Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYF1_LEIMU

TriTrypDb:

LmxM.26.1720

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.519
CLV_C14_Caspase3-7	86	90	PF00656	0.626
CLV_MEL_PAP_1	502	508	PF00089	0.568
CLV_NRD_NRD_1	252	254	PF00675	0.432
CLV_NRD_NRD_1	284	286	PF00675	0.391
CLV_NRD_NRD_1	312	314	PF00675	0.390
CLV_NRD_NRD_1	450	452	PF00675	0.583
CLV_NRD_NRD_1	611	613	PF00675	0.621
CLV_NRD_NRD_1	625	627	PF00675	0.632
CLV_NRD_NRD_1	629	631	PF00675	0.641
CLV_NRD_NRD_1	694	696	PF00675	0.651
CLV_PCSK_FUR_1	626	630	PF00082	0.642
CLV_PCSK_KEX2_1	252	254	PF00082	0.373
CLV_PCSK_KEX2_1	284	286	PF00082	0.452
CLV_PCSK_KEX2_1	399	401	PF00082	0.639
CLV_PCSK_KEX2_1	450	452	PF00082	0.583
CLV_PCSK_KEX2_1	610	612	PF00082	0.672
CLV_PCSK_KEX2_1	625	627	PF00082	0.530
CLV_PCSK_KEX2_1	628	630	PF00082	0.647
CLV_PCSK_KEX2_1	634	636	PF00082	0.654
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.639
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.672
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.618
CLV_PCSK_PC7_1	625	631	PF00082	0.641
CLV_PCSK_SKI1_1	140	144	PF00082	0.449
CLV_PCSK_SKI1_1	231	235	PF00082	0.480
CLV_PCSK_SKI1_1	277	281	PF00082	0.457
CLV_PCSK_SKI1_1	335	339	PF00082	0.437
CLV_PCSK_SKI1_1	41	45	PF00082	0.604
CLV_PCSK_SKI1_1	96	100	PF00082	0.599
DEG_SPOP_SBC_1	286	290	PF00917	0.479
DEG_SPOP_SBC_1	82	86	PF00917	0.565
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.473
DOC_MAPK_gen_1	10	20	PF00069	0.430
DOC_MAPK_gen_1	284	294	PF00069	0.443
DOC_MAPK_gen_1	335	344	PF00069	0.442
DOC_MAPK_HePTP_8	332	344	PF00069	0.402
DOC_MAPK_JIP1_4	105	111	PF00069	0.447
DOC_MAPK_MEF2A_6	335	344	PF00069	0.401
DOC_PP1_SILK_1	101	106	PF00149	0.585
DOC_PP2B_LxvP_1	546	549	PF13499	0.610
DOC_USP7_MATH_1	14	18	PF00917	0.426
DOC_USP7_MATH_1	232	236	PF00917	0.349
DOC_USP7_MATH_1	286	290	PF00917	0.479
DOC_USP7_MATH_1	381	385	PF00917	0.560
DOC_USP7_MATH_1	394	398	PF00917	0.622
DOC_USP7_MATH_1	43	47	PF00917	0.718
DOC_USP7_MATH_1	488	492	PF00917	0.576
DOC_USP7_MATH_1	551	555	PF00917	0.610
DOC_USP7_MATH_1	569	573	PF00917	0.466
DOC_USP7_MATH_1	618	622	PF00917	0.590
DOC_USP7_MATH_1	639	643	PF00917	0.669
DOC_USP7_MATH_1	680	684	PF00917	0.698
DOC_USP7_MATH_1	82	86	PF00917	0.573
DOC_USP7_MATH_2	92	98	PF00917	0.535
DOC_USP7_UBL2_3	652	656	PF12436	0.763
DOC_WW_Pin1_4	287	292	PF00397	0.461
DOC_WW_Pin1_4	53	58	PF00397	0.605
DOC_WW_Pin1_4	633	638	PF00397	0.534
DOC_WW_Pin1_4	676	681	PF00397	0.659
LIG_14-3-3_CanoR_1	174	183	PF00244	0.409
LIG_14-3-3_CanoR_1	231	239	PF00244	0.499
LIG_14-3-3_CanoR_1	284	294	PF00244	0.384
LIG_14-3-3_CanoR_1	400	406	PF00244	0.571
LIG_14-3-3_CanoR_1	415	419	PF00244	0.698
LIG_14-3-3_CanoR_1	430	436	PF00244	0.567
LIG_14-3-3_CanoR_1	550	558	PF00244	0.648
LIG_14-3-3_CanoR_1	611	616	PF00244	0.597
LIG_14-3-3_CanoR_1	619	625	PF00244	0.544
LIG_14-3-3_CanoR_1	682	692	PF00244	0.601
LIG_AP_GAE_1	218	224	PF02883	0.561
LIG_APCC_ABBA_1	157	162	PF00400	0.356
LIG_APCC_ABBA_1	315	320	PF00400	0.440
LIG_APCC_ABBAyCdc20_2	314	320	PF00400	0.472
LIG_BIR_III_2	89	93	PF00653	0.615
LIG_BIR_III_4	113	117	PF00653	0.539
LIG_BRCT_BRCA1_1	20	24	PF00533	0.444
LIG_BRCT_BRCA1_1	401	405	PF00533	0.598
LIG_BRCT_BRCA1_1	431	435	PF00533	0.601
LIG_BRCT_BRCA1_1	61	65	PF00533	0.479
LIG_eIF4E_1	183	189	PF01652	0.342
LIG_eIF4E_1	487	493	PF01652	0.573
LIG_FHA_1	320	326	PF00498	0.406
LIG_FHA_1	509	515	PF00498	0.516
LIG_FHA_2	173	179	PF00498	0.579
LIG_FHA_2	319	325	PF00498	0.444
LIG_FHA_2	374	380	PF00498	0.604
LIG_FHA_2	467	473	PF00498	0.544
LIG_FHA_2	585	591	PF00498	0.591
LIG_FHA_2	84	90	PF00498	0.668
LIG_LIR_Gen_1	21	32	PF02991	0.543
LIG_LIR_Gen_1	320	331	PF02991	0.368
LIG_LIR_Gen_1	432	443	PF02991	0.607
LIG_LIR_Gen_1	99	109	PF02991	0.527
LIG_LIR_Nem_3	21	27	PF02991	0.558
LIG_LIR_Nem_3	320	326	PF02991	0.372
LIG_LIR_Nem_3	432	438	PF02991	0.553
LIG_LIR_Nem_3	99	104	PF02991	0.537
LIG_RPA_C_Fungi	607	619	PF08784	0.543
LIG_SH2_CRK	101	105	PF00017	0.577
LIG_SH2_CRK	161	165	PF00017	0.327
LIG_SH2_CRK	300	304	PF00017	0.436
LIG_SH2_NCK_1	487	491	PF00017	0.587
LIG_SH2_SRC	487	490	PF00017	0.630
LIG_SH2_SRC	495	498	PF00017	0.558
LIG_SH2_STAP1	359	363	PF00017	0.515
LIG_SH2_STAT5	169	172	PF00017	0.391
LIG_SH2_STAT5	200	203	PF00017	0.600
LIG_SH2_STAT5	403	406	PF00017	0.477
LIG_SH2_STAT5	513	516	PF00017	0.509
LIG_SH3_3	117	123	PF00018	0.775
LIG_SH3_3	124	130	PF00018	0.585
LIG_SH3_3	325	331	PF00018	0.417
LIG_SH3_3	575	581	PF00018	0.606
LIG_SH3_3	8	14	PF00018	0.452
LIG_SUMO_SIM_anti_2	304	312	PF11976	0.306
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.604
LIG_SUMO_SIM_par_1	115	122	PF11976	0.525
LIG_SUMO_SIM_par_1	187	194	PF11976	0.545
LIG_SxIP_EBH_1	78	87	PF03271	0.563
LIG_TRAF2_1	469	472	PF00917	0.580
LIG_TYR_ITIM	159	164	PF00017	0.445
MOD_CDC14_SPxK_1	679	682	PF00782	0.621
MOD_CDK_SPxK_1	676	682	PF00069	0.624
MOD_CDK_SPxxK_3	633	640	PF00069	0.537
MOD_CK1_1	301	307	PF00069	0.372
MOD_CK1_1	373	379	PF00069	0.594
MOD_CK1_1	384	390	PF00069	0.611
MOD_CK1_1	410	416	PF00069	0.650
MOD_CK1_1	431	437	PF00069	0.614
MOD_CK1_1	633	639	PF00069	0.635
MOD_CK1_1	642	648	PF00069	0.679
MOD_CK1_1	683	689	PF00069	0.634
MOD_CK1_1	699	705	PF00069	0.766
MOD_CK1_1	77	83	PF00069	0.650
MOD_CK2_1	22	28	PF00069	0.440
MOD_CK2_1	318	324	PF00069	0.403
MOD_CK2_1	385	391	PF00069	0.654
MOD_CK2_1	466	472	PF00069	0.551
MOD_CK2_1	512	518	PF00069	0.618
MOD_CK2_1	535	541	PF00069	0.649
MOD_Cter_Amidation	448	451	PF01082	0.581
MOD_Cter_Amidation	654	657	PF01082	0.735
MOD_DYRK1A_RPxSP_1	287	291	PF00069	0.468
MOD_GlcNHglycan	106	109	PF01048	0.574
MOD_GlcNHglycan	113	117	PF01048	0.566
MOD_GlcNHglycan	121	126	PF01048	0.728
MOD_GlcNHglycan	262	265	PF01048	0.340
MOD_GlcNHglycan	381	384	PF01048	0.776
MOD_GlcNHglycan	394	397	PF01048	0.520
MOD_GlcNHglycan	45	48	PF01048	0.590
MOD_GlcNHglycan	553	556	PF01048	0.647
MOD_GlcNHglycan	637	640	PF01048	0.664
MOD_GlcNHglycan	641	644	PF01048	0.661
MOD_GlcNHglycan	665	668	PF01048	0.756
MOD_GlcNHglycan	676	679	PF01048	0.765
MOD_GlcNHglycan	687	690	PF01048	0.601
MOD_GlcNHglycan	69	72	PF01048	0.501
MOD_GlcNHglycan	702	705	PF01048	0.656
MOD_GlcNHglycan	96	99	PF01048	0.669
MOD_GSK3_1	14	21	PF00069	0.439
MOD_GSK3_1	168	175	PF00069	0.475
MOD_GSK3_1	298	305	PF00069	0.432
MOD_GSK3_1	369	376	PF00069	0.651
MOD_GSK3_1	381	388	PF00069	0.657
MOD_GSK3_1	410	417	PF00069	0.657
MOD_GSK3_1	429	436	PF00069	0.467
MOD_GSK3_1	455	462	PF00069	0.619
MOD_GSK3_1	508	515	PF00069	0.590
MOD_GSK3_1	620	627	PF00069	0.662
MOD_GSK3_1	635	642	PF00069	0.615
MOD_GSK3_1	661	668	PF00069	0.683
MOD_GSK3_1	672	679	PF00069	0.705
MOD_GSK3_1	680	687	PF00069	0.738
MOD_GSK3_1	696	703	PF00069	0.581
MOD_GSK3_1	73	80	PF00069	0.644
MOD_N-GLC_1	203	208	PF02516	0.486
MOD_N-GLC_1	326	331	PF02516	0.376
MOD_N-GLC_1	428	433	PF02516	0.654
MOD_NEK2_1	152	157	PF00069	0.347
MOD_NEK2_1	203	208	PF00069	0.480
MOD_NEK2_1	260	265	PF00069	0.412
MOD_NEK2_1	303	308	PF00069	0.276
MOD_NEK2_1	392	397	PF00069	0.575
MOD_NEK2_1	414	419	PF00069	0.606
MOD_NEK2_1	584	589	PF00069	0.573
MOD_NEK2_1	624	629	PF00069	0.640
MOD_PIKK_1	265	271	PF00454	0.300
MOD_PIKK_1	523	529	PF00454	0.564
MOD_PIKK_1	59	65	PF00454	0.641
MOD_PKA_1	399	405	PF00069	0.635
MOD_PKA_1	610	616	PF00069	0.670
MOD_PKA_1	630	636	PF00069	0.749
MOD_PKA_2	104	110	PF00069	0.591
MOD_PKA_2	173	179	PF00069	0.462
MOD_PKA_2	286	292	PF00069	0.461
MOD_PKA_2	399	405	PF00069	0.608
MOD_PKA_2	414	420	PF00069	0.668
MOD_PKA_2	429	435	PF00069	0.491
MOD_PKA_2	516	522	PF00069	0.565
MOD_PKA_2	551	557	PF00069	0.645
MOD_PKA_2	610	616	PF00069	0.718
MOD_PKA_2	618	624	PF00069	0.777
MOD_PKA_2	639	645	PF00069	0.552
MOD_PKA_2	661	667	PF00069	0.621
MOD_PKA_2	681	687	PF00069	0.764
MOD_PKA_2	699	705	PF00069	0.611
MOD_PKB_1	617	625	PF00069	0.549
MOD_PKB_1	628	636	PF00069	0.689
MOD_Plk_1	319	325	PF00069	0.426
MOD_Plk_1	407	413	PF00069	0.726
MOD_Plk_1	488	494	PF00069	0.536
MOD_Plk_4	262	268	PF00069	0.388
MOD_Plk_4	306	312	PF00069	0.457
MOD_Plk_4	434	440	PF00069	0.608
MOD_Plk_4	488	494	PF00069	0.522
MOD_Plk_4	556	562	PF00069	0.732
MOD_Plk_4	99	105	PF00069	0.606
MOD_ProDKin_1	287	293	PF00069	0.450
MOD_ProDKin_1	53	59	PF00069	0.607
MOD_ProDKin_1	633	639	PF00069	0.534
MOD_ProDKin_1	676	682	PF00069	0.662
MOD_SUMO_for_1	208	211	PF00179	0.442
MOD_SUMO_for_1	48	51	PF00179	0.548
MOD_SUMO_rev_2	134	142	PF00179	0.472
MOD_SUMO_rev_2	330	340	PF00179	0.385
MOD_SUMO_rev_2	358	364	PF00179	0.552
MOD_SUMO_rev_2	89	98	PF00179	0.607
TRG_DiLeu_BaEn_4	471	477	PF01217	0.574
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.394
TRG_ENDOCYTIC_2	101	104	PF00928	0.578
TRG_ENDOCYTIC_2	161	164	PF00928	0.434
TRG_ENDOCYTIC_2	200	203	PF00928	0.491
TRG_ENDOCYTIC_2	300	303	PF00928	0.421
TRG_ER_diArg_1	251	253	PF00400	0.434
TRG_ER_diArg_1	283	285	PF00400	0.430
TRG_ER_diArg_1	32	35	PF00400	0.486
TRG_ER_diArg_1	549	552	PF00400	0.646
TRG_ER_diArg_1	624	626	PF00400	0.659
TRG_ER_diArg_1	628	630	PF00400	0.693
TRG_NLS_Bipartite_1	634	654	PF00514	0.685
TRG_NLS_MonoCore_2	608	613	PF00514	0.571
TRG_NLS_MonoExtN_4	609	614	PF00514	0.611
TRG_Pf-PMV_PEXEL_1	271	276	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM04	Leptomonas seymouri	52%	98%
A0A3Q8IDQ2	Leishmania donovani	90%	100%
A0A3R7RDL2	Trypanosoma rangeli	35%	100%
A4HD56	Leishmania braziliensis	72%	100%
A4I2A4	Leishmania infantum	89%	100%
Q4Q921	Leishmania major	88%	100%