Proline dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Proline dehydrogenase, mitochondrial

Species:

Leishmania mexicana

UniProt:

E9AYE0_LEIMU

TriTrypDb:

LmxM.26.1610

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYE0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006520	amino acid metabolic process	3	12
GO:0006560	proline metabolic process	6	12
GO:0006562	proline catabolic process	5	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009063	amino acid catabolic process	4	12
GO:0009064	glutamine family amino acid metabolic process	5	12
GO:0009065	glutamine family amino acid catabolic process	6	12
GO:0009987	cellular process	1	12
GO:0016054	organic acid catabolic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046395	carboxylic acid catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12
GO:1901605	alpha-amino acid metabolic process	4	12
GO:1901606	alpha-amino acid catabolic process	5	12
GO:0006536	glutamate metabolic process	6	1
GO:0010133	proline catabolic process to glutamate	6	1
GO:0043648	dicarboxylic acid metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004657	proline dehydrogenase activity	5	12
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	6
GO:0016491	oxidoreductase activity	2	12
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	12
GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	4	12
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0000166	nucleotide binding	3	1
GO:0036094	small molecule binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.532
CLV_C14_Caspase3-7	542	546	PF00656	0.603
CLV_MEL_PAP_1	203	209	PF00089	0.328
CLV_MEL_PAP_1	487	493	PF00089	0.332
CLV_NRD_NRD_1	2	4	PF00675	0.640
CLV_NRD_NRD_1	240	242	PF00675	0.575
CLV_NRD_NRD_1	279	281	PF00675	0.505
CLV_NRD_NRD_1	532	534	PF00675	0.246
CLV_NRD_NRD_1	557	559	PF00675	0.400
CLV_PCSK_KEX2_1	2	4	PF00082	0.640
CLV_PCSK_KEX2_1	448	450	PF00082	0.287
CLV_PCSK_KEX2_1	483	485	PF00082	0.199
CLV_PCSK_KEX2_1	532	534	PF00082	0.246
CLV_PCSK_KEX2_1	556	558	PF00082	0.393
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.307
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.199
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.513
CLV_PCSK_SKI1_1	2	6	PF00082	0.655
CLV_PCSK_SKI1_1	220	224	PF00082	0.468
CLV_PCSK_SKI1_1	271	275	PF00082	0.551
CLV_PCSK_SKI1_1	291	295	PF00082	0.308
CLV_PCSK_SKI1_1	448	452	PF00082	0.287
CLV_PCSK_SKI1_1	553	557	PF00082	0.416
DEG_Nend_UBRbox_1	1	4	PF02207	0.675
DOC_CYCLIN_yClb5_NLxxxL_5	500	507	PF00134	0.532
DOC_MAPK_gen_1	241	247	PF00069	0.499
DOC_MAPK_gen_1	460	466	PF00069	0.532
DOC_MAPK_MEF2A_6	500	507	PF00069	0.532
DOC_MAPK_MEF2A_6	51	58	PF00069	0.442
DOC_PP1_RVXF_1	488	494	PF00149	0.532
DOC_PP2B_LxvP_1	503	506	PF13499	0.458
DOC_USP7_MATH_1	18	22	PF00917	0.677
DOC_USP7_MATH_1	205	209	PF00917	0.328
DOC_USP7_MATH_1	315	319	PF00917	0.532
DOC_USP7_MATH_1	65	69	PF00917	0.514
DOC_USP7_UBL2_3	322	326	PF12436	0.532
DOC_USP7_UBL2_3	73	77	PF12436	0.465
DOC_WW_Pin1_4	180	185	PF00397	0.537
DOC_WW_Pin1_4	301	306	PF00397	0.458
DOC_WW_Pin1_4	427	432	PF00397	0.438
LIG_14-3-3_CanoR_1	19	24	PF00244	0.621
LIG_14-3-3_CanoR_1	206	214	PF00244	0.328
LIG_14-3-3_CanoR_1	331	335	PF00244	0.443
LIG_14-3-3_CanoR_1	42	50	PF00244	0.413
LIG_14-3-3_CanoR_1	420	428	PF00244	0.551
LIG_14-3-3_CanoR_1	490	494	PF00244	0.532
LIG_14-3-3_CanoR_1	57	62	PF00244	0.533
LIG_Clathr_ClatBox_1	298	302	PF01394	0.532
LIG_EH1_1	47	55	PF00400	0.501
LIG_eIF4E_1	48	54	PF01652	0.497
LIG_FHA_1	272	278	PF00498	0.532
LIG_FHA_1	280	286	PF00498	0.347
LIG_FHA_1	293	299	PF00498	0.487
LIG_FHA_1	427	433	PF00498	0.532
LIG_FHA_1	476	482	PF00498	0.487
LIG_FHA_1	502	508	PF00498	0.446
LIG_FHA_1	82	88	PF00498	0.550
LIG_FHA_2	221	227	PF00498	0.523
LIG_FHA_2	384	390	PF00498	0.460
LIG_FHA_2	433	439	PF00498	0.447
LIG_FHA_2	540	546	PF00498	0.632
LIG_LIR_Gen_1	248	256	PF02991	0.435
LIG_LIR_Gen_1	60	71	PF02991	0.467
LIG_LIR_Gen_1	84	93	PF02991	0.431
LIG_LIR_Nem_3	248	252	PF02991	0.433
LIG_LIR_Nem_3	323	328	PF02991	0.425
LIG_LIR_Nem_3	351	357	PF02991	0.456
LIG_LIR_Nem_3	379	384	PF02991	0.444
LIG_LIR_Nem_3	430	436	PF02991	0.458
LIG_LIR_Nem_3	45	50	PF02991	0.360
LIG_LIR_Nem_3	492	496	PF02991	0.509
LIG_LIR_Nem_3	84	88	PF02991	0.403
LIG_LIR_Nem_3	92	97	PF02991	0.382
LIG_Pex14_1	218	222	PF04695	0.362
LIG_Pex14_2	493	497	PF04695	0.532
LIG_Pex14_2	93	97	PF04695	0.443
LIG_SH2_CRK	249	253	PF00017	0.447
LIG_SH2_CRK	428	432	PF00017	0.446
LIG_SH2_CRK	515	519	PF00017	0.461
LIG_SH2_CRK	520	524	PF00017	0.431
LIG_SH2_CRK	85	89	PF00017	0.394
LIG_SH2_NCK_1	443	447	PF00017	0.507
LIG_SH2_STAP1	124	128	PF00017	0.403
LIG_SH2_STAP1	85	89	PF00017	0.458
LIG_SH2_STAT3	415	418	PF00017	0.455
LIG_SH2_STAT5	287	290	PF00017	0.384
LIG_SH2_STAT5	384	387	PF00017	0.446
LIG_SH2_STAT5	415	418	PF00017	0.541
LIG_SH2_STAT5	428	431	PF00017	0.449
LIG_SH2_STAT5	48	51	PF00017	0.468
LIG_SH2_STAT5	517	520	PF00017	0.446
LIG_SH2_STAT5	529	532	PF00017	0.446
LIG_SH2_STAT5	63	66	PF00017	0.409
LIG_SH2_STAT5	96	99	PF00017	0.429
LIG_SH3_1	3	9	PF00018	0.666
LIG_SH3_1	516	522	PF00018	0.446
LIG_SH3_2	519	524	PF14604	0.446
LIG_SH3_3	148	154	PF00018	0.566
LIG_SH3_3	27	33	PF00018	0.514
LIG_SH3_3	273	279	PF00018	0.362
LIG_SH3_3	3	9	PF00018	0.666
LIG_SH3_3	516	522	PF00018	0.441
LIG_SH3_4	153	160	PF00018	0.488
LIG_SUMO_SIM_anti_2	472	478	PF11976	0.532
LIG_SUMO_SIM_par_1	297	302	PF11976	0.476
LIG_TRAF2_1	223	226	PF00917	0.448
LIG_TRAF2_1	435	438	PF00917	0.458
LIG_TYR_ITIM	247	252	PF00017	0.453
LIG_TYR_ITIM	518	523	PF00017	0.446
LIG_TYR_ITIM	83	88	PF00017	0.395
LIG_UBA3_1	334	340	PF00899	0.489
LIG_UBA3_1	551	556	PF00899	0.512
LIG_WRC_WIRS_1	451	456	PF05994	0.551
MOD_CDK_SPK_2	180	185	PF00069	0.564
MOD_CDK_SPxxK_3	301	308	PF00069	0.367
MOD_CK1_1	146	152	PF00069	0.431
MOD_CK1_1	180	186	PF00069	0.547
MOD_CK1_1	489	495	PF00069	0.509
MOD_CK1_1	539	545	PF00069	0.604
MOD_CK1_1	81	87	PF00069	0.502
MOD_CK2_1	220	226	PF00069	0.526
MOD_CK2_1	315	321	PF00069	0.453
MOD_CK2_1	383	389	PF00069	0.460
MOD_CK2_1	431	437	PF00069	0.443
MOD_Cter_Amidation	530	533	PF01082	0.246
MOD_GlcNHglycan	140	143	PF01048	0.640
MOD_GlcNHglycan	16	19	PF01048	0.623
MOD_GlcNHglycan	207	210	PF01048	0.335
MOD_GlcNHglycan	317	320	PF01048	0.351
MOD_GlcNHglycan	44	47	PF01048	0.494
MOD_GSK3_1	14	21	PF00069	0.622
MOD_GSK3_1	145	152	PF00069	0.374
MOD_GSK3_1	210	217	PF00069	0.404
MOD_GSK3_1	220	227	PF00069	0.425
MOD_GSK3_1	259	266	PF00069	0.464
MOD_GSK3_1	330	337	PF00069	0.560
MOD_GSK3_1	362	369	PF00069	0.549
MOD_GSK3_1	427	434	PF00069	0.460
MOD_GSK3_1	535	542	PF00069	0.476
MOD_N-GLC_1	501	506	PF02516	0.287
MOD_N-GLC_1	536	541	PF02516	0.271
MOD_N-GLC_1	545	550	PF02516	0.437
MOD_N-GLC_2	440	442	PF02516	0.307
MOD_NEK2_1	106	111	PF00069	0.410
MOD_NEK2_1	14	19	PF00069	0.623
MOD_NEK2_1	177	182	PF00069	0.411
MOD_NEK2_1	210	215	PF00069	0.448
MOD_NEK2_1	334	339	PF00069	0.551
MOD_NEK2_1	366	371	PF00069	0.551
MOD_NEK2_1	465	470	PF00069	0.446
MOD_NEK2_1	83	88	PF00069	0.488
MOD_NEK2_2	350	355	PF00069	0.458
MOD_PK_1	19	25	PF00069	0.640
MOD_PK_1	57	63	PF00069	0.553
MOD_PKA_2	106	112	PF00069	0.514
MOD_PKA_2	18	24	PF00069	0.702
MOD_PKA_2	205	211	PF00069	0.327
MOD_PKA_2	279	285	PF00069	0.358
MOD_PKA_2	330	336	PF00069	0.443
MOD_PKA_2	419	425	PF00069	0.471
MOD_PKA_2	489	495	PF00069	0.526
MOD_Plk_1	143	149	PF00069	0.412
MOD_Plk_1	224	230	PF00069	0.510
MOD_Plk_1	350	356	PF00069	0.446
MOD_Plk_1	36	42	PF00069	0.404
MOD_Plk_1	501	507	PF00069	0.478
MOD_Plk_1	535	541	PF00069	0.458
MOD_Plk_1	545	551	PF00069	0.410
MOD_Plk_4	106	112	PF00069	0.336
MOD_Plk_4	146	152	PF00069	0.435
MOD_Plk_4	172	178	PF00069	0.485
MOD_Plk_4	330	336	PF00069	0.443
MOD_Plk_4	350	356	PF00069	0.438
MOD_Plk_4	477	483	PF00069	0.523
MOD_Plk_4	536	542	PF00069	0.466
MOD_Plk_4	545	551	PF00069	0.430
MOD_Plk_4	59	65	PF00069	0.500
MOD_Plk_4	83	89	PF00069	0.375
MOD_ProDKin_1	180	186	PF00069	0.547
MOD_ProDKin_1	301	307	PF00069	0.458
MOD_ProDKin_1	427	433	PF00069	0.438
MOD_SUMO_for_1	228	231	PF00179	0.504
TRG_DiLeu_BaEn_4	225	231	PF01217	0.538
TRG_ENDOCYTIC_2	249	252	PF00928	0.446
TRG_ENDOCYTIC_2	290	293	PF00928	0.480
TRG_ENDOCYTIC_2	515	518	PF00928	0.461
TRG_ENDOCYTIC_2	520	523	PF00928	0.431
TRG_ENDOCYTIC_2	63	66	PF00928	0.477
TRG_ENDOCYTIC_2	85	88	PF00928	0.402
TRG_ENDOCYTIC_2	94	97	PF00928	0.369
TRG_ER_diArg_1	1	3	PF00400	0.641
TRG_ER_diArg_1	397	400	PF00400	0.532
TRG_ER_diArg_1	41	44	PF00400	0.503
TRG_NLS_MonoExtN_4	553	560	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.225
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUG0	Leptomonas seymouri	77%	99%
A0A0S4JS18	Bodo saltans	38%	99%
A0A1X0NS42	Trypanosomatidae	57%	100%
A0A3Q8IFX0	Leishmania donovani	97%	100%
A0A3R7N3G7	Trypanosoma rangeli	54%	100%
A4HF16	Leishmania braziliensis	91%	100%
A4I294	Leishmania infantum	97%	100%
C9ZRP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
O43272	Homo sapiens	30%	94%
O45228	Caenorhabditis elegans	30%	91%
Q04499	Drosophila melanogaster	30%	82%
Q148G5	Bos taurus	30%	95%
Q4Q933	Leishmania major	96%	100%
Q9WU79	Mus musculus	30%	94%
V5B5Q5	Trypanosoma cruzi	54%	99%