Methylated-DNA--protein-cysteine methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylated-DNA-[protein]-cysteine S-methyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AYG0_LEIMU

TriTrypDb:

LmxM.26.1800

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYG0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0032259	methylation	2	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	6	10
GO:0008168	methyltransferase activity	4	10
GO:0008172	S-methyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.561
CLV_NRD_NRD_1	9	11	PF00675	0.617
CLV_PCSK_KEX2_1	9	11	PF00082	0.614
CLV_PCSK_SKI1_1	158	162	PF00082	0.376
DEG_SPOP_SBC_1	235	239	PF00917	0.525
DEG_SPOP_SBC_1	29	33	PF00917	0.590
DOC_CKS1_1	60	65	PF01111	0.362
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.502
DOC_MAPK_gen_1	107	116	PF00069	0.432
DOC_MAPK_MEF2A_6	158	165	PF00069	0.409
DOC_PP2B_LxvP_1	161	164	PF13499	0.369
DOC_SPAK_OSR1_1	250	254	PF12202	0.488
DOC_USP7_MATH_1	46	50	PF00917	0.622
DOC_USP7_UBL2_3	19	23	PF12436	0.597
DOC_WW_Pin1_4	59	64	PF00397	0.354
LIG_14-3-3_CanoR_1	107	116	PF00244	0.491
LIG_14-3-3_CanoR_1	182	186	PF00244	0.488
LIG_14-3-3_CanoR_1	234	242	PF00244	0.525
LIG_APCC_ABBA_1	67	72	PF00400	0.419
LIG_BIR_III_4	72	76	PF00653	0.457
LIG_FHA_1	237	243	PF00498	0.525
LIG_FHA_1	48	54	PF00498	0.530
LIG_LIR_Gen_1	177	186	PF02991	0.514
LIG_LIR_Nem_3	177	181	PF02991	0.476
LIG_LIR_Nem_3	190	196	PF02991	0.416
LIG_NRBOX	155	161	PF00104	0.421
LIG_NRP_CendR_1	283	284	PF00754	0.660
LIG_SH2_CRK	193	197	PF00017	0.459
LIG_SH2_GRB2like	142	145	PF00017	0.448
LIG_SH2_NCK_1	94	98	PF00017	0.280
LIG_SH2_SRC	70	73	PF00017	0.436
LIG_SH2_STAT5	142	145	PF00017	0.386
LIG_SH2_STAT5	56	59	PF00017	0.342
LIG_SH2_STAT5	70	73	PF00017	0.302
LIG_SH2_STAT5	94	97	PF00017	0.277
LIG_SH3_1	23	29	PF00018	0.578
LIG_SH3_3	163	169	PF00018	0.280
LIG_SH3_3	225	231	PF00018	0.484
LIG_SH3_3	23	29	PF00018	0.578
LIG_SH3_3	57	63	PF00018	0.453
LIG_TYR_ITIM	191	196	PF00017	0.525
MOD_CK1_1	187	193	PF00069	0.535
MOD_CK1_1	238	244	PF00069	0.488
MOD_CK1_1	33	39	PF00069	0.597
MOD_CK1_1	92	98	PF00069	0.283
MOD_GlcNHglycan	186	189	PF01048	0.263
MOD_GlcNHglycan	208	211	PF01048	0.332
MOD_GlcNHglycan	32	35	PF01048	0.643
MOD_GlcNHglycan	43	46	PF01048	0.665
MOD_GlcNHglycan	84	87	PF01048	0.578
MOD_GSK3_1	108	115	PF00069	0.472
MOD_GSK3_1	177	184	PF00069	0.509
MOD_GSK3_1	234	241	PF00069	0.465
MOD_GSK3_1	272	279	PF00069	0.618
MOD_GSK3_1	28	35	PF00069	0.643
MOD_NEK2_1	174	179	PF00069	0.518
MOD_NEK2_1	181	186	PF00069	0.535
MOD_NEK2_1	236	241	PF00069	0.525
MOD_PK_1	110	116	PF00069	0.322
MOD_PKA_1	19	25	PF00069	0.568
MOD_PKA_1	9	15	PF00069	0.653
MOD_PKA_2	181	187	PF00069	0.531
MOD_PKA_2	9	15	PF00069	0.631
MOD_Plk_1	272	278	PF00069	0.625
MOD_Plk_4	89	95	PF00069	0.314
MOD_ProDKin_1	59	65	PF00069	0.345
MOD_SUMO_for_1	5	8	PF00179	0.550
TRG_DiLeu_BaEn_1	155	160	PF01217	0.461
TRG_DiLeu_LyEn_5	155	160	PF01217	0.408
TRG_ENDOCYTIC_2	193	196	PF00928	0.442
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Q0	Leptomonas seymouri	51%	100%
A0A1X0P7S0	Trypanosomatidae	31%	100%
A0A3Q8IFY3	Leishmania donovani	87%	100%
A0A3R7ML39	Trypanosoma rangeli	34%	100%
A4HF26	Leishmania braziliensis	79%	100%
A4I2B3	Leishmania infantum	87%	100%
Q4Q912	Leishmania major	88%	99%
V5AV65	Trypanosoma cruzi	33%	100%