Phosphatidate cytidylyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CDP-DAG synthase, putative

Species:

Leishmania mexicana

UniProt:

E9AYE1_LEIMU

TriTrypDb:

LmxM.26.1620

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

E9AYE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYE1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0016024	CDP-diacylglycerol biosynthetic process	6	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046341	CDP-diacylglycerol metabolic process	6	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006655	phosphatidylglycerol biosynthetic process	6	1
GO:0046471	phosphatidylglycerol metabolic process	6	1
GO:0046488	phosphatidylinositol metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004605	phosphatidate cytidylyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0070567	cytidylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.730
CLV_C14_Caspase3-7	51	55	PF00656	0.732
CLV_MEL_PAP_1	83	89	PF00089	0.530
CLV_NRD_NRD_1	110	112	PF00675	0.244
CLV_NRD_NRD_1	176	178	PF00675	0.255
CLV_NRD_NRD_1	238	240	PF00675	0.335
CLV_PCSK_KEX2_1	352	354	PF00082	0.244
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.244
CLV_PCSK_SKI1_1	240	244	PF00082	0.331
CLV_PCSK_SKI1_1	328	332	PF00082	0.525
CLV_PCSK_SKI1_1	352	356	PF00082	0.244
CLV_PCSK_SKI1_1	406	410	PF00082	0.395
CLV_PCSK_SKI1_1	421	425	PF00082	0.312
CLV_PCSK_SKI1_1	66	70	PF00082	0.282
CLV_PCSK_SKI1_1	8	12	PF00082	0.457
DEG_APCC_DBOX_1	238	246	PF00400	0.444
DEG_APCC_DBOX_1	7	15	PF00400	0.717
DEG_APCC_DBOX_1	85	93	PF00400	0.443
DOC_CYCLIN_RxL_1	235	246	PF00134	0.455
DOC_CYCLIN_RxL_1	415	426	PF00134	0.457
DOC_MAPK_DCC_7	111	121	PF00069	0.484
DOC_MAPK_gen_1	111	121	PF00069	0.455
DOC_MAPK_gen_1	239	245	PF00069	0.537
DOC_MAPK_gen_1	3	12	PF00069	0.693
DOC_MAPK_MEF2A_6	112	121	PF00069	0.478
DOC_MAPK_MEF2A_6	5	14	PF00069	0.715
DOC_MAPK_MEF2A_6	86	93	PF00069	0.416
DOC_MAPK_NFAT4_5	86	94	PF00069	0.416
DOC_MAPK_RevD_3	165	178	PF00069	0.303
DOC_PP2B_LxvP_1	339	342	PF13499	0.296
DOC_PP4_FxxP_1	216	219	PF00568	0.296
DOC_USP7_MATH_1	42	46	PF00917	0.726
DOC_USP7_MATH_1	48	52	PF00917	0.729
DOC_USP7_UBL2_3	352	356	PF12436	0.444
DOC_WW_Pin1_4	19	24	PF00397	0.676
DOC_WW_Pin1_4	243	248	PF00397	0.444
DOC_WW_Pin1_4	321	326	PF00397	0.328
LIG_14-3-3_CanoR_1	416	420	PF00244	0.562
LIG_14-3-3_CanoR_1	86	90	PF00244	0.151
LIG_Actin_WH2_2	162	179	PF00022	0.296
LIG_APCC_ABBAyCdc20_2	389	395	PF00400	0.571
LIG_BRCT_BRCA1_1	117	121	PF00533	0.530
LIG_BRCT_BRCA1_1	264	268	PF00533	0.381
LIG_BRCT_BRCA1_1	96	100	PF00533	0.404
LIG_BRCT_BRCA1_2	117	123	PF00533	0.530
LIG_Clathr_ClatBox_1	92	96	PF01394	0.443
LIG_deltaCOP1_diTrp_1	227	233	PF00928	0.296
LIG_FHA_1	219	225	PF00498	0.365
LIG_FHA_1	284	290	PF00498	0.325
LIG_FHA_1	317	323	PF00498	0.325
LIG_FHA_2	15	21	PF00498	0.691
LIG_FHA_2	289	295	PF00498	0.140
LIG_FHA_2	34	40	PF00498	0.692
LIG_GBD_Chelix_1	128	136	PF00786	0.151
LIG_GBD_Chelix_1	419	427	PF00786	0.407
LIG_LIR_Gen_1	144	154	PF02991	0.339
LIG_LIR_Gen_1	189	197	PF02991	0.312
LIG_LIR_Gen_1	227	237	PF02991	0.381
LIG_LIR_Gen_1	335	343	PF02991	0.381
LIG_LIR_Gen_1	390	401	PF02991	0.534
LIG_LIR_Gen_1	67	77	PF02991	0.312
LIG_LIR_Gen_1	88	95	PF02991	0.334
LIG_LIR_Nem_3	144	150	PF02991	0.278
LIG_LIR_Nem_3	151	157	PF02991	0.253
LIG_LIR_Nem_3	227	232	PF02991	0.353
LIG_LIR_Nem_3	265	271	PF02991	0.340
LIG_LIR_Nem_3	335	339	PF02991	0.381
LIG_LIR_Nem_3	359	363	PF02991	0.444
LIG_LIR_Nem_3	384	388	PF02991	0.440
LIG_LIR_Nem_3	390	396	PF02991	0.507
LIG_LIR_Nem_3	57	63	PF02991	0.523
LIG_LIR_Nem_3	67	72	PF02991	0.320
LIG_LIR_Nem_3	88	93	PF02991	0.316
LIG_LIR_Nem_3	97	103	PF02991	0.322
LIG_MAD2	8	16	PF02301	0.707
LIG_PCNA_yPIPBox_3	225	239	PF02747	0.416
LIG_PCNA_yPIPBox_3	410	424	PF02747	0.587
LIG_PDZ_Class_2	424	429	PF00595	0.636
LIG_Pex14_1	229	233	PF04695	0.296
LIG_Pex14_1	264	268	PF04695	0.298
LIG_Pex14_2	233	237	PF04695	0.444
LIG_Pex14_2	254	258	PF04695	0.296
LIG_Pex14_2	260	264	PF04695	0.296
LIG_Pex14_2	271	275	PF04695	0.296
LIG_Pex14_2	343	347	PF04695	0.296
LIG_PTB_Apo_2	293	300	PF02174	0.330
LIG_SH2_CRK	154	158	PF00017	0.349
LIG_SH2_CRK	183	187	PF00017	0.468
LIG_SH2_PTP2	75	78	PF00017	0.331
LIG_SH2_STAT3	181	184	PF00017	0.444
LIG_SH2_STAT5	125	128	PF00017	0.401
LIG_SH2_STAT5	231	234	PF00017	0.381
LIG_SH2_STAT5	279	282	PF00017	0.260
LIG_SH2_STAT5	385	388	PF00017	0.443
LIG_SH2_STAT5	391	394	PF00017	0.477
LIG_SH2_STAT5	75	78	PF00017	0.299
LIG_SH3_3	301	307	PF00018	0.261
LIG_SH3_3	7	13	PF00018	0.642
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.584
LIG_SUMO_SIM_par_1	241	246	PF11976	0.454
LIG_TRFH_1	154	158	PF08558	0.349
LIG_TYR_ITIM	58	63	PF00017	0.640
LIG_UBA3_1	171	178	PF00899	0.396
LIG_UBA3_1	242	249	PF00899	0.451
LIG_WRC_WIRS_1	263	268	PF05994	0.416
LIG_WRC_WIRS_1	318	323	PF05994	0.311
LIG_WRC_WIRS_1	333	338	PF05994	0.223
MOD_CDC14_SPxK_1	246	249	PF00782	0.444
MOD_CDK_SPK_2	243	248	PF00069	0.444
MOD_CDK_SPxK_1	243	249	PF00069	0.444
MOD_CDK_SPxxK_3	321	328	PF00069	0.330
MOD_CK1_1	46	52	PF00069	0.713
MOD_CK2_1	288	294	PF00069	0.293
MOD_CMANNOS	264	267	PF00535	0.312
MOD_Cter_Amidation	237	240	PF01082	0.349
MOD_GlcNHglycan	313	316	PF01048	0.530
MOD_GlcNHglycan	348	351	PF01048	0.296
MOD_GlcNHglycan	46	49	PF01048	0.550
MOD_GlcNHglycan	50	53	PF01048	0.532
MOD_GSK3_1	243	250	PF00069	0.450
MOD_GSK3_1	258	265	PF00069	0.296
MOD_GSK3_1	317	324	PF00069	0.284
MOD_GSK3_1	42	49	PF00069	0.730
MOD_N-GLC_1	64	69	PF02516	0.312
MOD_NEK2_1	143	148	PF00069	0.285
MOD_NEK2_1	172	177	PF00069	0.293
MOD_NEK2_1	258	263	PF00069	0.312
MOD_NEK2_1	317	322	PF00069	0.311
MOD_NEK2_1	346	351	PF00069	0.282
MOD_NEK2_1	423	428	PF00069	0.539
MOD_PIKK_1	288	294	PF00454	0.196
MOD_PKA_2	415	421	PF00069	0.536
MOD_PKA_2	85	91	PF00069	0.151
MOD_Plk_1	143	149	PF00069	0.140
MOD_Plk_1	25	31	PF00069	0.762
MOD_Plk_1	64	70	PF00069	0.312
MOD_Plk_1	95	101	PF00069	0.341
MOD_Plk_4	115	121	PF00069	0.455
MOD_Plk_4	132	138	PF00069	0.368
MOD_Plk_4	317	323	PF00069	0.319
MOD_Plk_4	335	341	PF00069	0.113
MOD_Plk_4	415	421	PF00069	0.599
MOD_Plk_4	95	101	PF00069	0.308
MOD_ProDKin_1	19	25	PF00069	0.678
MOD_ProDKin_1	243	249	PF00069	0.444
MOD_ProDKin_1	321	327	PF00069	0.328
MOD_SUMO_rev_2	51	58	PF00179	0.713
TRG_DiLeu_BaEn_1	7	12	PF01217	0.584
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.745
TRG_ENDOCYTIC_2	125	128	PF00928	0.409
TRG_ENDOCYTIC_2	154	157	PF00928	0.260
TRG_ENDOCYTIC_2	183	186	PF00928	0.455
TRG_ENDOCYTIC_2	385	388	PF00928	0.467
TRG_ENDOCYTIC_2	60	63	PF00928	0.541
TRG_ENDOCYTIC_2	75	78	PF00928	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P387	Leptomonas seymouri	81%	100%
A0A0S4JNH9	Bodo saltans	52%	100%
A0A1X0NS18	Trypanosomatidae	57%	100%
A0A3S7WZX3	Leishmania donovani	91%	100%
A0A422N205	Trypanosoma rangeli	54%	100%
A0JNC1	Bos taurus	34%	96%
A4HF17	Leishmania braziliensis	85%	100%
A4I295	Leishmania infantum	91%	100%
C9ZRP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
O04928	Arabidopsis thaliana	36%	100%
O04940	Solanum tuberosum	38%	100%
O35052	Rattus norvegicus	35%	93%
O49639	Arabidopsis thaliana	37%	100%
O95674	Homo sapiens	33%	96%
P38221	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	94%
P53439	Caenorhabditis elegans	32%	92%
P56079	Drosophila melanogaster	33%	96%
P98191	Mus musculus	35%	93%
Q1PE48	Arabidopsis thaliana	36%	91%
Q4Q932	Leishmania major	92%	100%
Q55D90	Dictyostelium discoideum	36%	90%
Q91XU8	Rattus norvegicus	34%	97%
Q92903	Homo sapiens	35%	93%
Q99L43	Mus musculus	34%	97%
Q9P381	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	98%
V5D1I7	Trypanosoma cruzi	56%	100%