Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYG4_LEIMU

TriTrypDb:

LmxM.26.1840

Length:

986

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.667
CLV_C14_Caspase3-7	441	445	PF00656	0.511
CLV_NRD_NRD_1	176	178	PF00675	0.562
CLV_NRD_NRD_1	202	204	PF00675	0.585
CLV_NRD_NRD_1	425	427	PF00675	0.619
CLV_NRD_NRD_1	512	514	PF00675	0.596
CLV_NRD_NRD_1	52	54	PF00675	0.594
CLV_NRD_NRD_1	762	764	PF00675	0.546
CLV_NRD_NRD_1	774	776	PF00675	0.473
CLV_NRD_NRD_1	907	909	PF00675	0.527
CLV_NRD_NRD_1	930	932	PF00675	0.576
CLV_PCSK_KEX2_1	176	178	PF00082	0.562
CLV_PCSK_KEX2_1	425	427	PF00082	0.616
CLV_PCSK_KEX2_1	52	54	PF00082	0.590
CLV_PCSK_KEX2_1	762	764	PF00082	0.546
CLV_PCSK_KEX2_1	774	776	PF00082	0.473
CLV_PCSK_KEX2_1	907	909	PF00082	0.527
CLV_PCSK_KEX2_1	930	932	PF00082	0.572
CLV_PCSK_SKI1_1	176	180	PF00082	0.640
CLV_PCSK_SKI1_1	207	211	PF00082	0.676
CLV_PCSK_SKI1_1	302	306	PF00082	0.696
CLV_PCSK_SKI1_1	411	415	PF00082	0.528
CLV_PCSK_SKI1_1	513	517	PF00082	0.576
CLV_PCSK_SKI1_1	524	528	PF00082	0.583
CLV_PCSK_SKI1_1	605	609	PF00082	0.552
CLV_PCSK_SKI1_1	775	779	PF00082	0.592
DEG_Nend_UBRbox_2	1	3	PF02207	0.464
DEG_SCF_FBW7_2	941	948	PF00400	0.667
DEG_SPOP_SBC_1	104	108	PF00917	0.574
DEG_SPOP_SBC_1	83	87	PF00917	0.540
DOC_CYCLIN_yCln2_LP_2	202	208	PF00134	0.637
DOC_CYCLIN_yCln2_LP_2	889	895	PF00134	0.489
DOC_MAPK_MEF2A_6	396	405	PF00069	0.555
DOC_MAPK_MEF2A_6	495	504	PF00069	0.514
DOC_MAPK_MEF2A_6	742	749	PF00069	0.489
DOC_PP1_RVXF_1	409	415	PF00149	0.531
DOC_PP2B_LxvP_1	288	291	PF13499	0.765
DOC_PP2B_LxvP_1	527	530	PF13499	0.581
DOC_PP2B_LxvP_1	79	82	PF13499	0.655
DOC_PP4_FxxP_1	627	630	PF00568	0.650
DOC_USP7_MATH_1	104	108	PF00917	0.581
DOC_USP7_MATH_1	246	250	PF00917	0.669
DOC_USP7_MATH_1	26	30	PF00917	0.497
DOC_USP7_MATH_1	282	286	PF00917	0.740
DOC_USP7_MATH_1	297	301	PF00917	0.606
DOC_USP7_MATH_1	366	370	PF00917	0.691
DOC_USP7_MATH_1	51	55	PF00917	0.674
DOC_USP7_MATH_1	528	532	PF00917	0.586
DOC_USP7_MATH_1	562	566	PF00917	0.641
DOC_USP7_MATH_1	571	575	PF00917	0.723
DOC_USP7_MATH_1	576	580	PF00917	0.593
DOC_USP7_MATH_1	657	661	PF00917	0.523
DOC_USP7_MATH_1	702	706	PF00917	0.569
DOC_USP7_MATH_1	729	733	PF00917	0.594
DOC_USP7_MATH_1	83	87	PF00917	0.769
DOC_USP7_MATH_1	832	836	PF00917	0.642
DOC_WW_Pin1_4	119	124	PF00397	0.714
DOC_WW_Pin1_4	154	159	PF00397	0.615
DOC_WW_Pin1_4	185	190	PF00397	0.749
DOC_WW_Pin1_4	255	260	PF00397	0.785
DOC_WW_Pin1_4	367	372	PF00397	0.679
DOC_WW_Pin1_4	428	433	PF00397	0.707
DOC_WW_Pin1_4	486	491	PF00397	0.554
DOC_WW_Pin1_4	558	563	PF00397	0.579
DOC_WW_Pin1_4	580	585	PF00397	0.654
DOC_WW_Pin1_4	591	596	PF00397	0.791
DOC_WW_Pin1_4	697	702	PF00397	0.490
DOC_WW_Pin1_4	782	787	PF00397	0.627
DOC_WW_Pin1_4	824	829	PF00397	0.652
DOC_WW_Pin1_4	830	835	PF00397	0.633
DOC_WW_Pin1_4	88	93	PF00397	0.612
DOC_WW_Pin1_4	941	946	PF00397	0.601
DOC_WW_Pin1_4	947	952	PF00397	0.542
LIG_14-3-3_CanoR_1	176	182	PF00244	0.657
LIG_14-3-3_CanoR_1	207	212	PF00244	0.677
LIG_14-3-3_CanoR_1	334	342	PF00244	0.676
LIG_14-3-3_CanoR_1	425	433	PF00244	0.665
LIG_14-3-3_CanoR_1	663	673	PF00244	0.670
LIG_14-3-3_CanoR_1	774	784	PF00244	0.616
LIG_14-3-3_CanoR_1	930	938	PF00244	0.521
LIG_Actin_WH2_2	761	776	PF00022	0.437
LIG_APCC_ABBAyCdc20_2	302	308	PF00400	0.690
LIG_BIR_III_2	444	448	PF00653	0.499
LIG_BIR_III_4	691	695	PF00653	0.496
LIG_BRCT_BRCA1_1	658	662	PF00533	0.717
LIG_BRCT_BRCA1_1	935	939	PF00533	0.581
LIG_deltaCOP1_diTrp_1	970	980	PF00928	0.561
LIG_EVH1_1	288	292	PF00568	0.767
LIG_FHA_1	136	142	PF00498	0.592
LIG_FHA_1	155	161	PF00498	0.483
LIG_FHA_1	248	254	PF00498	0.589
LIG_FHA_1	368	374	PF00498	0.586
LIG_FHA_1	43	49	PF00498	0.530
LIG_FHA_1	667	673	PF00498	0.606
LIG_FHA_1	680	686	PF00498	0.581
LIG_FHA_1	824	830	PF00498	0.511
LIG_FHA_1	857	863	PF00498	0.485
LIG_FHA_1	883	889	PF00498	0.419
LIG_FHA_1	897	903	PF00498	0.413
LIG_FHA_1	920	926	PF00498	0.489
LIG_FHA_1	942	948	PF00498	0.629
LIG_FHA_2	168	174	PF00498	0.489
LIG_FHA_2	265	271	PF00498	0.585
LIG_FHA_2	439	445	PF00498	0.514
LIG_FHA_2	539	545	PF00498	0.684
LIG_FHA_2	636	642	PF00498	0.526
LIG_FHA_2	738	744	PF00498	0.540
LIG_FHA_2	776	782	PF00498	0.624
LIG_FHA_2	835	841	PF00498	0.581
LIG_FHA_2	965	971	PF00498	0.531
LIG_FHA_2	97	103	PF00498	0.492
LIG_Integrin_isoDGR_2	332	334	PF01839	0.494
LIG_Integrin_isoDGR_2	409	411	PF01839	0.542
LIG_LIR_Gen_1	224	234	PF02991	0.504
LIG_LIR_Gen_1	415	423	PF02991	0.453
LIG_LIR_Gen_1	793	801	PF02991	0.645
LIG_LIR_LC3C_4	744	749	PF02991	0.558
LIG_LIR_Nem_3	190	196	PF02991	0.587
LIG_LIR_Nem_3	2	7	PF02991	0.425
LIG_LIR_Nem_3	224	230	PF02991	0.496
LIG_LIR_Nem_3	415	419	PF02991	0.525
LIG_LIR_Nem_3	726	730	PF02991	0.593
LIG_LIR_Nem_3	793	797	PF02991	0.676
LIG_LIR_Nem_3	899	903	PF02991	0.484
LIG_PDZ_Class_2	981	986	PF00595	0.417
LIG_Pex14_1	980	984	PF04695	0.408
LIG_SH2_CRK	482	486	PF00017	0.605
LIG_SH2_CRK	794	798	PF00017	0.653
LIG_SH2_CRK	910	914	PF00017	0.543
LIG_SH2_GRB2like	520	523	PF00017	0.655
LIG_SH2_SRC	166	169	PF00017	0.573
LIG_SH2_SRC	23	26	PF00017	0.381
LIG_SH2_STAP1	16	20	PF00017	0.314
LIG_SH2_STAP1	905	909	PF00017	0.432
LIG_SH2_STAT5	166	169	PF00017	0.641
LIG_SH2_STAT5	520	523	PF00017	0.573
LIG_SH2_STAT5	808	811	PF00017	0.503
LIG_SH3_1	256	262	PF00018	0.675
LIG_SH3_1	286	292	PF00018	0.755
LIG_SH3_3	125	131	PF00018	0.660
LIG_SH3_3	256	262	PF00018	0.732
LIG_SH3_3	286	292	PF00018	0.755
LIG_SH3_3	374	380	PF00018	0.686
LIG_SH3_3	533	539	PF00018	0.608
LIG_SH3_3	578	584	PF00018	0.650
LIG_SH3_3	596	602	PF00018	0.539
LIG_SH3_3	852	858	PF00018	0.539
LIG_SH3_3	892	898	PF00018	0.500
LIG_SH3_3	910	916	PF00018	0.555
LIG_Sin3_3	193	200	PF02671	0.530
LIG_Sin3_3	28	35	PF02671	0.485
LIG_SUMO_SIM_anti_2	885	891	PF11976	0.436
LIG_SUMO_SIM_par_1	399	404	PF11976	0.630
LIG_SUMO_SIM_par_1	635	642	PF11976	0.525
LIG_TRAF2_1	842	845	PF00917	0.661
LIG_TRFH_1	234	238	PF08558	0.524
LIG_TYR_ITIM	304	309	PF00017	0.594
LIG_WW_3	431	435	PF00397	0.594
MOD_CDC14_SPxK_1	431	434	PF00782	0.673
MOD_CDK_SPxK_1	428	434	PF00069	0.670
MOD_CDK_SPxxK_3	119	126	PF00069	0.670
MOD_CDK_SPxxK_3	591	598	PF00069	0.524
MOD_CK1_1	107	113	PF00069	0.512
MOD_CK1_1	135	141	PF00069	0.613
MOD_CK1_1	144	150	PF00069	0.692
MOD_CK1_1	162	168	PF00069	0.580
MOD_CK1_1	264	270	PF00069	0.754
MOD_CK1_1	321	327	PF00069	0.556
MOD_CK1_1	358	364	PF00069	0.724
MOD_CK1_1	454	460	PF00069	0.690
MOD_CK1_1	565	571	PF00069	0.622
MOD_CK1_1	583	589	PF00069	0.503
MOD_CK1_1	620	626	PF00069	0.600
MOD_CK1_1	668	674	PF00069	0.712
MOD_CK1_1	687	693	PF00069	0.749
MOD_CK1_1	705	711	PF00069	0.467
MOD_CK1_1	714	720	PF00069	0.557
MOD_CK1_1	803	809	PF00069	0.644
MOD_CK1_1	839	845	PF00069	0.593
MOD_CK1_1	88	94	PF00069	0.639
MOD_CK1_1	932	938	PF00069	0.600
MOD_CK2_1	185	191	PF00069	0.660
MOD_CK2_1	264	270	PF00069	0.685
MOD_CK2_1	358	364	PF00069	0.576
MOD_CK2_1	635	641	PF00069	0.527
MOD_CK2_1	737	743	PF00069	0.549
MOD_CK2_1	775	781	PF00069	0.630
MOD_CK2_1	834	840	PF00069	0.603
MOD_CK2_1	92	98	PF00069	0.494
MOD_CK2_1	964	970	PF00069	0.544
MOD_CMANNOS	494	497	PF00535	0.690
MOD_Cter_Amidation	928	931	PF01082	0.464
MOD_GlcNHglycan	134	137	PF01048	0.608
MOD_GlcNHglycan	162	165	PF01048	0.731
MOD_GlcNHglycan	377	380	PF01048	0.571
MOD_GlcNHglycan	406	409	PF01048	0.582
MOD_GlcNHglycan	456	459	PF01048	0.725
MOD_GlcNHglycan	53	56	PF01048	0.500
MOD_GlcNHglycan	530	533	PF01048	0.777
MOD_GlcNHglycan	536	539	PF01048	0.567
MOD_GlcNHglycan	562	565	PF01048	0.603
MOD_GlcNHglycan	567	570	PF01048	0.575
MOD_GlcNHglycan	602	605	PF01048	0.674
MOD_GlcNHglycan	61	65	PF01048	0.702
MOD_GlcNHglycan	716	719	PF01048	0.671
MOD_GlcNHglycan	775	778	PF01048	0.597
MOD_GlcNHglycan	87	90	PF01048	0.640
MOD_GlcNHglycan	953	956	PF01048	0.466
MOD_GSK3_1	103	110	PF00069	0.522
MOD_GSK3_1	132	139	PF00069	0.633
MOD_GSK3_1	144	151	PF00069	0.745
MOD_GSK3_1	152	159	PF00069	0.551
MOD_GSK3_1	257	264	PF00069	0.755
MOD_GSK3_1	26	33	PF00069	0.431
MOD_GSK3_1	292	299	PF00069	0.778
MOD_GSK3_1	318	325	PF00069	0.572
MOD_GSK3_1	351	358	PF00069	0.698
MOD_GSK3_1	375	382	PF00069	0.513
MOD_GSK3_1	448	455	PF00069	0.639
MOD_GSK3_1	456	463	PF00069	0.559
MOD_GSK3_1	464	471	PF00069	0.486
MOD_GSK3_1	534	541	PF00069	0.496
MOD_GSK3_1	556	563	PF00069	0.629
MOD_GSK3_1	565	572	PF00069	0.638
MOD_GSK3_1	576	583	PF00069	0.569
MOD_GSK3_1	587	594	PF00069	0.567
MOD_GSK3_1	60	67	PF00069	0.567
MOD_GSK3_1	635	642	PF00069	0.525
MOD_GSK3_1	662	669	PF00069	0.618
MOD_GSK3_1	708	715	PF00069	0.577
MOD_GSK3_1	775	782	PF00069	0.604
MOD_GSK3_1	830	837	PF00069	0.718
MOD_GSK3_1	84	91	PF00069	0.794
MOD_GSK3_1	862	869	PF00069	0.487
MOD_GSK3_1	92	99	PF00069	0.562
MOD_GSK3_1	925	932	PF00069	0.471
MOD_GSK3_1	933	940	PF00069	0.558
MOD_GSK3_1	947	954	PF00069	0.532
MOD_GSK3_1	964	971	PF00069	0.524
MOD_LATS_1	154	160	PF00433	0.503
MOD_N-GLC_1	141	146	PF02516	0.647
MOD_N-GLC_1	148	153	PF02516	0.594
MOD_N-GLC_1	349	354	PF02516	0.479
MOD_N-GLC_1	373	378	PF02516	0.629
MOD_N-GLC_1	620	625	PF02516	0.589
MOD_N-GLC_1	679	684	PF02516	0.610
MOD_N-GLC_1	702	707	PF02516	0.584
MOD_NEK2_1	105	110	PF00069	0.588
MOD_NEK2_1	141	146	PF00069	0.677
MOD_NEK2_1	160	165	PF00069	0.477
MOD_NEK2_1	179	184	PF00069	0.480
MOD_NEK2_1	30	35	PF00069	0.487
MOD_NEK2_1	322	327	PF00069	0.638
MOD_NEK2_1	351	356	PF00069	0.554
MOD_NEK2_1	452	457	PF00069	0.652
MOD_NEK2_1	548	553	PF00069	0.634
MOD_NEK2_1	556	561	PF00069	0.566
MOD_NEK2_1	639	644	PF00069	0.650
MOD_NEK2_1	65	70	PF00069	0.618
MOD_NEK2_1	662	667	PF00069	0.638
MOD_NEK2_1	679	684	PF00069	0.520
MOD_NEK2_1	773	778	PF00069	0.665
MOD_NEK2_1	84	89	PF00069	0.476
MOD_NEK2_1	924	929	PF00069	0.495
MOD_NEK2_1	96	101	PF00069	0.535
MOD_NEK2_1	969	974	PF00069	0.560
MOD_PIKK_1	210	216	PF00454	0.640
MOD_PKA_2	333	339	PF00069	0.694
MOD_PKA_2	51	57	PF00069	0.625
MOD_PKA_2	662	668	PF00069	0.697
MOD_PKA_2	773	779	PF00069	0.509
MOD_PKA_2	929	935	PF00069	0.535
MOD_Plk_1	141	147	PF00069	0.516
MOD_Plk_1	307	313	PF00069	0.635
MOD_Plk_1	373	379	PF00069	0.513
MOD_Plk_1	548	554	PF00069	0.635
MOD_Plk_1	620	626	PF00069	0.594
MOD_Plk_1	65	71	PF00069	0.638
MOD_Plk_1	657	663	PF00069	0.485
MOD_Plk_1	702	708	PF00069	0.560
MOD_Plk_1	919	925	PF00069	0.458
MOD_Plk_1	969	975	PF00069	0.436
MOD_Plk_2-3	42	48	PF00069	0.392
MOD_Plk_2-3	438	444	PF00069	0.517
MOD_Plk_2-3	635	641	PF00069	0.527
MOD_Plk_4	162	168	PF00069	0.682
MOD_Plk_4	26	32	PF00069	0.480
MOD_Plk_4	438	444	PF00069	0.706
MOD_Plk_4	723	729	PF00069	0.564
MOD_Plk_4	969	975	PF00069	0.589
MOD_ProDKin_1	119	125	PF00069	0.713
MOD_ProDKin_1	154	160	PF00069	0.616
MOD_ProDKin_1	185	191	PF00069	0.747
MOD_ProDKin_1	255	261	PF00069	0.787
MOD_ProDKin_1	367	373	PF00069	0.681
MOD_ProDKin_1	428	434	PF00069	0.711
MOD_ProDKin_1	486	492	PF00069	0.556
MOD_ProDKin_1	558	564	PF00069	0.580
MOD_ProDKin_1	580	586	PF00069	0.653
MOD_ProDKin_1	591	597	PF00069	0.791
MOD_ProDKin_1	697	703	PF00069	0.492
MOD_ProDKin_1	782	788	PF00069	0.627
MOD_ProDKin_1	824	830	PF00069	0.652
MOD_ProDKin_1	88	94	PF00069	0.614
MOD_ProDKin_1	941	947	PF00069	0.601
MOD_SUMO_rev_2	13	20	PF00179	0.314
TRG_DiLeu_BaEn_1	438	443	PF01217	0.667
TRG_DiLeu_BaEn_1	743	748	PF01217	0.484
TRG_DiLeu_BaEn_1	920	925	PF01217	0.576
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.532
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.499
TRG_DiLeu_LyEn_5	734	739	PF01217	0.612
TRG_ENDOCYTIC_2	306	309	PF00928	0.586
TRG_ENDOCYTIC_2	482	485	PF00928	0.601
TRG_ENDOCYTIC_2	520	523	PF00928	0.573
TRG_ENDOCYTIC_2	727	730	PF00928	0.564
TRG_ENDOCYTIC_2	794	797	PF00928	0.656
TRG_ENDOCYTIC_2	910	913	PF00928	0.530
TRG_ER_diArg_1	508	511	PF00400	0.587
TRG_ER_diArg_1	761	763	PF00400	0.529
TRG_ER_diArg_1	773	775	PF00400	0.449
TRG_ER_diArg_1	907	909	PF00400	0.527
TRG_ER_FFAT_1	17	29	PF00635	0.322
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	605	610	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	762	766	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFF4	Leptomonas seymouri	39%	100%
A0A3Q8IDY5	Leishmania donovani	81%	100%
A4HF29	Leishmania braziliensis	64%	99%
A4I2B7	Leishmania infantum	81%	100%
Q4Q908	Leishmania major	81%	100%