Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYD7_LEIMU

TriTrypDb:

LmxM.26.1580

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.504
CLV_C14_Caspase3-7	238	242	PF00656	0.363
CLV_C14_Caspase3-7	268	272	PF00656	0.300
CLV_C14_Caspase3-7	47	51	PF00656	0.533
CLV_C14_Caspase3-7	562	566	PF00656	0.580
CLV_C14_Caspase3-7	7	11	PF00656	0.593
CLV_NRD_NRD_1	25	27	PF00675	0.497
CLV_NRD_NRD_1	489	491	PF00675	0.482
CLV_NRD_NRD_1	56	58	PF00675	0.453
CLV_NRD_NRD_1	93	95	PF00675	0.507
CLV_PCSK_FUR_1	23	27	PF00082	0.510
CLV_PCSK_FUR_1	91	95	PF00082	0.566
CLV_PCSK_KEX2_1	25	27	PF00082	0.538
CLV_PCSK_KEX2_1	489	491	PF00082	0.482
CLV_PCSK_KEX2_1	91	93	PF00082	0.519
CLV_PCSK_PC7_1	87	93	PF00082	0.572
CLV_PCSK_SKI1_1	141	145	PF00082	0.437
CLV_PCSK_SKI1_1	185	189	PF00082	0.657
CLV_PCSK_SKI1_1	383	387	PF00082	0.366
CLV_PCSK_SKI1_1	399	403	PF00082	0.458
CLV_PCSK_SKI1_1	555	559	PF00082	0.461
DEG_Nend_UBRbox_2	1	3	PF02207	0.677
DEG_SPOP_SBC_1	253	257	PF00917	0.563
DEG_SPOP_SBC_1	310	314	PF00917	0.341
DOC_AGCK_PIF_1	570	575	PF00069	0.417
DOC_ANK_TNKS_1	80	87	PF00023	0.435
DOC_CKS1_1	155	160	PF01111	0.473
DOC_CYCLIN_RxL_1	343	354	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	215	218	PF00134	0.682
DOC_MAPK_gen_1	57	63	PF00069	0.478
DOC_MAPK_MEF2A_6	122	129	PF00069	0.388
DOC_MAPK_MEF2A_6	258	267	PF00069	0.445
DOC_PP1_RVXF_1	553	559	PF00149	0.367
DOC_PP2B_LxvP_1	215	218	PF13499	0.529
DOC_PP4_FxxP_1	46	49	PF00568	0.506
DOC_SPAK_OSR1_1	328	332	PF12202	0.383
DOC_USP7_MATH_1	113	117	PF00917	0.536
DOC_USP7_MATH_1	261	265	PF00917	0.484
DOC_USP7_MATH_1	34	38	PF00917	0.579
DOC_USP7_MATH_1	368	372	PF00917	0.694
DOC_USP7_MATH_1	381	385	PF00917	0.448
DOC_USP7_MATH_1	524	528	PF00917	0.377
DOC_USP7_MATH_1	557	561	PF00917	0.429
DOC_WW_Pin1_4	154	159	PF00397	0.507
DOC_WW_Pin1_4	450	455	PF00397	0.503
DOC_WW_Pin1_4	548	553	PF00397	0.489
DOC_WW_Pin1_4	573	578	PF00397	0.474
DOC_WW_Pin1_4	75	80	PF00397	0.309
LIG_14-3-3_CanoR_1	170	175	PF00244	0.733
LIG_14-3-3_CanoR_1	191	197	PF00244	0.629
LIG_14-3-3_CanoR_1	287	292	PF00244	0.409
LIG_14-3-3_CanoR_1	320	326	PF00244	0.461
LIG_14-3-3_CanoR_1	328	332	PF00244	0.487
LIG_14-3-3_CanoR_1	399	404	PF00244	0.468
LIG_14-3-3_CanoR_1	445	451	PF00244	0.414
LIG_14-3-3_CanoR_1	45	49	PF00244	0.532
LIG_14-3-3_CanoR_1	542	552	PF00244	0.649
LIG_APCC_ABBA_1	137	142	PF00400	0.461
LIG_BRCT_BRCA1_1	325	329	PF00533	0.335
LIG_Clathr_ClatBox_1	532	536	PF01394	0.408
LIG_DLG_GKlike_1	287	295	PF00625	0.419
LIG_FHA_1	155	161	PF00498	0.475
LIG_FHA_1	335	341	PF00498	0.476
LIG_FHA_1	432	438	PF00498	0.461
LIG_FHA_1	501	507	PF00498	0.506
LIG_FHA_1	528	534	PF00498	0.513
LIG_FHA_1	545	551	PF00498	0.407
LIG_FHA_2	131	137	PF00498	0.454
LIG_FHA_2	266	272	PF00498	0.425
LIG_FHA_2	291	297	PF00498	0.438
LIG_FHA_2	37	43	PF00498	0.573
LIG_FHA_2	45	51	PF00498	0.465
LIG_LIR_Apic_2	173	177	PF02991	0.590
LIG_LIR_Apic_2	43	49	PF02991	0.513
LIG_LIR_Gen_1	180	189	PF02991	0.566
LIG_LIR_Gen_1	208	218	PF02991	0.567
LIG_LIR_Gen_1	67	75	PF02991	0.490
LIG_LIR_Nem_3	134	140	PF02991	0.403
LIG_LIR_Nem_3	208	213	PF02991	0.553
LIG_LIR_Nem_3	384	389	PF02991	0.448
LIG_LIR_Nem_3	568	573	PF02991	0.400
LIG_LIR_Nem_3	574	578	PF02991	0.402
LIG_LIR_Nem_3	67	72	PF02991	0.401
LIG_PDZ_Class_2	582	587	PF00595	0.477
LIG_Pex14_1	245	249	PF04695	0.394
LIG_Pex14_1	325	329	PF04695	0.499
LIG_Pex14_2	188	192	PF04695	0.590
LIG_Pex14_2	386	390	PF04695	0.483
LIG_REV1ctd_RIR_1	135	144	PF16727	0.442
LIG_SH2_CRK	472	476	PF00017	0.409
LIG_SH2_GRB2like	249	252	PF00017	0.444
LIG_SH2_PTP2	69	72	PF00017	0.439
LIG_SH2_SRC	227	230	PF00017	0.491
LIG_SH2_SRC	249	252	PF00017	0.659
LIG_SH2_SRC	62	65	PF00017	0.456
LIG_SH2_SRC	69	72	PF00017	0.504
LIG_SH2_STAP1	227	231	PF00017	0.444
LIG_SH2_STAP1	249	253	PF00017	0.512
LIG_SH2_STAP1	579	583	PF00017	0.457
LIG_SH2_STAT3	465	468	PF00017	0.394
LIG_SH2_STAT3	578	581	PF00017	0.481
LIG_SH2_STAT5	246	249	PF00017	0.489
LIG_SH2_STAT5	282	285	PF00017	0.406
LIG_SH2_STAT5	323	326	PF00017	0.448
LIG_SH2_STAT5	573	576	PF00017	0.454
LIG_SH2_STAT5	579	582	PF00017	0.517
LIG_SH2_STAT5	62	65	PF00017	0.434
LIG_SH2_STAT5	69	72	PF00017	0.371
LIG_SH3_3	152	158	PF00018	0.619
LIG_SH3_3	328	334	PF00018	0.447
LIG_SH3_3	362	368	PF00018	0.612
LIG_SH3_3	417	423	PF00018	0.520
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.548
LIG_SUMO_SIM_par_1	307	314	PF11976	0.422
LIG_SUMO_SIM_par_1	521	527	PF11976	0.424
LIG_TYR_ITIM	470	475	PF00017	0.449
LIG_WRC_WIRS_1	162	167	PF05994	0.458
LIG_WRC_WIRS_1	400	405	PF05994	0.490
LIG_WRC_WIRS_1	572	577	PF05994	0.456
MOD_CDC14_SPxK_1	78	81	PF00782	0.294
MOD_CDK_SPK_2	450	455	PF00069	0.503
MOD_CDK_SPxK_1	75	81	PF00069	0.302
MOD_CDK_SPxxK_3	154	161	PF00069	0.476
MOD_CDK_SPxxK_3	548	555	PF00069	0.477
MOD_CK1_1	116	122	PF00069	0.695
MOD_CK1_1	130	136	PF00069	0.363
MOD_CK1_1	252	258	PF00069	0.569
MOD_CK1_1	290	296	PF00069	0.523
MOD_CK1_1	351	357	PF00069	0.394
MOD_CK1_1	36	42	PF00069	0.584
MOD_CK1_1	4	10	PF00069	0.601
MOD_CK1_1	459	465	PF00069	0.576
MOD_CK1_1	526	532	PF00069	0.444
MOD_CK1_1	551	557	PF00069	0.469
MOD_CK2_1	36	42	PF00069	0.646
MOD_GlcNHglycan	115	118	PF01048	0.616
MOD_GlcNHglycan	237	240	PF01048	0.325
MOD_GlcNHglycan	250	254	PF01048	0.491
MOD_GlcNHglycan	301	304	PF01048	0.400
MOD_GlcNHglycan	36	39	PF01048	0.535
MOD_GlcNHglycan	370	373	PF01048	0.550
MOD_GlcNHglycan	510	513	PF01048	0.478
MOD_GSK3_1	1	8	PF00069	0.574
MOD_GSK3_1	249	256	PF00069	0.527
MOD_GSK3_1	261	268	PF00069	0.306
MOD_GSK3_1	286	293	PF00069	0.511
MOD_GSK3_1	32	39	PF00069	0.599
MOD_GSK3_1	323	330	PF00069	0.322
MOD_GSK3_1	368	375	PF00069	0.578
MOD_GSK3_1	399	406	PF00069	0.433
MOD_GSK3_1	40	47	PF00069	0.493
MOD_GSK3_1	446	453	PF00069	0.565
MOD_GSK3_1	456	463	PF00069	0.591
MOD_GSK3_1	497	504	PF00069	0.490
MOD_GSK3_1	508	515	PF00069	0.532
MOD_GSK3_1	523	530	PF00069	0.324
MOD_GSK3_1	544	551	PF00069	0.529
MOD_GSK3_1	573	580	PF00069	0.389
MOD_LATS_1	285	291	PF00433	0.365
MOD_N-GLC_1	372	377	PF02516	0.457
MOD_N-GLC_1	431	436	PF02516	0.392
MOD_N-GLC_1	456	461	PF02516	0.462
MOD_NEK2_1	1	6	PF00069	0.629
MOD_NEK2_1	178	183	PF00069	0.525
MOD_NEK2_1	309	314	PF00069	0.386
MOD_NEK2_1	321	326	PF00069	0.318
MOD_NEK2_1	348	353	PF00069	0.437
MOD_NEK2_1	44	49	PF00069	0.413
MOD_NEK2_1	501	506	PF00069	0.464
MOD_NEK2_1	523	528	PF00069	0.425
MOD_NEK2_1	543	548	PF00069	0.319
MOD_NEK2_2	334	339	PF00069	0.414
MOD_NEK2_2	381	386	PF00069	0.421
MOD_PIKK_1	544	550	PF00454	0.528
MOD_PIKK_1	577	583	PF00454	0.476
MOD_PK_1	339	345	PF00069	0.457
MOD_PKA_2	104	110	PF00069	0.457
MOD_PKA_2	127	133	PF00069	0.463
MOD_PKA_2	286	292	PF00069	0.390
MOD_PKA_2	32	38	PF00069	0.718
MOD_PKA_2	327	333	PF00069	0.391
MOD_PKA_2	44	50	PF00069	0.465
MOD_PKB_1	397	405	PF00069	0.589
MOD_Plk_1	227	233	PF00069	0.369
MOD_Plk_1	372	378	PF00069	0.483
MOD_Plk_1	406	412	PF00069	0.423
MOD_Plk_1	459	465	PF00069	0.500
MOD_Plk_2-3	50	56	PF00069	0.560
MOD_Plk_4	339	345	PF00069	0.530
MOD_Plk_4	460	466	PF00069	0.436
MOD_Plk_4	497	503	PF00069	0.583
MOD_ProDKin_1	154	160	PF00069	0.504
MOD_ProDKin_1	450	456	PF00069	0.493
MOD_ProDKin_1	548	554	PF00069	0.479
MOD_ProDKin_1	573	579	PF00069	0.477
MOD_ProDKin_1	75	81	PF00069	0.312
MOD_SUMO_for_1	338	341	PF00179	0.457
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.597
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.525
TRG_ENDOCYTIC_2	472	475	PF00928	0.429
TRG_ENDOCYTIC_2	69	72	PF00928	0.419
TRG_ER_diArg_1	397	400	PF00400	0.546
TRG_ER_diArg_1	488	490	PF00400	0.488
TRG_ER_diArg_1	90	93	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	489	494	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II93	Leptomonas seymouri	45%	100%
A0A1X0NTK2	Trypanosomatidae	23%	100%
A0A3S7WZW7	Leishmania donovani	90%	100%
A4HF13	Leishmania braziliensis	80%	100%
A4I292	Leishmania infantum	90%	100%
C9ZRP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
Q4Q936	Leishmania major	90%	100%