RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9AYD2_LEIMU

TriTrypDb:

LmxM.26.1530

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AYD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYD2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	119	123	PF00082	0.346
CLV_PCSK_SKI1_1	167	171	PF00082	0.346
DEG_Nend_UBRbox_2	1	3	PF02207	0.713
DEG_SCF_TRCP1_1	40	45	PF00400	0.729
DOC_CYCLIN_RxL_1	116	123	PF00134	0.546
DOC_MAPK_gen_1	140	149	PF00069	0.546
DOC_WW_Pin1_4	179	184	PF00397	0.619
LIG_14-3-3_CanoR_1	119	128	PF00244	0.546
LIG_FHA_1	200	206	PF00498	0.639
LIG_FHA_1	3	9	PF00498	0.577
LIG_FHA_2	149	155	PF00498	0.538
LIG_LIR_Nem_3	123	128	PF02991	0.546
LIG_LIR_Nem_3	78	82	PF02991	0.693
LIG_PAM2_1	6	18	PF00658	0.702
LIG_SH2_CRK	166	170	PF00017	0.546
LIG_SH2_CRK	79	83	PF00017	0.693
LIG_SH3_3	11	17	PF00018	0.710
LIG_SH3_3	19	25	PF00018	0.719
LIG_SH3_3	198	204	PF00018	0.644
LIG_SH3_3	66	72	PF00018	0.500
LIG_TRAF2_1	151	154	PF00917	0.546
MOD_CK1_1	138	144	PF00069	0.546
MOD_CK1_1	199	205	PF00069	0.645
MOD_CK1_1	38	44	PF00069	0.683
MOD_CK1_1	65	71	PF00069	0.717
MOD_CK2_1	148	154	PF00069	0.538
MOD_CK2_1	189	195	PF00069	0.647
MOD_GlcNHglycan	122	125	PF01048	0.313
MOD_GlcNHglycan	17	20	PF01048	0.765
MOD_GlcNHglycan	191	194	PF01048	0.648
MOD_GlcNHglycan	40	43	PF01048	0.784
MOD_GlcNHglycan	64	67	PF01048	0.673
MOD_GlcNHglycan	8	11	PF01048	0.720
MOD_GSK3_1	154	161	PF00069	0.543
MOD_GSK3_1	179	186	PF00069	0.626
MOD_GSK3_1	2	9	PF00069	0.538
MOD_GSK3_1	27	34	PF00069	0.731
MOD_GSK3_1	38	45	PF00069	0.673
MOD_LATS_1	29	35	PF00433	0.812
MOD_N-GLC_1	138	143	PF02516	0.346
MOD_N-GLC_1	183	188	PF02516	0.629
MOD_N-GLC_1	6	11	PF02516	0.691
MOD_N-GLC_1	62	67	PF02516	0.688
MOD_NEK2_1	27	32	PF00069	0.587
MOD_NEK2_1	97	102	PF00069	0.550
MOD_NEK2_2	158	163	PF00069	0.546
MOD_PIKK_1	210	216	PF00454	0.669
MOD_PIKK_1	35	41	PF00454	0.796
MOD_PKB_1	165	173	PF00069	0.546
MOD_Plk_4	65	71	PF00069	0.670
MOD_ProDKin_1	179	185	PF00069	0.624
TRG_ENDOCYTIC_2	125	128	PF00928	0.546
TRG_ENDOCYTIC_2	166	169	PF00928	0.546
TRG_ENDOCYTIC_2	79	82	PF00928	0.808
TRG_ER_diArg_1	55	58	PF00400	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I044	Leptomonas seymouri	71%	95%
A0A3Q8IC83	Leishmania donovani	93%	99%
A4HF08	Leishmania braziliensis	86%	100%
A4I287	Leishmania infantum	93%	99%
Q4Q941	Leishmania major	95%	100%