Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYE6_LEIMU

TriTrypDb:

LmxM.26.1665

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.566
CLV_NRD_NRD_1	100	102	PF00675	0.512
CLV_NRD_NRD_1	113	115	PF00675	0.487
CLV_NRD_NRD_1	117	119	PF00675	0.377
CLV_NRD_NRD_1	242	244	PF00675	0.643
CLV_NRD_NRD_1	39	41	PF00675	0.588
CLV_NRD_NRD_1	65	67	PF00675	0.575
CLV_NRD_NRD_1	79	81	PF00675	0.412
CLV_NRD_NRD_1	91	93	PF00675	0.482
CLV_PCSK_KEX2_1	113	115	PF00082	0.728
CLV_PCSK_KEX2_1	117	119	PF00082	0.716
CLV_PCSK_KEX2_1	242	244	PF00082	0.643
CLV_PCSK_KEX2_1	65	67	PF00082	0.575
CLV_PCSK_KEX2_1	79	81	PF00082	0.412
CLV_PCSK_KEX2_1	91	93	PF00082	0.482
CLV_PCSK_PC7_1	113	119	PF00082	0.729
CLV_PCSK_SKI1_1	22	26	PF00082	0.524
CLV_PCSK_SKI1_1	235	239	PF00082	0.517
CLV_PCSK_SKI1_1	73	77	PF00082	0.607
DOC_CYCLIN_yClb3_PxF_3	206	212	PF00134	0.530
DOC_MAPK_gen_1	82	90	PF00069	0.546
DOC_MAPK_gen_1	91	99	PF00069	0.443
DOC_MAPK_MEF2A_6	145	153	PF00069	0.483
DOC_USP7_MATH_1	197	201	PF00917	0.660
DOC_WW_Pin1_4	199	204	PF00397	0.757
DOC_WW_Pin1_4	206	211	PF00397	0.701
LIG_14-3-3_CanoR_1	117	124	PF00244	0.552
LIG_BIR_II_1	1	5	PF00653	0.478
LIG_BRCT_BRCA1_1	208	212	PF00533	0.536
LIG_CtBP_PxDLS_1	217	221	PF00389	0.514
LIG_FHA_1	136	142	PF00498	0.487
LIG_FHA_1	146	152	PF00498	0.418
LIG_FHA_1	167	173	PF00498	0.583
LIG_FHA_1	209	215	PF00498	0.660
LIG_FHA_1	43	49	PF00498	0.526
LIG_FHA_1	70	76	PF00498	0.338
LIG_FHA_2	57	63	PF00498	0.445
LIG_GSK3_LRP6_1	206	211	PF00069	0.526
LIG_LIR_Gen_1	47	54	PF02991	0.450
LIG_LIR_Nem_3	185	190	PF02991	0.606
LIG_LIR_Nem_3	226	232	PF02991	0.664
LIG_LIR_Nem_3	47	52	PF02991	0.467
LIG_NRP_CendR_1	242	245	PF00754	0.741
LIG_REV1ctd_RIR_1	87	96	PF16727	0.475
LIG_RPA_C_Fungi	89	101	PF08784	0.575
LIG_SH2_CRK	33	37	PF00017	0.533
LIG_SH2_CRK	49	53	PF00017	0.503
LIG_SH2_NCK_1	104	108	PF00017	0.698
LIG_SH2_STAT5	187	190	PF00017	0.549
LIG_SH3_1	33	39	PF00018	0.501
LIG_SH3_2	36	41	PF14604	0.493
LIG_SH3_3	200	206	PF00018	0.779
LIG_SH3_3	211	217	PF00018	0.626
LIG_SH3_3	234	240	PF00018	0.443
LIG_SH3_3	33	39	PF00018	0.501
LIG_SUMO_SIM_par_1	168	173	PF11976	0.466
LIG_TYR_ITSM	45	52	PF00017	0.449
LIG_WW_3	239	243	PF00397	0.486
MOD_CK1_1	225	231	PF00069	0.671
MOD_CK2_1	56	62	PF00069	0.447
MOD_GlcNHglycan	119	122	PF01048	0.656
MOD_GlcNHglycan	124	127	PF01048	0.507
MOD_GlcNHglycan	172	175	PF01048	0.453
MOD_GlcNHglycan	52	55	PF01048	0.497
MOD_GSK3_1	166	173	PF00069	0.460
MOD_GSK3_1	179	186	PF00069	0.599
MOD_GSK3_1	197	204	PF00069	0.556
MOD_GSK3_1	221	228	PF00069	0.728
MOD_GSK3_1	44	51	PF00069	0.498
MOD_GSK3_1	69	76	PF00069	0.442
MOD_NEK2_1	191	196	PF00069	0.640
MOD_NEK2_1	50	55	PF00069	0.623
MOD_NEK2_1	74	79	PF00069	0.537
MOD_PKA_1	117	123	PF00069	0.665
MOD_PKA_2	117	123	PF00069	0.591
MOD_PKA_2	78	84	PF00069	0.482
MOD_Plk_1	56	62	PF00069	0.402
MOD_Plk_4	166	172	PF00069	0.463
MOD_Plk_4	183	189	PF00069	0.631
MOD_Plk_4	191	197	PF00069	0.446
MOD_Plk_4	44	50	PF00069	0.460
MOD_ProDKin_1	199	205	PF00069	0.757
MOD_ProDKin_1	206	212	PF00069	0.705
TRG_ENDOCYTIC_2	229	232	PF00928	0.592
TRG_ENDOCYTIC_2	49	52	PF00928	0.518
TRG_ER_diArg_1	241	243	PF00400	0.654
TRG_ER_diArg_1	79	82	PF00400	0.531
TRG_ER_diArg_1	90	92	PF00400	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I008	Leptomonas seymouri	37%	100%
A0A3S7WZY2	Leishmania donovani	90%	100%
A4HF22	Leishmania braziliensis	81%	100%
A4I2A1	Leishmania infantum	90%	94%
Q4Q927	Leishmania major	87%	100%