Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYF3_LEIMU

TriTrypDb:

LmxM.26.1750

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.307
CLV_C14_Caspase3-7	380	384	PF00656	0.379
CLV_C14_Caspase3-7	405	409	PF00656	0.548
CLV_NRD_NRD_1	145	147	PF00675	0.499
CLV_NRD_NRD_1	247	249	PF00675	0.526
CLV_NRD_NRD_1	326	328	PF00675	0.393
CLV_NRD_NRD_1	419	421	PF00675	0.472
CLV_NRD_NRD_1	487	489	PF00675	0.498
CLV_NRD_NRD_1	68	70	PF00675	0.608
CLV_PCSK_KEX2_1	145	147	PF00082	0.487
CLV_PCSK_KEX2_1	247	249	PF00082	0.402
CLV_PCSK_KEX2_1	419	421	PF00082	0.489
CLV_PCSK_KEX2_1	68	70	PF00082	0.506
CLV_PCSK_PC7_1	243	249	PF00082	0.385
CLV_PCSK_SKI1_1	247	251	PF00082	0.447
CLV_PCSK_SKI1_1	254	258	PF00082	0.405
CLV_PCSK_SKI1_1	298	302	PF00082	0.350
CLV_PCSK_SKI1_1	389	393	PF00082	0.524
CLV_PCSK_SKI1_1	420	424	PF00082	0.403
CLV_PCSK_SKI1_1	69	73	PF00082	0.580
DEG_APCC_DBOX_1	419	427	PF00400	0.367
DEG_APCC_DBOX_1	505	513	PF00400	0.509
DEG_SPOP_SBC_1	78	82	PF00917	0.587
DOC_CYCLIN_RxL_1	66	76	PF00134	0.320
DOC_MAPK_DCC_7	127	136	PF00069	0.428
DOC_MAPK_gen_1	127	136	PF00069	0.383
DOC_MAPK_gen_1	251	261	PF00069	0.346
DOC_MAPK_MEF2A_6	127	136	PF00069	0.408
DOC_MAPK_MEF2A_6	254	263	PF00069	0.476
DOC_MAPK_RevD_3	132	146	PF00069	0.473
DOC_PP4_FxxP_1	13	16	PF00568	0.482
DOC_PP4_FxxP_1	165	168	PF00568	0.449
DOC_USP7_MATH_1	112	116	PF00917	0.772
DOC_USP7_MATH_1	125	129	PF00917	0.355
DOC_USP7_MATH_1	216	220	PF00917	0.593
DOC_USP7_MATH_1	396	400	PF00917	0.585
DOC_USP7_MATH_1	430	434	PF00917	0.305
DOC_USP7_MATH_1	439	443	PF00917	0.400
DOC_USP7_MATH_1	6	10	PF00917	0.481
DOC_USP7_MATH_1	83	87	PF00917	0.603
DOC_USP7_MATH_1	92	96	PF00917	0.669
DOC_WW_Pin1_4	101	106	PF00397	0.472
DOC_WW_Pin1_4	220	225	PF00397	0.414
DOC_WW_Pin1_4	403	408	PF00397	0.607
DOC_WW_Pin1_4	79	84	PF00397	0.673
DOC_WW_Pin1_4	88	93	PF00397	0.755
LIG_14-3-3_CanoR_1	119	126	PF00244	0.574
LIG_14-3-3_CanoR_1	27	31	PF00244	0.566
LIG_14-3-3_CanoR_1	318	326	PF00244	0.539
LIG_14-3-3_CanoR_1	480	485	PF00244	0.372
LIG_14-3-3_CanoR_1	506	510	PF00244	0.499
LIG_Actin_WH2_2	283	300	PF00022	0.457
LIG_APCC_ABBA_1	375	380	PF00400	0.409
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BIR_III_2	32	36	PF00653	0.298
LIG_BIR_III_2	443	447	PF00653	0.433
LIG_BIR_III_4	155	159	PF00653	0.494
LIG_BRCT_BRCA1_1	470	474	PF00533	0.362
LIG_deltaCOP1_diTrp_1	280	287	PF00928	0.489
LIG_FHA_1	137	143	PF00498	0.438
LIG_FHA_1	244	250	PF00498	0.479
LIG_FHA_1	79	85	PF00498	0.614
LIG_FHA_2	27	33	PF00498	0.598
LIG_FHA_2	453	459	PF00498	0.476
LIG_LIR_Apic_2	163	168	PF02991	0.419
LIG_LIR_Apic_2	401	407	PF02991	0.427
LIG_LIR_Gen_1	280	290	PF02991	0.349
LIG_LIR_Gen_1	361	371	PF02991	0.407
LIG_LIR_Nem_3	172	177	PF02991	0.490
LIG_LIR_Nem_3	361	366	PF02991	0.376
LIG_MYND_3	509	513	PF01753	0.510
LIG_NRBOX	199	205	PF00104	0.353
LIG_NRBOX	494	500	PF00104	0.406
LIG_PCNA_yPIPBox_3	197	209	PF02747	0.429
LIG_Pex14_1	283	287	PF04695	0.492
LIG_Pex14_2	363	367	PF04695	0.450
LIG_RPA_C_Fungi	141	153	PF08784	0.433
LIG_SH2_CRK	74	78	PF00017	0.578
LIG_SH2_NCK_1	404	408	PF00017	0.431
LIG_SH2_NCK_1	460	464	PF00017	0.510
LIG_SH2_NCK_1	74	78	PF00017	0.578
LIG_SH2_PTP2	133	136	PF00017	0.467
LIG_SH2_STAP1	19	23	PF00017	0.596
LIG_SH2_STAT5	133	136	PF00017	0.354
LIG_SH2_STAT5	189	192	PF00017	0.395
LIG_SH2_STAT5	440	443	PF00017	0.534
LIG_SH2_STAT5	482	485	PF00017	0.412
LIG_SH3_3	187	193	PF00018	0.423
LIG_SH3_3	86	92	PF00018	0.598
LIG_SUMO_SIM_par_1	354	359	PF11976	0.389
LIG_SUMO_SIM_par_1	50	57	PF11976	0.430
LIG_TRAF2_1	2	5	PF00917	0.339
LIG_TRAF2_1	95	98	PF00917	0.754
LIG_TYR_ITIM	131	136	PF00017	0.360
MOD_CK1_1	115	121	PF00069	0.731
MOD_CK1_1	235	241	PF00069	0.421
MOD_CK1_1	406	412	PF00069	0.709
MOD_CK1_1	433	439	PF00069	0.355
MOD_CK1_1	452	458	PF00069	0.378
MOD_CK1_1	508	514	PF00069	0.430
MOD_CK2_1	101	107	PF00069	0.558
MOD_CK2_1	268	274	PF00069	0.389
MOD_CK2_1	452	458	PF00069	0.488
MOD_CK2_1	79	85	PF00069	0.700
MOD_CK2_1	92	98	PF00069	0.726
MOD_GlcNHglycan	115	118	PF01048	0.669
MOD_GlcNHglycan	127	130	PF01048	0.500
MOD_GlcNHglycan	21	24	PF01048	0.519
MOD_GlcNHglycan	234	237	PF01048	0.614
MOD_GlcNHglycan	35	38	PF01048	0.411
MOD_GlcNHglycan	398	401	PF01048	0.649
MOD_GlcNHglycan	484	487	PF01048	0.555
MOD_GlcNHglycan	8	11	PF01048	0.457
MOD_GSK3_1	108	115	PF00069	0.744
MOD_GSK3_1	216	223	PF00069	0.450
MOD_GSK3_1	264	271	PF00069	0.428
MOD_GSK3_1	336	343	PF00069	0.587
MOD_GSK3_1	398	405	PF00069	0.566
MOD_GSK3_1	444	451	PF00069	0.561
MOD_GSK3_1	73	80	PF00069	0.613
MOD_GSK3_1	84	91	PF00069	0.774
MOD_GSK3_1	97	104	PF00069	0.741
MOD_N-GLC_1	47	52	PF02516	0.368
MOD_N-GLC_2	351	353	PF02516	0.383
MOD_NEK2_1	241	246	PF00069	0.503
MOD_NEK2_1	268	273	PF00069	0.455
MOD_NEK2_1	42	47	PF00069	0.478
MOD_NEK2_1	449	454	PF00069	0.434
MOD_NEK2_1	474	479	PF00069	0.368
MOD_NEK2_1	84	89	PF00069	0.518
MOD_OFUCOSY	353	360	PF10250	0.384
MOD_PK_1	73	79	PF00069	0.488
MOD_PKA_2	118	124	PF00069	0.610
MOD_PKA_2	170	176	PF00069	0.498
MOD_PKA_2	26	32	PF00069	0.575
MOD_PKA_2	505	511	PF00069	0.438
MOD_Plk_1	84	90	PF00069	0.614
MOD_Plk_1	97	103	PF00069	0.537
MOD_Plk_4	474	480	PF00069	0.467
MOD_ProDKin_1	101	107	PF00069	0.471
MOD_ProDKin_1	220	226	PF00069	0.415
MOD_ProDKin_1	403	409	PF00069	0.608
MOD_ProDKin_1	79	85	PF00069	0.681
MOD_ProDKin_1	88	94	PF00069	0.757
MOD_SUMO_for_1	461	464	PF00179	0.488
MOD_SUMO_rev_2	485	490	PF00179	0.465
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.525
TRG_ENDOCYTIC_2	133	136	PF00928	0.381
TRG_ENDOCYTIC_2	201	204	PF00928	0.355
TRG_ENDOCYTIC_2	74	77	PF00928	0.568
TRG_ER_diArg_1	144	146	PF00400	0.488
TRG_ER_diArg_1	247	249	PF00400	0.494
TRG_ER_diArg_1	418	420	PF00400	0.384
TRG_NES_CRM1_1	292	305	PF08389	0.447
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU4	Leptomonas seymouri	54%	99%
A0A1X0P8W2	Trypanosomatidae	33%	100%
A0A3S7X019	Leishmania donovani	90%	100%
A0A422N4R1	Trypanosoma rangeli	30%	100%
A4HD54	Leishmania braziliensis	80%	100%
A4I2A7	Leishmania infantum	90%	100%
C9ZXD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q918	Leishmania major	91%	100%
V5BF90	Trypanosoma cruzi	34%	100%