LeishMANIAdb
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Metallophos domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Metallophos domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9AYC8_LEIMU
TriTrypDb:
LmxM.26.1490
Length:
652

Annotations

LeishMANIAdb annotations

PhoD domain containing alkaline phosphatase. Based on distant Eukaryotic orthologs, an N-terminal signal peptide is likely.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 5, no: 6
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

E9AYC8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYC8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 177 179 PF00675 0.672
CLV_NRD_NRD_1 191 193 PF00675 0.534
CLV_NRD_NRD_1 302 304 PF00675 0.514
CLV_NRD_NRD_1 428 430 PF00675 0.591
CLV_NRD_NRD_1 590 592 PF00675 0.658
CLV_PCSK_KEX2_1 177 179 PF00082 0.672
CLV_PCSK_KEX2_1 191 193 PF00082 0.534
CLV_PCSK_KEX2_1 302 304 PF00082 0.514
CLV_PCSK_KEX2_1 428 430 PF00082 0.591
CLV_PCSK_KEX2_1 589 591 PF00082 0.620
CLV_PCSK_PC1ET2_1 589 591 PF00082 0.620
CLV_PCSK_PC7_1 173 179 PF00082 0.519
CLV_PCSK_SKI1_1 144 148 PF00082 0.586
CLV_PCSK_SKI1_1 207 211 PF00082 0.726
CLV_PCSK_SKI1_1 25 29 PF00082 0.222
CLV_PCSK_SKI1_1 363 367 PF00082 0.499
CLV_PCSK_SKI1_1 375 379 PF00082 0.468
CLV_PCSK_SKI1_1 474 478 PF00082 0.668
DEG_APCC_DBOX_1 191 199 PF00400 0.384
DEG_APCC_DBOX_1 24 32 PF00400 0.385
DEG_APCC_DBOX_1 360 368 PF00400 0.287
DEG_APCC_DBOX_1 428 436 PF00400 0.354
DEG_Nend_Nbox_1 1 3 PF02207 0.595
DOC_ANK_TNKS_1 176 183 PF00023 0.336
DOC_CYCLIN_RxL_1 188 196 PF00134 0.326
DOC_CYCLIN_RxL_1 471 482 PF00134 0.361
DOC_MAPK_gen_1 361 368 PF00069 0.297
DOC_MAPK_gen_1 369 379 PF00069 0.277
DOC_MAPK_gen_1 428 435 PF00069 0.358
DOC_MAPK_gen_1 517 524 PF00069 0.343
DOC_MAPK_MEF2A_6 106 115 PF00069 0.316
DOC_MAPK_MEF2A_6 361 368 PF00069 0.316
DOC_MAPK_MEF2A_6 517 524 PF00069 0.313
DOC_MAPK_MEF2A_6 529 537 PF00069 0.381
DOC_MAPK_MEF2A_6 612 621 PF00069 0.362
DOC_MAPK_NFAT4_5 361 369 PF00069 0.316
DOC_USP7_MATH_1 133 137 PF00917 0.350
DOC_USP7_MATH_1 180 184 PF00917 0.358
DOC_USP7_MATH_1 272 276 PF00917 0.331
DOC_USP7_MATH_1 359 363 PF00917 0.306
DOC_USP7_MATH_1 601 605 PF00917 0.389
DOC_WW_Pin1_4 211 216 PF00397 0.482
DOC_WW_Pin1_4 319 324 PF00397 0.434
DOC_WW_Pin1_4 336 341 PF00397 0.353
DOC_WW_Pin1_4 400 405 PF00397 0.540
DOC_WW_Pin1_4 413 418 PF00397 0.528
LIG_14-3-3_CanoR_1 192 198 PF00244 0.362
LIG_14-3-3_CanoR_1 248 254 PF00244 0.420
LIG_14-3-3_CanoR_1 263 270 PF00244 0.508
LIG_14-3-3_CanoR_1 310 316 PF00244 0.321
LIG_14-3-3_CanoR_1 428 433 PF00244 0.355
LIG_14-3-3_CanoR_1 480 485 PF00244 0.433
LIG_14-3-3_CanoR_1 519 525 PF00244 0.372
LIG_14-3-3_CanoR_1 60 70 PF00244 0.418
LIG_14-3-3_CanoR_1 77 85 PF00244 0.397
LIG_APCC_ABBA_1 576 581 PF00400 0.369
LIG_BIR_III_4 208 212 PF00653 0.417
LIG_BIR_III_4 325 329 PF00653 0.367
LIG_BIR_III_4 465 469 PF00653 0.380
LIG_BRCT_BRCA1_1 29 33 PF00533 0.329
LIG_CaM_NSCaTE_8 85 92 PF13499 0.312
LIG_Clathr_ClatBox_1 534 538 PF01394 0.389
LIG_FHA_1 107 113 PF00498 0.352
LIG_FHA_1 242 248 PF00498 0.351
LIG_FHA_1 403 409 PF00498 0.499
LIG_FHA_1 439 445 PF00498 0.395
LIG_FHA_1 488 494 PF00498 0.374
LIG_FHA_1 502 508 PF00498 0.507
LIG_FHA_1 516 522 PF00498 0.368
LIG_FHA_1 62 68 PF00498 0.405
LIG_FHA_2 183 189 PF00498 0.259
LIG_FHA_2 397 403 PF00498 0.534
LIG_FHA_2 429 435 PF00498 0.414
LIG_FHA_2 441 447 PF00498 0.428
LIG_FHA_2 480 486 PF00498 0.379
LIG_GBD_Chelix_1 449 457 PF00786 0.617
LIG_IBAR_NPY_1 149 151 PF08397 0.258
LIG_Integrin_isoDGR_2 469 471 PF01839 0.582
LIG_LIR_Apic_2 314 318 PF02991 0.332
LIG_LIR_Gen_1 339 345 PF02991 0.351
LIG_LIR_Gen_1 374 383 PF02991 0.394
LIG_LIR_Nem_3 140 146 PF02991 0.346
LIG_LIR_Nem_3 196 202 PF02991 0.227
LIG_LIR_Nem_3 220 224 PF02991 0.331
LIG_LIR_Nem_3 309 315 PF02991 0.303
LIG_LIR_Nem_3 339 344 PF02991 0.312
LIG_LIR_Nem_3 352 357 PF02991 0.294
LIG_LIR_Nem_3 374 379 PF02991 0.389
LIG_LIR_Nem_3 485 491 PF02991 0.326
LIG_LYPXL_yS_3 585 588 PF13949 0.386
LIG_MYND_2 254 258 PF01753 0.292
LIG_NRBOX 363 369 PF00104 0.301
LIG_PTB_Apo_2 114 121 PF02174 0.346
LIG_PTB_Apo_2 146 153 PF02174 0.282
LIG_PTB_Phospho_1 114 120 PF10480 0.346
LIG_PTB_Phospho_1 146 152 PF10480 0.280
LIG_SH2_CRK 143 147 PF00017 0.378
LIG_SH2_NCK_1 120 124 PF00017 0.333
LIG_SH2_NCK_1 579 583 PF00017 0.378
LIG_SH2_SRC 120 123 PF00017 0.300
LIG_SH2_STAT3 632 635 PF00017 0.427
LIG_SH2_STAT5 184 187 PF00017 0.387
LIG_SH2_STAT5 194 197 PF00017 0.358
LIG_SH2_STAT5 315 318 PF00017 0.373
LIG_SH3_1 414 420 PF00018 0.535
LIG_SH3_3 398 404 PF00018 0.561
LIG_SH3_3 414 420 PF00018 0.445
LIG_SUMO_SIM_anti_2 362 368 PF11976 0.356
LIG_SUMO_SIM_anti_2 7 13 PF11976 0.541
LIG_SUMO_SIM_par_1 202 208 PF11976 0.448
LIG_SUMO_SIM_par_1 241 246 PF11976 0.316
LIG_SUMO_SIM_par_1 430 438 PF11976 0.350
LIG_SUMO_SIM_par_1 520 526 PF11976 0.303
LIG_SUMO_SIM_par_1 533 538 PF11976 0.362
LIG_TRAF2_1 264 267 PF00917 0.354
LIG_TRAF2_1 510 513 PF00917 0.432
LIG_TRAF2_1 551 554 PF00917 0.515
LIG_TYR_ITIM 631 636 PF00017 0.509
LIG_UBA3_1 364 372 PF00899 0.301
LIG_WRC_WIRS_1 218 223 PF05994 0.326
MOD_CK1_1 4 10 PF00069 0.720
MOD_CK1_1 438 444 PF00069 0.337
MOD_CK1_1 54 60 PF00069 0.464
MOD_CK1_1 543 549 PF00069 0.399
MOD_CK1_1 61 67 PF00069 0.377
MOD_CK1_1 88 94 PF00069 0.277
MOD_CK2_1 182 188 PF00069 0.249
MOD_CK2_1 261 267 PF00069 0.351
MOD_CK2_1 391 397 PF00069 0.339
MOD_CK2_1 428 434 PF00069 0.444
MOD_CK2_1 440 446 PF00069 0.386
MOD_CK2_1 457 463 PF00069 0.507
MOD_CK2_1 479 485 PF00069 0.445
MOD_CK2_1 507 513 PF00069 0.495
MOD_Cter_Amidation 175 178 PF01082 0.521
MOD_Cter_Amidation 300 303 PF01082 0.506
MOD_DYRK1A_RPxSP_1 400 404 PF00069 0.384
MOD_GlcNHglycan 166 169 PF01048 0.536
MOD_GlcNHglycan 379 382 PF01048 0.461
MOD_GlcNHglycan 437 440 PF01048 0.527
MOD_GlcNHglycan 603 606 PF01048 0.683
MOD_GSK3_1 102 109 PF00069 0.499
MOD_GSK3_1 180 187 PF00069 0.425
MOD_GSK3_1 207 214 PF00069 0.413
MOD_GSK3_1 332 339 PF00069 0.290
MOD_GSK3_1 392 399 PF00069 0.443
MOD_GSK3_1 400 407 PF00069 0.517
MOD_GSK3_1 415 422 PF00069 0.485
MOD_GSK3_1 434 441 PF00069 0.295
MOD_GSK3_1 476 483 PF00069 0.447
MOD_GSK3_1 533 540 PF00069 0.310
MOD_GSK3_1 54 61 PF00069 0.444
MOD_GSK3_1 76 83 PF00069 0.404
MOD_GSK3_1 84 91 PF00069 0.338
MOD_N-GLC_1 480 485 PF02516 0.555
MOD_NEK2_1 1 6 PF00069 0.673
MOD_NEK2_1 193 198 PF00069 0.408
MOD_NEK2_1 236 241 PF00069 0.359
MOD_NEK2_1 27 32 PF00069 0.366
MOD_NEK2_1 308 313 PF00069 0.342
MOD_NEK2_1 391 396 PF00069 0.411
MOD_NEK2_1 408 413 PF00069 0.530
MOD_NEK2_1 427 432 PF00069 0.330
MOD_NEK2_1 440 445 PF00069 0.352
MOD_NEK2_1 457 462 PF00069 0.448
MOD_NEK2_1 476 481 PF00069 0.381
MOD_NEK2_1 515 520 PF00069 0.342
MOD_NEK2_1 84 89 PF00069 0.364
MOD_PIKK_1 182 188 PF00454 0.344
MOD_PIKK_1 246 252 PF00454 0.394
MOD_PIKK_1 469 475 PF00454 0.412
MOD_PIKK_1 58 64 PF00454 0.470
MOD_PKA_1 428 434 PF00069 0.335
MOD_PKA_2 133 139 PF00069 0.339
MOD_PKA_2 164 170 PF00069 0.250
MOD_PKA_2 262 268 PF00069 0.453
MOD_PKA_2 272 278 PF00069 0.480
MOD_PKA_2 392 398 PF00069 0.428
MOD_PKA_2 427 433 PF00069 0.366
MOD_PKA_2 479 485 PF00069 0.438
MOD_PKA_2 501 507 PF00069 0.503
MOD_PKA_2 76 82 PF00069 0.427
MOD_Plk_1 308 314 PF00069 0.389
MOD_Plk_1 480 486 PF00069 0.351
MOD_Plk_1 537 543 PF00069 0.372
MOD_Plk_1 568 574 PF00069 0.280
MOD_Plk_1 80 86 PF00069 0.355
MOD_Plk_4 193 199 PF00069 0.272
MOD_Plk_4 27 33 PF00069 0.396
MOD_Plk_4 311 317 PF00069 0.320
MOD_Plk_4 332 338 PF00069 0.257
MOD_Plk_4 428 434 PF00069 0.395
MOD_Plk_4 80 86 PF00069 0.330
MOD_ProDKin_1 211 217 PF00069 0.476
MOD_ProDKin_1 319 325 PF00069 0.430
MOD_ProDKin_1 336 342 PF00069 0.355
MOD_ProDKin_1 400 406 PF00069 0.540
MOD_ProDKin_1 413 419 PF00069 0.527
MOD_SUMO_rev_2 136 146 PF00179 0.389
MOD_SUMO_rev_2 275 285 PF00179 0.288
MOD_SUMO_rev_2 50 59 PF00179 0.349
TRG_DiLeu_BaEn_2 373 379 PF01217 0.338
TRG_DiLeu_BaLyEn_6 360 365 PF01217 0.344
TRG_DiLeu_BaLyEn_6 530 535 PF01217 0.400
TRG_ENDOCYTIC_2 120 123 PF00928 0.325
TRG_ENDOCYTIC_2 143 146 PF00928 0.327
TRG_ENDOCYTIC_2 152 155 PF00928 0.287
TRG_ENDOCYTIC_2 585 588 PF00928 0.504
TRG_ENDOCYTIC_2 633 636 PF00928 0.612
TRG_ER_diArg_1 190 192 PF00400 0.375
TRG_ER_diArg_1 270 273 PF00400 0.408
TRG_ER_diArg_1 290 293 PF00400 0.243
TRG_ER_diArg_1 361 364 PF00400 0.328
TRG_ER_diArg_1 427 429 PF00400 0.403
TRG_ER_diArg_1 517 520 PF00400 0.367
TRG_ER_diArg_1 590 592 PF00400 0.458
TRG_ER_diLys_1 648 652 PF00400 0.625
TRG_NLS_MonoExtC_3 368 374 PF00514 0.287
TRG_NLS_MonoExtN_4 586 593 PF00514 0.449
TRG_Pf-PMV_PEXEL_1 144 148 PF00026 0.530
TRG_Pf-PMV_PEXEL_1 639 643 PF00026 0.298

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1M6 Leptomonas seymouri 59% 100%
A0A0S4JKY7 Bodo saltans 27% 100%
A0A1X0P7Z9 Trypanosomatidae 27% 100%
A0A3S5H7G3 Leishmania donovani 88% 100%
A4HF04 Leishmania braziliensis 77% 100%
A4I283 Leishmania infantum 88% 100%
C9ZZS6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
Q4Q945 Leishmania major 87% 100%
Q4QDT9 Leishmania major 24% 100%
V5B6M4 Trypanosoma cruzi 25% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS