Putative thimet oligopeptidase (Metallo-peptidase, clan ma(E), family m3)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thimet oligopeptidase, putative

Species:

Leishmania mexicana

UniProt:

E9AYD6_LEIMU

TriTrypDb:

LmxM.26.1570

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYD6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.453
CLV_PCSK_FUR_1	496	500	PF00082	0.377
CLV_PCSK_KEX2_1	151	153	PF00082	0.452
CLV_PCSK_KEX2_1	263	265	PF00082	0.357
CLV_PCSK_KEX2_1	498	500	PF00082	0.375
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.357
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.375
CLV_PCSK_SKI1_1	284	288	PF00082	0.357
CLV_PCSK_SKI1_1	306	310	PF00082	0.317
CLV_PCSK_SKI1_1	32	36	PF00082	0.544
CLV_PCSK_SKI1_1	344	348	PF00082	0.488
CLV_PCSK_SKI1_1	365	369	PF00082	0.357
CLV_PCSK_SKI1_1	460	464	PF00082	0.488
CLV_PCSK_SKI1_1	488	492	PF00082	0.375
CLV_PCSK_SKI1_1	544	548	PF00082	0.412
DEG_APCC_DBOX_1	263	271	PF00400	0.357
DEG_APCC_DBOX_1	549	557	PF00400	0.357
DEG_SCF_FBW7_2	120	127	PF00400	0.328
DOC_CYCLIN_RxL_1	341	351	PF00134	0.484
DOC_CYCLIN_RxL_1	362	369	PF00134	0.357
DOC_CYCLIN_RxL_1	550	562	PF00134	0.435
DOC_MAPK_gen_1	151	157	PF00069	0.453
DOC_MAPK_gen_1	263	271	PF00069	0.435
DOC_MAPK_gen_1	343	349	PF00069	0.392
DOC_MAPK_gen_1	496	504	PF00069	0.375
DOC_MAPK_MEF2A_6	263	271	PF00069	0.432
DOC_PP1_RVXF_1	552	559	PF00149	0.357
DOC_PP4_FxxP_1	566	569	PF00568	0.375
DOC_USP7_MATH_1	2	6	PF00917	0.671
DOC_USP7_MATH_1	320	324	PF00917	0.488
DOC_USP7_MATH_1	38	42	PF00917	0.486
DOC_USP7_MATH_1	479	483	PF00917	0.488
DOC_USP7_MATH_1	574	578	PF00917	0.251
DOC_USP7_UBL2_3	284	288	PF12436	0.527
DOC_USP7_UBL2_3	302	306	PF12436	0.480
DOC_USP7_UBL2_3	540	544	PF12436	0.449
DOC_WW_Pin1_4	120	125	PF00397	0.393
DOC_WW_Pin1_4	322	327	PF00397	0.488
DOC_WW_Pin1_4	440	445	PF00397	0.357
DOC_WW_Pin1_4	80	85	PF00397	0.471
LIG_14-3-3_CanoR_1	111	120	PF00244	0.544
LIG_14-3-3_CanoR_1	488	493	PF00244	0.400
LIG_APCC_ABBA_1	463	468	PF00400	0.375
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BRCT_BRCA1_1	622	626	PF00533	0.372
LIG_deltaCOP1_diTrp_1	510	514	PF00928	0.357
LIG_EH1_1	477	485	PF00400	0.375
LIG_eIF4E_1	409	415	PF01652	0.488
LIG_FHA_1	393	399	PF00498	0.358
LIG_FHA_1	558	564	PF00498	0.409
LIG_FHA_1	578	584	PF00498	0.362
LIG_FHA_1	91	97	PF00498	0.520
LIG_FHA_1	99	105	PF00498	0.458
LIG_FHA_2	307	313	PF00498	0.469
LIG_FHA_2	599	605	PF00498	0.375
LIG_IRF3_LxIS_1	276	282	PF10401	0.488
LIG_LIR_Gen_1	123	131	PF02991	0.340
LIG_LIR_Gen_1	159	168	PF02991	0.526
LIG_LIR_Gen_1	224	234	PF02991	0.488
LIG_LIR_Gen_1	275	281	PF02991	0.419
LIG_LIR_Gen_1	369	379	PF02991	0.370
LIG_LIR_Gen_1	4	13	PF02991	0.554
LIG_LIR_Gen_1	470	480	PF02991	0.359
LIG_LIR_Gen_1	500	509	PF02991	0.376
LIG_LIR_Nem_3	123	129	PF02991	0.341
LIG_LIR_Nem_3	159	165	PF02991	0.474
LIG_LIR_Nem_3	221	225	PF02991	0.447
LIG_LIR_Nem_3	275	279	PF02991	0.398
LIG_LIR_Nem_3	369	374	PF02991	0.434
LIG_LIR_Nem_3	376	382	PF02991	0.488
LIG_LIR_Nem_3	4	10	PF02991	0.558
LIG_LIR_Nem_3	470	476	PF02991	0.359
LIG_LIR_Nem_3	500	504	PF02991	0.376
LIG_LIR_Nem_3	581	587	PF02991	0.436
LIG_LIR_Nem_3	604	610	PF02991	0.357
LIG_LIR_Nem_3	629	634	PF02991	0.357
LIG_NRBOX	266	272	PF00104	0.303
LIG_PCNA_yPIPBox_3	663	672	PF02747	0.478
LIG_PDZ_Class_2	680	685	PF00595	0.358
LIG_Pex14_1	622	626	PF04695	0.357
LIG_Pex14_2	375	379	PF04695	0.357
LIG_Pex14_2	472	476	PF04695	0.357
LIG_Pex14_2	566	570	PF04695	0.357
LIG_Pex14_2	603	607	PF04695	0.378
LIG_PTB_Apo_2	244	251	PF02174	0.435
LIG_PTB_Phospho_1	244	250	PF10480	0.435
LIG_Rb_pABgroove_1	362	370	PF01858	0.357
LIG_SH2_CRK	114	118	PF00017	0.489
LIG_SH2_CRK	333	337	PF00017	0.488
LIG_SH2_NCK_1	126	130	PF00017	0.470
LIG_SH2_NCK_1	333	337	PF00017	0.437
LIG_SH2_PTP2	409	412	PF00017	0.488
LIG_SH2_SRC	333	336	PF00017	0.469
LIG_SH2_STAP1	126	130	PF00017	0.555
LIG_SH2_STAP1	139	143	PF00017	0.356
LIG_SH2_STAP1	561	565	PF00017	0.357
LIG_SH2_STAT3	561	564	PF00017	0.432
LIG_SH2_STAT5	139	142	PF00017	0.417
LIG_SH2_STAT5	225	228	PF00017	0.461
LIG_SH2_STAT5	280	283	PF00017	0.439
LIG_SH2_STAT5	357	360	PF00017	0.357
LIG_SH2_STAT5	409	412	PF00017	0.488
LIG_SH2_STAT5	633	636	PF00017	0.411
LIG_SH2_STAT5	649	652	PF00017	0.346
LIG_SH3_3	426	432	PF00018	0.394
LIG_SH3_3	499	505	PF00018	0.357
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.437
LIG_SUMO_SIM_par_1	394	400	PF11976	0.439
LIG_SUMO_SIM_par_1	431	438	PF11976	0.435
LIG_SUMO_SIM_par_1	95	101	PF11976	0.455
LIG_TRAF2_1	158	161	PF00917	0.551
LIG_TRFH_1	585	589	PF08558	0.384
LIG_TYR_ITIM	407	412	PF00017	0.488
LIG_UBA3_1	338	344	PF00899	0.400
LIG_UBA3_1	518	527	PF00899	0.357
LIG_UBA3_1	6	15	PF00899	0.542
LIG_WRC_WIRS_1	273	278	PF05994	0.435
LIG_WRC_WIRS_1	371	376	PF05994	0.432
LIG_WRC_WIRS_1	469	474	PF05994	0.357
LIG_WRC_WIRS_1	489	494	PF05994	0.375
LIG_WRC_WIRS_1	99	104	PF05994	0.442
MOD_CDC14_SPxK_1	83	86	PF00782	0.530
MOD_CDK_SPxK_1	80	86	PF00069	0.514
MOD_CK1_1	174	180	PF00069	0.528
MOD_CK1_1	203	209	PF00069	0.612
MOD_CK1_1	577	583	PF00069	0.295
MOD_CK1_1	74	80	PF00069	0.405
MOD_CK2_1	306	312	PF00069	0.270
MOD_CK2_1	347	353	PF00069	0.359
MOD_CK2_1	598	604	PF00069	0.375
MOD_GlcNHglycan	114	117	PF01048	0.532
MOD_GlcNHglycan	131	134	PF01048	0.597
MOD_GlcNHglycan	205	208	PF01048	0.562
MOD_GlcNHglycan	402	405	PF01048	0.473
MOD_GlcNHglycan	547	550	PF01048	0.391
MOD_GlcNHglycan	604	607	PF01048	0.464
MOD_GlcNHglycan	70	74	PF01048	0.450
MOD_GSK3_1	181	188	PF00069	0.515
MOD_GSK3_1	318	325	PF00069	0.357
MOD_GSK3_1	388	395	PF00069	0.492
MOD_GSK3_1	484	491	PF00069	0.361
MOD_GSK3_1	51	58	PF00069	0.496
MOD_GSK3_1	521	528	PF00069	0.410
MOD_GSK3_1	545	552	PF00069	0.414
MOD_GSK3_1	574	581	PF00069	0.362
MOD_GSK3_1	598	605	PF00069	0.488
MOD_GSK3_1	74	81	PF00069	0.487
MOD_N-GLC_1	181	186	PF02516	0.480
MOD_N-GLC_1	347	352	PF02516	0.357
MOD_N-GLC_1	383	388	PF02516	0.405
MOD_N-GLC_1	51	56	PF02516	0.661
MOD_N-GLC_1	578	583	PF02516	0.405
MOD_NEK2_1	1	6	PF00069	0.634
MOD_NEK2_1	360	365	PF00069	0.382
MOD_NEK2_1	375	380	PF00069	0.357
MOD_NEK2_1	484	489	PF00069	0.370
MOD_NEK2_1	492	497	PF00069	0.368
MOD_NEK2_1	55	60	PF00069	0.480
MOD_NEK2_1	578	583	PF00069	0.405
MOD_NEK2_1	679	684	PF00069	0.303
MOD_NEK2_1	69	74	PF00069	0.439
MOD_NEK2_2	2	7	PF00069	0.572
MOD_NEK2_2	214	219	PF00069	0.498
MOD_NEK2_2	549	554	PF00069	0.375
MOD_PIKK_1	503	509	PF00454	0.357
MOD_PIKK_1	569	575	PF00454	0.546
MOD_PIKK_1	578	584	PF00454	0.474
MOD_PIKK_1	656	662	PF00454	0.484
MOD_PKA_2	549	555	PF00069	0.416
MOD_PKA_2	574	580	PF00069	0.251
MOD_PKB_1	486	494	PF00069	0.400
MOD_Plk_1	137	143	PF00069	0.397
MOD_Plk_1	214	220	PF00069	0.494
MOD_Plk_1	360	366	PF00069	0.365
MOD_Plk_1	375	381	PF00069	0.357
MOD_Plk_1	38	44	PF00069	0.581
MOD_Plk_1	51	57	PF00069	0.634
MOD_Plk_1	578	584	PF00069	0.400
MOD_Plk_1	8	14	PF00069	0.613
MOD_Plk_2-3	100	106	PF00069	0.474
MOD_Plk_2-3	392	398	PF00069	0.469
MOD_Plk_2-3	63	69	PF00069	0.427
MOD_Plk_4	137	143	PF00069	0.397
MOD_Plk_4	174	180	PF00069	0.602
MOD_Plk_4	2	8	PF00069	0.655
MOD_Plk_4	200	206	PF00069	0.591
MOD_Plk_4	221	227	PF00069	0.421
MOD_Plk_4	342	348	PF00069	0.488
MOD_Plk_4	370	376	PF00069	0.571
MOD_Plk_4	425	431	PF00069	0.423
MOD_Plk_4	468	474	PF00069	0.455
MOD_Plk_4	479	485	PF00069	0.378
MOD_Plk_4	71	77	PF00069	0.374
MOD_ProDKin_1	120	126	PF00069	0.389
MOD_ProDKin_1	322	328	PF00069	0.488
MOD_ProDKin_1	440	446	PF00069	0.357
MOD_ProDKin_1	80	86	PF00069	0.479
MOD_SUMO_rev_2	184	188	PF00179	0.536
MOD_SUMO_rev_2	386	396	PF00179	0.530
MOD_SUMO_rev_2	397	403	PF00179	0.426
MOD_SUMO_rev_2	413	422	PF00179	0.279
MOD_SUMO_rev_2	636	645	PF00179	0.488
TRG_ENDOCYTIC_2	114	117	PF00928	0.444
TRG_ENDOCYTIC_2	126	129	PF00928	0.475
TRG_ENDOCYTIC_2	225	228	PF00928	0.415
TRG_ENDOCYTIC_2	273	276	PF00928	0.449
TRG_ENDOCYTIC_2	357	360	PF00928	0.396
TRG_ENDOCYTIC_2	371	374	PF00928	0.396
TRG_ENDOCYTIC_2	409	412	PF00928	0.470
TRG_ENDOCYTIC_2	618	621	PF00928	0.357
TRG_ER_diArg_1	150	152	PF00400	0.461
TRG_ER_diArg_1	486	489	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	534	538	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N6	Leptomonas seymouri	23%	100%
A0A0N1HT30	Leptomonas seymouri	25%	100%
A0A0N1PBM8	Leptomonas seymouri	82%	100%
A0A0N1PDB7	Leptomonas seymouri	26%	100%
A0A0S4JRG5	Bodo saltans	58%	100%
A0A0S4JWM4	Bodo saltans	26%	100%
A0A1X0NTS0	Trypanosomatidae	63%	100%
A0A1X0P0Z5	Trypanosomatidae	22%	99%
A0A3Q8IKU0	Leishmania donovani	24%	100%
A0A3S5H518	Leishmania donovani	26%	100%
A0A3S7WZY5	Leishmania donovani	95%	100%
A0A422MUB5	Trypanosoma rangeli	62%	100%
A0A422P572	Trypanosoma rangeli	23%	100%
A1CTP5	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	23%	86%
A1DMR2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	86%
A2QWM4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	86%
A2VDQ5	Bos taurus	33%	97%
A3LUT4	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	26%	84%
A4HF12	Leishmania braziliensis	90%	100%
A4HFS7	Leishmania braziliensis	27%	96%
A4HFS8	Leishmania braziliensis	27%	96%
A4HG35	Leishmania braziliensis	26%	100%
A4HG37	Leishmania braziliensis	27%	100%
A4HPW2	Leishmania braziliensis	24%	100%
A4HRR9	Leishmania infantum	26%	100%
A4I291	Leishmania infantum	95%	100%
A4IDM4	Leishmania infantum	24%	100%
A4RF25	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	84%
A5DI46	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	87%
A5E4V6	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	24%	84%
A6H611	Mus musculus	25%	96%
A6SHZ5	Botryotinia fuckeliana (strain B05.10)	27%	90%
A6ZZI7	Saccharomyces cerevisiae (strain YJM789)	28%	89%
A7E7L8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	26%	87%
A7TSL2	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	27%	87%
A8N2T3	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	24%	88%
A8QB25	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	25%	85%
B0CRC2	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	25%	89%
B0Y7Q2	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	23%	86%
C9ZRP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	92%
D0A4B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AC74	Leishmania major	24%	100%
E9ACE8	Leishmania major	26%	100%
E9AJN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ATM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
F4HTQ1	Arabidopsis thaliana	28%	96%
F4KDA5	Arabidopsis thaliana	26%	97%
P0CQ18	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	90%
P0CQ19	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	90%
P0CQ20	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	25%	83%
P0CQ21	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	25%	83%
P24155	Rattus norvegicus	34%	100%
P24171	Escherichia coli (strain K12)	26%	100%
P25375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	96%
P27236	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	100%
P27237	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	29%	100%
P27298	Escherichia coli (strain K12)	29%	100%
P35999	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	89%
P37932	Schizophyllum commune	25%	88%
P42675	Oryctolagus cuniculus	33%	97%
P42676	Rattus norvegicus	33%	97%
P44573	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
P47788	Sus scrofa	34%	100%
P52888	Homo sapiens	34%	99%
Q01992	Rattus norvegicus	26%	96%
Q02038	Sus scrofa	33%	97%
Q0CI79	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	23%	85%
Q0TXL7	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	25%	87%
Q10415	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	90%
Q1E8M9	Coccidioides immitis (strain RS)	25%	86%
Q1JPJ8	Bos taurus	35%	100%
Q2HFL8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	26%	88%
Q2UN31	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	22%	86%
Q4PBS8	Ustilago maydis (strain 521 / FGSC 9021)	24%	77%
Q4Q0W9	Leishmania major	23%	100%
Q4Q937	Leishmania major	94%	100%
Q4WMU9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	86%
Q54DD2	Dictyostelium discoideum	31%	100%
Q59RK9	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	87%
Q5R9V6	Pongo abelii	33%	97%
Q5RF14	Pongo abelii	26%	96%
Q6BJ61	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	86%
Q6CVF7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	88%
Q6FW88	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	90%
Q6VMB4	Leucoagaricus gongylophorus	24%	90%
Q6Y5M5	Pleurotus djamor	26%	87%
Q6Y5M6	Coprinellus disseminatus	25%	89%
Q6Y5M7	Coprinopsis scobicola	27%	89%
Q753X4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	88%
Q7SDD5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	85%
Q8C1A5	Mus musculus	34%	100%
Q91YP2	Mus musculus	33%	97%
Q949P2	Arabidopsis thaliana	27%	98%
Q94AM1	Arabidopsis thaliana	26%	87%
Q99797	Homo sapiens	27%	96%
Q9BYT8	Homo sapiens	33%	97%
V5B526	Trypanosoma cruzi	22%	100%