U-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AYD9_LEIMU

TriTrypDb:

LmxM.26.1600

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYD9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.656
CLV_C14_Caspase3-7	382	386	PF00656	0.573
CLV_C14_Caspase3-7	423	427	PF00656	0.524
CLV_C14_Caspase3-7	568	572	PF00656	0.741
CLV_NRD_NRD_1	309	311	PF00675	0.461
CLV_NRD_NRD_1	43	45	PF00675	0.673
CLV_NRD_NRD_1	476	478	PF00675	0.720
CLV_NRD_NRD_1	488	490	PF00675	0.761
CLV_NRD_NRD_1	587	589	PF00675	0.553
CLV_PCSK_FUR_1	485	489	PF00082	0.837
CLV_PCSK_FUR_1	509	513	PF00082	0.711
CLV_PCSK_FUR_1	585	589	PF00082	0.506
CLV_PCSK_KEX2_1	476	478	PF00082	0.721
CLV_PCSK_KEX2_1	487	489	PF00082	0.760
CLV_PCSK_KEX2_1	511	513	PF00082	0.816
CLV_PCSK_KEX2_1	587	589	PF00082	0.520
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.813
CLV_PCSK_SKI1_1	120	124	PF00082	0.561
CLV_PCSK_SKI1_1	193	197	PF00082	0.563
CLV_PCSK_SKI1_1	279	283	PF00082	0.598
CLV_PCSK_SKI1_1	310	314	PF00082	0.558
CLV_PCSK_SKI1_1	378	382	PF00082	0.430
CLV_PCSK_SKI1_1	458	462	PF00082	0.535
DEG_APCC_DBOX_1	119	127	PF00400	0.554
DEG_APCC_DBOX_1	278	286	PF00400	0.563
DEG_APCC_DBOX_1	288	296	PF00400	0.422
DEG_Nend_UBRbox_2	1	3	PF02207	0.579
DEG_SCF_FBW7_1	608	615	PF00400	0.303
DEG_SCF_FBW7_1	93	99	PF00400	0.574
DEG_SPOP_SBC_1	269	273	PF00917	0.427
DEG_SPOP_SBC_1	530	534	PF00917	0.650
DEG_SPOP_SBC_1	613	617	PF00917	0.590
DOC_CKS1_1	93	98	PF01111	0.567
DOC_CYCLIN_RxL_1	187	200	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.609
DOC_MAPK_gen_1	137	146	PF00069	0.512
DOC_MAPK_gen_1	522	530	PF00069	0.550
DOC_MAPK_MEF2A_6	279	287	PF00069	0.413
DOC_MAPK_MEF2A_6	321	329	PF00069	0.474
DOC_PP1_RVXF_1	191	198	PF00149	0.559
DOC_PP1_RVXF_1	74	81	PF00149	0.593
DOC_PP2B_LxvP_1	230	233	PF13499	0.325
DOC_PP4_FxxP_1	250	253	PF00568	0.423
DOC_USP7_MATH_1	174	178	PF00917	0.518
DOC_USP7_MATH_1	269	273	PF00917	0.689
DOC_USP7_MATH_1	349	353	PF00917	0.432
DOC_USP7_MATH_1	376	380	PF00917	0.514
DOC_USP7_MATH_1	391	395	PF00917	0.404
DOC_USP7_MATH_1	52	56	PF00917	0.688
DOC_USP7_MATH_1	554	558	PF00917	0.561
DOC_USP7_MATH_1	572	576	PF00917	0.768
DOC_USP7_MATH_1	94	98	PF00917	0.687
DOC_USP7_MATH_2	579	585	PF00917	0.408
DOC_WW_Pin1_4	265	270	PF00397	0.642
DOC_WW_Pin1_4	34	39	PF00397	0.681
DOC_WW_Pin1_4	448	453	PF00397	0.527
DOC_WW_Pin1_4	50	55	PF00397	0.416
DOC_WW_Pin1_4	531	536	PF00397	0.712
DOC_WW_Pin1_4	608	613	PF00397	0.301
DOC_WW_Pin1_4	92	97	PF00397	0.596
LIG_14-3-3_CanoR_1	109	115	PF00244	0.719
LIG_14-3-3_CanoR_1	120	130	PF00244	0.494
LIG_14-3-3_CanoR_1	228	233	PF00244	0.550
LIG_14-3-3_CanoR_1	378	384	PF00244	0.581
LIG_14-3-3_CanoR_1	392	398	PF00244	0.410
LIG_Actin_WH2_2	294	312	PF00022	0.478
LIG_APCC_ABBA_1	189	194	PF00400	0.255
LIG_BRCT_BRCA1_1	230	234	PF00533	0.504
LIG_EH1_1	182	190	PF00400	0.555
LIG_EH1_1	235	243	PF00400	0.465
LIG_FHA_1	152	158	PF00498	0.566
LIG_FHA_1	194	200	PF00498	0.458
LIG_FHA_1	30	36	PF00498	0.607
LIG_FHA_1	345	351	PF00498	0.427
LIG_FHA_1	534	540	PF00498	0.717
LIG_FHA_1	592	598	PF00498	0.652
LIG_FHA_1	609	615	PF00498	0.340
LIG_FHA_1	93	99	PF00498	0.594
LIG_FHA_2	110	116	PF00498	0.762
LIG_FHA_2	198	204	PF00498	0.493
LIG_FHA_2	298	304	PF00498	0.460
LIG_FHA_2	380	386	PF00498	0.592
LIG_FHA_2	391	397	PF00498	0.443
LIG_LIR_Apic_2	249	253	PF02991	0.436
LIG_LIR_Gen_1	200	208	PF02991	0.594
LIG_LIR_Gen_1	302	313	PF02991	0.588
LIG_LIR_Gen_1	420	425	PF02991	0.536
LIG_LIR_Gen_1	451	461	PF02991	0.618
LIG_LIR_Gen_1	77	88	PF02991	0.395
LIG_LIR_LC3C_4	647	650	PF02991	0.494
LIG_LIR_Nem_3	160	165	PF02991	0.480
LIG_LIR_Nem_3	190	195	PF02991	0.460
LIG_LIR_Nem_3	196	201	PF02991	0.573
LIG_LIR_Nem_3	255	260	PF02991	0.403
LIG_LIR_Nem_3	302	308	PF02991	0.558
LIG_LIR_Nem_3	41	46	PF02991	0.366
LIG_LIR_Nem_3	420	424	PF02991	0.543
LIG_LIR_Nem_3	451	457	PF02991	0.608
LIG_LIR_Nem_3	628	632	PF02991	0.466
LIG_LIR_Nem_3	77	83	PF02991	0.379
LIG_NRBOX	294	300	PF00104	0.555
LIG_NRBOX	64	70	PF00104	0.627
LIG_SH2_CRK	162	166	PF00017	0.555
LIG_SH2_CRK	305	309	PF00017	0.586
LIG_SH2_CRK	454	458	PF00017	0.622
LIG_SH2_CRK	526	530	PF00017	0.700
LIG_SH2_STAP1	305	309	PF00017	0.551
LIG_SH2_STAT5	244	247	PF00017	0.344
LIG_SH2_STAT5	257	260	PF00017	0.499
LIG_SH2_STAT5	265	268	PF00017	0.468
LIG_SH2_STAT5	432	435	PF00017	0.515
LIG_SH2_STAT5	599	602	PF00017	0.472
LIG_SH2_STAT5	619	622	PF00017	0.225
LIG_SH2_STAT5	629	632	PF00017	0.467
LIG_SH3_3	319	325	PF00018	0.451
LIG_SH3_3	32	38	PF00018	0.609
LIG_SH3_3	465	471	PF00018	0.717
LIG_Sin3_3	646	653	PF02671	0.548
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.606
LIG_SUMO_SIM_anti_2	152	160	PF11976	0.566
LIG_SUMO_SIM_anti_2	290	297	PF11976	0.275
LIG_SUMO_SIM_par_1	127	133	PF11976	0.592
LIG_SUMO_SIM_par_1	290	297	PF11976	0.474
LIG_SUMO_SIM_par_1	369	377	PF11976	0.501
LIG_SUMO_SIM_par_1	444	451	PF11976	0.504
LIG_TRAF2_1	200	203	PF00917	0.591
LIG_TYR_ITIM	199	204	PF00017	0.303
LIG_TYR_ITIM	630	635	PF00017	0.590
LIG_WW_3	590	594	PF00397	0.548
MOD_CDK_SPK_2	265	270	PF00069	0.587
MOD_CK1_1	110	116	PF00069	0.605
MOD_CK1_1	121	127	PF00069	0.513
MOD_CK1_1	133	139	PF00069	0.636
MOD_CK1_1	219	225	PF00069	0.586
MOD_CK1_1	268	274	PF00069	0.698
MOD_CK1_1	352	358	PF00069	0.493
MOD_CK1_1	379	385	PF00069	0.547
MOD_CK1_1	408	414	PF00069	0.483
MOD_CK1_1	438	444	PF00069	0.524
MOD_CK1_1	450	456	PF00069	0.547
MOD_CK1_1	504	510	PF00069	0.581
MOD_CK1_1	555	561	PF00069	0.754
MOD_CK1_1	92	98	PF00069	0.582
MOD_CK2_1	109	115	PF00069	0.714
MOD_CK2_1	150	156	PF00069	0.578
MOD_CK2_1	197	203	PF00069	0.585
MOD_CK2_1	28	34	PF00069	0.567
MOD_CK2_1	390	396	PF00069	0.505
MOD_CK2_1	555	561	PF00069	0.829
MOD_CK2_1	78	84	PF00069	0.483
MOD_GlcNHglycan	109	112	PF01048	0.633
MOD_GlcNHglycan	132	135	PF01048	0.632
MOD_GlcNHglycan	176	179	PF01048	0.528
MOD_GlcNHglycan	223	226	PF01048	0.620
MOD_GlcNHglycan	230	233	PF01048	0.507
MOD_GlcNHglycan	357	360	PF01048	0.437
MOD_GlcNHglycan	393	396	PF01048	0.521
MOD_GlcNHglycan	410	413	PF01048	0.342
MOD_GlcNHglycan	426	429	PF01048	0.578
MOD_GlcNHglycan	46	49	PF01048	0.641
MOD_GlcNHglycan	506	509	PF01048	0.600
MOD_GlcNHglycan	638	641	PF01048	0.502
MOD_GlcNHglycan	98	101	PF01048	0.599
MOD_GSK3_1	110	117	PF00069	0.620
MOD_GSK3_1	157	164	PF00069	0.511
MOD_GSK3_1	193	200	PF00069	0.461
MOD_GSK3_1	219	226	PF00069	0.678
MOD_GSK3_1	265	272	PF00069	0.633
MOD_GSK3_1	283	290	PF00069	0.312
MOD_GSK3_1	30	37	PF00069	0.686
MOD_GSK3_1	4	11	PF00069	0.575
MOD_GSK3_1	420	427	PF00069	0.607
MOD_GSK3_1	435	442	PF00069	0.441
MOD_GSK3_1	46	53	PF00069	0.388
MOD_GSK3_1	497	504	PF00069	0.828
MOD_GSK3_1	529	536	PF00069	0.702
MOD_GSK3_1	552	559	PF00069	0.748
MOD_GSK3_1	599	606	PF00069	0.466
MOD_GSK3_1	608	615	PF00069	0.345
MOD_GSK3_1	92	99	PF00069	0.655
MOD_N-GLC_1	367	372	PF02516	0.499
MOD_NEK2_1	101	106	PF00069	0.742
MOD_NEK2_1	204	209	PF00069	0.544
MOD_NEK2_1	28	33	PF00069	0.559
MOD_NEK2_1	283	288	PF00069	0.511
MOD_NEK2_1	294	299	PF00069	0.377
MOD_NEK2_1	344	349	PF00069	0.549
MOD_NEK2_1	4	9	PF00069	0.642
MOD_NEK2_1	447	452	PF00069	0.536
MOD_NEK2_1	46	51	PF00069	0.545
MOD_NEK2_1	529	534	PF00069	0.584
MOD_NEK2_1	603	608	PF00069	0.475
MOD_NEK2_1	614	619	PF00069	0.482
MOD_NEK2_2	223	228	PF00069	0.417
MOD_NEK2_2	339	344	PF00069	0.530
MOD_NEK2_2	376	381	PF00069	0.298
MOD_NEK2_2	38	43	PF00069	0.382
MOD_PIKK_1	121	127	PF00454	0.540
MOD_PIKK_1	216	222	PF00454	0.678
MOD_PIKK_1	541	547	PF00454	0.733
MOD_PIKK_1	57	63	PF00454	0.659
MOD_PKA_1	44	50	PF00069	0.650
MOD_PKA_2	269	275	PF00069	0.425
MOD_PKA_2	391	397	PF00069	0.597
MOD_PKA_2	504	510	PF00069	0.594
MOD_PKB_1	501	509	PF00069	0.655
MOD_Plk_1	118	124	PF00069	0.619
MOD_Plk_1	151	157	PF00069	0.468
MOD_Plk_1	193	199	PF00069	0.454
MOD_Plk_1	339	345	PF00069	0.500
MOD_Plk_1	366	372	PF00069	0.543
MOD_Plk_1	376	382	PF00069	0.548
MOD_Plk_1	541	547	PF00069	0.629
MOD_Plk_1	581	587	PF00069	0.564
MOD_Plk_2-3	556	562	PF00069	0.805
MOD_Plk_4	193	199	PF00069	0.476
MOD_Plk_4	252	258	PF00069	0.528
MOD_Plk_4	283	289	PF00069	0.494
MOD_Plk_4	294	300	PF00069	0.404
MOD_Plk_4	339	345	PF00069	0.523
MOD_Plk_4	367	373	PF00069	0.457
MOD_Plk_4	38	44	PF00069	0.385
MOD_Plk_4	4	10	PF00069	0.647
MOD_Plk_4	420	426	PF00069	0.618
MOD_Plk_4	603	609	PF00069	0.476
MOD_ProDKin_1	265	271	PF00069	0.656
MOD_ProDKin_1	34	40	PF00069	0.687
MOD_ProDKin_1	448	454	PF00069	0.522
MOD_ProDKin_1	50	56	PF00069	0.415
MOD_ProDKin_1	531	537	PF00069	0.717
MOD_ProDKin_1	608	614	PF00069	0.305
MOD_ProDKin_1	92	98	PF00069	0.598
MOD_SUMO_for_1	654	657	PF00179	0.509
MOD_SUMO_rev_2	133	138	PF00179	0.349
TRG_DiLeu_BaEn_2	117	123	PF01217	0.566
TRG_DiLeu_BaEn_2	339	345	PF01217	0.500
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.535
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.587
TRG_ENDOCYTIC_2	162	165	PF00928	0.450
TRG_ENDOCYTIC_2	201	204	PF00928	0.590
TRG_ENDOCYTIC_2	248	251	PF00928	0.485
TRG_ENDOCYTIC_2	257	260	PF00928	0.526
TRG_ENDOCYTIC_2	305	308	PF00928	0.599
TRG_ENDOCYTIC_2	454	457	PF00928	0.612
TRG_ENDOCYTIC_2	526	529	PF00928	0.701
TRG_ENDOCYTIC_2	632	635	PF00928	0.599
TRG_ER_diArg_1	443	446	PF00400	0.561
TRG_ER_diArg_1	476	479	PF00400	0.713
TRG_ER_diArg_1	484	487	PF00400	0.816
TRG_ER_diArg_1	586	588	PF00400	0.500
TRG_NES_CRM1_1	181	194	PF08389	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I134	Leptomonas seymouri	43%	100%
A0A3S7WZX2	Leishmania donovani	88%	100%
A4HF15	Leishmania braziliensis	74%	100%
A4I293	Leishmania infantum	88%	100%
Q4Q934	Leishmania major	89%	100%