Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYG1_LEIMU

TriTrypDb:

LmxM.26.1810

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	490	494	PF00656	0.525
CLV_NRD_NRD_1	134	136	PF00675	0.587
CLV_NRD_NRD_1	317	319	PF00675	0.575
CLV_NRD_NRD_1	323	325	PF00675	0.595
CLV_NRD_NRD_1	349	351	PF00675	0.554
CLV_NRD_NRD_1	352	354	PF00675	0.568
CLV_NRD_NRD_1	426	428	PF00675	0.536
CLV_NRD_NRD_1	429	431	PF00675	0.521
CLV_NRD_NRD_1	61	63	PF00675	0.478
CLV_NRD_NRD_1	64	66	PF00675	0.494
CLV_PCSK_FUR_1	427	431	PF00082	0.537
CLV_PCSK_FUR_1	62	66	PF00082	0.506
CLV_PCSK_KEX2_1	134	136	PF00082	0.590
CLV_PCSK_KEX2_1	225	227	PF00082	0.654
CLV_PCSK_KEX2_1	317	319	PF00082	0.576
CLV_PCSK_KEX2_1	323	325	PF00082	0.602
CLV_PCSK_KEX2_1	331	333	PF00082	0.566
CLV_PCSK_KEX2_1	349	351	PF00082	0.601
CLV_PCSK_KEX2_1	426	428	PF00082	0.591
CLV_PCSK_KEX2_1	429	431	PF00082	0.570
CLV_PCSK_KEX2_1	61	63	PF00082	0.478
CLV_PCSK_KEX2_1	64	66	PF00082	0.494
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.594
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.491
CLV_PCSK_PC7_1	57	63	PF00082	0.501
CLV_PCSK_SKI1_1	326	330	PF00082	0.520
DEG_APCC_DBOX_1	150	158	PF00400	0.488
DEG_APCC_DBOX_1	159	167	PF00400	0.537
DEG_SPOP_SBC_1	236	240	PF00917	0.532
DEG_SPOP_SBC_1	390	394	PF00917	0.719
DOC_CKS1_1	380	385	PF01111	0.523
DOC_CKS1_1	408	413	PF01111	0.602
DOC_MAPK_gen_1	134	144	PF00069	0.642
DOC_MAPK_gen_1	454	463	PF00069	0.387
DOC_MAPK_MEF2A_6	138	146	PF00069	0.620
DOC_PP2B_LxvP_1	221	224	PF13499	0.531
DOC_PP2B_LxvP_1	257	260	PF13499	0.607
DOC_PP4_FxxP_1	133	136	PF00568	0.495
DOC_PP4_FxxP_1	439	442	PF00568	0.473
DOC_PP4_FxxP_1	75	78	PF00568	0.476
DOC_USP7_MATH_1	158	162	PF00917	0.698
DOC_USP7_MATH_1	169	173	PF00917	0.555
DOC_USP7_MATH_1	234	238	PF00917	0.616
DOC_USP7_MATH_1	28	32	PF00917	0.575
DOC_USP7_MATH_1	388	392	PF00917	0.722
DOC_USP7_MATH_1	404	408	PF00917	0.472
DOC_WW_Pin1_4	194	199	PF00397	0.790
DOC_WW_Pin1_4	210	215	PF00397	0.692
DOC_WW_Pin1_4	224	229	PF00397	0.829
DOC_WW_Pin1_4	232	237	PF00397	0.820
DOC_WW_Pin1_4	260	265	PF00397	0.730
DOC_WW_Pin1_4	279	284	PF00397	0.645
DOC_WW_Pin1_4	303	308	PF00397	0.517
DOC_WW_Pin1_4	344	349	PF00397	0.548
DOC_WW_Pin1_4	379	384	PF00397	0.688
DOC_WW_Pin1_4	407	412	PF00397	0.608
LIG_14-3-3_CanoR_1	135	144	PF00244	0.572
LIG_14-3-3_CanoR_1	200	204	PF00244	0.680
LIG_14-3-3_CanoR_1	474	483	PF00244	0.445
LIG_14-3-3_CanoR_1	98	103	PF00244	0.562
LIG_Actin_WH2_2	150	166	PF00022	0.485
LIG_APCC_ABBA_1	461	466	PF00400	0.505
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.483
LIG_CSL_BTD_1	304	307	PF09270	0.541
LIG_FHA_1	137	143	PF00498	0.581
LIG_FHA_1	260	266	PF00498	0.603
LIG_FHA_1	408	414	PF00498	0.595
LIG_FHA_1	6	12	PF00498	0.611
LIG_FHA_2	145	151	PF00498	0.477
LIG_FHA_2	286	292	PF00498	0.672
LIG_FHA_2	304	310	PF00498	0.508
LIG_FHA_2	44	50	PF00498	0.498
LIG_LIR_Apic_2	424	428	PF02991	0.437
LIG_LIR_Apic_2	72	78	PF02991	0.490
LIG_LIR_Gen_1	446	451	PF02991	0.457
LIG_LIR_Nem_3	446	450	PF02991	0.440
LIG_MAD2	474	482	PF02301	0.549
LIG_SH2_CRK	399	403	PF00017	0.635
LIG_SH2_CRK	447	451	PF00017	0.454
LIG_SH2_CRK	99	103	PF00017	0.507
LIG_SH2_NCK_1	99	103	PF00017	0.480
LIG_SH2_PTP2	401	404	PF00017	0.473
LIG_SH2_SRC	399	402	PF00017	0.489
LIG_SH2_STAP1	447	451	PF00017	0.454
LIG_SH2_STAT3	86	89	PF00017	0.538
LIG_SH2_STAT5	153	156	PF00017	0.452
LIG_SH2_STAT5	401	404	PF00017	0.553
LIG_SH2_STAT5	443	446	PF00017	0.500
LIG_SH2_STAT5	447	450	PF00017	0.462
LIG_SH2_STAT5	67	70	PF00017	0.447
LIG_SH3_1	349	355	PF00018	0.507
LIG_SH3_2	211	216	PF14604	0.688
LIG_SH3_3	126	132	PF00018	0.494
LIG_SH3_3	202	208	PF00018	0.688
LIG_SH3_3	269	275	PF00018	0.523
LIG_SH3_3	349	355	PF00018	0.587
LIG_SH3_3	384	390	PF00018	0.517
LIG_SH3_3	8	14	PF00018	0.783
LIG_SUMO_SIM_anti_2	253	259	PF11976	0.538
LIG_SUMO_SIM_anti_2	33	38	PF11976	0.472
LIG_SUMO_SIM_anti_2	418	424	PF11976	0.521
LIG_SUMO_SIM_par_1	139	148	PF11976	0.568
LIG_SUMO_SIM_par_1	418	424	PF11976	0.413
LIG_TRAF2_1	482	485	PF00917	0.600
MOD_CDC14_SPxK_1	197	200	PF00782	0.681
MOD_CDC14_SPxK_1	213	216	PF00782	0.704
MOD_CDC14_SPxK_1	347	350	PF00782	0.562
MOD_CDK_SPK_2	279	284	PF00069	0.645
MOD_CDK_SPK_2	344	349	PF00069	0.489
MOD_CDK_SPxK_1	194	200	PF00069	0.673
MOD_CDK_SPxK_1	210	216	PF00069	0.530
MOD_CDK_SPxK_1	344	350	PF00069	0.552
MOD_CDK_SPxxK_3	260	267	PF00069	0.701
MOD_CK1_1	100	106	PF00069	0.572
MOD_CK1_1	137	143	PF00069	0.707
MOD_CK1_1	16	22	PF00069	0.585
MOD_CK1_1	172	178	PF00069	0.598
MOD_CK1_1	186	192	PF00069	0.628
MOD_CK1_1	194	200	PF00069	0.648
MOD_CK1_1	235	241	PF00069	0.660
MOD_CK1_1	247	253	PF00069	0.640
MOD_CK1_1	285	291	PF00069	0.768
MOD_CK1_1	391	397	PF00069	0.723
MOD_CK1_1	407	413	PF00069	0.459
MOD_CK2_1	104	110	PF00069	0.527
MOD_CK2_1	144	150	PF00069	0.442
MOD_CK2_1	285	291	PF00069	0.695
MOD_GlcNHglycan	104	107	PF01048	0.570
MOD_GlcNHglycan	159	163	PF01048	0.586
MOD_GlcNHglycan	173	177	PF01048	0.565
MOD_GlcNHglycan	191	194	PF01048	0.639
MOD_GlcNHglycan	221	224	PF01048	0.760
MOD_GlcNHglycan	252	255	PF01048	0.698
MOD_GlcNHglycan	319	322	PF01048	0.577
MOD_GlcNHglycan	383	386	PF01048	0.606
MOD_GSK3_1	13	20	PF00069	0.701
MOD_GSK3_1	134	141	PF00069	0.741
MOD_GSK3_1	183	190	PF00069	0.628
MOD_GSK3_1	232	239	PF00069	0.667
MOD_GSK3_1	244	251	PF00069	0.670
MOD_GSK3_1	278	285	PF00069	0.640
MOD_GSK3_1	445	452	PF00069	0.545
MOD_GSK3_1	97	104	PF00069	0.554
MOD_LATS_1	315	321	PF00433	0.633
MOD_N-GLC_1	260	265	PF02516	0.603
MOD_NEK2_1	185	190	PF00069	0.695
MOD_NEK2_1	245	250	PF00069	0.722
MOD_NEK2_1	421	426	PF00069	0.443
MOD_NEK2_1	85	90	PF00069	0.544
MOD_PIKK_1	245	251	PF00454	0.627
MOD_PIKK_1	402	408	PF00454	0.624
MOD_PIKK_1	449	455	PF00454	0.467
MOD_PIKK_1	85	91	PF00454	0.548
MOD_PK_1	98	104	PF00069	0.589
MOD_PKA_1	134	140	PF00069	0.551
MOD_PKA_1	317	323	PF00069	0.557
MOD_PKA_2	134	140	PF00069	0.578
MOD_PKA_2	199	205	PF00069	0.724
MOD_PKA_2	317	323	PF00069	0.557
MOD_PKA_2	97	103	PF00069	0.533
MOD_PKB_1	96	104	PF00069	0.640
MOD_Plk_1	298	304	PF00069	0.492
MOD_Plk_1	374	380	PF00069	0.572
MOD_Plk_1	445	451	PF00069	0.517
MOD_Plk_4	199	205	PF00069	0.594
MOD_Plk_4	253	259	PF00069	0.626
MOD_Plk_4	30	36	PF00069	0.501
MOD_Plk_4	404	410	PF00069	0.552
MOD_Plk_4	416	422	PF00069	0.517
MOD_Plk_4	445	451	PF00069	0.355
MOD_ProDKin_1	194	200	PF00069	0.794
MOD_ProDKin_1	210	216	PF00069	0.694
MOD_ProDKin_1	224	230	PF00069	0.831
MOD_ProDKin_1	232	238	PF00069	0.820
MOD_ProDKin_1	260	266	PF00069	0.730
MOD_ProDKin_1	279	285	PF00069	0.643
MOD_ProDKin_1	303	309	PF00069	0.513
MOD_ProDKin_1	344	350	PF00069	0.552
MOD_ProDKin_1	379	385	PF00069	0.685
MOD_ProDKin_1	407	413	PF00069	0.604
MOD_SUMO_rev_2	490	497	PF00179	0.632
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.649
TRG_ENDOCYTIC_2	399	402	PF00928	0.624
TRG_ENDOCYTIC_2	447	450	PF00928	0.500
TRG_ENDOCYTIC_2	67	70	PF00928	0.447
TRG_ENDOCYTIC_2	99	102	PF00928	0.588
TRG_ER_diArg_1	133	135	PF00400	0.595
TRG_ER_diArg_1	316	318	PF00400	0.617
TRG_ER_diArg_1	348	350	PF00400	0.504
TRG_ER_diArg_1	425	427	PF00400	0.586
TRG_ER_diArg_1	428	430	PF00400	0.567
TRG_ER_diArg_1	471	474	PF00400	0.555
TRG_ER_diArg_1	54	57	PF00400	0.415
TRG_ER_diArg_1	60	62	PF00400	0.425
TRG_ER_diArg_1	64	66	PF00400	0.442
TRG_ER_diArg_1	96	99	PF00400	0.637
TRG_NLS_Bipartite_1	317	335	PF00514	0.528
TRG_NLS_MonoCore_2	352	357	PF00514	0.542
TRG_NLS_MonoExtN_4	350	357	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B6	Leptomonas seymouri	36%	86%
A0A3Q8ID10	Leishmania donovani	83%	100%
A4HF27	Leishmania braziliensis	65%	100%
A4I2B4	Leishmania infantum	83%	100%
Q4Q911	Leishmania major	82%	100%