Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYE5_LEIMU

TriTrypDb:

LmxM.26.1660

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AYE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.421
CLV_NRD_NRD_1	145	147	PF00675	0.391
CLV_NRD_NRD_1	548	550	PF00675	0.429
CLV_NRD_NRD_1	58	60	PF00675	0.529
CLV_NRD_NRD_1	87	89	PF00675	0.408
CLV_PCSK_FUR_1	143	147	PF00082	0.401
CLV_PCSK_KEX2_1	145	147	PF00082	0.391
CLV_PCSK_KEX2_1	373	375	PF00082	0.403
CLV_PCSK_KEX2_1	392	394	PF00082	0.336
CLV_PCSK_KEX2_1	548	550	PF00082	0.394
CLV_PCSK_KEX2_1	58	60	PF00082	0.640
CLV_PCSK_KEX2_1	86	88	PF00082	0.539
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.437
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.336
CLV_PCSK_SKI1_1	136	140	PF00082	0.345
CLV_PCSK_SKI1_1	18	22	PF00082	0.568
CLV_PCSK_SKI1_1	228	232	PF00082	0.294
CLV_PCSK_SKI1_1	291	295	PF00082	0.410
CLV_PCSK_SKI1_1	354	358	PF00082	0.470
CLV_PCSK_SKI1_1	367	371	PF00082	0.505
CLV_PCSK_SKI1_1	46	50	PF00082	0.525
CLV_PCSK_SKI1_1	541	545	PF00082	0.468
CLV_PCSK_SKI1_1	576	580	PF00082	0.515
CLV_PCSK_SKI1_1	589	593	PF00082	0.394
DEG_APCC_DBOX_1	45	53	PF00400	0.570
DEG_Nend_UBRbox_3	1	3	PF02207	0.589
DEG_SPOP_SBC_1	104	108	PF00917	0.384
DEG_SPOP_SBC_1	401	405	PF00917	0.311
DOC_CYCLIN_RxL_1	13	23	PF00134	0.546
DOC_MAPK_DCC_7	46	54	PF00069	0.344
DOC_MAPK_DCC_7	505	514	PF00069	0.457
DOC_MAPK_gen_1	289	296	PF00069	0.385
DOC_MAPK_gen_1	372	381	PF00069	0.350
DOC_MAPK_MEF2A_6	46	54	PF00069	0.344
DOC_MAPK_MEF2A_6	505	514	PF00069	0.412
DOC_MAPK_MEF2A_6	551	560	PF00069	0.586
DOC_MAPK_RevD_3	73	88	PF00069	0.453
DOC_PP1_RVXF_1	143	150	PF00149	0.406
DOC_PP1_RVXF_1	521	528	PF00149	0.454
DOC_USP7_MATH_1	256	260	PF00917	0.399
DOC_USP7_MATH_1	401	405	PF00917	0.383
DOC_USP7_MATH_1	487	491	PF00917	0.404
DOC_USP7_MATH_1	533	537	PF00917	0.426
DOC_USP7_MATH_1	597	601	PF00917	0.529
DOC_WW_Pin1_4	69	74	PF00397	0.602
LIG_14-3-3_CanoR_1	175	180	PF00244	0.466
LIG_14-3-3_CanoR_1	232	238	PF00244	0.358
LIG_14-3-3_CanoR_1	239	244	PF00244	0.371
LIG_14-3-3_CanoR_1	317	325	PF00244	0.407
LIG_14-3-3_CanoR_1	367	376	PF00244	0.384
LIG_14-3-3_CanoR_1	489	494	PF00244	0.370
LIG_14-3-3_CanoR_1	541	547	PF00244	0.547
LIG_14-3-3_CanoR_1	589	596	PF00244	0.465
LIG_Actin_WH2_2	561	578	PF00022	0.518
LIG_BRCT_BRCA1_1	302	306	PF00533	0.400
LIG_BRCT_BRCA1_1	312	316	PF00533	0.379
LIG_BRCT_BRCA1_1	41	45	PF00533	0.582
LIG_BRCT_BRCA1_1	479	483	PF00533	0.465
LIG_CtBP_PxDLS_1	456	460	PF00389	0.423
LIG_FHA_1	20	26	PF00498	0.486
LIG_FHA_1	347	353	PF00498	0.467
LIG_FHA_1	401	407	PF00498	0.348
LIG_FHA_1	49	55	PF00498	0.421
LIG_FHA_1	577	583	PF00498	0.450
LIG_FHA_1	70	76	PF00498	0.553
LIG_FHA_2	122	128	PF00498	0.482
LIG_FHA_2	329	335	PF00498	0.456
LIG_GBD_Chelix_1	161	169	PF00786	0.347
LIG_HP1_1	510	514	PF01393	0.375
LIG_IRF3_LxIS_1	260	266	PF10401	0.358
LIG_LIR_Gen_1	176	185	PF02991	0.395
LIG_LIR_Gen_1	193	201	PF02991	0.225
LIG_LIR_Gen_1	203	212	PF02991	0.305
LIG_LIR_Gen_1	245	255	PF02991	0.450
LIG_LIR_Gen_1	303	314	PF02991	0.319
LIG_LIR_Gen_1	433	444	PF02991	0.226
LIG_LIR_Gen_1	478	488	PF02991	0.537
LIG_LIR_Gen_1	521	532	PF02991	0.404
LIG_LIR_LC3C_4	115	118	PF02991	0.451
LIG_LIR_Nem_3	130	135	PF02991	0.376
LIG_LIR_Nem_3	15	20	PF02991	0.421
LIG_LIR_Nem_3	176	182	PF02991	0.482
LIG_LIR_Nem_3	193	197	PF02991	0.301
LIG_LIR_Nem_3	203	207	PF02991	0.393
LIG_LIR_Nem_3	245	250	PF02991	0.479
LIG_LIR_Nem_3	303	309	PF02991	0.309
LIG_LIR_Nem_3	388	394	PF02991	0.497
LIG_LIR_Nem_3	433	439	PF02991	0.217
LIG_LIR_Nem_3	478	484	PF02991	0.556
LIG_LIR_Nem_3	521	527	PF02991	0.378
LIG_LIR_Nem_3	569	575	PF02991	0.549
LIG_NRBOX	134	140	PF00104	0.467
LIG_PAM2_1	261	273	PF00658	0.215
LIG_REV1ctd_RIR_1	388	397	PF16727	0.359
LIG_SH2_CRK	132	136	PF00017	0.425
LIG_SH2_CRK	204	208	PF00017	0.449
LIG_SH2_CRK	436	440	PF00017	0.239
LIG_SH2_SRC	495	498	PF00017	0.397
LIG_SH2_STAP1	204	208	PF00017	0.381
LIG_SH2_STAT3	167	170	PF00017	0.422
LIG_SH2_STAT5	167	170	PF00017	0.564
LIG_SH2_STAT5	226	229	PF00017	0.382
LIG_SH2_STAT5	436	439	PF00017	0.476
LIG_SH2_STAT5	495	498	PF00017	0.397
LIG_SH3_3	395	401	PF00018	0.344
LIG_SH3_3	421	427	PF00018	0.289
LIG_SH3_3	44	50	PF00018	0.565
LIG_SH3_3	504	510	PF00018	0.462
LIG_SH3_3	51	57	PF00018	0.593
LIG_SH3_3	565	571	PF00018	0.418
LIG_SH3_3	70	76	PF00018	0.579
LIG_SUMO_SIM_anti_2	257	262	PF11976	0.354
LIG_SUMO_SIM_par_1	510	516	PF11976	0.333
LIG_TYR_ITIM	434	439	PF00017	0.220
MOD_CK1_1	173	179	PF00069	0.569
MOD_CK1_1	193	199	PF00069	0.320
MOD_CK1_1	355	361	PF00069	0.388
MOD_CK1_1	39	45	PF00069	0.450
MOD_CK1_1	435	441	PF00069	0.440
MOD_CK1_1	528	534	PF00069	0.369
MOD_CK2_1	175	181	PF00069	0.390
MOD_CK2_1	328	334	PF00069	0.469
MOD_CK2_1	446	452	PF00069	0.442
MOD_CK2_1	564	570	PF00069	0.507
MOD_Cter_Amidation	84	87	PF01082	0.457
MOD_GlcNHglycan	170	173	PF01048	0.444
MOD_GlcNHglycan	228	231	PF01048	0.493
MOD_GlcNHglycan	265	268	PF01048	0.299
MOD_GlcNHglycan	408	411	PF01048	0.443
MOD_GlcNHglycan	41	44	PF01048	0.488
MOD_GlcNHglycan	448	451	PF01048	0.486
MOD_GlcNHglycan	491	494	PF01048	0.468
MOD_GlcNHglycan	500	504	PF01048	0.396
MOD_GlcNHglycan	534	538	PF01048	0.404
MOD_GlcNHglycan	66	69	PF01048	0.524
MOD_GSK3_1	173	180	PF00069	0.468
MOD_GSK3_1	196	203	PF00069	0.350
MOD_GSK3_1	234	241	PF00069	0.488
MOD_GSK3_1	295	302	PF00069	0.269
MOD_GSK3_1	348	355	PF00069	0.460
MOD_GSK3_1	402	409	PF00069	0.472
MOD_GSK3_1	495	502	PF00069	0.453
MOD_GSK3_1	576	583	PF00069	0.572
MOD_GSK3_1	64	71	PF00069	0.561
MOD_N-GLC_1	263	268	PF02516	0.414
MOD_N-GLC_1	471	476	PF02516	0.551
MOD_N-GLC_1	525	530	PF02516	0.449
MOD_NEK2_1	103	108	PF00069	0.496
MOD_NEK2_1	139	144	PF00069	0.438
MOD_NEK2_1	168	173	PF00069	0.368
MOD_NEK2_1	238	243	PF00069	0.454
MOD_NEK2_1	263	268	PF00069	0.363
MOD_NEK2_1	279	284	PF00069	0.332
MOD_NEK2_1	294	299	PF00069	0.370
MOD_NEK2_1	300	305	PF00069	0.376
MOD_NEK2_1	346	351	PF00069	0.405
MOD_NEK2_1	352	357	PF00069	0.467
MOD_NEK2_1	36	41	PF00069	0.556
MOD_NEK2_1	386	391	PF00069	0.348
MOD_NEK2_1	406	411	PF00069	0.390
MOD_NEK2_1	432	437	PF00069	0.306
MOD_NEK2_1	462	467	PF00069	0.397
MOD_NEK2_1	499	504	PF00069	0.379
MOD_NEK2_1	527	532	PF00069	0.328
MOD_NEK2_2	518	523	PF00069	0.466
MOD_OFUCOSY	102	109	PF10250	0.385
MOD_PIKK_1	581	587	PF00454	0.526
MOD_PKA_2	231	237	PF00069	0.377
MOD_PKA_2	238	244	PF00069	0.405
MOD_PKB_1	539	547	PF00069	0.463
MOD_PKB_1	86	94	PF00069	0.513
MOD_Plk_1	335	341	PF00069	0.538
MOD_Plk_1	432	438	PF00069	0.342
MOD_Plk_1	528	534	PF00069	0.470
MOD_Plk_1	592	598	PF00069	0.632
MOD_Plk_4	256	262	PF00069	0.366
MOD_Plk_4	386	392	PF00069	0.286
MOD_Plk_4	402	408	PF00069	0.368
MOD_Plk_4	477	483	PF00069	0.496
MOD_Plk_4	542	548	PF00069	0.412
MOD_ProDKin_1	69	75	PF00069	0.592
MOD_SUMO_for_1	12	15	PF00179	0.475
TRG_DiLeu_BaEn_1	164	169	PF01217	0.462
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.363
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.428
TRG_ENDOCYTIC_2	132	135	PF00928	0.363
TRG_ENDOCYTIC_2	204	207	PF00928	0.425
TRG_ENDOCYTIC_2	344	347	PF00928	0.460
TRG_ENDOCYTIC_2	436	439	PF00928	0.233
TRG_ER_diArg_1	143	146	PF00400	0.543
TRG_ER_diArg_1	288	291	PF00400	0.438
TRG_ER_diArg_1	539	542	PF00400	0.435
TRG_ER_diArg_1	547	549	PF00400	0.400
TRG_ER_diArg_1	57	59	PF00400	0.615
TRG_ER_diArg_1	86	88	PF00400	0.533
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	589	593	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P389	Leptomonas seymouri	68%	100%
A0A1X0NSQ4	Trypanosomatidae	32%	100%
A0A3Q8IPA0	Leishmania donovani	94%	100%
A0A422N1Z7	Trypanosoma rangeli	34%	100%
A4HF21	Leishmania braziliensis	91%	100%
A4I2A0	Leishmania infantum	95%	88%
C9ZRP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	93%
Q4Q928	Leishmania major	94%	100%
V5B197	Trypanosoma cruzi	33%	100%