.425
MOD_GlcNHglycan	46	49	PF01048	0.699
MOD_GSK3_1	10	17	PF00069	0.717
MOD_GSK3_1	2	9	PF00069	0.752
MOD_GSK3_1	287	294	PF00069	0.467
MOD_GSK3_1	400	407	PF00069	0.538
MOD_NEK2_1	343	348	PF00069	0.533
MOD_NEK2_1	357	362	PF00069	0.544
MOD_NEK2_1	405	410	PF00069	0.590
MOD_NEK2_2	182	187	PF00069	0.603
MOD_PIKK_1	292	298	PF00454	0.510
MOD_Plk_1	182	188	PF00069	0.590
MOD_Plk_1	411	417	PF00069	0.650
MOD_Plk_4	133	139	PF00069	0.618
MOD_Plk_4	141	147	PF00069	0.573
MOD_Plk_4	279	285	PF00069	0.510
MOD_Plk_4	392	398	PF00069	0.479
MOD_Plk_4	401	407	PF00069	0.488
MOD_Plk_4	90	96	PF00069	0.231
MOD_ProDKin_1	160	166	PF00069	0.686
MOD_ProDKin_1	19	25	PF00069	0.673
MOD_ProDKin_1	192	198	PF00069	0.533
MOD_ProDKin_1	220	226	PF00069	0.518
MOD_ProDKin_1	98	104	PF00069	0.469
MOD_SUMO_rev_2	273	282	PF00179	0.553
TRG_DiLeu_BaEn_2	89	95	PF01217	0.374
TRG_ENDOCYTIC_2	173	176	PF00928	0.525
TRG_ENDOCYTIC_2	222	225	PF00928	0.546
TRG_ENDOCYTIC_2	314	317	PF00928	0.476
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	187	192	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILP2	Leptomonas seymouri	64%	100%
A0A1X0P7Q3	Trypanosomatidae	34%	93%
A0A3Q8IDR4	Leishmania donovani	93%	100%
A4HF30	Leishmania braziliensis	80%	100%
A4I273	Leishmania infantum	93%	100%
C9ZXA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4Q907	Leishmania major	92%	100%
V5BAK6	Trypanosoma cruzi	36%	88%