Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYF4_LEIMU

TriTrypDb:

LmxM.26.1760

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.705
CLV_C14_Caspase3-7	127	131	PF00656	0.832
CLV_C14_Caspase3-7	268	272	PF00656	0.561
CLV_NRD_NRD_1	139	141	PF00675	0.737
CLV_NRD_NRD_1	16	18	PF00675	0.725
CLV_NRD_NRD_1	189	191	PF00675	0.684
CLV_NRD_NRD_1	252	254	PF00675	0.643
CLV_NRD_NRD_1	294	296	PF00675	0.500
CLV_NRD_NRD_1	315	317	PF00675	0.631
CLV_NRD_NRD_1	32	34	PF00675	0.554
CLV_NRD_NRD_1	368	370	PF00675	0.661
CLV_NRD_NRD_1	9	11	PF00675	0.827
CLV_PCSK_FUR_1	189	193	PF00082	0.618
CLV_PCSK_FUR_1	249	253	PF00082	0.616
CLV_PCSK_FUR_1	362	366	PF00082	0.666
CLV_PCSK_KEX2_1	15	17	PF00082	0.741
CLV_PCSK_KEX2_1	189	191	PF00082	0.684
CLV_PCSK_KEX2_1	251	253	PF00082	0.620
CLV_PCSK_KEX2_1	294	296	PF00082	0.500
CLV_PCSK_KEX2_1	32	34	PF00082	0.547
CLV_PCSK_KEX2_1	364	366	PF00082	0.674
CLV_PCSK_KEX2_1	367	369	PF00082	0.634
CLV_PCSK_KEX2_1	456	458	PF00082	0.704
CLV_PCSK_KEX2_1	9	11	PF00082	0.827
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.608
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.674
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.704
CLV_PCSK_SKI1_1	169	173	PF00082	0.727
CLV_PCSK_SKI1_1	207	211	PF00082	0.647
CLV_PCSK_SKI1_1	295	299	PF00082	0.458
CLV_PCSK_SKI1_1	302	306	PF00082	0.467
CLV_PCSK_SKI1_1	316	320	PF00082	0.339
CLV_PCSK_SKI1_1	368	372	PF00082	0.668
CLV_PCSK_SKI1_1	375	379	PF00082	0.397
CLV_PCSK_SKI1_1	429	433	PF00082	0.710
DEG_APCC_DBOX_1	301	309	PF00400	0.543
DEG_Nend_Nbox_1	1	3	PF02207	0.751
DOC_CKS1_1	142	147	PF01111	0.674
DOC_CKS1_1	350	355	PF01111	0.673
DOC_CYCLIN_RxL_1	369	382	PF00134	0.654
DOC_MAPK_gen_1	300	307	PF00069	0.548
DOC_MAPK_gen_1	367	379	PF00069	0.665
DOC_MAPK_MEF2A_6	270	279	PF00069	0.641
DOC_MAPK_RevD_3	2	16	PF00069	0.623
DOC_PP1_RVXF_1	412	418	PF00149	0.629
DOC_PP4_MxPP_1	433	436	PF00568	0.491
DOC_USP7_MATH_1	115	119	PF00917	0.563
DOC_USP7_MATH_1	174	178	PF00917	0.542
DOC_USP7_MATH_1	320	324	PF00917	0.336
DOC_USP7_MATH_1	46	50	PF00917	0.649
DOC_USP7_MATH_1	462	466	PF00917	0.713
DOC_USP7_MATH_1	74	78	PF00917	0.653
DOC_USP7_UBL2_3	473	477	PF12436	0.765
DOC_WW_Pin1_4	135	140	PF00397	0.797
DOC_WW_Pin1_4	141	146	PF00397	0.705
DOC_WW_Pin1_4	349	354	PF00397	0.678
DOC_WW_Pin1_4	99	104	PF00397	0.783
LIG_14-3-3_CanoR_1	140	145	PF00244	0.636
LIG_14-3-3_CanoR_1	169	179	PF00244	0.703
LIG_14-3-3_CanoR_1	21	29	PF00244	0.511
LIG_14-3-3_CanoR_1	234	243	PF00244	0.673
LIG_14-3-3_CanoR_1	3	7	PF00244	0.598
LIG_14-3-3_CanoR_1	302	308	PF00244	0.541
LIG_14-3-3_CanoR_1	369	379	PF00244	0.661
LIG_14-3-3_CanoR_1	52	58	PF00244	0.740
LIG_14-3-3_CanoR_1	79	88	PF00244	0.707
LIG_Actin_RPEL_3	358	377	PF02755	0.600
LIG_APCC_ABBA_1	377	382	PF00400	0.638
LIG_BRCT_BRCA1_1	322	326	PF00533	0.636
LIG_BRCT_BRCA1_1	41	45	PF00533	0.774
LIG_CaM_IQ_9	221	236	PF13499	0.579
LIG_DCNL_PONY_1	1	4	PF03556	0.555
LIG_FHA_1	120	126	PF00498	0.729
LIG_FHA_1	231	237	PF00498	0.402
LIG_FHA_1	304	310	PF00498	0.439
LIG_FHA_1	371	377	PF00498	0.663
LIG_FHA_1	393	399	PF00498	0.554
LIG_FHA_1	68	74	PF00498	0.805
LIG_FHA_2	105	111	PF00498	0.734
LIG_FHA_2	170	176	PF00498	0.647
LIG_LIR_Gen_1	144	153	PF02991	0.635
LIG_LIR_Gen_1	306	315	PF02991	0.601
LIG_LIR_Nem_3	144	150	PF02991	0.627
LIG_LIR_Nem_3	306	310	PF02991	0.601
LIG_NRBOX	314	320	PF00104	0.336
LIG_Pex14_2	326	330	PF04695	0.648
LIG_SH2_CRK	147	151	PF00017	0.622
LIG_SH2_PTP2	424	427	PF00017	0.623
LIG_SH2_SRC	128	131	PF00017	0.652
LIG_SH2_STAT3	245	248	PF00017	0.567
LIG_SH2_STAT3	258	261	PF00017	0.422
LIG_SH2_STAT5	187	190	PF00017	0.601
LIG_SH2_STAT5	245	248	PF00017	0.567
LIG_SH2_STAT5	424	427	PF00017	0.595
LIG_SH3_1	432	438	PF00018	0.695
LIG_SH3_2	136	141	PF14604	0.739
LIG_SH3_3	133	139	PF00018	0.802
LIG_SH3_3	158	164	PF00018	0.561
LIG_SH3_3	432	438	PF00018	0.695
LIG_SH3_3	55	61	PF00018	0.810
LIG_SH3_3	70	76	PF00018	0.546
LIG_SH3_3	91	97	PF00018	0.804
LIG_TRAF2_1	331	334	PF00917	0.463
LIG_WW_3	57	61	PF00397	0.512
MOD_CDC14_SPxK_1	138	141	PF00782	0.737
MOD_CDK_SPK_2	135	140	PF00069	0.742
MOD_CDK_SPxK_1	135	141	PF00069	0.742
MOD_CK1_1	104	110	PF00069	0.594
MOD_CK1_1	19	25	PF00069	0.834
MOD_CK1_1	28	34	PF00069	0.665
MOD_CK1_1	35	41	PF00069	0.541
MOD_CK1_1	77	83	PF00069	0.659
MOD_CK2_1	169	175	PF00069	0.717
MOD_CK2_1	285	291	PF00069	0.590
MOD_Cter_Amidation	13	16	PF01082	0.646
MOD_GlcNHglycan	113	116	PF01048	0.622
MOD_GlcNHglycan	117	120	PF01048	0.575
MOD_GlcNHglycan	165	168	PF01048	0.706
MOD_GlcNHglycan	172	175	PF01048	0.589
MOD_GlcNHglycan	236	239	PF01048	0.671
MOD_GlcNHglycan	322	325	PF01048	0.635
MOD_GlcNHglycan	40	44	PF01048	0.725
MOD_GlcNHglycan	464	467	PF01048	0.679
MOD_GlcNHglycan	48	51	PF01048	0.680
MOD_GlcNHglycan	70	73	PF01048	0.674
MOD_GSK3_1	111	118	PF00069	0.624
MOD_GSK3_1	130	137	PF00069	0.668
MOD_GSK3_1	151	158	PF00069	0.510
MOD_GSK3_1	170	177	PF00069	0.639
MOD_GSK3_1	21	28	PF00069	0.781
MOD_GSK3_1	230	237	PF00069	0.399
MOD_GSK3_1	281	288	PF00069	0.579
MOD_GSK3_1	35	42	PF00069	0.527
MOD_GSK3_1	392	399	PF00069	0.564
MOD_GSK3_1	468	475	PF00069	0.477
MOD_GSK3_1	86	93	PF00069	0.545
MOD_N-GLC_1	19	24	PF02516	0.756
MOD_NEK2_1	111	116	PF00069	0.687
MOD_NEK2_1	2	7	PF00069	0.506
MOD_NEK2_1	326	331	PF00069	0.648
MOD_NEK2_1	472	477	PF00069	0.476
MOD_NEK2_2	396	401	PF00069	0.649
MOD_PIKK_1	19	25	PF00454	0.619
MOD_PIKK_1	2	8	PF00454	0.734
MOD_PKA_1	140	146	PF00069	0.709
MOD_PKA_1	16	22	PF00069	0.836
MOD_PKA_1	32	38	PF00069	0.547
MOD_PKA_2	16	22	PF00069	0.605
MOD_PKA_2	2	8	PF00069	0.800
MOD_PKA_2	32	38	PF00069	0.547
MOD_PKB_1	232	240	PF00069	0.685
MOD_Plk_1	174	180	PF00069	0.682
MOD_Plk_4	303	309	PF00069	0.514
MOD_Plk_4	396	402	PF00069	0.653
MOD_ProDKin_1	135	141	PF00069	0.796
MOD_ProDKin_1	349	355	PF00069	0.676
MOD_ProDKin_1	99	105	PF00069	0.785
MOD_SUMO_rev_2	333	339	PF00179	0.654
MOD_SUMO_rev_2	445	451	PF00179	0.673
TRG_DiLeu_BaEn_1	205	210	PF01217	0.504
TRG_DiLeu_BaEn_1	314	319	PF01217	0.549
TRG_ENDOCYTIC_2	147	150	PF00928	0.615
TRG_ENDOCYTIC_2	424	427	PF00928	0.623
TRG_ER_diArg_1	15	17	PF00400	0.724
TRG_ER_diArg_1	189	192	PF00400	0.626
TRG_ER_diArg_1	231	234	PF00400	0.433
TRG_ER_diArg_1	249	252	PF00400	0.609
TRG_ER_diArg_1	273	276	PF00400	0.568
TRG_ER_diArg_1	32	34	PF00400	0.526
TRG_ER_diArg_1	367	369	PF00400	0.668
TRG_ER_diArg_1	412	415	PF00400	0.490
TRG_ER_diArg_1	8	10	PF00400	0.825
TRG_ER_diLys_1	473	477	PF00400	0.765
TRG_Pf-PMV_PEXEL_1	207	212	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC93	Leishmania donovani	89%	100%
A4HD53	Leishmania braziliensis	68%	99%
A4I2A8	Leishmania infantum	89%	100%
Q4Q917	Leishmania major	89%	100%