Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase subunit NuA4, putative

Species:

Leishmania mexicana

UniProt:

E9AYF8_LEIMU

TriTrypDb:

LmxM.26.1785

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000123	histone acetyltransferase complex	4	7
GO:0031248	protein acetyltransferase complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140535	intracellular protein-containing complex	2	7
GO:1902493	acetyltransferase complex	4	7
GO:1902494	catalytic complex	2	7
GO:1990234	transferase complex	3	7
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYF8

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	7
GO:0006473	protein acetylation	6	7
GO:0006475	internal protein amino acid acetylation	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0016570	histone modification	5	7
GO:0016573	histone acetylation	6	7
GO:0018193	peptidyl-amino acid modification	5	7
GO:0018205	peptidyl-lysine modification	6	7
GO:0018393	internal peptidyl-lysine acetylation	8	7
GO:0018394	peptidyl-lysine acetylation	7	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0043543	protein acylation	5	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	80	84	PF00656	0.620
CLV_NRD_NRD_1	296	298	PF00675	0.641
CLV_NRD_NRD_1	3	5	PF00675	0.608
CLV_NRD_NRD_1	321	323	PF00675	0.662
CLV_NRD_NRD_1	325	327	PF00675	0.644
CLV_NRD_NRD_1	40	42	PF00675	0.329
CLV_NRD_NRD_1	81	83	PF00675	0.539
CLV_PCSK_FUR_1	322	326	PF00082	0.611
CLV_PCSK_KEX2_1	261	263	PF00082	0.611
CLV_PCSK_KEX2_1	296	298	PF00082	0.637
CLV_PCSK_KEX2_1	3	5	PF00082	0.608
CLV_PCSK_KEX2_1	321	323	PF00082	0.658
CLV_PCSK_KEX2_1	324	326	PF00082	0.653
CLV_PCSK_KEX2_1	40	42	PF00082	0.329
CLV_PCSK_KEX2_1	81	83	PF00082	0.559
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.597
CLV_PCSK_PC7_1	321	327	PF00082	0.690
CLV_PCSK_SKI1_1	300	304	PF00082	0.658
DEG_SCF_FBW7_1	92	98	PF00400	0.605
DEG_SPOP_SBC_1	240	244	PF00917	0.644
DEG_SPOP_SBC_1	95	99	PF00917	0.597
DOC_CKS1_1	92	97	PF01111	0.605
DOC_MAPK_MEF2A_6	46	55	PF00069	0.529
DOC_PP1_RVXF_1	203	209	PF00149	0.564
DOC_PP4_FxxP_1	208	211	PF00568	0.493
DOC_PP4_FxxP_1	25	28	PF00568	0.558
DOC_USP7_MATH_1	142	146	PF00917	0.673
DOC_USP7_MATH_1	165	169	PF00917	0.610
DOC_USP7_MATH_1	176	180	PF00917	0.663
DOC_USP7_MATH_1	181	185	PF00917	0.484
DOC_USP7_MATH_1	240	244	PF00917	0.757
DOC_USP7_UBL2_3	257	261	PF12436	0.580
DOC_WW_Pin1_4	119	124	PF00397	0.749
DOC_WW_Pin1_4	167	172	PF00397	0.712
DOC_WW_Pin1_4	179	184	PF00397	0.526
DOC_WW_Pin1_4	207	212	PF00397	0.524
DOC_WW_Pin1_4	91	96	PF00397	0.603
LIG_14-3-3_CanoR_1	141	147	PF00244	0.648
LIG_14-3-3_CanoR_1	214	221	PF00244	0.685
LIG_14-3-3_CanoR_1	262	272	PF00244	0.782
LIG_14-3-3_CterR_2	324	329	PF00244	0.617
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_BRCT_BRCA1_1	143	147	PF00533	0.647
LIG_FHA_1	277	283	PF00498	0.639
LIG_LIR_Nem_3	139	143	PF02991	0.554
LIG_LIR_Nem_3	144	149	PF02991	0.550
LIG_LIR_Nem_3	72	77	PF02991	0.475
LIG_MLH1_MIPbox_1	143	147	PF16413	0.538
LIG_SH2_CRK	140	144	PF00017	0.573
LIG_SH3_3	120	126	PF00018	0.560
LIG_SH3_3	89	95	PF00018	0.598
LIG_SUMO_SIM_par_1	88	94	PF11976	0.594
LIG_TRAF2_1	302	305	PF00917	0.648
LIG_WRC_WIRS_1	143	148	PF05994	0.537
MOD_CDK_SPxxK_3	207	214	PF00069	0.516
MOD_CK1_1	122	128	PF00069	0.702
MOD_CK1_1	153	159	PF00069	0.586
MOD_CK1_1	170	176	PF00069	0.586
MOD_CK1_1	179	185	PF00069	0.539
MOD_CK1_1	217	223	PF00069	0.500
MOD_CK1_1	241	247	PF00069	0.617
MOD_CK1_1	274	280	PF00069	0.643
MOD_CK1_1	281	287	PF00069	0.716
MOD_CK1_1	99	105	PF00069	0.579
MOD_CK2_1	207	213	PF00069	0.514
MOD_CK2_1	222	228	PF00069	0.615
MOD_CK2_1	99	105	PF00069	0.559
MOD_Cter_Amidation	192	195	PF01082	0.464
MOD_Cter_Amidation	259	262	PF01082	0.596
MOD_GlcNHglycan	10	13	PF01048	0.612
MOD_GlcNHglycan	107	110	PF01048	0.576
MOD_GlcNHglycan	132	135	PF01048	0.627
MOD_GlcNHglycan	152	155	PF01048	0.581
MOD_GlcNHglycan	158	161	PF01048	0.606
MOD_GlcNHglycan	178	181	PF01048	0.519
MOD_GlcNHglycan	183	186	PF01048	0.550
MOD_GlcNHglycan	216	219	PF01048	0.513
MOD_GlcNHglycan	266	269	PF01048	0.773
MOD_GlcNHglycan	273	276	PF01048	0.664
MOD_GlcNHglycan	283	286	PF01048	0.530
MOD_GlcNHglycan	59	62	PF01048	0.237
MOD_GSK3_1	118	125	PF00069	0.636
MOD_GSK3_1	126	133	PF00069	0.658
MOD_GSK3_1	165	172	PF00069	0.694
MOD_GSK3_1	230	237	PF00069	0.564
MOD_GSK3_1	238	245	PF00069	0.613
MOD_GSK3_1	274	281	PF00069	0.699
MOD_GSK3_1	65	72	PF00069	0.491
MOD_GSK3_1	91	98	PF00069	0.612
MOD_N-GLC_1	156	161	PF02516	0.674
MOD_N-GLC_1	315	320	PF02516	0.640
MOD_NEK2_1	127	132	PF00069	0.560
MOD_NEK2_1	234	239	PF00069	0.607
MOD_NEK2_1	96	101	PF00069	0.569
MOD_NEK2_2	142	147	PF00069	0.465
MOD_PIKK_1	65	71	PF00454	0.400
MOD_PK_1	40	46	PF00069	0.529
MOD_PKA_1	194	200	PF00069	0.433
MOD_PKA_1	40	46	PF00069	0.529
MOD_PKA_2	263	269	PF00069	0.652
MOD_PKA_2	287	293	PF00069	0.628
MOD_PKA_2	40	46	PF00069	0.529
MOD_PKB_1	262	270	PF00069	0.605
MOD_Plk_2-3	304	310	PF00069	0.538
MOD_Plk_2-3	315	321	PF00069	0.556
MOD_Plk_4	142	148	PF00069	0.524
MOD_Plk_4	69	75	PF00069	0.475
MOD_ProDKin_1	119	125	PF00069	0.752
MOD_ProDKin_1	167	173	PF00069	0.713
MOD_ProDKin_1	179	185	PF00069	0.526
MOD_ProDKin_1	207	213	PF00069	0.521
MOD_ProDKin_1	91	97	PF00069	0.603
MOD_SUMO_for_1	302	305	PF00179	0.648
TRG_DiLeu_BaEn_2	20	26	PF01217	0.594
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.534
TRG_ENDOCYTIC_2	140	143	PF00928	0.576
TRG_ER_diArg_1	321	324	PF00400	0.622
TRG_NES_CRM1_1	42	57	PF08389	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C1	Leptomonas seymouri	53%	100%
A0A3S7WZY7	Leishmania donovani	87%	100%
A4HF24	Leishmania braziliensis	71%	99%
E9ACT4	Leishmania major	87%	100%
E9AHB5	Leishmania infantum	88%	100%